SWIB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7R1_LEIMA

TriTrypDb:

LmjF.30.0470 , LMJLV39_300010200 , LMJSD75_300010000

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.568
CLV_C14_Caspase3-7	309	313	PF00656	0.767
CLV_NRD_NRD_1	195	197	PF00675	0.454
CLV_NRD_NRD_1	254	256	PF00675	0.580
CLV_NRD_NRD_1	425	427	PF00675	0.494
CLV_NRD_NRD_1	464	466	PF00675	0.509
CLV_NRD_NRD_1	508	510	PF00675	0.539
CLV_NRD_NRD_1	521	523	PF00675	0.582
CLV_NRD_NRD_1	527	529	PF00675	0.625
CLV_PCSK_FUR_1	192	196	PF00082	0.567
CLV_PCSK_KEX2_1	194	196	PF00082	0.452
CLV_PCSK_KEX2_1	253	255	PF00082	0.509
CLV_PCSK_KEX2_1	425	427	PF00082	0.501
CLV_PCSK_KEX2_1	464	466	PF00082	0.474
CLV_PCSK_KEX2_1	508	510	PF00082	0.504
CLV_PCSK_KEX2_1	521	523	PF00082	0.540
CLV_PCSK_KEX2_1	529	531	PF00082	0.640
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.509
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.684
CLV_PCSK_SKI1_1	115	119	PF00082	0.660
DEG_APCC_DBOX_1	39	47	PF00400	0.335
DEG_APCC_DBOX_1	429	437	PF00400	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_ODPH_VHL_1	398	411	PF01847	0.560
DEG_SCF_FBW7_2	235	242	PF00400	0.558
DEG_SPOP_SBC_1	320	324	PF00917	0.797
DOC_CKS1_1	117	122	PF01111	0.730
DOC_CKS1_1	351	356	PF01111	0.682
DOC_CYCLIN_RxL_1	112	119	PF00134	0.649
DOC_CYCLIN_RxL_1	369	380	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.652
DOC_MAPK_DCC_7	195	205	PF00069	0.472
DOC_MAPK_DCC_7	379	389	PF00069	0.579
DOC_MAPK_gen_1	128	137	PF00069	0.665
DOC_MAPK_gen_1	464	472	PF00069	0.530
DOC_MAPK_gen_1	525	535	PF00069	0.688
DOC_PP2B_LxvP_1	118	121	PF13499	0.652
DOC_PP2B_LxvP_1	13	16	PF13499	0.505
DOC_USP7_MATH_1	310	314	PF00917	0.788
DOC_USP7_MATH_1	316	320	PF00917	0.782
DOC_USP7_MATH_1	321	325	PF00917	0.607
DOC_USP7_MATH_1	341	345	PF00917	0.718
DOC_USP7_MATH_1	449	453	PF00917	0.602
DOC_USP7_UBL2_3	249	253	PF12436	0.387
DOC_USP7_UBL2_3	442	446	PF12436	0.558
DOC_USP7_UBL2_3	525	529	PF12436	0.578
DOC_WW_Pin1_4	116	121	PF00397	0.733
DOC_WW_Pin1_4	210	215	PF00397	0.411
DOC_WW_Pin1_4	235	240	PF00397	0.548
DOC_WW_Pin1_4	284	289	PF00397	0.649
DOC_WW_Pin1_4	314	319	PF00397	0.744
DOC_WW_Pin1_4	334	339	PF00397	0.572
DOC_WW_Pin1_4	350	355	PF00397	0.646
DOC_WW_Pin1_4	445	450	PF00397	0.599
LIG_14-3-3_CanoR_1	140	145	PF00244	0.520
LIG_14-3-3_CanoR_1	254	260	PF00244	0.534
LIG_14-3-3_CanoR_1	425	433	PF00244	0.485
LIG_APCC_ABBA_1	66	71	PF00400	0.541
LIG_BRCT_BRCA1_1	409	413	PF00533	0.594
LIG_Clathr_ClatBox_1	384	388	PF01394	0.556
LIG_CtBP_PxDLS_1	386	390	PF00389	0.591
LIG_CtBP_PxDLS_1	432	436	PF00389	0.531
LIG_FHA_1	15	21	PF00498	0.354
LIG_FHA_1	210	216	PF00498	0.464
LIG_FHA_1	272	278	PF00498	0.553
LIG_FHA_1	351	357	PF00498	0.640
LIG_FHA_1	373	379	PF00498	0.514
LIG_FHA_1	389	395	PF00498	0.482
LIG_FHA_1	418	424	PF00498	0.515
LIG_FHA_1	8	14	PF00498	0.405
LIG_FHA_1	91	97	PF00498	0.629
LIG_FHA_2	148	154	PF00498	0.509
LIG_FHA_2	307	313	PF00498	0.741
LIG_LIR_Gen_1	148	155	PF02991	0.459
LIG_LIR_Gen_1	17	26	PF02991	0.488
LIG_LIR_Gen_1	184	193	PF02991	0.452
LIG_LIR_Gen_1	238	247	PF02991	0.481
LIG_LIR_Gen_1	280	290	PF02991	0.643
LIG_LIR_LC3C_4	55	59	PF02991	0.472
LIG_LIR_Nem_3	10	14	PF02991	0.414
LIG_LIR_Nem_3	148	152	PF02991	0.412
LIG_LIR_Nem_3	162	168	PF02991	0.446
LIG_LIR_Nem_3	17	22	PF02991	0.417
LIG_LIR_Nem_3	184	189	PF02991	0.442
LIG_LIR_Nem_3	238	244	PF02991	0.456
LIG_LIR_Nem_3	258	262	PF02991	0.198
LIG_LIR_Nem_3	280	285	PF02991	0.587
LIG_MAD2	115	123	PF02301	0.656
LIG_MYND_1	198	202	PF01753	0.492
LIG_Pex14_1	366	370	PF04695	0.543
LIG_Pex14_2	165	169	PF04695	0.475
LIG_Pex14_2	409	413	PF04695	0.594
LIG_Pex14_2	50	54	PF04695	0.517
LIG_PTB_Apo_2	361	368	PF02174	0.449
LIG_PTB_Phospho_1	361	367	PF10480	0.538
LIG_Rb_LxCxE_1	100	110	PF01857	0.696
LIG_SH2_CRK	440	444	PF00017	0.525
LIG_SH2_GRB2like	168	171	PF00017	0.588
LIG_SH2_NCK_1	440	444	PF00017	0.584
LIG_SH2_STAT5	14	17	PF00017	0.428
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	19	22	PF00017	0.425
LIG_SH2_STAT5	357	360	PF00017	0.489
LIG_SH2_STAT5	408	411	PF00017	0.416
LIG_SH2_STAT5	95	98	PF00017	0.569
LIG_SH3_3	117	123	PF00018	0.659
LIG_SH3_3	282	288	PF00018	0.635
LIG_SH3_3	328	334	PF00018	0.765
LIG_SH3_3	348	354	PF00018	0.411
LIG_SH3_3	93	99	PF00018	0.620
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.578
LIG_SUMO_SIM_par_1	201	207	PF11976	0.478
LIG_SUMO_SIM_par_1	55	61	PF11976	0.578
LIG_SxIP_EBH_1	223	237	PF03271	0.330
LIG_TRAF2_1	154	157	PF00917	0.564
LIG_TRAF2_1	3	6	PF00917	0.475
LIG_TRAF2_1	414	417	PF00917	0.554
LIG_TRAF2_1	500	503	PF00917	0.642
LIG_UBA3_1	175	181	PF00899	0.515
LIG_WRC_WIRS_1	19	24	PF05994	0.424
LIG_WRC_WIRS_1	256	261	PF05994	0.428
MOD_CK1_1	286	292	PF00069	0.628
MOD_CK1_1	314	320	PF00069	0.740
MOD_CK1_1	322	328	PF00069	0.735
MOD_CK1_1	345	351	PF00069	0.753
MOD_CK2_1	155	161	PF00069	0.509
MOD_GlcNHglycan	292	295	PF01048	0.731
MOD_GlcNHglycan	299	302	PF01048	0.752
MOD_GlcNHglycan	312	316	PF01048	0.679
MOD_GlcNHglycan	318	321	PF01048	0.683
MOD_GlcNHglycan	344	347	PF01048	0.714
MOD_GlcNHglycan	348	351	PF01048	0.658
MOD_GlcNHglycan	391	394	PF01048	0.556
MOD_GlcNHglycan	451	454	PF01048	0.610
MOD_GlcNHglycan	60	63	PF01048	0.634
MOD_GSK3_1	14	21	PF00069	0.539
MOD_GSK3_1	206	213	PF00069	0.430
MOD_GSK3_1	266	273	PF00069	0.448
MOD_GSK3_1	286	293	PF00069	0.392
MOD_GSK3_1	306	313	PF00069	0.522
MOD_GSK3_1	316	323	PF00069	0.709
MOD_GSK3_1	341	348	PF00069	0.759
MOD_GSK3_1	389	396	PF00069	0.573
MOD_GSK3_1	445	452	PF00069	0.599
MOD_GSK3_1	542	549	PF00069	0.719
MOD_NEK2_1	155	160	PF00069	0.543
MOD_NEK2_1	277	282	PF00069	0.518
MOD_NEK2_1	389	394	PF00069	0.555
MOD_NEK2_1	542	547	PF00069	0.705
MOD_PIKK_1	323	329	PF00454	0.801
MOD_PKA_1	425	431	PF00069	0.502
MOD_PKA_1	521	527	PF00069	0.675
MOD_PKA_2	310	316	PF00069	0.754
MOD_PKA_2	389	395	PF00069	0.509
MOD_PKA_2	425	431	PF00069	0.502
MOD_PKA_2	521	527	PF00069	0.687
MOD_Plk_1	147	153	PF00069	0.507
MOD_Plk_1	155	161	PF00069	0.474
MOD_Plk_1	206	212	PF00069	0.493
MOD_Plk_1	542	548	PF00069	0.709
MOD_Plk_2-3	157	163	PF00069	0.508
MOD_Plk_2-3	206	212	PF00069	0.559
MOD_Plk_4	14	20	PF00069	0.357
MOD_Plk_4	24	30	PF00069	0.343
MOD_Plk_4	277	283	PF00069	0.523
MOD_Plk_4	7	13	PF00069	0.382
MOD_Plk_4	91	97	PF00069	0.691
MOD_ProDKin_1	116	122	PF00069	0.731
MOD_ProDKin_1	210	216	PF00069	0.416
MOD_ProDKin_1	235	241	PF00069	0.552
MOD_ProDKin_1	284	290	PF00069	0.654
MOD_ProDKin_1	314	320	PF00069	0.745
MOD_ProDKin_1	334	340	PF00069	0.575
MOD_ProDKin_1	350	356	PF00069	0.637
MOD_ProDKin_1	445	451	PF00069	0.600
MOD_SUMO_for_1	97	100	PF00179	0.636
MOD_SUMO_rev_2	517	527	PF00179	0.596
TRG_DiLeu_BaEn_1	217	222	PF01217	0.524
TRG_ENDOCYTIC_2	19	22	PF00928	0.444
TRG_ENDOCYTIC_2	241	244	PF00928	0.419
TRG_ENDOCYTIC_2	256	259	PF00928	0.410
TRG_ENDOCYTIC_2	367	370	PF00928	0.462
TRG_ENDOCYTIC_2	408	411	PF00928	0.459
TRG_ENDOCYTIC_2	440	443	PF00928	0.462
TRG_ER_diArg_1	127	130	PF00400	0.668
TRG_ER_diArg_1	192	195	PF00400	0.423
TRG_ER_diArg_1	254	256	PF00400	0.580
TRG_ER_diArg_1	40	43	PF00400	0.503
TRG_ER_diArg_1	424	426	PF00400	0.487
TRG_ER_diArg_1	463	465	PF00400	0.494
TRG_ER_diArg_1	507	509	PF00400	0.526
TRG_ER_diArg_1	527	530	PF00400	0.364
TRG_NLS_MonoExtC_3	252	257	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T4	Leptomonas seymouri	57%	89%
A0A0S4IL03	Bodo saltans	40%	94%
A0A1X0NR90	Trypanosomatidae	28%	77%
A0A1X0P2A9	Trypanosomatidae	45%	87%
A0A3S7X313	Leishmania donovani	96%	100%
A0A422N566	Trypanosoma rangeli	47%	90%
A0A422NYX8	Trypanosoma rangeli	27%	81%
A4HHZ8	Leishmania braziliensis	82%	100%
A4I575	Leishmania infantum	96%	100%
C9ZQK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	82%
V5B7S2	Trypanosoma cruzi	45%	90%
V5BJS6	Trypanosoma cruzi	27%	81%