Bardet-Biedl syndrome 2 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 2 protein

Species:

Leishmania major

UniProt:

Q4Q7P7_LEIMA

TriTrypDb:

LmjF.30.0590 , LMJLV39_300011400 , LMJSD75_300011200

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0030666	endocytic vesicle membrane	5	2
GO:0030669	clathrin-coated endocytic vesicle membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005856	cytoskeleton	5	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10

Expansion

Sequence features

Q4Q7P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.668
CLV_C14_Caspase3-7	548	552	PF00656	0.476
CLV_NRD_NRD_1	226	228	PF00675	0.339
CLV_NRD_NRD_1	263	265	PF00675	0.313
CLV_PCSK_KEX2_1	263	265	PF00082	0.301
CLV_PCSK_KEX2_1	305	307	PF00082	0.356
CLV_PCSK_KEX2_1	595	597	PF00082	0.312
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.356
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.260
CLV_PCSK_SKI1_1	219	223	PF00082	0.323
CLV_PCSK_SKI1_1	401	405	PF00082	0.357
CLV_PCSK_SKI1_1	417	421	PF00082	0.318
CLV_PCSK_SKI1_1	529	533	PF00082	0.337
CLV_PCSK_SKI1_1	557	561	PF00082	0.261
CLV_PCSK_SKI1_1	604	608	PF00082	0.270
CLV_PCSK_SKI1_1	634	638	PF00082	0.299
CLV_Separin_Metazoa	418	422	PF03568	0.417
DEG_APCC_KENBOX_2	637	641	PF00400	0.537
DOC_CYCLIN_RxL_1	216	226	PF00134	0.512
DOC_CYCLIN_RxL_1	414	423	PF00134	0.537
DOC_CYCLIN_RxL_1	554	564	PF00134	0.537
DOC_MAPK_gen_1	135	143	PF00069	0.553
DOC_MAPK_gen_1	305	311	PF00069	0.563
DOC_MAPK_MEF2A_6	202	210	PF00069	0.539
DOC_MAPK_MEF2A_6	291	299	PF00069	0.481
DOC_MAPK_MEF2A_6	370	378	PF00069	0.519
DOC_MAPK_MEF2A_6	417	424	PF00069	0.540
DOC_MAPK_MEF2A_6	518	525	PF00069	0.556
DOC_MAPK_NFAT4_5	417	425	PF00069	0.537
DOC_MAPK_NFAT4_5	518	526	PF00069	0.556
DOC_PP4_FxxP_1	433	436	PF00568	0.486
DOC_USP7_MATH_1	108	112	PF00917	0.556
DOC_USP7_MATH_1	335	339	PF00917	0.504
DOC_USP7_MATH_1	472	476	PF00917	0.537
DOC_USP7_MATH_1	48	52	PF00917	0.551
DOC_USP7_UBL2_3	604	608	PF12436	0.463
LIG_14-3-3_CanoR_1	137	142	PF00244	0.476
LIG_14-3-3_CanoR_1	219	224	PF00244	0.519
LIG_14-3-3_CanoR_1	32	37	PF00244	0.491
LIG_14-3-3_CanoR_1	398	404	PF00244	0.497
LIG_14-3-3_CanoR_1	430	434	PF00244	0.519
LIG_Actin_WH2_2	415	432	PF00022	0.556
LIG_Actin_WH2_2	514	531	PF00022	0.522
LIG_APCC_ABBA_1	293	298	PF00400	0.485
LIG_BRCT_BRCA1_1	143	147	PF00533	0.451
LIG_BRCT_BRCA1_1	181	185	PF00533	0.529
LIG_BRCT_BRCA1_1	65	69	PF00533	0.463
LIG_Clathr_ClatBox_1	419	423	PF01394	0.537
LIG_deltaCOP1_diTrp_1	426	433	PF00928	0.537
LIG_FHA_1	288	294	PF00498	0.460
LIG_FHA_1	337	343	PF00498	0.463
LIG_FHA_1	373	379	PF00498	0.548
LIG_FHA_1	446	452	PF00498	0.542
LIG_FHA_1	479	485	PF00498	0.483
LIG_FHA_2	220	226	PF00498	0.501
LIG_FHA_2	253	259	PF00498	0.537
LIG_FHA_2	270	276	PF00498	0.509
LIG_FHA_2	321	327	PF00498	0.492
LIG_FHA_2	80	86	PF00498	0.496
LIG_Integrin_isoDGR_2	164	166	PF01839	0.292
LIG_Integrin_RGD_1	306	308	PF01839	0.337
LIG_LIR_Apic_2	402	408	PF02991	0.494
LIG_LIR_Apic_2	432	436	PF02991	0.488
LIG_LIR_Gen_1	144	155	PF02991	0.452
LIG_LIR_Gen_1	536	545	PF02991	0.489
LIG_LIR_Gen_1	578	585	PF02991	0.537
LIG_LIR_Nem_3	144	150	PF02991	0.443
LIG_LIR_Nem_3	31	36	PF02991	0.417
LIG_LIR_Nem_3	536	541	PF02991	0.489
LIG_LIR_Nem_3	578	582	PF02991	0.537
LIG_SH2_CRK	115	119	PF00017	0.556
LIG_SH2_CRK	384	388	PF00017	0.537
LIG_SH2_CRK	579	583	PF00017	0.451
LIG_SH2_NCK_1	388	392	PF00017	0.564
LIG_SH2_STAP1	115	119	PF00017	0.556
LIG_SH2_STAP1	189	193	PF00017	0.537
LIG_SH2_STAP1	579	583	PF00017	0.463
LIG_SH2_STAT5	117	120	PF00017	0.463
LIG_SH2_STAT5	388	391	PF00017	0.566
LIG_SH3_3	203	209	PF00018	0.473
LIG_SH3_3	296	302	PF00018	0.501
LIG_SH3_3	373	379	PF00018	0.491
LIG_SH3_3	444	450	PF00018	0.484
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.501
LIG_SUMO_SIM_anti_2	644	651	PF11976	0.539
LIG_SUMO_SIM_par_1	480	487	PF11976	0.501
LIG_SUMO_SIM_par_1	520	526	PF11976	0.543
LIG_TRAF2_1	256	259	PF00917	0.512
LIG_UBA3_1	568	577	PF00899	0.512
LIG_WRC_WIRS_1	342	347	PF05994	0.529
MOD_CK1_1	4	10	PF00069	0.713
MOD_CK2_1	219	225	PF00069	0.460
MOD_CK2_1	252	258	PF00069	0.514
MOD_CK2_1	269	275	PF00069	0.537
MOD_CK2_1	320	326	PF00069	0.503
MOD_CK2_1	641	647	PF00069	0.537
MOD_CK2_1	648	654	PF00069	0.623
MOD_CK2_1	79	85	PF00069	0.475
MOD_GlcNHglycan	110	113	PF01048	0.312
MOD_GlcNHglycan	143	146	PF01048	0.265
MOD_GlcNHglycan	190	193	PF01048	0.301
MOD_GlcNHglycan	275	278	PF01048	0.336
MOD_GlcNHglycan	284	287	PF01048	0.340
MOD_GlcNHglycan	355	358	PF01048	0.365
MOD_GlcNHglycan	474	477	PF01048	0.333
MOD_GlcNHglycan	54	57	PF01048	0.625
MOD_GlcNHglycan	6	9	PF01048	0.674
MOD_GSK3_1	137	144	PF00069	0.537
MOD_GSK3_1	210	217	PF00069	0.450
MOD_GSK3_1	219	226	PF00069	0.430
MOD_GSK3_1	269	276	PF00069	0.505
MOD_GSK3_1	337	344	PF00069	0.477
MOD_GSK3_1	48	55	PF00069	0.505
MOD_GSK3_1	551	558	PF00069	0.494
MOD_GSK3_1	571	578	PF00069	0.485
MOD_LATS_1	458	464	PF00433	0.537
MOD_N-GLC_1	120	125	PF02516	0.252
MOD_N-GLC_1	18	23	PF02516	0.471
MOD_N-GLC_1	353	358	PF02516	0.301
MOD_N-GLC_2	611	613	PF02516	0.356
MOD_NEK2_1	185	190	PF00069	0.476
MOD_NEK2_1	223	228	PF00069	0.509
MOD_NEK2_1	341	346	PF00069	0.531
MOD_NEK2_1	353	358	PF00069	0.460
MOD_NEK2_1	365	370	PF00069	0.467
MOD_NEK2_1	429	434	PF00069	0.477
MOD_NEK2_1	575	580	PF00069	0.516
MOD_NEK2_1	629	634	PF00069	0.523
MOD_NEK2_2	18	23	PF00069	0.493
MOD_NEK2_2	79	84	PF00069	0.537
MOD_PK_1	137	143	PF00069	0.556
MOD_PK_1	179	185	PF00069	0.412
MOD_PK_1	2	8	PF00069	0.571
MOD_PKA_2	185	191	PF00069	0.492
MOD_PKA_2	429	435	PF00069	0.524
MOD_PKB_1	135	143	PF00069	0.543
MOD_Plk_1	18	24	PF00069	0.452
MOD_Plk_1	269	275	PF00069	0.463
MOD_Plk_1	372	378	PF00069	0.511
MOD_Plk_4	179	185	PF00069	0.415
MOD_Plk_4	18	24	PF00069	0.451
MOD_Plk_4	219	225	PF00069	0.473
MOD_Plk_4	337	343	PF00069	0.485
MOD_Plk_4	551	557	PF00069	0.536
MOD_Plk_4	58	64	PF00069	0.422
MOD_Plk_4	641	647	PF00069	0.489
MOD_SUMO_rev_2	601	606	PF00179	0.517
TRG_DiLeu_BaEn_1	437	442	PF01217	0.542
TRG_DiLeu_BaEn_1	564	569	PF01217	0.463
TRG_DiLeu_LyEn_5	564	569	PF01217	0.476
TRG_ENDOCYTIC_2	115	118	PF00928	0.556
TRG_ENDOCYTIC_2	33	36	PF00928	0.424
TRG_ENDOCYTIC_2	579	582	PF00928	0.451
TRG_ENDOCYTIC_2	600	603	PF00928	0.476
TRG_ER_diArg_1	134	137	PF00400	0.545
TRG_NES_CRM1_1	423	438	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.190
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK5	Leptomonas seymouri	72%	79%
A0A0S4JJZ6	Bodo saltans	38%	91%
A0A1X0P2D4	Trypanosomatidae	43%	87%
A0A3Q8IE31	Leishmania donovani	96%	100%
A0A422NII3	Trypanosoma rangeli	43%	86%
A4HI10	Leishmania braziliensis	89%	100%
A4I587	Leishmania infantum	96%	79%
C9ZQL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	88%
E9B0I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q19640	Caenorhabditis elegans	25%	92%
Q98SP7	Danio rerio	30%	91%
Q99MH9	Rattus norvegicus	31%	91%
Q9BXC9	Homo sapiens	31%	91%
Q9CWF6	Mus musculus	31%	91%
V5D873	Trypanosoma cruzi	41%	86%