Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7Q7_LEIMA

TriTrypDb:

LmjF.30.0490 , LMJLV39_300010400 , LMJSD75_300010200

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.579
CLV_NRD_NRD_1	284	286	PF00675	0.557
CLV_NRD_NRD_1	484	486	PF00675	0.520
CLV_NRD_NRD_1	585	587	PF00675	0.410
CLV_NRD_NRD_1	623	625	PF00675	0.468
CLV_NRD_NRD_1	670	672	PF00675	0.423
CLV_NRD_NRD_1	673	675	PF00675	0.437
CLV_NRD_NRD_1	93	95	PF00675	0.707
CLV_PCSK_FUR_1	668	672	PF00082	0.423
CLV_PCSK_KEX2_1	12	14	PF00082	0.533
CLV_PCSK_KEX2_1	284	286	PF00082	0.565
CLV_PCSK_KEX2_1	484	486	PF00082	0.598
CLV_PCSK_KEX2_1	527	529	PF00082	0.563
CLV_PCSK_KEX2_1	584	586	PF00082	0.449
CLV_PCSK_KEX2_1	614	616	PF00082	0.500
CLV_PCSK_KEX2_1	625	627	PF00082	0.410
CLV_PCSK_KEX2_1	670	672	PF00082	0.423
CLV_PCSK_KEX2_1	677	679	PF00082	0.443
CLV_PCSK_KEX2_1	688	690	PF00082	0.420
CLV_PCSK_KEX2_1	697	699	PF00082	0.314
CLV_PCSK_KEX2_1	93	95	PF00082	0.707
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.539
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.449
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.500
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.410
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.443
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.420
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.314
CLV_PCSK_SKI1_1	484	488	PF00082	0.468
CLV_PCSK_SKI1_1	569	573	PF00082	0.569
CLV_PCSK_SKI1_1	586	590	PF00082	0.357
CLV_PCSK_SKI1_1	697	701	PF00082	0.445
DEG_APCC_DBOX_1	19	27	PF00400	0.576
DEG_SCF_FBW7_1	454	460	PF00400	0.534
DEG_SPOP_SBC_1	100	104	PF00917	0.636
DOC_CKS1_1	454	459	PF01111	0.535
DOC_CYCLIN_RxL_1	552	562	PF00134	0.509
DOC_MAPK_gen_1	272	279	PF00069	0.605
DOC_MAPK_gen_1	584	595	PF00069	0.451
DOC_MAPK_gen_1	597	605	PF00069	0.368
DOC_MAPK_gen_1	688	695	PF00069	0.497
DOC_PP4_FxxP_1	505	508	PF00568	0.564
DOC_PP4_MxPP_1	144	147	PF00568	0.552
DOC_USP7_MATH_1	119	123	PF00917	0.691
DOC_USP7_MATH_1	127	131	PF00917	0.643
DOC_USP7_MATH_1	177	181	PF00917	0.769
DOC_USP7_MATH_1	182	186	PF00917	0.712
DOC_USP7_MATH_1	308	312	PF00917	0.656
DOC_USP7_MATH_1	407	411	PF00917	0.644
DOC_USP7_MATH_1	413	417	PF00917	0.742
DOC_USP7_MATH_1	457	461	PF00917	0.594
DOC_USP7_MATH_1	537	541	PF00917	0.729
DOC_USP7_MATH_1	567	571	PF00917	0.506
DOC_WW_Pin1_4	130	135	PF00397	0.725
DOC_WW_Pin1_4	164	169	PF00397	0.622
DOC_WW_Pin1_4	187	192	PF00397	0.686
DOC_WW_Pin1_4	218	223	PF00397	0.570
DOC_WW_Pin1_4	298	303	PF00397	0.710
DOC_WW_Pin1_4	311	316	PF00397	0.564
DOC_WW_Pin1_4	323	328	PF00397	0.608
DOC_WW_Pin1_4	340	345	PF00397	0.524
DOC_WW_Pin1_4	373	378	PF00397	0.580
DOC_WW_Pin1_4	453	458	PF00397	0.622
DOC_WW_Pin1_4	68	73	PF00397	0.668
DOC_WW_Pin1_4	708	713	PF00397	0.609
LIG_14-3-3_CanoR_1	196	204	PF00244	0.637
LIG_14-3-3_CanoR_1	272	278	PF00244	0.598
LIG_14-3-3_CanoR_1	29	33	PF00244	0.510
LIG_14-3-3_CanoR_1	334	344	PF00244	0.654
LIG_14-3-3_CanoR_1	411	416	PF00244	0.651
LIG_14-3-3_CanoR_1	462	470	PF00244	0.509
LIG_14-3-3_CanoR_1	585	589	PF00244	0.470
LIG_14-3-3_CanoR_1	698	706	PF00244	0.565
LIG_14-3-3_CterR_2	714	716	PF00244	0.703
LIG_Actin_WH2_2	675	690	PF00022	0.507
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	81	85	PF00533	0.696
LIG_DLG_GKlike_1	318	326	PF00625	0.591
LIG_FHA_1	102	108	PF00498	0.648
LIG_FHA_1	399	405	PF00498	0.699
LIG_FHA_1	554	560	PF00498	0.483
LIG_FHA_1	688	694	PF00498	0.468
LIG_FHA_1	698	704	PF00498	0.437
LIG_FHA_1	86	92	PF00498	0.593
LIG_FHA_2	276	282	PF00498	0.653
LIG_FHA_2	384	390	PF00498	0.634
LIG_FHA_2	456	462	PF00498	0.632
LIG_LIR_Apic_2	503	508	PF02991	0.640
LIG_LIR_Gen_1	230	238	PF02991	0.509
LIG_LIR_Gen_1	659	665	PF02991	0.417
LIG_LIR_Nem_3	230	235	PF02991	0.548
LIG_LIR_Nem_3	347	352	PF02991	0.552
LIG_LIR_Nem_3	480	486	PF02991	0.433
LIG_LIR_Nem_3	659	664	PF02991	0.418
LIG_LYPXL_yS_3	349	352	PF13949	0.545
LIG_MYND_1	72	76	PF01753	0.574
LIG_SH2_CRK	483	487	PF00017	0.437
LIG_SH2_NCK_1	24	28	PF00017	0.524
LIG_SH2_STAP1	630	634	PF00017	0.494
LIG_SH2_STAT5	260	263	PF00017	0.580
LIG_SH2_STAT5	495	498	PF00017	0.492
LIG_SH3_1	704	710	PF00018	0.561
LIG_SH3_2	191	196	PF14604	0.701
LIG_SH3_2	709	714	PF14604	0.593
LIG_SH3_3	139	145	PF00018	0.654
LIG_SH3_3	188	194	PF00018	0.779
LIG_SH3_3	704	710	PF00018	0.561
LIG_SH3_CIN85_PxpxPR_1	506	511	PF14604	0.632
LIG_SUMO_SIM_anti_2	659	667	PF11976	0.414
LIG_TRAF2_1	367	370	PF00917	0.550
LIG_TRAF2_1	386	389	PF00917	0.523
LIG_TRAF2_1	510	513	PF00917	0.616
LIG_TRAF2_1	643	646	PF00917	0.536
LIG_UBA3_1	486	494	PF00899	0.609
LIG_WW_3	711	715	PF00397	0.600
MOD_CDC14_SPxK_1	172	175	PF00782	0.701
MOD_CDC14_SPxK_1	711	714	PF00782	0.597
MOD_CDK_SPxK_1	169	175	PF00069	0.700
MOD_CDK_SPxK_1	708	714	PF00069	0.591
MOD_CDK_SPxxK_3	311	318	PF00069	0.692
MOD_CDK_SPxxK_3	68	75	PF00069	0.580
MOD_CK1_1	115	121	PF00069	0.643
MOD_CK1_1	130	136	PF00069	0.600
MOD_CK1_1	164	170	PF00069	0.758
MOD_CK1_1	178	184	PF00069	0.560
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	237	243	PF00069	0.615
MOD_CK1_1	311	317	PF00069	0.659
MOD_CK1_1	321	327	PF00069	0.604
MOD_CK1_1	398	404	PF00069	0.710
MOD_CK1_1	414	420	PF00069	0.663
MOD_CK1_1	78	84	PF00069	0.593
MOD_CK2_1	119	125	PF00069	0.631
MOD_CK2_1	203	209	PF00069	0.648
MOD_CK2_1	298	304	PF00069	0.582
MOD_CK2_1	382	388	PF00069	0.640
MOD_CK2_1	393	399	PF00069	0.508
MOD_CK2_1	537	543	PF00069	0.537
MOD_Cter_Amidation	582	585	PF01082	0.509
MOD_GlcNHglycan	1	4	PF01048	0.607
MOD_GlcNHglycan	112	115	PF01048	0.681
MOD_GlcNHglycan	121	124	PF01048	0.613
MOD_GlcNHglycan	163	166	PF01048	0.654
MOD_GlcNHglycan	180	183	PF01048	0.704
MOD_GlcNHglycan	184	187	PF01048	0.688
MOD_GlcNHglycan	205	208	PF01048	0.710
MOD_GlcNHglycan	290	293	PF01048	0.583
MOD_GlcNHglycan	310	313	PF01048	0.563
MOD_GlcNHglycan	36	39	PF01048	0.703
MOD_GlcNHglycan	411	414	PF01048	0.807
MOD_GlcNHglycan	417	420	PF01048	0.633
MOD_GlcNHglycan	438	441	PF01048	0.613
MOD_GlcNHglycan	44	47	PF01048	0.586
MOD_GlcNHglycan	463	466	PF01048	0.600
MOD_GlcNHglycan	471	474	PF01048	0.558
MOD_GlcNHglycan	549	552	PF01048	0.461
MOD_GlcNHglycan	627	633	PF01048	0.487
MOD_GlcNHglycan	68	71	PF01048	0.678
MOD_GlcNHglycan	77	80	PF01048	0.555
MOD_GSK3_1	115	122	PF00069	0.669
MOD_GSK3_1	171	178	PF00069	0.710
MOD_GSK3_1	208	215	PF00069	0.697
MOD_GSK3_1	28	35	PF00069	0.515
MOD_GSK3_1	340	347	PF00069	0.776
MOD_GSK3_1	373	380	PF00069	0.599
MOD_GSK3_1	383	390	PF00069	0.636
MOD_GSK3_1	394	401	PF00069	0.604
MOD_GSK3_1	405	412	PF00069	0.794
MOD_GSK3_1	413	420	PF00069	0.574
MOD_GSK3_1	449	456	PF00069	0.748
MOD_GSK3_1	457	464	PF00069	0.528
MOD_GSK3_1	56	63	PF00069	0.679
MOD_GSK3_1	652	659	PF00069	0.417
MOD_GSK3_1	74	81	PF00069	0.553
MOD_N-GLC_1	110	115	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	161	166	PF00069	0.686
MOD_NEK2_1	449	454	PF00069	0.606
MOD_NEK2_1	85	90	PF00069	0.731
MOD_NEK2_2	567	572	PF00069	0.515
MOD_PIKK_1	2	8	PF00454	0.615
MOD_PIKK_1	365	371	PF00454	0.599
MOD_PIKK_1	697	703	PF00454	0.461
MOD_PK_1	411	417	PF00069	0.537
MOD_PKA_1	527	533	PF00069	0.578
MOD_PKA_1	584	590	PF00069	0.471
MOD_PKA_1	697	703	PF00069	0.461
MOD_PKA_2	115	121	PF00069	0.564
MOD_PKA_2	178	184	PF00069	0.709
MOD_PKA_2	195	201	PF00069	0.580
MOD_PKA_2	28	34	PF00069	0.605
MOD_PKA_2	333	339	PF00069	0.644
MOD_PKA_2	461	467	PF00069	0.521
MOD_PKA_2	527	533	PF00069	0.578
MOD_PKA_2	547	553	PF00069	0.317
MOD_PKA_2	584	590	PF00069	0.471
MOD_PKA_2	697	703	PF00069	0.537
MOD_Plk_1	387	393	PF00069	0.704
MOD_Plk_1	553	559	PF00069	0.510
MOD_Plk_2-3	388	394	PF00069	0.696
MOD_Plk_4	657	663	PF00069	0.413
MOD_ProDKin_1	130	136	PF00069	0.721
MOD_ProDKin_1	164	170	PF00069	0.625
MOD_ProDKin_1	187	193	PF00069	0.684
MOD_ProDKin_1	218	224	PF00069	0.569
MOD_ProDKin_1	298	304	PF00069	0.709
MOD_ProDKin_1	311	317	PF00069	0.565
MOD_ProDKin_1	323	329	PF00069	0.608
MOD_ProDKin_1	340	346	PF00069	0.518
MOD_ProDKin_1	373	379	PF00069	0.586
MOD_ProDKin_1	453	459	PF00069	0.622
MOD_ProDKin_1	68	74	PF00069	0.668
MOD_ProDKin_1	708	714	PF00069	0.615
MOD_SUMO_rev_2	230	237	PF00179	0.600
TRG_DiLeu_BaEn_4	513	519	PF01217	0.433
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.513
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.430
TRG_ENDOCYTIC_2	232	235	PF00928	0.505
TRG_ENDOCYTIC_2	349	352	PF00928	0.545
TRG_ENDOCYTIC_2	483	486	PF00928	0.442
TRG_ER_diArg_1	12	14	PF00400	0.579
TRG_ER_diArg_1	283	285	PF00400	0.528
TRG_ER_diArg_1	359	362	PF00400	0.553
TRG_ER_diArg_1	483	485	PF00400	0.519
TRG_ER_diArg_1	545	548	PF00400	0.468
TRG_ER_diArg_1	623	626	PF00400	0.521
TRG_ER_diArg_1	670	672	PF00400	0.423
TRG_ER_diArg_1	92	94	PF00400	0.692
TRG_NES_CRM1_1	652	667	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	507	512	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA1	Leptomonas seymouri	42%	100%
A0A3S7X301	Leishmania donovani	91%	100%
A4HI00	Leishmania braziliensis	73%	100%
A4I577	Leishmania infantum	91%	100%
E9B0H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%