Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

quiescin sulfhydryl oxidase, putative

Species:

Leishmania major

UniProt:

Q4Q7R5_LEIMA

TriTrypDb:

LmjF.30.0430 , LMJLV39_300009800 , LMJSD75_300009600

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005615	extracellular space	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	9

Expansion

Sequence features

Q4Q7R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	2
GO:0003824	catalytic activity	1	11
GO:0015035	protein-disulfide reductase activity	3	11
GO:0015036	disulfide oxidoreductase activity	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	11
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	11
GO:0016853	isomerase activity	2	2
GO:0016860	intramolecular oxidoreductase activity	3	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	2
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	11
GO:0016972	thiol oxidase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.650
CLV_NRD_NRD_1	194	196	PF00675	0.629
CLV_NRD_NRD_1	265	267	PF00675	0.598
CLV_NRD_NRD_1	418	420	PF00675	0.537
CLV_NRD_NRD_1	489	491	PF00675	0.665
CLV_NRD_NRD_1	532	534	PF00675	0.418
CLV_NRD_NRD_1	542	544	PF00675	0.443
CLV_PCSK_KEX2_1	264	266	PF00082	0.609
CLV_PCSK_KEX2_1	418	420	PF00082	0.562
CLV_PCSK_KEX2_1	433	435	PF00082	0.564
CLV_PCSK_KEX2_1	491	493	PF00082	0.795
CLV_PCSK_KEX2_1	532	534	PF00082	0.409
CLV_PCSK_KEX2_1	540	542	PF00082	0.462
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.564
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.740
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.550
CLV_PCSK_SKI1_1	146	150	PF00082	0.598
CLV_PCSK_SKI1_1	265	269	PF00082	0.533
CLV_PCSK_SKI1_1	316	320	PF00082	0.594
CLV_PCSK_SKI1_1	33	37	PF00082	0.577
CLV_PCSK_SKI1_1	383	387	PF00082	0.506
CLV_PCSK_SKI1_1	433	437	PF00082	0.642
CLV_PCSK_SKI1_1	543	547	PF00082	0.572
DOC_CYCLIN_RxL_1	143	150	PF00134	0.384
DOC_CYCLIN_RxL_1	193	204	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.449
DOC_MAPK_FxFP_2	126	129	PF00069	0.353
DOC_MAPK_gen_1	540	548	PF00069	0.744
DOC_MAPK_MEF2A_6	195	202	PF00069	0.401
DOC_MAPK_MEF2A_6	540	548	PF00069	0.724
DOC_MAPK_NFAT4_5	195	203	PF00069	0.263
DOC_PP1_RVXF_1	328	335	PF00149	0.372
DOC_PP2B_PxIxI_1	60	66	PF00149	0.395
DOC_PP4_FxxP_1	126	129	PF00568	0.280
DOC_USP7_MATH_1	224	228	PF00917	0.438
DOC_USP7_MATH_1	300	304	PF00917	0.506
DOC_USP7_UBL2_3	51	55	PF12436	0.278
LIG_14-3-3_CanoR_1	117	122	PF00244	0.367
LIG_14-3-3_CanoR_1	330	335	PF00244	0.390
LIG_14-3-3_CanoR_1	418	424	PF00244	0.330
LIG_14-3-3_CanoR_1	75	79	PF00244	0.334
LIG_AP2alpha_1	36	40	PF02296	0.403
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	122	126	PF00533	0.353
LIG_Clathr_ClatBox_1	507	511	PF01394	0.422
LIG_EH1_1	512	520	PF00400	0.386
LIG_FHA_1	160	166	PF00498	0.377
LIG_FHA_1	234	240	PF00498	0.347
LIG_FHA_1	370	376	PF00498	0.396
LIG_FHA_1	391	397	PF00498	0.372
LIG_FHA_1	480	486	PF00498	0.580
LIG_FHA_1	510	516	PF00498	0.311
LIG_FHA_2	135	141	PF00498	0.396
LIG_FHA_2	192	198	PF00498	0.449
LIG_FHA_2	449	455	PF00498	0.439
LIG_FHA_2	64	70	PF00498	0.302
LIG_FHA_2	86	92	PF00498	0.320
LIG_LIR_Apic_2	123	129	PF02991	0.353
LIG_LIR_Gen_1	234	245	PF02991	0.368
LIG_LIR_Gen_1	248	259	PF02991	0.303
LIG_LIR_Gen_1	312	321	PF02991	0.410
LIG_LIR_Gen_1	373	382	PF02991	0.347
LIG_LIR_Gen_1	38	48	PF02991	0.396
LIG_LIR_Gen_1	393	400	PF02991	0.328
LIG_LIR_Gen_1	511	521	PF02991	0.292
LIG_LIR_Gen_1	59	68	PF02991	0.288
LIG_LIR_Nem_3	123	128	PF02991	0.362
LIG_LIR_Nem_3	234	240	PF02991	0.383
LIG_LIR_Nem_3	248	254	PF02991	0.295
LIG_LIR_Nem_3	312	317	PF02991	0.412
LIG_LIR_Nem_3	341	347	PF02991	0.323
LIG_LIR_Nem_3	373	379	PF02991	0.369
LIG_LIR_Nem_3	38	43	PF02991	0.411
LIG_LIR_Nem_3	393	398	PF02991	0.334
LIG_LIR_Nem_3	511	516	PF02991	0.292
LIG_LIR_Nem_3	59	65	PF02991	0.288
LIG_MLH1_MIPbox_1	122	126	PF16413	0.330
LIG_Pex14_2	124	128	PF04695	0.330
LIG_Pex14_2	247	251	PF04695	0.335
LIG_Pex14_2	36	40	PF04695	0.410
LIG_PTB_Apo_2	241	248	PF02174	0.364
LIG_SH2_CRK	355	359	PF00017	0.313
LIG_SH2_CRK	504	508	PF00017	0.512
LIG_SH2_STAP1	289	293	PF00017	0.445
LIG_SH2_STAP1	381	385	PF00017	0.386
LIG_SH2_STAT5	125	128	PF00017	0.391
LIG_SH2_STAT5	205	208	PF00017	0.394
LIG_SH2_STAT5	21	24	PF00017	0.675
LIG_SH2_STAT5	466	469	PF00017	0.384
LIG_SH2_STAT5	529	532	PF00017	0.634
LIG_SH2_STAT5	67	70	PF00017	0.330
LIG_SH3_1	541	547	PF00018	0.736
LIG_SH3_2	429	434	PF14604	0.354
LIG_SH3_2	544	549	PF14604	0.763
LIG_SH3_3	116	122	PF00018	0.383
LIG_SH3_3	426	432	PF00018	0.345
LIG_SH3_3	541	547	PF00018	0.736
LIG_SUMO_SIM_anti_2	511	518	PF11976	0.368
LIG_SUMO_SIM_par_1	117	123	PF11976	0.219
LIG_SUMO_SIM_par_1	41	47	PF11976	0.373
LIG_TRFH_1	125	129	PF08558	0.362
LIG_TYR_ITIM	353	358	PF00017	0.313
LIG_WRC_WIRS_1	121	126	PF05994	0.353
LIG_WRC_WIRS_1	510	515	PF05994	0.384
MOD_CK1_1	120	126	PF00069	0.351
MOD_CK1_1	209	215	PF00069	0.412
MOD_CK1_1	333	339	PF00069	0.381
MOD_CK1_1	448	454	PF00069	0.430
MOD_CK1_1	506	512	PF00069	0.436
MOD_CK1_1	56	62	PF00069	0.399
MOD_CK2_1	134	140	PF00069	0.420
MOD_CK2_1	191	197	PF00069	0.395
MOD_CK2_1	419	425	PF00069	0.473
MOD_CK2_1	448	454	PF00069	0.455
MOD_CK2_1	46	52	PF00069	0.377
MOD_GlcNHglycan	260	263	PF01048	0.638
MOD_GlcNHglycan	319	322	PF01048	0.587
MOD_GlcNHglycan	536	539	PF01048	0.499
MOD_GlcNHglycan	55	58	PF01048	0.541
MOD_GlcNHglycan	76	79	PF01048	0.561
MOD_GlcNHglycan	90	94	PF01048	0.397
MOD_GSK3_1	27	34	PF00069	0.588
MOD_GSK3_1	289	296	PF00069	0.366
MOD_GSK3_1	333	340	PF00069	0.327
MOD_GSK3_1	479	486	PF00069	0.516
MOD_GSK3_1	63	70	PF00069	0.393
MOD_GSK3_1	85	92	PF00069	0.362
MOD_N-GLC_1	134	139	PF02516	0.633
MOD_N-GLC_1	293	298	PF02516	0.591
MOD_N-GLC_1	369	374	PF02516	0.502
MOD_NEK2_1	184	189	PF00069	0.411
MOD_NEK2_1	246	251	PF00069	0.326
MOD_NEK2_1	287	292	PF00069	0.418
MOD_NEK2_1	29	34	PF00069	0.471
MOD_NEK2_1	317	322	PF00069	0.345
MOD_NEK2_1	354	359	PF00069	0.297
MOD_NEK2_1	53	58	PF00069	0.369
MOD_PK_1	117	123	PF00069	0.219
MOD_PK_1	490	496	PF00069	0.587
MOD_PKA_1	490	496	PF00069	0.427
MOD_PKA_2	206	212	PF00069	0.328
MOD_PKA_2	74	80	PF00069	0.343
MOD_Plk_1	106	112	PF00069	0.360
MOD_Plk_1	134	140	PF00069	0.481
MOD_Plk_1	232	238	PF00069	0.401
MOD_Plk_1	293	299	PF00069	0.463
MOD_Plk_1	97	103	PF00069	0.360
MOD_Plk_4	120	126	PF00069	0.362
MOD_Plk_4	246	252	PF00069	0.319
MOD_Plk_4	503	509	PF00069	0.455
MOD_Plk_4	63	69	PF00069	0.393
MOD_SUMO_rev_2	150	159	PF00179	0.508
TRG_AP2beta_CARGO_1	373	383	PF09066	0.386
TRG_DiLeu_BaEn_2	453	459	PF01217	0.422
TRG_ENDOCYTIC_2	125	128	PF00928	0.386
TRG_ENDOCYTIC_2	344	347	PF00928	0.325
TRG_ENDOCYTIC_2	355	358	PF00928	0.243
TRG_ENDOCYTIC_2	504	507	PF00928	0.522
TRG_ER_diArg_1	264	266	PF00400	0.405
TRG_ER_diArg_1	418	420	PF00400	0.362
TRG_ER_diArg_1	467	470	PF00400	0.341
TRG_ER_diArg_1	531	533	PF00400	0.592
TRG_ER_diArg_1	541	543	PF00400	0.658
TRG_ER_diArg_1	548	551	PF00400	0.734
TRG_NLS_MonoCore_2	539	544	PF00514	0.753
TRG_NLS_MonoExtC_3	539	544	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H4	Leptomonas seymouri	45%	95%
A0A0S4ILW1	Bodo saltans	29%	71%
A0A1X0P2E7	Trypanosomatidae	40%	100%
A0A3S7X306	Leishmania donovani	90%	99%
A0A422NMK4	Trypanosoma rangeli	37%	100%
A4HHZ4	Leishmania braziliensis	68%	100%
A4I571	Leishmania infantum	90%	99%
C9ZQJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%