Dolichyldiphosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl pyrophosphate phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q7R8_LEIMA

TriTrypDb:

LmjF.30.0405 , LMJLV39_300009500 , LMJSD75_300009300

Length:

272

Annotations

LeishMANIAdb annotations

Involved in N-glycan biogenesis, conserved eukaryotic protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q7R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R8

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	6
GO:0006487	protein N-linked glycosylation	5	6
GO:0006629	lipid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	6
GO:0030258	lipid modification	4	2
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043413	macromolecule glycosylation	3	6
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	9
GO:0044255	cellular lipid metabolic process	3	2
GO:0046839	phospholipid dephosphorylation	5	2
GO:0070085	glycosylation	2	6
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	2
GO:0042577	lipid phosphatase activity	6	2
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0047874	dolichyldiphosphatase activity	6	6
GO:0008195	phosphatidate phosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.264
CLV_NRD_NRD_1	173	175	PF00675	0.271
CLV_NRD_NRD_1	181	183	PF00675	0.154
CLV_NRD_NRD_1	99	101	PF00675	0.375
CLV_PCSK_FUR_1	165	169	PF00082	0.286
CLV_PCSK_FUR_1	97	101	PF00082	0.388
CLV_PCSK_KEX2_1	167	169	PF00082	0.303
CLV_PCSK_KEX2_1	173	175	PF00082	0.307
CLV_PCSK_KEX2_1	181	183	PF00082	0.154
CLV_PCSK_KEX2_1	99	101	PF00082	0.375
CLV_PCSK_SKI1_1	247	251	PF00082	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.414
DEG_SPOP_SBC_1	192	196	PF00917	0.486
DOC_CYCLIN_yClb5_NLxxxL_5	101	110	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.450
DOC_MAPK_gen_1	97	106	PF00069	0.537
DOC_MAPK_MEF2A_6	99	108	PF00069	0.502
DOC_PP1_RVXF_1	6	12	PF00149	0.417
DOC_USP7_MATH_1	134	138	PF00917	0.286
DOC_USP7_MATH_1	185	189	PF00917	0.514
DOC_USP7_MATH_1	190	194	PF00917	0.423
DOC_USP7_MATH_1	39	43	PF00917	0.544
DOC_USP7_MATH_1	75	79	PF00917	0.258
DOC_WW_Pin1_4	123	128	PF00397	0.296
DOC_WW_Pin1_4	193	198	PF00397	0.579
LIG_14-3-3_CanoR_1	247	252	PF00244	0.573
LIG_Actin_WH2_2	105	123	PF00022	0.464
LIG_BRCT_BRCA1_1	70	74	PF00533	0.344
LIG_DCNL_PONY_1	1	4	PF03556	0.347
LIG_EH1_1	73	81	PF00400	0.386
LIG_eIF4E_1	198	204	PF01652	0.464
LIG_eIF4E_1	64	70	PF01652	0.444
LIG_FHA_1	206	212	PF00498	0.368
LIG_FHA_1	240	246	PF00498	0.407
LIG_FHA_1	266	272	PF00498	0.542
LIG_FHA_1	4	10	PF00498	0.417
LIG_FHA_1	58	64	PF00498	0.433
LIG_FHA_2	38	44	PF00498	0.498
LIG_FHA_2	45	51	PF00498	0.431
LIG_LIR_Apic_2	139	145	PF02991	0.314
LIG_LYPXL_SIV_4	197	205	PF13949	0.514
LIG_NRBOX	199	205	PF00104	0.464
LIG_Pex14_2	151	155	PF04695	0.362
LIG_RPA_C_Fungi	27	39	PF08784	0.679
LIG_SH2_CRK	142	146	PF00017	0.405
LIG_SH2_CRK	220	224	PF00017	0.351
LIG_SH2_NCK_1	138	142	PF00017	0.386
LIG_SH2_NCK_1	198	202	PF00017	0.464
LIG_SH2_STAP1	138	142	PF00017	0.393
LIG_SH2_STAP1	198	202	PF00017	0.396
LIG_SH2_STAT5	109	112	PF00017	0.410
LIG_SH2_STAT5	13	16	PF00017	0.596
LIG_SH2_STAT5	138	141	PF00017	0.410
LIG_SH2_STAT5	158	161	PF00017	0.362
LIG_SH3_3	121	127	PF00018	0.379
LIG_SH3_3	253	259	PF00018	0.457
LIG_SUMO_SIM_par_1	202	208	PF11976	0.230
LIG_TYR_ITIM	107	112	PF00017	0.410
LIG_WRC_WIRS_1	263	268	PF05994	0.516
MOD_CDK_SPK_2	123	128	PF00069	0.362
MOD_CK1_1	137	143	PF00069	0.365
MOD_CK1_1	193	199	PF00069	0.443
MOD_CK1_1	42	48	PF00069	0.679
MOD_CK2_1	14	20	PF00069	0.596
MOD_CK2_1	37	43	PF00069	0.635
MOD_CK2_1	44	50	PF00069	0.558
MOD_CMANNOS	54	57	PF00535	0.506
MOD_Cter_Amidation	171	174	PF01082	0.304
MOD_GlcNHglycan	16	19	PF01048	0.596
MOD_GlcNHglycan	175	178	PF01048	0.435
MOD_GlcNHglycan	183	186	PF01048	0.405
MOD_GlcNHglycan	187	190	PF01048	0.449
MOD_GlcNHglycan	92	95	PF01048	0.423
MOD_GSK3_1	181	188	PF00069	0.445
MOD_GSK3_1	37	44	PF00069	0.698
MOD_NEK2_1	110	115	PF00069	0.410
MOD_NEK2_1	136	141	PF00069	0.328
MOD_NEK2_1	205	210	PF00069	0.245
MOD_NEK2_1	238	243	PF00069	0.404
MOD_NEK2_1	262	267	PF00069	0.504
MOD_NEK2_1	3	8	PF00069	0.605
MOD_NEK2_1	74	79	PF00069	0.362
MOD_NEK2_2	153	158	PF00069	0.426
MOD_PKA_1	173	179	PF00069	0.431
MOD_PKA_1	181	187	PF00069	0.219
MOD_PKA_2	173	179	PF00069	0.436
MOD_PKA_2	181	187	PF00069	0.257
MOD_Plk_1	42	48	PF00069	0.537
MOD_Plk_4	205	211	PF00069	0.374
MOD_Plk_4	262	268	PF00069	0.489
MOD_Plk_4	75	81	PF00069	0.328
MOD_ProDKin_1	123	129	PF00069	0.362
MOD_ProDKin_1	193	199	PF00069	0.478
TRG_DiLeu_BaEn_1	5	10	PF01217	0.531
TRG_ENDOCYTIC_2	109	112	PF00928	0.410
TRG_ENDOCYTIC_2	13	16	PF00928	0.596
TRG_ENDOCYTIC_2	220	223	PF00928	0.351
TRG_ER_diArg_1	165	168	PF00400	0.369
TRG_ER_diArg_1	99	101	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGH8	Leptomonas seymouri	54%	100%
A0A1X0P264	Trypanosomatidae	36%	100%
A0A3S7X373	Leishmania donovani	88%	100%
A0A422NMI8	Trypanosoma rangeli	35%	100%
A4HHZ1	Leishmania braziliensis	78%	100%
A4I568	Leishmania infantum	89%	100%
B0CM95	Papio anubis	31%	100%
B0KWE9	Callithrix jacchus	31%	100%
B1MTH4	Plecturocebus moloch	31%	100%
B2KI79	Rhinolophus ferrumequinum	31%	100%
C9ZQJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B0G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q86IX2	Dictyostelium discoideum	29%	100%
Q86YN1	Homo sapiens	31%	100%
Q9JMF7	Mus musculus	30%	100%