LMBR1-like membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q7Q1_LEIMA

TriTrypDb:

LmjF.30.0550 , LMJLV39_300011000 , LMJSD75_300010800

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q7Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.453
CLV_NRD_NRD_1	195	197	PF00675	0.203
CLV_NRD_NRD_1	302	304	PF00675	0.291
CLV_NRD_NRD_1	521	523	PF00675	0.367
CLV_PCSK_FUR_1	321	325	PF00082	0.226
CLV_PCSK_KEX2_1	191	193	PF00082	0.232
CLV_PCSK_KEX2_1	195	197	PF00082	0.211
CLV_PCSK_KEX2_1	323	325	PF00082	0.278
CLV_PCSK_KEX2_1	569	571	PF00082	0.462
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.315
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.278
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.486
CLV_PCSK_SKI1_1	191	195	PF00082	0.286
CLV_PCSK_SKI1_1	286	290	PF00082	0.278
CLV_PCSK_SKI1_1	313	317	PF00082	0.264
DEG_APCC_DBOX_1	233	241	PF00400	0.471
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.339
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.260
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.506
DOC_MAPK_gen_1	112	121	PF00069	0.426
DOC_MAPK_gen_1	283	290	PF00069	0.420
DOC_MAPK_HePTP_8	111	123	PF00069	0.502
DOC_MAPK_MEF2A_6	114	123	PF00069	0.436
DOC_MAPK_MEF2A_6	363	372	PF00069	0.235
DOC_MAPK_MEF2A_6	426	433	PF00069	0.279
DOC_MAPK_MEF2A_6	459	468	PF00069	0.231
DOC_MAPK_MEF2A_6	474	482	PF00069	0.217
DOC_MAPK_NFAT4_5	426	434	PF00069	0.279
DOC_PP2B_LxvP_1	171	174	PF13499	0.391
DOC_PP2B_LxvP_1	353	356	PF13499	0.235
DOC_PP2B_LxvP_1	427	430	PF13499	0.245
DOC_PP2B_LxvP_1	478	481	PF13499	0.339
DOC_USP7_MATH_1	227	231	PF00917	0.468
DOC_USP7_MATH_1	601	605	PF00917	0.666
DOC_USP7_MATH_1	93	97	PF00917	0.360
DOC_USP7_UBL2_3	285	289	PF12436	0.422
DOC_USP7_UBL2_3	29	33	PF12436	0.453
DOC_WW_Pin1_4	532	537	PF00397	0.573
DOC_WW_Pin1_4	545	550	PF00397	0.659
LIG_14-3-3_CanoR_1	260	265	PF00244	0.473
LIG_14-3-3_CanoR_1	297	303	PF00244	0.460
LIG_Actin_WH2_2	270	287	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.334
LIG_BRCT_BRCA1_1	374	378	PF00533	0.232
LIG_BRCT_BRCA1_1	415	419	PF00533	0.411
LIG_Clathr_ClatBox_1	222	226	PF01394	0.478
LIG_Clathr_ClatBox_1	274	278	PF01394	0.457
LIG_Clathr_ClatBox_1	56	60	PF01394	0.260
LIG_CSL_BTD_1	325	328	PF09270	0.453
LIG_deltaCOP1_diTrp_1	76	82	PF00928	0.239
LIG_EH1_1	422	430	PF00400	0.391
LIG_FHA_1	343	349	PF00498	0.254
LIG_FHA_1	352	358	PF00498	0.223
LIG_FHA_1	420	426	PF00498	0.346
LIG_FHA_1	490	496	PF00498	0.555
LIG_FHA_2	265	271	PF00498	0.469
LIG_FHA_2	442	448	PF00498	0.324
LIG_FHA_2	601	607	PF00498	0.664
LIG_GBD_Chelix_1	57	65	PF00786	0.316
LIG_IRF3_LxIS_1	433	439	PF10401	0.391
LIG_LIR_Apic_2	76	80	PF02991	0.226
LIG_LIR_Gen_1	144	154	PF02991	0.191
LIG_LIR_Gen_1	2	13	PF02991	0.329
LIG_LIR_Gen_1	528	539	PF02991	0.454
LIG_LIR_Nem_3	144	150	PF02991	0.262
LIG_LIR_Nem_3	2	8	PF02991	0.278
LIG_LIR_Nem_3	23	27	PF02991	0.291
LIG_LIR_Nem_3	403	408	PF02991	0.448
LIG_LIR_Nem_3	451	457	PF02991	0.257
LIG_LIR_Nem_3	486	491	PF02991	0.395
LIG_LIR_Nem_3	528	534	PF02991	0.440
LIG_LIR_Nem_3	9	15	PF02991	0.269
LIG_LYPXL_S_1	407	411	PF13949	0.315
LIG_LYPXL_yS_3	408	411	PF13949	0.515
LIG_NRBOX	423	429	PF00104	0.391
LIG_PCNA_yPIPBox_3	120	129	PF02747	0.457
LIG_PCNA_yPIPBox_3	313	326	PF02747	0.457
LIG_Pex14_1	82	86	PF04695	0.391
LIG_Pex14_2	419	423	PF04695	0.245
LIG_SH2_CRK	126	130	PF00017	0.346
LIG_SH2_CRK	147	151	PF00017	0.310
LIG_SH2_CRK	27	31	PF00017	0.462
LIG_SH2_CRK	531	535	PF00017	0.494
LIG_SH2_GRB2like	471	474	PF00017	0.391
LIG_SH2_NCK_1	103	107	PF00017	0.453
LIG_SH2_NCK_1	147	151	PF00017	0.260
LIG_SH2_NCK_1	27	31	PF00017	0.462
LIG_SH2_PTP2	5	8	PF00017	0.391
LIG_SH2_SRC	187	190	PF00017	0.515
LIG_SH2_STAP1	126	130	PF00017	0.283
LIG_SH2_STAP1	147	151	PF00017	0.357
LIG_SH2_STAT5	103	106	PF00017	0.453
LIG_SH2_STAT5	139	142	PF00017	0.263
LIG_SH2_STAT5	27	30	PF00017	0.453
LIG_SH2_STAT5	332	335	PF00017	0.400
LIG_SH2_STAT5	390	393	PF00017	0.260
LIG_SH2_STAT5	405	408	PF00017	0.422
LIG_SH2_STAT5	471	474	PF00017	0.319
LIG_SH2_STAT5	5	8	PF00017	0.339
LIG_SH2_STAT5	577	580	PF00017	0.581
LIG_SH2_STAT5	90	93	PF00017	0.270
LIG_SH3_3	175	181	PF00018	0.245
LIG_SH3_3	403	409	PF00018	0.435
LIG_SH3_3	500	506	PF00018	0.585
LIG_SH3_3	533	539	PF00018	0.580
LIG_SH3_3	92	98	PF00018	0.305
LIG_SH3_CIN85_PxpxPR_1	549	554	PF14604	0.664
LIG_SUMO_SIM_anti_2	239	245	PF11976	0.445
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.453
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.427
LIG_SUMO_SIM_par_1	165	170	PF11976	0.391
LIG_SUMO_SIM_par_1	221	226	PF11976	0.466
LIG_SUMO_SIM_par_1	239	245	PF11976	0.380
LIG_SUMO_SIM_par_1	54	60	PF11976	0.281
LIG_TYR_ITIM	124	129	PF00017	0.346
LIG_TYR_ITIM	137	142	PF00017	0.323
LIG_TYR_ITIM	406	411	PF00017	0.391
LIG_TYR_ITIM	452	457	PF00017	0.245
LIG_TYR_ITIM	529	534	PF00017	0.285
LIG_UBA3_1	115	120	PF00899	0.300
MOD_CDK_SPK_2	549	554	PF00069	0.717
MOD_CDK_SPxxK_3	547	554	PF00069	0.600
MOD_CK1_1	146	152	PF00069	0.314
MOD_CK1_1	342	348	PF00069	0.309
MOD_CK1_1	351	357	PF00069	0.264
MOD_CK1_1	439	445	PF00069	0.391
MOD_CK1_1	593	599	PF00069	0.563
MOD_CK1_1	69	75	PF00069	0.338
MOD_CK2_1	236	242	PF00069	0.293
MOD_CK2_1	441	447	PF00069	0.310
MOD_CK2_1	600	606	PF00069	0.674
MOD_Cter_Amidation	520	523	PF01082	0.420
MOD_GlcNHglycan	1	4	PF01048	0.506
MOD_GlcNHglycan	244	247	PF01048	0.370
MOD_GlcNHglycan	438	441	PF01048	0.332
MOD_GlcNHglycan	583	586	PF01048	0.618
MOD_GSK3_1	141	148	PF00069	0.342
MOD_GSK3_1	260	267	PF00069	0.436
MOD_GSK3_1	436	443	PF00069	0.381
MOD_GSK3_1	541	548	PF00069	0.530
MOD_N-GLC_1	298	303	PF02516	0.310
MOD_N-GLC_1	413	418	PF02516	0.260
MOD_N-GLC_1	419	424	PF02516	0.260
MOD_NEK2_1	115	120	PF00069	0.382
MOD_NEK2_1	167	172	PF00069	0.281
MOD_NEK2_1	339	344	PF00069	0.400
MOD_NEK2_1	372	377	PF00069	0.283
MOD_NEK2_1	378	383	PF00069	0.239
MOD_NEK2_1	419	424	PF00069	0.250
MOD_NEK2_1	436	441	PF00069	0.279
MOD_NEK2_1	467	472	PF00069	0.311
MOD_NEK2_1	489	494	PF00069	0.422
MOD_NEK2_1	86	91	PF00069	0.312
MOD_NEK2_2	107	112	PF00069	0.339
MOD_NEK2_2	298	303	PF00069	0.245
MOD_PIKK_1	489	495	PF00454	0.516
MOD_PIKK_1	69	75	PF00454	0.463
MOD_Plk_1	107	113	PF00069	0.391
MOD_Plk_1	270	276	PF00069	0.260
MOD_Plk_1	298	304	PF00069	0.260
MOD_Plk_1	351	357	PF00069	0.339
MOD_Plk_1	413	419	PF00069	0.261
MOD_Plk_1	61	67	PF00069	0.391
MOD_Plk_2-3	221	227	PF00069	0.367
MOD_Plk_4	167	173	PF00069	0.384
MOD_Plk_4	236	242	PF00069	0.274
MOD_Plk_4	270	276	PF00069	0.310
MOD_Plk_4	339	345	PF00069	0.264
MOD_Plk_4	378	384	PF00069	0.309
MOD_Plk_4	419	425	PF00069	0.260
MOD_Plk_4	467	473	PF00069	0.273
MOD_Plk_4	483	489	PF00069	0.271
MOD_Plk_4	494	500	PF00069	0.543
MOD_Plk_4	6	12	PF00069	0.348
MOD_Plk_4	61	67	PF00069	0.308
MOD_Plk_4	86	92	PF00069	0.290
MOD_ProDKin_1	532	538	PF00069	0.485
MOD_ProDKin_1	545	551	PF00069	0.594
MOD_SUMO_for_1	218	221	PF00179	0.260
MOD_SUMO_rev_2	540	549	PF00179	0.608
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.288
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.391
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.245
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.260
TRG_ENDOCYTIC_2	103	106	PF00928	0.391
TRG_ENDOCYTIC_2	126	129	PF00928	0.271
TRG_ENDOCYTIC_2	139	142	PF00928	0.205
TRG_ENDOCYTIC_2	147	150	PF00928	0.272
TRG_ENDOCYTIC_2	27	30	PF00928	0.267
TRG_ENDOCYTIC_2	408	411	PF00928	0.309
TRG_ENDOCYTIC_2	454	457	PF00928	0.308
TRG_ENDOCYTIC_2	48	51	PF00928	0.444
TRG_ENDOCYTIC_2	5	8	PF00928	0.310
TRG_ENDOCYTIC_2	531	534	PF00928	0.357
TRG_ER_diArg_1	194	196	PF00400	0.227
TRG_ER_diArg_1	514	517	PF00400	0.401
TRG_NES_CRM1_1	490	502	PF08389	0.505
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F3	Leptomonas seymouri	75%	100%
A0A0S4JAG6	Bodo saltans	40%	100%
A0A1X0P250	Trypanosomatidae	48%	100%
A0A3Q8IFN1	Leishmania donovani	97%	100%
A0A422NIP4	Trypanosoma rangeli	48%	100%
A4HI06	Leishmania braziliensis	89%	100%
A4I583	Leishmania infantum	97%	100%
C9ZQL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q18695	Caenorhabditis elegans	22%	95%
Q29BL9	Drosophila pseudoobscura pseudoobscura	22%	87%
Q54Q92	Dictyostelium discoideum	22%	83%
Q54TM2	Dictyostelium discoideum	23%	77%
Q5F3F5	Gallus gallus	21%	89%
Q61ZW5	Caenorhabditis briggsae	22%	95%
Q68DH5	Homo sapiens	21%	88%
Q6P4P2	Danio rerio	22%	87%
Q7ZYA0	Xenopus laevis	21%	85%
Q8C561	Mus musculus	21%	88%
Q8MRQ4	Drosophila melanogaster	24%	88%
V5D878	Trypanosoma cruzi	47%	100%