Putative spliceosome-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosome-associated protein, putative

Species:

Leishmania major

UniProt:

Q4Q7P9_LEIMA

TriTrypDb:

LmjF.30.0570 , LMJLV39_300011200 , LMJSD75_300011000

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071011	precatalytic spliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q7P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.668
CLV_NRD_NRD_1	12	14	PF00675	0.500
CLV_NRD_NRD_1	125	127	PF00675	0.571
CLV_NRD_NRD_1	296	298	PF00675	0.351
CLV_PCSK_KEX2_1	117	119	PF00082	0.677
CLV_PCSK_KEX2_1	12	14	PF00082	0.500
CLV_PCSK_KEX2_1	272	274	PF00082	0.479
CLV_PCSK_KEX2_1	296	298	PF00082	0.335
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.479
CLV_PCSK_SKI1_1	101	105	PF00082	0.729
CLV_PCSK_SKI1_1	185	189	PF00082	0.354
CLV_PCSK_SKI1_1	275	279	PF00082	0.354
CLV_PCSK_SKI1_1	29	33	PF00082	0.575
CLV_Separin_Metazoa	329	333	PF03568	0.588
DEG_APCC_DBOX_1	100	108	PF00400	0.634
DEG_SIAH_1	423	431	PF03145	0.699
DOC_CKS1_1	406	411	PF01111	0.704
DOC_CKS1_1	50	55	PF01111	0.683
DOC_CYCLIN_RxL_1	25	34	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.457
DOC_MAPK_DCC_7	404	412	PF00069	0.606
DOC_MAPK_FxFP_2	338	341	PF00069	0.491
DOC_MAPK_gen_1	272	280	PF00069	0.449
DOC_PP2B_LxvP_1	305	308	PF13499	0.344
DOC_PP2B_LxvP_1	310	313	PF13499	0.324
DOC_PP4_FxxP_1	338	341	PF00568	0.491
DOC_USP7_MATH_1	349	353	PF00917	0.739
DOC_USP7_MATH_1	376	380	PF00917	0.772
DOC_USP7_MATH_1	90	94	PF00917	0.732
DOC_USP7_UBL2_3	21	25	PF12436	0.450
DOC_USP7_UBL2_3	258	262	PF12436	0.503
DOC_USP7_UBL2_3	5	9	PF12436	0.598
DOC_WW_Pin1_4	233	238	PF00397	0.482
DOC_WW_Pin1_4	263	268	PF00397	0.567
DOC_WW_Pin1_4	382	387	PF00397	0.701
DOC_WW_Pin1_4	396	401	PF00397	0.727
DOC_WW_Pin1_4	405	410	PF00397	0.584
DOC_WW_Pin1_4	426	431	PF00397	0.672
DOC_WW_Pin1_4	49	54	PF00397	0.631
LIG_14-3-3_CanoR_1	117	123	PF00244	0.707
LIG_14-3-3_CanoR_1	130	134	PF00244	0.443
LIG_Actin_WH2_2	42	59	PF00022	0.646
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	336	340	PF00533	0.608
LIG_EVH1_1	49	53	PF00568	0.689
LIG_FHA_1	147	153	PF00498	0.411
LIG_FHA_1	172	178	PF00498	0.362
LIG_FHA_1	240	246	PF00498	0.621
LIG_FHA_1	264	270	PF00498	0.408
LIG_FHA_1	442	448	PF00498	0.595
LIG_FHA_2	130	136	PF00498	0.588
LIG_FHA_2	351	357	PF00498	0.715
LIG_FHA_2	365	371	PF00498	0.524
LIG_FHA_2	427	433	PF00498	0.674
LIG_FHA_2	50	56	PF00498	0.656
LIG_LIR_Apic_2	325	330	PF02991	0.483
LIG_LIR_Apic_2	335	341	PF02991	0.508
LIG_LIR_Apic_2	44	50	PF02991	0.636
LIG_LIR_Apic_2	464	469	PF02991	0.672
LIG_LIR_Gen_1	132	141	PF02991	0.475
LIG_LIR_Gen_1	432	438	PF02991	0.605
LIG_LIR_Nem_3	132	136	PF02991	0.485
LIG_LIR_Nem_3	337	343	PF02991	0.500
LIG_LIR_Nem_3	356	362	PF02991	0.407
LIG_LIR_Nem_3	432	436	PF02991	0.609
LIG_LYPXL_yS_3	302	305	PF13949	0.335
LIG_Pex14_2	228	232	PF04695	0.490
LIG_PTAP_UEV_1	281	286	PF05743	0.440
LIG_SH2_CRK	47	51	PF00017	0.713
LIG_SH2_NCK_1	47	51	PF00017	0.681
LIG_SH2_PTP2	433	436	PF00017	0.607
LIG_SH2_STAT3	290	293	PF00017	0.319
LIG_SH2_STAT3	417	420	PF00017	0.696
LIG_SH2_STAT5	417	420	PF00017	0.584
LIG_SH2_STAT5	433	436	PF00017	0.618
LIG_SH2_STAT5	47	50	PF00017	0.580
LIG_SH3_1	297	303	PF00018	0.354
LIG_SH3_1	47	53	PF00018	0.703
LIG_SH3_3	172	178	PF00018	0.335
LIG_SH3_3	279	285	PF00018	0.329
LIG_SH3_3	297	303	PF00018	0.331
LIG_SH3_3	403	409	PF00018	0.670
LIG_SH3_3	47	53	PF00018	0.703
LIG_SH3_3	99	105	PF00018	0.619
LIG_TRAF2_1	132	135	PF00917	0.613
LIG_TRAF2_1	368	371	PF00917	0.773
LIG_TRAF2_1	429	432	PF00917	0.618
LIG_TRAF2_1	58	61	PF00917	0.679
LIG_TRFH_1	47	51	PF08558	0.681
LIG_WW_1	299	302	PF00397	0.335
LIG_WW_3	329	333	PF00397	0.476
MOD_CK1_1	121	127	PF00069	0.696
MOD_CK1_1	291	297	PF00069	0.479
MOD_CK2_1	1	7	PF00069	0.634
MOD_CK2_1	129	135	PF00069	0.608
MOD_CK2_1	350	356	PF00069	0.677
MOD_CK2_1	364	370	PF00069	0.552
MOD_CK2_1	426	432	PF00069	0.668
MOD_CK2_1	49	55	PF00069	0.624
MOD_Cter_Amidation	115	118	PF01082	0.777
MOD_Cter_Amidation	124	127	PF01082	0.671
MOD_GlcNHglycan	123	126	PF01048	0.720
MOD_GlcNHglycan	380	383	PF01048	0.713
MOD_GlcNHglycan	92	95	PF01048	0.661
MOD_GSK3_1	117	124	PF00069	0.754
MOD_GSK3_1	227	234	PF00069	0.489
MOD_GSK3_1	378	385	PF00069	0.711
MOD_GSK3_1	437	444	PF00069	0.583
MOD_GSK3_1	45	52	PF00069	0.674
MOD_N-GLC_1	438	443	PF02516	0.699
MOD_NEK2_1	1	6	PF00069	0.675
MOD_NEK2_1	183	188	PF00069	0.415
MOD_NEK2_2	162	167	PF00069	0.378
MOD_NEK2_2	227	232	PF00069	0.501
MOD_PIKK_1	20	26	PF00454	0.583
MOD_PIKK_1	350	356	PF00454	0.724
MOD_PIKK_1	456	462	PF00454	0.798
MOD_PK_1	118	124	PF00069	0.534
MOD_PKA_1	117	123	PF00069	0.732
MOD_PKA_1	20	26	PF00069	0.577
MOD_PKA_2	117	123	PF00069	0.654
MOD_PKA_2	129	135	PF00069	0.433
MOD_PKA_2	213	219	PF00069	0.383
MOD_Plk_1	334	340	PF00069	0.576
MOD_Plk_1	441	447	PF00069	0.617
MOD_Plk_4	118	124	PF00069	0.593
MOD_Plk_4	334	340	PF00069	0.523
MOD_ProDKin_1	233	239	PF00069	0.483
MOD_ProDKin_1	263	269	PF00069	0.567
MOD_ProDKin_1	382	388	PF00069	0.697
MOD_ProDKin_1	396	402	PF00069	0.725
MOD_ProDKin_1	405	411	PF00069	0.568
MOD_ProDKin_1	426	432	PF00069	0.675
MOD_ProDKin_1	49	55	PF00069	0.631
MOD_SUMO_for_1	168	171	PF00179	0.447
MOD_SUMO_rev_2	134	138	PF00179	0.594
MOD_SUMO_rev_2	4	11	PF00179	0.631
TRG_DiLeu_BaEn_1	147	152	PF01217	0.432
TRG_DiLeu_BaEn_2	333	339	PF01217	0.505
TRG_DiLeu_BaEn_3	195	201	PF01217	0.447
TRG_ENDOCYTIC_2	302	305	PF00928	0.335
TRG_ENDOCYTIC_2	433	436	PF00928	0.607
TRG_ENDOCYTIC_2	449	452	PF00928	0.625
TRG_ER_diArg_1	295	297	PF00400	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T1	Leptomonas seymouri	70%	98%
A0A1X0P248	Trypanosomatidae	47%	100%
A0A3R7MML5	Trypanosoma rangeli	49%	100%
A0A3S5H7M4	Leishmania donovani	95%	100%
A4HI08	Leishmania braziliensis	86%	99%
A4I585	Leishmania infantum	95%	100%
C9ZQL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9B0I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B7R6	Trypanosoma cruzi	47%	100%