N-acetyltransferase B complex non catalytic subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase B complex (NatB) non catalytic subunit, putative

Species:

Leishmania major

UniProt:

Q4Q7Q4_LEIMA

TriTrypDb:

LmjF.30.0520 , LMJLV39_300010700 , LMJSD75_300010500

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031248	protein acetyltransferase complex	3	2
GO:0031414	N-terminal protein acetyltransferase complex	4	2
GO:0031416	NatB complex	5	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902493	acetyltransferase complex	4	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q7Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Q4

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	2
GO:0006474	N-terminal protein amino acid acetylation	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0017196	N-terminal peptidyl-methionine acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018206	peptidyl-methionine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0031365	N-terminal protein amino acid modification	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.377
CLV_C14_Caspase3-7	638	642	PF00656	0.340
CLV_NRD_NRD_1	323	325	PF00675	0.310
CLV_NRD_NRD_1	354	356	PF00675	0.304
CLV_NRD_NRD_1	396	398	PF00675	0.236
CLV_NRD_NRD_1	485	487	PF00675	0.216
CLV_NRD_NRD_1	679	681	PF00675	0.470
CLV_NRD_NRD_1	710	712	PF00675	0.630
CLV_PCSK_KEX2_1	323	325	PF00082	0.275
CLV_PCSK_KEX2_1	396	398	PF00082	0.248
CLV_PCSK_KEX2_1	485	487	PF00082	0.252
CLV_PCSK_KEX2_1	679	681	PF00082	0.438
CLV_PCSK_SKI1_1	208	212	PF00082	0.404
CLV_PCSK_SKI1_1	396	400	PF00082	0.263
CLV_PCSK_SKI1_1	418	422	PF00082	0.261
CLV_PCSK_SKI1_1	508	512	PF00082	0.230
CLV_PCSK_SKI1_1	54	58	PF00082	0.527
CLV_PCSK_SKI1_1	610	614	PF00082	0.229
CLV_PCSK_SKI1_1	66	70	PF00082	0.451
CLV_PCSK_SKI1_1	682	686	PF00082	0.407
DEG_APCC_DBOX_1	507	515	PF00400	0.430
DEG_APCC_DBOX_1	681	689	PF00400	0.408
DEG_APCC_DBOX_1	774	782	PF00400	0.394
DEG_Nend_UBRbox_2	1	3	PF02207	0.515
DEG_SCF_FBW7_1	733	739	PF00400	0.450
DEG_SCF_FBW7_1	847	854	PF00400	0.479
DEG_SPOP_SBC_1	463	467	PF00917	0.367
DOC_CKS1_1	366	371	PF01111	0.510
DOC_CKS1_1	733	738	PF01111	0.451
DOC_CYCLIN_RxL_1	679	687	PF00134	0.427
DOC_MAPK_FxFP_2	795	798	PF00069	0.294
DOC_MAPK_gen_1	355	363	PF00069	0.460
DOC_MAPK_gen_1	54	63	PF00069	0.411
DOC_PP4_FxxP_1	366	369	PF00568	0.510
DOC_PP4_FxxP_1	795	798	PF00568	0.294
DOC_USP7_MATH_1	153	157	PF00917	0.492
DOC_USP7_MATH_1	296	300	PF00917	0.354
DOC_USP7_MATH_1	427	431	PF00917	0.445
DOC_USP7_MATH_1	695	699	PF00917	0.373
DOC_USP7_MATH_1	705	709	PF00917	0.392
DOC_USP7_MATH_1	736	740	PF00917	0.588
DOC_USP7_MATH_1	765	769	PF00917	0.461
DOC_USP7_MATH_1	851	855	PF00917	0.598
DOC_USP7_MATH_1	857	861	PF00917	0.517
DOC_USP7_UBL2_3	162	166	PF12436	0.365
DOC_USP7_UBL2_3	317	321	PF12436	0.510
DOC_USP7_UBL2_3	613	617	PF12436	0.430
DOC_USP7_UBL2_3	814	818	PF12436	0.461
DOC_WW_Pin1_4	281	286	PF00397	0.318
DOC_WW_Pin1_4	365	370	PF00397	0.510
DOC_WW_Pin1_4	408	413	PF00397	0.510
DOC_WW_Pin1_4	464	469	PF00397	0.512
DOC_WW_Pin1_4	732	737	PF00397	0.463
DOC_WW_Pin1_4	847	852	PF00397	0.539
LIG_14-3-3_CanoR_1	104	111	PF00244	0.464
LIG_14-3-3_CanoR_1	132	137	PF00244	0.415
LIG_14-3-3_CanoR_1	231	238	PF00244	0.426
LIG_14-3-3_CanoR_1	240	250	PF00244	0.460
LIG_14-3-3_CanoR_1	288	292	PF00244	0.433
LIG_14-3-3_CanoR_1	432	440	PF00244	0.471
LIG_14-3-3_CanoR_1	629	633	PF00244	0.394
LIG_14-3-3_CanoR_1	682	691	PF00244	0.293
LIG_14-3-3_CanoR_1	838	844	PF00244	0.517
LIG_APCC_ABBA_1	253	258	PF00400	0.427
LIG_BRCT_BRCA1_1	685	689	PF00533	0.288
LIG_Clathr_ClatBox_2	542	547	PF01394	0.461
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.307
LIG_deltaCOP1_diTrp_1	621	627	PF00928	0.552
LIG_FHA_1	163	169	PF00498	0.365
LIG_FHA_1	257	263	PF00498	0.341
LIG_FHA_1	366	372	PF00498	0.510
LIG_FHA_1	393	399	PF00498	0.471
LIG_FHA_1	449	455	PF00498	0.436
LIG_FHA_1	489	495	PF00498	0.449
LIG_FHA_1	584	590	PF00498	0.417
LIG_FHA_1	598	604	PF00498	0.487
LIG_FHA_1	641	647	PF00498	0.341
LIG_FHA_1	769	775	PF00498	0.374
LIG_FHA_1	867	873	PF00498	0.422
LIG_FHA_2	184	190	PF00498	0.438
LIG_FHA_2	197	203	PF00498	0.443
LIG_FHA_2	215	221	PF00498	0.382
LIG_FHA_2	287	293	PF00498	0.448
LIG_FHA_2	464	470	PF00498	0.430
LIG_FHA_2	606	612	PF00498	0.474
LIG_FHA_2	636	642	PF00498	0.481
LIG_IRF3_LxIS_1	357	364	PF10401	0.461
LIG_LIR_Apic_2	351	357	PF02991	0.549
LIG_LIR_Apic_2	364	369	PF02991	0.448
LIG_LIR_Apic_2	793	798	PF02991	0.306
LIG_LIR_Gen_1	113	121	PF02991	0.236
LIG_LIR_Gen_1	186	192	PF02991	0.324
LIG_LIR_Gen_1	247	256	PF02991	0.302
LIG_LIR_Gen_1	358	367	PF02991	0.472
LIG_LIR_Gen_1	447	457	PF02991	0.428
LIG_LIR_Gen_1	467	477	PF02991	0.510
LIG_LIR_Gen_1	837	847	PF02991	0.579
LIG_LIR_Gen_1	93	100	PF02991	0.375
LIG_LIR_LC3C_4	666	670	PF02991	0.342
LIG_LIR_Nem_3	186	190	PF02991	0.327
LIG_LIR_Nem_3	247	253	PF02991	0.307
LIG_LIR_Nem_3	358	363	PF02991	0.472
LIG_LIR_Nem_3	447	452	PF02991	0.417
LIG_LIR_Nem_3	467	473	PF02991	0.510
LIG_LIR_Nem_3	491	495	PF02991	0.419
LIG_LIR_Nem_3	549	554	PF02991	0.469
LIG_LIR_Nem_3	837	843	PF02991	0.580
LIG_LIR_Nem_3	93	97	PF02991	0.347
LIG_NRBOX	802	808	PF00104	0.353
LIG_PCNA_yPIPBox_3	343	356	PF02747	0.461
LIG_Pex14_1	547	551	PF04695	0.461
LIG_PTB_Apo_2	47	54	PF02174	0.370
LIG_PTB_Phospho_1	47	53	PF10480	0.364
LIG_SH2_CRK	120	124	PF00017	0.386
LIG_SH2_CRK	354	358	PF00017	0.510
LIG_SH2_CRK	470	474	PF00017	0.510
LIG_SH2_NCK_1	120	124	PF00017	0.350
LIG_SH2_PTP2	187	190	PF00017	0.302
LIG_SH2_PTP2	449	452	PF00017	0.428
LIG_SH2_SRC	187	190	PF00017	0.311
LIG_SH2_SRC	360	363	PF00017	0.492
LIG_SH2_SRC	742	745	PF00017	0.437
LIG_SH2_STAP1	197	201	PF00017	0.400
LIG_SH2_STAP1	470	474	PF00017	0.510
LIG_SH2_STAP1	495	499	PF00017	0.445
LIG_SH2_STAP1	729	733	PF00017	0.367
LIG_SH2_STAT3	552	555	PF00017	0.510
LIG_SH2_STAT3	590	593	PF00017	0.461
LIG_SH2_STAT5	114	117	PF00017	0.322
LIG_SH2_STAT5	187	190	PF00017	0.302
LIG_SH2_STAT5	241	244	PF00017	0.375
LIG_SH2_STAT5	327	330	PF00017	0.510
LIG_SH2_STAT5	349	352	PF00017	0.484
LIG_SH2_STAT5	360	363	PF00017	0.395
LIG_SH2_STAT5	449	452	PF00017	0.415
LIG_SH2_STAT5	472	475	PF00017	0.510
LIG_SH2_STAT5	569	572	PF00017	0.532
LIG_SH2_STAT5	742	745	PF00017	0.444
LIG_SH2_STAT5	756	759	PF00017	0.388
LIG_SH2_STAT5	777	780	PF00017	0.511
LIG_SH2_STAT5	883	886	PF00017	0.441
LIG_SH3_3	666	672	PF00018	0.368
LIG_SUMO_SIM_anti_2	186	192	PF11976	0.432
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.375
LIG_SUMO_SIM_anti_2	330	336	PF11976	0.458
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.332
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.461
LIG_SUMO_SIM_anti_2	666	673	PF11976	0.347
LIG_SUMO_SIM_par_1	666	673	PF11976	0.388
LIG_TRAF2_1	407	410	PF00917	0.529
LIG_TRAF2_1	553	556	PF00917	0.560
LIG_TYR_ITIM	527	532	PF00017	0.445
LIG_UBA3_1	159	166	PF00899	0.365
LIG_UBA3_1	802	808	PF00899	0.408
LIG_WRC_WIRS_1	363	368	PF05994	0.510
MOD_CDK_SPxxK_3	281	288	PF00069	0.316
MOD_CK1_1	244	250	PF00069	0.388
MOD_CK1_1	336	342	PF00069	0.510
MOD_CK1_1	768	774	PF00069	0.384
MOD_CK1_1	785	791	PF00069	0.426
MOD_CK1_1	839	845	PF00069	0.283
MOD_CK2_1	214	220	PF00069	0.393
MOD_CK2_1	273	279	PF00069	0.523
MOD_CK2_1	371	377	PF00069	0.447
MOD_CK2_1	404	410	PF00069	0.501
MOD_CK2_1	550	556	PF00069	0.491
MOD_CK2_1	696	702	PF00069	0.480
MOD_CK2_1	756	762	PF00069	0.500
MOD_CMANNOS	544	547	PF00535	0.310
MOD_CMANNOS	624	627	PF00535	0.426
MOD_GlcNHglycan	232	235	PF01048	0.368
MOD_GlcNHglycan	274	278	PF01048	0.475
MOD_GlcNHglycan	600	603	PF01048	0.373
MOD_GlcNHglycan	721	724	PF01048	0.658
MOD_GlcNHglycan	736	739	PF01048	0.620
MOD_GlcNHglycan	768	771	PF01048	0.506
MOD_GlcNHglycan	786	790	PF01048	0.463
MOD_GlcNHglycan	803	806	PF01048	0.307
MOD_GlcNHglycan	853	856	PF01048	0.575
MOD_GSK3_1	179	186	PF00069	0.390
MOD_GSK3_1	287	294	PF00069	0.416
MOD_GSK3_1	333	340	PF00069	0.479
MOD_GSK3_1	361	368	PF00069	0.489
MOD_GSK3_1	404	411	PF00069	0.510
MOD_GSK3_1	428	435	PF00069	0.450
MOD_GSK3_1	464	471	PF00069	0.461
MOD_GSK3_1	728	735	PF00069	0.466
MOD_GSK3_1	773	780	PF00069	0.424
MOD_GSK3_1	834	841	PF00069	0.513
MOD_GSK3_1	843	850	PF00069	0.490
MOD_N-GLC_1	567	572	PF02516	0.310
MOD_N-GLC_1	66	71	PF02516	0.447
MOD_N-GLC_2	83	85	PF02516	0.435
MOD_NEK2_1	110	115	PF00069	0.316
MOD_NEK2_1	161	166	PF00069	0.322
MOD_NEK2_1	214	219	PF00069	0.408
MOD_NEK2_1	333	338	PF00069	0.510
MOD_NEK2_1	361	366	PF00069	0.420
MOD_NEK2_1	434	439	PF00069	0.560
MOD_NEK2_1	567	572	PF00069	0.487
MOD_NEK2_1	664	669	PF00069	0.373
MOD_NEK2_1	684	689	PF00069	0.146
MOD_NEK2_1	728	733	PF00069	0.475
MOD_NEK2_1	843	848	PF00069	0.586
MOD_NEK2_2	251	256	PF00069	0.310
MOD_NEK2_2	883	888	PF00069	0.366
MOD_PIKK_1	241	247	PF00454	0.399
MOD_PIKK_1	605	611	PF00454	0.462
MOD_PKA_1	355	361	PF00069	0.430
MOD_PKA_2	230	236	PF00069	0.428
MOD_PKA_2	287	293	PF00069	0.441
MOD_PKA_2	520	526	PF00069	0.510
MOD_PKA_2	628	634	PF00069	0.405
MOD_PKA_2	678	684	PF00069	0.430
MOD_PKA_2	824	830	PF00069	0.353
MOD_Plk_1	273	279	PF00069	0.514
MOD_Plk_1	291	297	PF00069	0.314
MOD_Plk_1	35	41	PF00069	0.450
MOD_Plk_1	361	367	PF00069	0.454
MOD_Plk_1	468	474	PF00069	0.553
MOD_Plk_1	557	563	PF00069	0.416
MOD_Plk_1	567	573	PF00069	0.415
MOD_Plk_2-3	478	484	PF00069	0.445
MOD_Plk_2-3	550	556	PF00069	0.461
MOD_Plk_4	183	189	PF00069	0.410
MOD_Plk_4	256	262	PF00069	0.459
MOD_Plk_4	362	368	PF00069	0.440
MOD_Plk_4	371	377	PF00069	0.415
MOD_Plk_4	468	474	PF00069	0.461
MOD_Plk_4	478	484	PF00069	0.466
MOD_Plk_4	488	494	PF00069	0.412
MOD_Plk_4	557	563	PF00069	0.442
MOD_Plk_4	585	591	PF00069	0.517
MOD_Plk_4	635	641	PF00069	0.465
MOD_Plk_4	647	653	PF00069	0.392
MOD_Plk_4	664	670	PF00069	0.253
MOD_Plk_4	684	690	PF00069	0.146
MOD_Plk_4	777	783	PF00069	0.421
MOD_ProDKin_1	281	287	PF00069	0.315
MOD_ProDKin_1	365	371	PF00069	0.510
MOD_ProDKin_1	408	414	PF00069	0.510
MOD_ProDKin_1	464	470	PF00069	0.512
MOD_ProDKin_1	732	738	PF00069	0.464
MOD_ProDKin_1	847	853	PF00069	0.532
MOD_SUMO_for_1	870	873	PF00179	0.382
MOD_SUMO_for_1	887	890	PF00179	0.218
MOD_SUMO_rev_2	309	319	PF00179	0.496
MOD_SUMO_rev_2	605	615	PF00179	0.430
TRG_DiLeu_BaEn_1	475	480	PF01217	0.512
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.490
TRG_ENDOCYTIC_2	114	117	PF00928	0.182
TRG_ENDOCYTIC_2	120	123	PF00928	0.309
TRG_ENDOCYTIC_2	187	190	PF00928	0.302
TRG_ENDOCYTIC_2	360	363	PF00928	0.510
TRG_ENDOCYTIC_2	449	452	PF00928	0.428
TRG_ENDOCYTIC_2	470	473	PF00928	0.538
TRG_ENDOCYTIC_2	529	532	PF00928	0.415
TRG_ENDOCYTIC_2	551	554	PF00928	0.463
TRG_ENDOCYTIC_2	94	97	PF00928	0.377
TRG_ER_diArg_1	396	398	PF00400	0.429
TRG_ER_diArg_1	485	487	PF00400	0.510
TRG_ER_diArg_1	678	680	PF00400	0.472
TRG_NLS_MonoExtN_4	709	715	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I184	Leptomonas seymouri	66%	98%
A0A1X0P396	Trypanosomatidae	44%	100%
A0A3S5IR93	Trypanosoma rangeli	43%	100%
A0A3S7X316	Leishmania donovani	96%	100%
A4HI03	Leishmania braziliensis	85%	100%
A4I580	Leishmania infantum	96%	100%
C9ZQK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B0H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q17DK2	Aedes aegypti	22%	95%
Q294E0	Drosophila pseudoobscura pseudoobscura	22%	93%
Q6QI44	Rattus norvegicus	23%	92%
Q7PYI4	Anopheles gambiae	21%	91%
Q8BWZ3	Mus musculus	23%	92%
Q9VDQ7	Drosophila melanogaster	22%	95%
V5BGT7	Trypanosoma cruzi	47%	100%