Putative eukaryotic translation initiation factor 4e

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-4

Species:

Leishmania major

UniProt:

Q4Q7R3_LEIMA

TriTrypDb:

LmjF.30.0450 , LMJLV39_300010000 , LMJSD75_300009800

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R3

PDB structure(s): 6h7b_B , 6h7b_D

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0003743	translation initiation factor activity	4	14
GO:0005488	binding	1	14
GO:0008135	translation factor activity, RNA binding	3	14
GO:0045182	translation regulator activity	1	14
GO:0090079	translation regulator activity, nucleic acid binding	2	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.536
CLV_NRD_NRD_1	12	14	PF00675	0.728
CLV_NRD_NRD_1	306	308	PF00675	0.547
CLV_NRD_NRD_1	54	56	PF00675	0.705
CLV_PCSK_KEX2_1	12	14	PF00082	0.728
CLV_PCSK_KEX2_1	305	307	PF00082	0.532
CLV_PCSK_KEX2_1	54	56	PF00082	0.705
CLV_PCSK_SKI1_1	100	104	PF00082	0.669
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_ODPH_VHL_1	111	124	PF01847	0.543
DOC_ANK_TNKS_1	12	19	PF00023	0.717
DOC_MAPK_gen_1	243	251	PF00069	0.506
DOC_MAPK_MEF2A_6	245	253	PF00069	0.517
DOC_PP4_FxxP_1	133	136	PF00568	0.465
DOC_USP7_MATH_1	170	174	PF00917	0.535
DOC_WW_Pin1_4	104	109	PF00397	0.555
DOC_WW_Pin1_4	225	230	PF00397	0.505
DOC_WW_Pin1_4	32	37	PF00397	0.658
DOC_WW_Pin1_4	57	62	PF00397	0.601
LIG_14-3-3_CanoR_1	100	106	PF00244	0.540
LIG_14-3-3_CanoR_1	54	58	PF00244	0.692
LIG_14-3-3_CanoR_1	67	71	PF00244	0.566
LIG_APCC_ABBA_1	180	185	PF00400	0.511
LIG_CSL_BTD_1	267	270	PF09270	0.486
LIG_deltaCOP1_diTrp_1	127	133	PF00928	0.470
LIG_EH1_1	153	161	PF00400	0.442
LIG_FHA_1	177	183	PF00498	0.511
LIG_FHA_1	276	282	PF00498	0.484
LIG_FHA_2	136	142	PF00498	0.585
LIG_FHA_2	220	226	PF00498	0.479
LIG_LIR_Apic_2	188	194	PF02991	0.486
LIG_LIR_Gen_1	127	136	PF02991	0.470
LIG_LIR_Gen_1	212	223	PF02991	0.495
LIG_LIR_Nem_3	127	133	PF02991	0.457
LIG_LIR_Nem_3	161	166	PF02991	0.486
LIG_LIR_Nem_3	212	218	PF02991	0.496
LIG_LIR_Nem_3	266	271	PF02991	0.540
LIG_MAD2	100	108	PF02301	0.616
LIG_MAD2	164	172	PF02301	0.549
LIG_PAM2_1	83	95	PF00658	0.568
LIG_PCNA_PIPBox_1	261	270	PF02747	0.549
LIG_PCNA_yPIPBox_3	255	268	PF02747	0.549
LIG_Pex14_1	130	134	PF04695	0.507
LIG_SH2_STAT3	92	95	PF00017	0.664
LIG_SH2_STAT5	134	137	PF00017	0.486
LIG_SH2_STAT5	181	184	PF00017	0.464
LIG_SH2_STAT5	280	283	PF00017	0.400
LIG_SH2_STAT5	92	95	PF00017	0.664
LIG_SH3_3	41	47	PF00018	0.561
LIG_WRC_WIRS_1	159	164	PF05994	0.468
MOD_CDK_SPxxK_3	225	232	PF00069	0.486
MOD_CK1_1	158	164	PF00069	0.490
MOD_CK1_1	275	281	PF00069	0.444
MOD_CK1_1	66	72	PF00069	0.577
MOD_CK1_1	80	86	PF00069	0.492
MOD_CK2_1	135	141	PF00069	0.490
MOD_CK2_1	227	233	PF00069	0.521
MOD_CK2_1	69	75	PF00069	0.485
MOD_Cter_Amidation	10	13	PF01082	0.726
MOD_GlcNHglycan	257	260	PF01048	0.384
MOD_GlcNHglycan	71	74	PF01048	0.551
MOD_GlcNHglycan	82	85	PF01048	0.552
MOD_GSK3_1	219	226	PF00069	0.457
MOD_GSK3_1	227	234	PF00069	0.451
MOD_GSK3_1	251	258	PF00069	0.549
MOD_GSK3_1	272	279	PF00069	0.591
MOD_GSK3_1	53	60	PF00069	0.620
MOD_N-GLC_1	255	260	PF02516	0.257
MOD_N-GLC_1	3	8	PF02516	0.646
MOD_NEK2_1	175	180	PF00069	0.573
MOD_NEK2_1	219	224	PF00069	0.499
MOD_NEK2_1	251	256	PF00069	0.582
MOD_NEK2_1	272	277	PF00069	0.612
MOD_PIKK_1	101	107	PF00454	0.660
MOD_PK_1	155	161	PF00069	0.511
MOD_PKA_2	231	237	PF00069	0.468
MOD_PKA_2	53	59	PF00069	0.699
MOD_PKA_2	66	72	PF00069	0.561
MOD_Plk_1	255	261	PF00069	0.486
MOD_Plk_4	148	154	PF00069	0.513
MOD_Plk_4	155	161	PF00069	0.499
MOD_Plk_4	176	182	PF00069	0.570
MOD_Plk_4	276	282	PF00069	0.526
MOD_ProDKin_1	104	110	PF00069	0.553
MOD_ProDKin_1	225	231	PF00069	0.505
MOD_ProDKin_1	32	38	PF00069	0.658
MOD_ProDKin_1	57	63	PF00069	0.600
MOD_SUMO_for_1	143	146	PF00179	0.549
MOD_SUMO_for_1	189	192	PF00179	0.468
TRG_DiLeu_BaEn_1	213	218	PF01217	0.549
TRG_ER_diArg_1	305	307	PF00400	0.513
TRG_ER_diArg_1	53	55	PF00400	0.614
TRG_NLS_MonoExtC_3	301	306	PF00514	0.584
TRG_NLS_MonoExtN_4	300	306	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F6	Leptomonas seymouri	78%	68%
A0A1X0P285	Trypanosomatidae	45%	74%
A0A3Q8IE78	Leishmania donovani	27%	100%
A0A3Q8IEL7	Leishmania donovani	99%	69%
A0A3R7L212	Trypanosoma rangeli	26%	68%
A0A422N533	Trypanosoma rangeli	49%	75%
A4HHZ6	Leishmania braziliensis	89%	100%
A4I2V4	Leishmania infantum	27%	100%
A4I573	Leishmania infantum	99%	100%
C9ZQJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	72%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%