Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD-40 repeat protein

Species:

Leishmania major

UniProt:

Q4Q7R7_LEIMA

TriTrypDb:

LmjF.30.0410 , LMJLV39_300009600 , LMJSD75_300009400

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005840	ribosome	5	12
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	2
GO:0005849	mRNA cleavage factor complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10

Expansion

Sequence features

Q4Q7R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006378	mRNA polyadenylation	7	2
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.448
CLV_NRD_NRD_1	144	146	PF00675	0.328
CLV_NRD_NRD_1	185	187	PF00675	0.550
CLV_NRD_NRD_1	347	349	PF00675	0.538
CLV_NRD_NRD_1	40	42	PF00675	0.626
CLV_NRD_NRD_1	54	56	PF00675	0.482
CLV_NRD_NRD_1	8	10	PF00675	0.709
CLV_PCSK_KEX2_1	144	146	PF00082	0.328
CLV_PCSK_KEX2_1	185	187	PF00082	0.566
CLV_PCSK_KEX2_1	355	357	PF00082	0.515
CLV_PCSK_KEX2_1	39	41	PF00082	0.641
CLV_PCSK_KEX2_1	54	56	PF00082	0.486
CLV_PCSK_KEX2_1	7	9	PF00082	0.717
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.515
CLV_PCSK_PC7_1	3	9	PF00082	0.640
CLV_PCSK_SKI1_1	144	148	PF00082	0.309
CLV_PCSK_SKI1_1	331	335	PF00082	0.312
CLV_PCSK_SKI1_1	355	359	PF00082	0.493
CLV_PCSK_SKI1_1	71	75	PF00082	0.399
DEG_APCC_DBOX_1	130	138	PF00400	0.353
DEG_APCC_DBOX_1	70	78	PF00400	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DOC_ANK_TNKS_1	324	331	PF00023	0.519
DOC_CKS1_1	130	135	PF01111	0.494
DOC_MAPK_gen_1	185	191	PF00069	0.513
DOC_PP1_RVXF_1	177	184	PF00149	0.315
DOC_PP1_RVXF_1	218	225	PF00149	0.318
DOC_PP1_RVXF_1	364	370	PF00149	0.322
DOC_PP1_RVXF_1	59	66	PF00149	0.430
DOC_PP4_FxxP_1	65	68	PF00568	0.507
DOC_USP7_MATH_1	255	259	PF00917	0.660
DOC_USP7_MATH_1	290	294	PF00917	0.440
DOC_USP7_MATH_1	371	375	PF00917	0.446
DOC_USP7_MATH_1	382	386	PF00917	0.288
DOC_USP7_UBL2_3	418	422	PF12436	0.578
DOC_WW_Pin1_4	129	134	PF00397	0.516
DOC_WW_Pin1_4	137	142	PF00397	0.464
DOC_WW_Pin1_4	429	434	PF00397	0.449
DOC_WW_Pin1_4	64	69	PF00397	0.456
DOC_WW_Pin1_4	79	84	PF00397	0.373
LIG_14-3-3_CanoR_1	145	155	PF00244	0.305
LIG_14-3-3_CanoR_1	348	352	PF00244	0.551
LIG_14-3-3_CanoR_1	40	48	PF00244	0.670
LIG_BRCT_BRCA1_1	373	377	PF00533	0.486
LIG_CSL_BTD_1	201	204	PF09270	0.370
LIG_CSL_BTD_1	430	433	PF09270	0.459
LIG_deltaCOP1_diTrp_1	221	231	PF00928	0.337
LIG_eIF4E_1	93	99	PF01652	0.461
LIG_FHA_1	112	118	PF00498	0.216
LIG_FHA_1	243	249	PF00498	0.377
LIG_FHA_1	339	345	PF00498	0.496
LIG_FHA_1	359	365	PF00498	0.514
LIG_FHA_1	397	403	PF00498	0.672
LIG_FHA_1	73	79	PF00498	0.415
LIG_FHA_1	93	99	PF00498	0.238
LIG_FHA_2	348	354	PF00498	0.535
LIG_FHA_2	370	376	PF00498	0.493
LIG_FHA_2	378	384	PF00498	0.446
LIG_LIR_Apic_2	64	68	PF02991	0.516
LIG_LIR_Gen_1	154	163	PF02991	0.302
LIG_LIR_Nem_3	154	158	PF02991	0.282
LIG_LIR_Nem_3	221	227	PF02991	0.458
LIG_LIR_Nem_3	279	285	PF02991	0.416
LIG_LIR_Nem_3	385	391	PF02991	0.363
LIG_PDZ_Class_2	471	476	PF00595	0.525
LIG_Pex14_1	202	206	PF04695	0.339
LIG_Pex14_2	42	46	PF04695	0.688
LIG_PTB_Apo_2	202	209	PF02174	0.488
LIG_SH2_CRK	285	289	PF00017	0.460
LIG_SH2_STAP1	135	139	PF00017	0.388
LIG_SH2_STAP1	84	88	PF00017	0.514
LIG_SH2_STAP1	94	98	PF00017	0.346
LIG_SH2_STAT3	135	138	PF00017	0.461
LIG_SH2_STAT5	94	97	PF00017	0.447
LIG_TRAF2_1	455	458	PF00917	0.510
LIG_TYR_ITIM	386	391	PF00017	0.342
MOD_CDK_SPxxK_3	137	144	PF00069	0.454
MOD_CDK_SPxxK_3	64	71	PF00069	0.399
MOD_CK1_1	27	33	PF00069	0.689
MOD_CK1_1	293	299	PF00069	0.352
MOD_CK1_1	307	313	PF00069	0.397
MOD_CK2_1	347	353	PF00069	0.540
MOD_CK2_1	438	444	PF00069	0.397
MOD_Cter_Amidation	142	145	PF01082	0.352
MOD_Cter_Amidation	183	186	PF01082	0.499
MOD_GlcNHglycan	141	144	PF01048	0.483
MOD_GlcNHglycan	191	194	PF01048	0.321
MOD_GlcNHglycan	237	241	PF01048	0.352
MOD_GlcNHglycan	26	29	PF01048	0.736
MOD_GlcNHglycan	334	337	PF01048	0.262
MOD_GlcNHglycan	440	443	PF01048	0.291
MOD_GSK3_1	107	114	PF00069	0.296
MOD_GSK3_1	207	214	PF00069	0.404
MOD_GSK3_1	251	258	PF00069	0.618
MOD_GSK3_1	315	322	PF00069	0.357
MOD_GSK3_1	334	341	PF00069	0.145
MOD_GSK3_1	78	85	PF00069	0.581
MOD_GSK3_1	97	104	PF00069	0.275
MOD_N-GLC_1	106	111	PF02516	0.432
MOD_N-GLC_1	117	122	PF02516	0.301
MOD_NEK2_1	146	151	PF00069	0.277
MOD_NEK2_1	288	293	PF00069	0.256
MOD_NEK2_1	376	381	PF00069	0.301
MOD_NEK2_1	438	443	PF00069	0.311
MOD_PIKK_1	111	117	PF00454	0.332
MOD_PIKK_1	290	296	PF00454	0.253
MOD_PIKK_1	315	321	PF00454	0.347
MOD_PIKK_1	347	353	PF00454	0.540
MOD_PKA_1	355	361	PF00069	0.527
MOD_PKA_2	307	313	PF00069	0.399
MOD_PKA_2	347	353	PF00069	0.540
MOD_PKA_2	355	361	PF00069	0.527
MOD_PKB_1	39	47	PF00069	0.692
MOD_Plk_1	117	123	PF00069	0.354
MOD_Plk_1	220	226	PF00069	0.327
MOD_Plk_4	382	388	PF00069	0.324
MOD_ProDKin_1	129	135	PF00069	0.510
MOD_ProDKin_1	137	143	PF00069	0.465
MOD_ProDKin_1	429	435	PF00069	0.300
MOD_ProDKin_1	64	70	PF00069	0.457
MOD_ProDKin_1	79	85	PF00069	0.370
MOD_SUMO_for_1	268	271	PF00179	0.382
MOD_SUMO_rev_2	162	170	PF00179	0.384
MOD_SUMO_rev_2	223	231	PF00179	0.421
MOD_SUMO_rev_2	266	270	PF00179	0.375
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.328
TRG_ENDOCYTIC_2	285	288	PF00928	0.314
TRG_ENDOCYTIC_2	388	391	PF00928	0.357
TRG_ER_diArg_1	144	146	PF00400	0.339
TRG_ER_diArg_1	38	41	PF00400	0.589
TRG_ER_diArg_1	53	55	PF00400	0.500
TRG_ER_diArg_1	6	9	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	22%	91%
A0A0N1PBX5	Leptomonas seymouri	89%	99%
A0A0S4J5T5	Bodo saltans	27%	88%
A0A0S4JFE0	Bodo saltans	56%	100%
A0A0S4KJ87	Bodo saltans	25%	79%
A0A1X0P2X5	Trypanosomatidae	64%	100%
A0A3Q8IE21	Leishmania donovani	97%	98%
A0A3Q8IGC4	Leishmania donovani	24%	91%
A0A3R7N6M9	Trypanosoma rangeli	23%	91%
A0A3R7NRU0	Trypanosoma rangeli	63%	100%
A4HHZ2	Leishmania braziliensis	93%	99%
A4I135	Leishmania infantum	24%	91%
A4I569	Leishmania infantum	99%	99%
B5X212	Salmo salar	22%	100%
B5X9P2	Salmo salar	21%	100%
B7FNU7	Phaeodactylum tricornutum (strain CCAP 1055/1)	25%	100%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	77%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	91%
E9B0G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	98%
O60907	Homo sapiens	21%	82%
O76071	Homo sapiens	23%	100%
P0CS46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	67%
P0CS47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	67%
P42841	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P49177	Arabidopsis thaliana	25%	100%
P49178	Zea mays	23%	100%
Q28DW0	Xenopus tropicalis	24%	100%
Q28I85	Xenopus tropicalis	24%	100%
Q2TZG4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	78%
Q32PJ6	Bos taurus	22%	100%
Q4I7X1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	78%
Q4QAA4	Leishmania major	24%	91%
Q4R8H1	Macaca fascicularis	21%	84%
Q4V8C4	Rattus norvegicus	22%	100%
Q4X1Y0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	93%
Q54KL5	Dictyostelium discoideum	23%	100%
Q55DA2	Dictyostelium discoideum	21%	100%
Q58D20	Bos taurus	24%	98%
Q59WJ4	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	88%
Q5AZX0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	84%
Q5DFU0	Schistosoma japonicum	24%	100%
Q5M7T1	Rattus norvegicus	22%	100%
Q5RD06	Pongo abelii	22%	100%
Q5RE95	Pongo abelii	22%	100%
Q5RFF8	Pongo abelii	24%	98%
Q6BVZ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	94%
Q6CGP9	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	89%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	100%
Q6NLV4	Arabidopsis thaliana	32%	74%
Q75AV4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7RY68	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	72%
Q7T0P4	Xenopus laevis	24%	100%
Q86VZ2	Homo sapiens	22%	100%
Q8VEJ4	Mus musculus	24%	98%
Q95RJ9	Drosophila melanogaster	25%	68%
Q99KN2	Mus musculus	23%	100%
Q9D7H2	Mus musculus	22%	100%
Q9FLX9	Arabidopsis thaliana	22%	100%
Q9FN19	Arabidopsis thaliana	22%	78%
Q9NVX2	Homo sapiens	24%	98%
Q9QXE7	Mus musculus	22%	90%
Q9UTN4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	94%
Q9V3J8	Drosophila melanogaster	24%	100%
V5BEB2	Trypanosoma cruzi	24%	88%
V5DD51	Trypanosoma cruzi	63%	100%