DAGKc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Diacylglycerol kinase catalytic domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7R6_LEIMA

TriTrypDb:

LmjF.30.0420 , LMJLV39_300009700 , LMJSD75_300009500

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R6

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006665	sphingolipid metabolic process	4	2
GO:0006670	sphingosine metabolic process	6	2
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	4
GO:0019751	polyol metabolic process	4	2
GO:0030148	sphingolipid biosynthetic process	5	2
GO:0034311	diol metabolic process	5	2
GO:0034312	diol biosynthetic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046165	alcohol biosynthetic process	4	2
GO:0046173	polyol biosynthetic process	5	2
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0046512	sphingosine biosynthetic process	5	2
GO:0046519	sphingoid metabolic process	5	2
GO:0046520	sphingoid biosynthetic process	6	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0001727	lipid kinase activity	5	2
GO:0003824	catalytic activity	1	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0003951	NAD+ kinase activity	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.504
CLV_NRD_NRD_1	257	259	PF00675	0.601
CLV_PCSK_KEX2_1	175	177	PF00082	0.461
CLV_PCSK_KEX2_1	257	259	PF00082	0.601
CLV_PCSK_KEX2_1	5	7	PF00082	0.536
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.536
CLV_PCSK_SKI1_1	258	262	PF00082	0.551
CLV_PCSK_SKI1_1	55	59	PF00082	0.399
CLV_PCSK_SKI1_1	6	10	PF00082	0.444
DEG_APCC_DBOX_1	137	145	PF00400	0.538
DEG_SCF_FBW7_1	249	254	PF00400	0.444
DEG_SPOP_SBC_1	81	85	PF00917	0.291
DOC_CDC14_PxL_1	99	107	PF14671	0.369
DOC_CYCLIN_RxL_1	52	61	PF00134	0.252
DOC_MAPK_gen_1	5	11	PF00069	0.408
DOC_PP1_RVXF_1	301	307	PF00149	0.524
DOC_PP2B_LxvP_1	105	108	PF13499	0.362
DOC_USP7_MATH_1	127	131	PF00917	0.337
DOC_USP7_MATH_1	225	229	PF00917	0.543
DOC_USP7_MATH_1	23	27	PF00917	0.252
DOC_USP7_MATH_1	307	311	PF00917	0.587
DOC_USP7_MATH_1	316	320	PF00917	0.671
DOC_USP7_MATH_1	322	326	PF00917	0.688
DOC_USP7_MATH_1	347	351	PF00917	0.561
DOC_USP7_MATH_1	81	85	PF00917	0.443
DOC_WW_Pin1_4	148	153	PF00397	0.571
DOC_WW_Pin1_4	247	252	PF00397	0.426
DOC_WW_Pin1_4	352	357	PF00397	0.434
LIG_14-3-3_CanoR_1	126	132	PF00244	0.344
LIG_14-3-3_CanoR_1	159	165	PF00244	0.341
LIG_14-3-3_CanoR_1	257	263	PF00244	0.532
LIG_14-3-3_CanoR_1	318	322	PF00244	0.713
LIG_14-3-3_CanoR_1	87	96	PF00244	0.393
LIG_Clathr_ClatBox_1	336	340	PF01394	0.464
LIG_FHA_1	134	140	PF00498	0.369
LIG_FHA_1	212	218	PF00498	0.478
LIG_FHA_1	318	324	PF00498	0.778
LIG_FHA_2	120	126	PF00498	0.485
LIG_FHA_2	202	208	PF00498	0.561
LIG_FHA_2	353	359	PF00498	0.504
LIG_GBD_Chelix_1	49	57	PF00786	0.408
LIG_LIR_Gen_1	185	194	PF02991	0.527
LIG_LIR_LC3C_4	129	133	PF02991	0.444
LIG_LIR_LC3C_4	334	339	PF02991	0.489
LIG_LIR_Nem_3	185	190	PF02991	0.476
LIG_LIR_Nem_3	305	309	PF02991	0.446
LIG_MYND_1	241	245	PF01753	0.572
LIG_RPA_C_Fungi	9	21	PF08784	0.408
LIG_SH2_PTP2	187	190	PF00017	0.470
LIG_SH2_STAP1	170	174	PF00017	0.408
LIG_SH2_STAT5	164	167	PF00017	0.352
LIG_SH2_STAT5	187	190	PF00017	0.516
LIG_SH2_STAT5	286	289	PF00017	0.523
LIG_SH2_STAT5	31	34	PF00017	0.380
LIG_SH3_3	134	140	PF00018	0.429
LIG_SH3_3	146	152	PF00018	0.573
LIG_SH3_3	185	191	PF00018	0.556
LIG_SH3_3	341	347	PF00018	0.558
LIG_SH3_3	39	45	PF00018	0.434
LIG_SH3_3	90	96	PF00018	0.408
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.471
LIG_SUMO_SIM_par_1	103	109	PF11976	0.422
LIG_SUMO_SIM_par_1	334	340	PF11976	0.532
LIG_TRAF2_1	294	297	PF00917	0.569
LIG_TRFH_1	247	251	PF08558	0.416
MOD_CK1_1	114	120	PF00069	0.293
MOD_CK1_1	350	356	PF00069	0.419
MOD_CK1_1	94	100	PF00069	0.489
MOD_CK2_1	119	125	PF00069	0.485
MOD_CK2_1	201	207	PF00069	0.550
MOD_CK2_1	291	297	PF00069	0.422
MOD_CK2_1	352	358	PF00069	0.464
MOD_CK2_1	94	100	PF00069	0.491
MOD_GlcNHglycan	14	17	PF01048	0.369
MOD_GlcNHglycan	152	155	PF01048	0.622
MOD_GlcNHglycan	333	336	PF01048	0.529
MOD_GlcNHglycan	73	76	PF01048	0.408
MOD_GlcNHglycan	84	87	PF01048	0.269
MOD_GSK3_1	111	118	PF00069	0.281
MOD_GSK3_1	160	167	PF00069	0.513
MOD_GSK3_1	211	218	PF00069	0.448
MOD_GSK3_1	221	228	PF00069	0.494
MOD_GSK3_1	247	254	PF00069	0.424
MOD_GSK3_1	263	270	PF00069	0.567
MOD_GSK3_1	348	355	PF00069	0.457
MOD_GSK3_1	87	94	PF00069	0.394
MOD_LATS_1	256	262	PF00433	0.581
MOD_N-GLC_1	12	17	PF02516	0.429
MOD_NEK2_1	111	116	PF00069	0.344
MOD_NEK2_1	119	124	PF00069	0.344
MOD_NEK2_1	235	240	PF00069	0.396
MOD_NEK2_1	24	29	PF00069	0.499
MOD_NEK2_1	260	265	PF00069	0.403
MOD_NEK2_1	82	87	PF00069	0.414
MOD_NEK2_2	170	175	PF00069	0.549
MOD_PIKK_1	235	241	PF00454	0.417
MOD_PIKK_1	317	323	PF00454	0.741
MOD_PKA_2	317	323	PF00069	0.762
MOD_Plk_1	211	217	PF00069	0.525
MOD_Plk_1	267	273	PF00069	0.473
MOD_Plk_1	357	363	PF00069	0.520
MOD_Plk_2-3	291	297	PF00069	0.361
MOD_Plk_4	127	133	PF00069	0.444
MOD_Plk_4	160	166	PF00069	0.354
MOD_Plk_4	94	100	PF00069	0.429
MOD_ProDKin_1	148	154	PF00069	0.576
MOD_ProDKin_1	247	253	PF00069	0.424
MOD_ProDKin_1	352	358	PF00069	0.444
TRG_DiLeu_BaEn_2	184	190	PF01217	0.475
TRG_DiLeu_BaEn_4	185	191	PF01217	0.407
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.558
TRG_DiLeu_LyEn_5	100	105	PF01217	0.485
TRG_ENDOCYTIC_2	187	190	PF00928	0.521
TRG_ER_diArg_1	174	176	PF00400	0.499
TRG_ER_diArg_1	271	274	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHE5	Leptomonas seymouri	57%	95%
A0A1X0P2A6	Trypanosomatidae	40%	100%
A0A3R7L399	Trypanosoma rangeli	37%	100%
A0A3S7X308	Leishmania donovani	91%	100%
A4HHZ3	Leishmania braziliensis	78%	100%
A4I570	Leishmania infantum	91%	100%
C9ZQJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B0G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%