Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7S0_LEIMA

TriTrypDb:

LmjF.30.0390 , LMJLV39_300009300 , LMJSD75_300009100

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q7S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.740
CLV_C14_Caspase3-7	61	65	PF00656	0.501
CLV_NRD_NRD_1	230	232	PF00675	0.504
CLV_NRD_NRD_1	242	244	PF00675	0.539
CLV_NRD_NRD_1	246	248	PF00675	0.576
CLV_PCSK_KEX2_1	230	232	PF00082	0.504
CLV_PCSK_KEX2_1	242	244	PF00082	0.539
CLV_PCSK_SKI1_1	16	20	PF00082	0.474
DEG_Kelch_Keap1_1	145	150	PF01344	0.745
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SCF_FBW7_1	215	222	PF00400	0.749
DEG_SCF_TRCP1_1	68	74	PF00400	0.546
DOC_CKS1_1	161	166	PF01111	0.756
DOC_MAPK_gen_1	230	238	PF00069	0.646
DOC_MAPK_MEF2A_6	11	19	PF00069	0.658
DOC_MAPK_MEF2A_6	95	103	PF00069	0.375
DOC_PP2B_LxvP_1	211	214	PF13499	0.722
DOC_PP4_FxxP_1	212	215	PF00568	0.763
DOC_PP4_MxPP_1	169	172	PF00568	0.720
DOC_USP7_MATH_1	30	34	PF00917	0.346
DOC_USP7_MATH_1	45	49	PF00917	0.473
DOC_WW_Pin1_4	160	165	PF00397	0.784
DOC_WW_Pin1_4	2	7	PF00397	0.673
DOC_WW_Pin1_4	215	220	PF00397	0.790
DOC_WW_Pin1_4	71	76	PF00397	0.613
LIG_14-3-3_CanoR_1	235	239	PF00244	0.804
LIG_Actin_WH2_2	6	22	PF00022	0.656
LIG_BRCT_BRCA1_1	206	210	PF00533	0.742
LIG_DCNL_PONY_1	1	4	PF03556	0.681
LIG_deltaCOP1_diTrp_1	87	96	PF00928	0.485
LIG_FHA_1	132	138	PF00498	0.796
LIG_FHA_1	177	183	PF00498	0.737
LIG_FHA_2	126	132	PF00498	0.767
LIG_LIR_Apic_2	209	215	PF02991	0.766
LIG_LIR_Gen_1	207	215	PF02991	0.762
LIG_LIR_Gen_1	87	97	PF02991	0.460
LIG_LIR_Nem_3	122	126	PF02991	0.710
LIG_LIR_Nem_3	207	213	PF02991	0.765
LIG_LIR_Nem_3	87	92	PF02991	0.516
LIG_LIR_Nem_3	93	99	PF02991	0.357
LIG_NRP_CendR_1	247	250	PF00754	0.534
LIG_Pex14_2	96	100	PF04695	0.521
LIG_SH2_PTP2	161	164	PF00017	0.690
LIG_SH2_STAT5	119	122	PF00017	0.699
LIG_SH2_STAT5	161	164	PF00017	0.690
LIG_SH3_1	167	173	PF00018	0.706
LIG_SH3_3	167	173	PF00018	0.706
LIG_SH3_3	72	78	PF00018	0.585
LIG_SUMO_SIM_par_1	33	38	PF11976	0.470
LIG_TRAF2_1	183	186	PF00917	0.738
LIG_UBA3_1	12	16	PF00899	0.638
MOD_CDK_SPK_2	160	165	PF00069	0.757
MOD_CDK_SPxxK_3	160	167	PF00069	0.754
MOD_CK1_1	129	135	PF00069	0.783
MOD_CK1_1	136	142	PF00069	0.731
MOD_CK1_1	143	149	PF00069	0.668
MOD_CK1_1	151	157	PF00069	0.655
MOD_CK1_1	204	210	PF00069	0.802
MOD_CK1_1	234	240	PF00069	0.773
MOD_CK1_1	38	44	PF00069	0.551
MOD_CK1_1	47	53	PF00069	0.487
MOD_CK1_1	5	11	PF00069	0.630
MOD_CK1_1	58	64	PF00069	0.388
MOD_CK1_1	66	72	PF00069	0.449
MOD_CK1_1	76	82	PF00069	0.487
MOD_CK2_1	129	135	PF00069	0.783
MOD_CK2_1	144	150	PF00069	0.659
MOD_GlcNHglycan	112	115	PF01048	0.328
MOD_GlcNHglycan	147	150	PF01048	0.612
MOD_GlcNHglycan	37	40	PF01048	0.733
MOD_GlcNHglycan	47	50	PF01048	0.657
MOD_GlcNHglycan	55	58	PF01048	0.602
MOD_GlcNHglycan	60	63	PF01048	0.665
MOD_GlcNHglycan	68	71	PF01048	0.669
MOD_GSK3_1	125	132	PF00069	0.764
MOD_GSK3_1	135	142	PF00069	0.701
MOD_GSK3_1	144	151	PF00069	0.619
MOD_GSK3_1	201	208	PF00069	0.800
MOD_GSK3_1	215	222	PF00069	0.687
MOD_GSK3_1	234	241	PF00069	0.780
MOD_GSK3_1	35	42	PF00069	0.670
MOD_GSK3_1	44	51	PF00069	0.469
MOD_N-GLC_1	204	209	PF02516	0.586
MOD_N-GLC_1	90	95	PF02516	0.684
MOD_NEK2_1	229	234	PF00069	0.736
MOD_NEK2_1	238	243	PF00069	0.798
MOD_PIKK_1	140	146	PF00454	0.766
MOD_PKA_2	229	235	PF00069	0.752
MOD_Plk_1	176	182	PF00069	0.646
MOD_Plk_1	63	69	PF00069	0.518
MOD_Plk_1	90	96	PF00069	0.483
MOD_Plk_2-3	152	158	PF00069	0.739
MOD_Plk_4	30	36	PF00069	0.310
MOD_ProDKin_1	160	166	PF00069	0.783
MOD_ProDKin_1	2	8	PF00069	0.666
MOD_ProDKin_1	215	221	PF00069	0.793
MOD_ProDKin_1	71	77	PF00069	0.612
TRG_DiLeu_BaEn_2	205	211	PF01217	0.742
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.667
TRG_ENDOCYTIC_2	123	126	PF00928	0.754
TRG_ER_diArg_1	164	167	PF00400	0.794
TRG_ER_diArg_1	229	231	PF00400	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X330	Leishmania donovani	84%	100%
A4HHY6	Leishmania braziliensis	55%	100%
A4I566	Leishmania infantum	84%	100%
E9B0G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%