Hydrolase_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4Q7R9_LEIMA

TriTrypDb:

LmjF.30.0400 , LMJLV39_300009400 , LMJSD75_300009200

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.413
CLV_C14_Caspase3-7	16	20	PF00656	0.554
CLV_C14_Caspase3-7	231	235	PF00656	0.434
CLV_C14_Caspase3-7	3	7	PF00656	0.650
CLV_NRD_NRD_1	218	220	PF00675	0.390
CLV_NRD_NRD_1	79	81	PF00675	0.419
CLV_PCSK_KEX2_1	220	222	PF00082	0.479
CLV_PCSK_KEX2_1	224	226	PF00082	0.411
CLV_PCSK_KEX2_1	79	81	PF00082	0.419
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.479
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.411
CLV_PCSK_SKI1_1	221	225	PF00082	0.417
CLV_PCSK_SKI1_1	237	241	PF00082	0.418
CLV_PCSK_SKI1_1	266	270	PF00082	0.509
CLV_PCSK_SKI1_1	295	299	PF00082	0.469
CLV_PCSK_SKI1_1	339	343	PF00082	0.647
DEG_APCC_DBOX_1	132	140	PF00400	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	392	396	PF00917	0.711
DOC_CKS1_1	276	281	PF01111	0.552
DOC_CYCLIN_RxL_1	310	323	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	356	359	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	402	408	PF00134	0.745
DOC_MAPK_DCC_7	201	211	PF00069	0.398
DOC_MAPK_DCC_7	240	249	PF00069	0.488
DOC_MAPK_gen_1	201	211	PF00069	0.449
DOC_MAPK_MEF2A_6	204	211	PF00069	0.398
DOC_MAPK_MEF2A_6	240	249	PF00069	0.488
DOC_MAPK_MEF2A_6	286	294	PF00069	0.527
DOC_MAPK_MEF2A_6	295	302	PF00069	0.454
DOC_MAPK_NFAT4_5	295	303	PF00069	0.443
DOC_PP1_RVXF_1	62	69	PF00149	0.496
DOC_PP2B_LxvP_1	356	359	PF13499	0.620
DOC_PP2B_LxvP_1	408	411	PF13499	0.580
DOC_PP2B_PxIxI_1	206	212	PF00149	0.398
DOC_PP4_FxxP_1	256	259	PF00568	0.395
DOC_PP4_FxxP_1	269	272	PF00568	0.426
DOC_USP7_MATH_1	183	187	PF00917	0.449
DOC_USP7_MATH_1	327	331	PF00917	0.675
DOC_USP7_MATH_1	343	347	PF00917	0.647
DOC_USP7_MATH_1	379	383	PF00917	0.762
DOC_USP7_MATH_1	384	388	PF00917	0.706
DOC_USP7_MATH_1	392	396	PF00917	0.784
DOC_USP7_UBL2_3	220	224	PF12436	0.404
DOC_WW_Pin1_4	179	184	PF00397	0.344
DOC_WW_Pin1_4	255	260	PF00397	0.544
DOC_WW_Pin1_4	275	280	PF00397	0.230
DOC_WW_Pin1_4	322	327	PF00397	0.621
DOC_WW_Pin1_4	339	344	PF00397	0.471
DOC_WW_Pin1_4	380	385	PF00397	0.756
DOC_WW_Pin1_4	401	406	PF00397	0.689
DOC_WW_Pin1_4	410	415	PF00397	0.568
LIG_14-3-3_CanoR_1	27	35	PF00244	0.549
LIG_14-3-3_CanoR_1	67	73	PF00244	0.414
LIG_AP2alpha_2	172	174	PF02296	0.437
LIG_BIR_III_2	267	271	PF00653	0.540
LIG_BRCT_BRCA1_1	126	130	PF00533	0.328
LIG_BRCT_BRCA1_1	245	249	PF00533	0.427
LIG_BRCT_BRCA1_1	394	398	PF00533	0.699
LIG_Clathr_ClatBox_1	110	114	PF01394	0.344
LIG_eIF4E_1	131	137	PF01652	0.475
LIG_FHA_1	200	206	PF00498	0.463
LIG_FHA_1	30	36	PF00498	0.486
LIG_FHA_1	367	373	PF00498	0.696
LIG_FHA_1	383	389	PF00498	0.759
LIG_FHA_2	394	400	PF00498	0.696
LIG_LIR_Apic_2	253	259	PF02991	0.408
LIG_LIR_Apic_2	267	272	PF02991	0.417
LIG_LIR_Apic_2	71	75	PF02991	0.320
LIG_LIR_Gen_1	106	115	PF02991	0.407
LIG_LIR_Gen_1	122	131	PF02991	0.273
LIG_LIR_Gen_1	141	150	PF02991	0.449
LIG_LIR_Gen_1	181	191	PF02991	0.328
LIG_LIR_Nem_3	106	111	PF02991	0.412
LIG_LIR_Nem_3	122	128	PF02991	0.273
LIG_LIR_Nem_3	141	145	PF02991	0.449
LIG_LIR_Nem_3	181	187	PF02991	0.328
LIG_LIR_Nem_3	71	76	PF02991	0.406
LIG_Pex14_1	72	76	PF04695	0.473
LIG_Pex14_2	111	115	PF04695	0.449
LIG_Pex14_2	68	72	PF04695	0.462
LIG_SH2_PTP2	125	128	PF00017	0.385
LIG_SH2_STAT3	131	134	PF00017	0.328
LIG_SH2_STAT5	125	128	PF00017	0.385
LIG_SH2_STAT5	301	304	PF00017	0.381
LIG_SH2_STAT5	86	89	PF00017	0.340
LIG_SH3_3	342	348	PF00018	0.734
LIG_SH3_3	408	414	PF00018	0.581
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.475
LIG_SUMO_SIM_par_1	135	141	PF11976	0.475
LIG_WRPW_2	73	76	PF00400	0.386
LIG_WW_3	27	31	PF00397	0.470
MOD_CDK_SPK_2	339	344	PF00069	0.533
MOD_CDK_SPxxK_3	410	417	PF00069	0.551
MOD_CK1_1	118	124	PF00069	0.323
MOD_CK1_1	13	19	PF00069	0.537
MOD_CK1_1	144	150	PF00069	0.242
MOD_CK1_1	373	379	PF00069	0.701
MOD_CK1_1	382	388	PF00069	0.690
MOD_CK1_1	391	397	PF00069	0.599
MOD_CK1_1	401	407	PF00069	0.592
MOD_CK2_1	118	124	PF00069	0.320
MOD_CK2_1	28	34	PF00069	0.540
MOD_GlcNHglycan	117	120	PF01048	0.330
MOD_GlcNHglycan	12	15	PF01048	0.509
MOD_GlcNHglycan	2	5	PF01048	0.577
MOD_GlcNHglycan	330	333	PF01048	0.594
MOD_GlcNHglycan	377	380	PF01048	0.753
MOD_GlcNHglycan	390	393	PF01048	0.665
MOD_GSK3_1	179	186	PF00069	0.377
MOD_GSK3_1	335	342	PF00069	0.581
MOD_GSK3_1	366	373	PF00069	0.688
MOD_GSK3_1	375	382	PF00069	0.648
MOD_GSK3_1	383	390	PF00069	0.613
MOD_GSK3_1	393	400	PF00069	0.494
MOD_GSK3_1	406	413	PF00069	0.548
MOD_GSK3_1	9	16	PF00069	0.590
MOD_NEK2_1	115	120	PF00069	0.369
MOD_NEK2_1	17	22	PF00069	0.417
MOD_NEK2_1	320	325	PF00069	0.604
MOD_NEK2_1	371	376	PF00069	0.727
MOD_NEK2_1	388	393	PF00069	0.685
MOD_NEK2_1	398	403	PF00069	0.741
MOD_NEK2_1	68	73	PF00069	0.410
MOD_NEK2_1	9	14	PF00069	0.678
MOD_NEK2_2	183	188	PF00069	0.344
MOD_PKA_2	29	35	PF00069	0.528
MOD_PKA_2	343	349	PF00069	0.662
MOD_Plk_1	398	404	PF00069	0.706
MOD_Plk_4	13	19	PF00069	0.627
MOD_Plk_4	162	168	PF00069	0.243
MOD_Plk_4	243	249	PF00069	0.369
MOD_Plk_4	68	74	PF00069	0.351
MOD_ProDKin_1	179	185	PF00069	0.344
MOD_ProDKin_1	255	261	PF00069	0.538
MOD_ProDKin_1	275	281	PF00069	0.230
MOD_ProDKin_1	322	328	PF00069	0.625
MOD_ProDKin_1	339	345	PF00069	0.474
MOD_ProDKin_1	380	386	PF00069	0.757
MOD_ProDKin_1	401	407	PF00069	0.686
MOD_ProDKin_1	410	416	PF00069	0.554
TRG_DiLeu_BaEn_1	132	137	PF01217	0.475
TRG_DiLeu_BaEn_1	99	104	PF01217	0.340
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.363
TRG_ENDOCYTIC_2	125	128	PF00928	0.409
TRG_ENDOCYTIC_2	95	98	PF00928	0.363
TRG_ER_diArg_1	218	221	PF00400	0.394
TRG_ER_diArg_1	79	81	PF00400	0.425
TRG_NES_CRM1_1	134	149	PF08389	0.449
TRG_NES_CRM1_1	288	304	PF08389	0.469
TRG_NES_CRM1_1	99	114	PF08389	0.344
TRG_NLS_MonoExtN_4	217	223	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ3	Leptomonas seymouri	75%	100%
A0A0S4JBE5	Bodo saltans	47%	97%
A0A1X0P2B9	Trypanosomatidae	61%	100%
A0A3S5H7M3	Leishmania donovani	92%	85%
A0A422NMM6	Trypanosoma rangeli	58%	100%
A4HHZ0	Leishmania braziliensis	78%	100%
A4I567	Leishmania infantum	93%	85%
C9ZQJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B0G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	88%
V5BCE0	Trypanosoma cruzi	54%	100%