RRF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosome recycling factor, putative

Species:

Leishmania major

UniProt:

Q4Q7R4_LEIMA

TriTrypDb:

LmjF.30.0440 , LMJLV39_300009900 , LMJSD75_300009700

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R4

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043023	ribosomal large subunit binding	4	2
GO:0044877	protein-containing complex binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	97	103	PF00089	0.361
CLV_NRD_NRD_1	128	130	PF00675	0.290
CLV_PCSK_KEX2_1	128	130	PF00082	0.290
CLV_PCSK_SKI1_1	153	157	PF00082	0.363
DOC_CYCLIN_RxL_1	47	61	PF00134	0.369
DOC_MAPK_gen_1	100	110	PF00069	0.490
DOC_MAPK_gen_1	148	157	PF00069	0.561
DOC_MAPK_MEF2A_6	112	121	PF00069	0.490
DOC_MAPK_MEF2A_6	53	62	PF00069	0.501
DOC_USP7_MATH_1	134	138	PF00917	0.517
DOC_USP7_MATH_1	35	39	PF00917	0.480
DOC_USP7_UBL2_3	112	116	PF12436	0.490
DOC_USP7_UBL2_3	36	40	PF12436	0.537
DOC_WW_Pin1_4	84	89	PF00397	0.518
LIG_BRCT_BRCA1_1	22	26	PF00533	0.499
LIG_BRCT_BRCA1_1	89	93	PF00533	0.561
LIG_Clathr_ClatBox_1	57	61	PF01394	0.508
LIG_FHA_1	150	156	PF00498	0.509
LIG_FHA_1	170	176	PF00498	0.239
LIG_FHA_1	65	71	PF00498	0.563
LIG_FHA_1	79	85	PF00498	0.498
LIG_FHA_2	130	136	PF00498	0.561
LIG_FHA_2	80	86	PF00498	0.530
LIG_SH3_3	116	122	PF00018	0.491
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.503
LIG_SUMO_SIM_anti_2	67	72	PF11976	0.599
LIG_SUMO_SIM_par_1	56	61	PF11976	0.508
LIG_SUMO_SIM_par_1	81	87	PF11976	0.581
LIG_WRC_WIRS_1	140	145	PF05994	0.536
MOD_CK2_1	129	135	PF00069	0.561
MOD_CK2_1	79	85	PF00069	0.502
MOD_GlcNHglycan	105	108	PF01048	0.254
MOD_GlcNHglycan	43	46	PF01048	0.475
MOD_GlcNHglycan	89	92	PF01048	0.363
MOD_GSK3_1	108	115	PF00069	0.451
MOD_GSK3_1	134	141	PF00069	0.567
MOD_GSK3_1	76	83	PF00069	0.486
MOD_GSK3_1	99	106	PF00069	0.484
MOD_N-GLC_1	41	46	PF02516	0.475
MOD_NEK2_1	139	144	PF00069	0.536
MOD_NEK2_1	174	179	PF00069	0.481
MOD_PKA_2	7	13	PF00069	0.596
MOD_PKA_2	99	105	PF00069	0.490
MOD_Plk_1	129	135	PF00069	0.591
MOD_Plk_1	169	175	PF00069	0.487
MOD_Plk_1	41	47	PF00069	0.452
MOD_Plk_2-3	191	197	PF00069	0.580
MOD_Plk_4	64	70	PF00069	0.557
MOD_ProDKin_1	84	90	PF00069	0.518
TRG_DiLeu_BaEn_1	135	140	PF01217	0.561
TRG_DiLeu_BaEn_1	170	175	PF01217	0.512
TRG_ER_diArg_1	143	146	PF00400	0.519
TRG_NES_CRM1_1	191	206	PF08389	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR8	Leptomonas seymouri	79%	73%
A0A0S4KKH0	Bodo saltans	45%	79%
A0A1X0P2I0	Trypanosomatidae	59%	75%
A0A3Q8IJ57	Leishmania donovani	97%	73%
A0A422N514	Trypanosoma rangeli	57%	74%
A4HHZ5	Leishmania braziliensis	88%	100%
A4I572	Leishmania infantum	97%	100%
E9B0G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%