PWI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7Q0_LEIMA

TriTrypDb:

LmjF.30.0560 , LMJLV39_300011100 , LMJSD75_300010900

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.743
CLV_C14_Caspase3-7	82	86	PF00656	0.602
CLV_NRD_NRD_1	122	124	PF00675	0.655
CLV_NRD_NRD_1	132	134	PF00675	0.574
CLV_NRD_NRD_1	163	165	PF00675	0.629
CLV_NRD_NRD_1	244	246	PF00675	0.548
CLV_NRD_NRD_1	288	290	PF00675	0.658
CLV_NRD_NRD_1	89	91	PF00675	0.606
CLV_PCSK_KEX2_1	132	134	PF00082	0.566
CLV_PCSK_KEX2_1	152	154	PF00082	0.401
CLV_PCSK_KEX2_1	244	246	PF00082	0.548
CLV_PCSK_KEX2_1	288	290	PF00082	0.658
CLV_PCSK_KEX2_1	97	99	PF00082	0.781
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.566
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.640
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.781
CLV_PCSK_SKI1_1	278	282	PF00082	0.553
CLV_PCSK_SKI1_1	288	292	PF00082	0.486
CLV_PCSK_SKI1_1	45	49	PF00082	0.565
CLV_PCSK_SKI1_1	92	96	PF00082	0.629
DEG_APCC_DBOX_1	301	309	PF00400	0.553
DOC_ANK_TNKS_1	252	259	PF00023	0.603
DOC_CYCLIN_RxL_1	42	52	PF00134	0.597
DOC_MAPK_gen_1	210	219	PF00069	0.559
DOC_MAPK_gen_1	286	293	PF00069	0.510
DOC_MAPK_MEF2A_6	210	219	PF00069	0.540
DOC_MAPK_MEF2A_6	312	319	PF00069	0.544
DOC_USP7_MATH_1	243	247	PF00917	0.545
DOC_USP7_UBL2_3	191	195	PF12436	0.645
DOC_USP7_UBL2_3	265	269	PF12436	0.641
DOC_USP7_UBL2_3	88	92	PF12436	0.670
DOC_WW_Pin1_4	37	42	PF00397	0.605
LIG_14-3-3_CanoR_1	244	248	PF00244	0.540
LIG_Actin_WH2_2	65	83	PF00022	0.657
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_FHA_1	18	24	PF00498	0.596
LIG_FHA_2	114	120	PF00498	0.502
LIG_FHA_2	229	235	PF00498	0.485
LIG_FHA_2	98	104	PF00498	0.761
LIG_LIR_Gen_1	143	150	PF02991	0.599
LIG_LIR_Gen_1	40	51	PF02991	0.540
LIG_LIR_Nem_3	143	148	PF02991	0.657
LIG_LIR_Nem_3	40	46	PF02991	0.582
LIG_LIR_Nem_3	49	54	PF02991	0.518
LIG_LIR_Nem_3	9	15	PF02991	0.614
LIG_PDZ_Class_3	320	325	PF00595	0.616
LIG_SH2_CRK	145	149	PF00017	0.648
LIG_SH2_STAP1	21	25	PF00017	0.521
LIG_SH2_STAP1	43	47	PF00017	0.504
LIG_SH2_STAP1	8	12	PF00017	0.572
LIG_SH2_STAT3	8	11	PF00017	0.648
LIG_SH2_STAT5	8	11	PF00017	0.566
LIG_SH3_2	260	265	PF14604	0.644
LIG_SH3_3	257	263	PF00018	0.709
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.554
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.472
LIG_SUMO_SIM_par_1	303	310	PF11976	0.554
LIG_SUMO_SIM_par_1	46	52	PF11976	0.558
LIG_TRAF2_1	116	119	PF00917	0.615
LIG_TRAF2_1	125	128	PF00917	0.537
LIG_TRAF2_1	232	235	PF00917	0.608
LIG_TRAF2_1	239	242	PF00917	0.566
LIG_UBA3_1	50	56	PF00899	0.643
LIG_WRC_WIRS_1	7	12	PF05994	0.655
MOD_CK2_1	107	113	PF00069	0.677
MOD_CK2_1	228	234	PF00069	0.501
MOD_CK2_1	243	249	PF00069	0.554
MOD_CK2_1	265	271	PF00069	0.637
MOD_CK2_1	304	310	PF00069	0.616
MOD_CK2_1	46	52	PF00069	0.638
MOD_GlcNHglycan	1	4	PF01048	0.642
MOD_GlcNHglycan	106	110	PF01048	0.721
MOD_GlcNHglycan	184	187	PF01048	0.732
MOD_GlcNHglycan	203	206	PF01048	0.622
MOD_GSK3_1	224	231	PF00069	0.442
MOD_GSK3_1	261	268	PF00069	0.697
MOD_GSK3_1	33	40	PF00069	0.673
MOD_GSK3_1	52	59	PF00069	0.378
MOD_NEK2_1	182	187	PF00069	0.720
MOD_NEK2_1	32	37	PF00069	0.562
MOD_NEK2_1	46	51	PF00069	0.507
MOD_PIKK_1	270	276	PF00454	0.666
MOD_PKA_1	97	103	PF00069	0.776
MOD_PKA_2	243	249	PF00069	0.538
MOD_PKA_2	97	103	PF00069	0.706
MOD_Plk_1	270	276	PF00069	0.666
MOD_Plk_2-3	107	113	PF00069	0.743
MOD_Plk_2-3	304	310	PF00069	0.601
MOD_Plk_4	304	310	PF00069	0.493
MOD_Plk_4	46	52	PF00069	0.584
MOD_ProDKin_1	37	43	PF00069	0.597
MOD_SUMO_rev_2	55	65	PF00179	0.612
MOD_SUMO_rev_2	85	93	PF00179	0.662
TRG_DiLeu_BaEn_1	213	218	PF01217	0.553
TRG_DiLeu_BaEn_3	213	219	PF01217	0.527
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.485
TRG_ENDOCYTIC_2	12	15	PF00928	0.708
TRG_ENDOCYTIC_2	145	148	PF00928	0.653
TRG_ENDOCYTIC_2	43	46	PF00928	0.509
TRG_NLS_MonoExtN_4	188	194	PF00514	0.772
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM18	Leptomonas seymouri	70%	100%
A0A3Q8IFH1	Leishmania donovani	97%	100%
A0A422NIF5	Trypanosoma rangeli	39%	99%
A4HI07	Leishmania braziliensis	87%	100%
A4I584	Leishmania infantum	97%	100%
E9B0I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AS86	Trypanosoma cruzi	36%	98%