LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
STE/STE11 serine/threonine-protein kinase, putative
Species:
Leishmania major
UniProt:
Q4Q7P6_LEIMA
TriTrypDb:
LmjF.30.0600 , LMJLV39_300011500 * , LMJSD75_300011300
Length:
928

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7P6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 355 361 PF00089 0.304
CLV_NRD_NRD_1 107 109 PF00675 0.601
CLV_NRD_NRD_1 136 138 PF00675 0.608
CLV_NRD_NRD_1 212 214 PF00675 0.616
CLV_NRD_NRD_1 35 37 PF00675 0.589
CLV_NRD_NRD_1 409 411 PF00675 0.304
CLV_NRD_NRD_1 605 607 PF00675 0.303
CLV_NRD_NRD_1 631 633 PF00675 0.676
CLV_NRD_NRD_1 675 677 PF00675 0.571
CLV_NRD_NRD_1 778 780 PF00675 0.597
CLV_NRD_NRD_1 804 806 PF00675 0.713
CLV_NRD_NRD_1 846 848 PF00675 0.700
CLV_PCSK_FUR_1 134 138 PF00082 0.608
CLV_PCSK_FUR_1 802 806 PF00082 0.717
CLV_PCSK_KEX2_1 107 109 PF00082 0.601
CLV_PCSK_KEX2_1 136 138 PF00082 0.608
CLV_PCSK_KEX2_1 35 37 PF00082 0.589
CLV_PCSK_KEX2_1 409 411 PF00082 0.304
CLV_PCSK_KEX2_1 605 607 PF00082 0.395
CLV_PCSK_KEX2_1 778 780 PF00082 0.625
CLV_PCSK_KEX2_1 804 806 PF00082 0.769
CLV_PCSK_KEX2_1 845 847 PF00082 0.699
CLV_PCSK_KEX2_1 909 911 PF00082 0.672
CLV_PCSK_PC1ET2_1 845 847 PF00082 0.634
CLV_PCSK_PC1ET2_1 909 911 PF00082 0.699
CLV_PCSK_PC7_1 132 138 PF00082 0.605
CLV_PCSK_PC7_1 774 780 PF00082 0.571
CLV_PCSK_SKI1_1 39 43 PF00082 0.579
CLV_PCSK_SKI1_1 478 482 PF00082 0.304
CLV_PCSK_SKI1_1 664 668 PF00082 0.624
CLV_PCSK_SKI1_1 778 782 PF00082 0.673
CLV_PCSK_SKI1_1 910 914 PF00082 0.566
DEG_APCC_DBOX_1 83 91 PF00400 0.570
DEG_SCF_TRCP1_1 55 60 PF00400 0.660
DEG_SPOP_SBC_1 686 690 PF00917 0.666
DEG_SPOP_SBC_1 840 844 PF00917 0.648
DOC_CKS1_1 514 519 PF01111 0.304
DOC_CKS1_1 857 862 PF01111 0.703
DOC_MAPK_gen_1 347 355 PF00069 0.458
DOC_MAPK_gen_1 478 487 PF00069 0.304
DOC_MAPK_MEF2A_6 11 19 PF00069 0.662
DOC_MAPK_MEF2A_6 275 282 PF00069 0.611
DOC_MAPK_MEF2A_6 424 433 PF00069 0.304
DOC_PP4_FxxP_1 212 215 PF00568 0.632
DOC_PP4_FxxP_1 519 522 PF00568 0.304
DOC_USP7_MATH_1 140 144 PF00917 0.621
DOC_USP7_MATH_1 162 166 PF00917 0.657
DOC_USP7_MATH_1 191 195 PF00917 0.579
DOC_USP7_MATH_1 250 254 PF00917 0.599
DOC_USP7_MATH_1 284 288 PF00917 0.674
DOC_USP7_MATH_1 294 298 PF00917 0.578
DOC_USP7_MATH_1 304 308 PF00917 0.587
DOC_USP7_MATH_1 309 313 PF00917 0.523
DOC_USP7_MATH_1 400 404 PF00917 0.304
DOC_USP7_MATH_1 53 57 PF00917 0.745
DOC_USP7_MATH_1 577 581 PF00917 0.325
DOC_USP7_MATH_1 686 690 PF00917 0.677
DOC_USP7_MATH_1 78 82 PF00917 0.599
DOC_USP7_MATH_1 839 843 PF00917 0.762
DOC_USP7_MATH_1 880 884 PF00917 0.679
DOC_USP7_MATH_1 892 896 PF00917 0.573
DOC_USP7_UBL2_3 392 396 PF12436 0.304
DOC_USP7_UBL2_3 592 596 PF12436 0.304
DOC_USP7_UBL2_3 923 927 PF12436 0.642
DOC_WW_Pin1_4 280 285 PF00397 0.612
DOC_WW_Pin1_4 335 340 PF00397 0.641
DOC_WW_Pin1_4 513 518 PF00397 0.304
DOC_WW_Pin1_4 687 692 PF00397 0.670
DOC_WW_Pin1_4 714 719 PF00397 0.714
DOC_WW_Pin1_4 739 744 PF00397 0.698
DOC_WW_Pin1_4 753 758 PF00397 0.532
DOC_WW_Pin1_4 778 783 PF00397 0.762
DOC_WW_Pin1_4 804 809 PF00397 0.832
DOC_WW_Pin1_4 823 828 PF00397 0.514
DOC_WW_Pin1_4 848 853 PF00397 0.654
DOC_WW_Pin1_4 856 861 PF00397 0.618
DOC_WW_Pin1_4 867 872 PF00397 0.584
DOC_WW_Pin1_4 896 901 PF00397 0.660
DOC_WW_Pin1_4 902 907 PF00397 0.700
LIG_14-3-3_CanoR_1 134 140 PF00244 0.602
LIG_14-3-3_CanoR_1 29 38 PF00244 0.616
LIG_14-3-3_CanoR_1 290 299 PF00244 0.608
LIG_14-3-3_CanoR_1 349 354 PF00244 0.514
LIG_14-3-3_CanoR_1 598 608 PF00244 0.304
LIG_14-3-3_CanoR_1 68 75 PF00244 0.664
LIG_14-3-3_CanoR_1 772 782 PF00244 0.567
LIG_14-3-3_CanoR_1 887 892 PF00244 0.550
LIG_14-3-3_CanoR_1 902 906 PF00244 0.526
LIG_ActinCP_TwfCPI_2 212 222 PF01115 0.628
LIG_APCC_ABBA_1 429 434 PF00400 0.304
LIG_BRCT_BRCA1_1 100 104 PF00533 0.616
LIG_BRCT_BRCA1_1 223 227 PF00533 0.625
LIG_Clathr_ClatBox_1 51 55 PF01394 0.594
LIG_FHA_1 294 300 PF00498 0.619
LIG_FHA_1 389 395 PF00498 0.437
LIG_FHA_1 458 464 PF00498 0.304
LIG_FHA_1 508 514 PF00498 0.304
LIG_FHA_1 69 75 PF00498 0.639
LIG_FHA_2 361 367 PF00498 0.304
LIG_FHA_2 486 492 PF00498 0.304
LIG_LIR_Apic_2 210 215 PF02991 0.631
LIG_LIR_Apic_2 516 522 PF02991 0.304
LIG_LIR_Gen_1 180 191 PF02991 0.588
LIG_LIR_Gen_1 468 476 PF02991 0.369
LIG_LIR_Nem_3 148 154 PF02991 0.657
LIG_LIR_Nem_3 180 186 PF02991 0.596
LIG_LIR_Nem_3 224 230 PF02991 0.694
LIG_LIR_Nem_3 363 367 PF02991 0.304
LIG_LIR_Nem_3 468 472 PF02991 0.369
LIG_MAD2 36 44 PF02301 0.565
LIG_MLH1_MIPbox_1 100 104 PF16413 0.612
LIG_Pex14_1 208 212 PF04695 0.607
LIG_Pex14_2 227 231 PF04695 0.667
LIG_REV1ctd_RIR_1 101 112 PF16727 0.602
LIG_SH2_CRK 183 187 PF00017 0.590
LIG_SH2_CRK 9 13 PF00017 0.671
LIG_SH2_NCK_1 183 187 PF00017 0.590
LIG_SH2_NCK_1 9 13 PF00017 0.671
LIG_SH2_SRC 469 472 PF00017 0.313
LIG_SH2_SRC 694 697 PF00017 0.629
LIG_SH2_STAP1 459 463 PF00017 0.304
LIG_SH2_STAP1 530 534 PF00017 0.304
LIG_SH2_STAT3 368 371 PF00017 0.325
LIG_SH2_STAT3 459 462 PF00017 0.304
LIG_SH2_STAT5 183 186 PF00017 0.594
LIG_SH2_STAT5 419 422 PF00017 0.304
LIG_SH2_STAT5 459 462 PF00017 0.315
LIG_SH2_STAT5 469 472 PF00017 0.322
LIG_SH3_1 805 811 PF00018 0.693
LIG_SH3_2 659 664 PF14604 0.671
LIG_SH3_3 212 218 PF00018 0.632
LIG_SH3_3 278 284 PF00018 0.631
LIG_SH3_3 649 655 PF00018 0.667
LIG_SH3_3 656 662 PF00018 0.632
LIG_SH3_3 805 811 PF00018 0.664
LIG_SH3_3 812 818 PF00018 0.604
LIG_SH3_CIN85_PxpxPR_1 850 855 PF14604 0.560
LIG_SUMO_SIM_par_1 276 283 PF11976 0.654
LIG_SUMO_SIM_par_1 377 383 PF11976 0.303
LIG_TRAF2_1 91 94 PF00917 0.587
LIG_TYR_ITIM 467 472 PF00017 0.369
LIG_UBA3_1 563 570 PF00899 0.304
LIG_WW_3 661 665 PF00397 0.606
MOD_CDC14_SPxK_1 870 873 PF00782 0.692
MOD_CDC14_SPxK_1 905 908 PF00782 0.629
MOD_CDK_SPK_2 823 828 PF00069 0.626
MOD_CDK_SPxK_1 867 873 PF00069 0.696
MOD_CDK_SPxK_1 896 902 PF00069 0.655
MOD_CDK_SPxxK_3 823 830 PF00069 0.605
MOD_CDK_SPxxK_3 848 855 PF00069 0.651
MOD_CDK_SPxxK_3 902 909 PF00069 0.636
MOD_CK1_1 117 123 PF00069 0.610
MOD_CK1_1 138 144 PF00069 0.584
MOD_CK1_1 150 156 PF00069 0.588
MOD_CK1_1 165 171 PF00069 0.585
MOD_CK1_1 177 183 PF00069 0.580
MOD_CK1_1 189 195 PF00069 0.580
MOD_CK1_1 226 232 PF00069 0.629
MOD_CK1_1 285 291 PF00069 0.665
MOD_CK1_1 307 313 PF00069 0.624
MOD_CK1_1 338 344 PF00069 0.637
MOD_CK1_1 518 524 PF00069 0.304
MOD_CK1_1 528 534 PF00069 0.331
MOD_CK1_1 687 693 PF00069 0.671
MOD_CK1_1 713 719 PF00069 0.630
MOD_CK1_1 73 79 PF00069 0.574
MOD_CK1_1 739 745 PF00069 0.718
MOD_CK1_1 749 755 PF00069 0.622
MOD_CK1_1 796 802 PF00069 0.665
MOD_CK1_1 848 854 PF00069 0.656
MOD_CK1_1 895 901 PF00069 0.781
MOD_CK1_1 99 105 PF00069 0.606
MOD_CK2_1 140 146 PF00069 0.598
MOD_CK2_1 440 446 PF00069 0.304
MOD_CK2_1 566 572 PF00069 0.310
MOD_CK2_1 76 82 PF00069 0.562
MOD_CK2_1 804 810 PF00069 0.699
MOD_Cter_Amidation 802 805 PF01082 0.717
MOD_Cter_Amidation 906 909 PF01082 0.654
MOD_GlcNHglycan 140 143 PF01048 0.661
MOD_GlcNHglycan 170 173 PF01048 0.610
MOD_GlcNHglycan 232 235 PF01048 0.667
MOD_GlcNHglycan 252 255 PF01048 0.493
MOD_GlcNHglycan 284 287 PF01048 0.662
MOD_GlcNHglycan 306 309 PF01048 0.660
MOD_GlcNHglycan 311 314 PF01048 0.704
MOD_GlcNHglycan 328 331 PF01048 0.590
MOD_GlcNHglycan 374 377 PF01048 0.347
MOD_GlcNHglycan 527 530 PF01048 0.310
MOD_GlcNHglycan 55 58 PF01048 0.659
MOD_GlcNHglycan 621 624 PF01048 0.647
MOD_GlcNHglycan 738 741 PF01048 0.809
MOD_GlcNHglycan 775 778 PF01048 0.636
MOD_GlcNHglycan 794 798 PF01048 0.669
MOD_GlcNHglycan 835 838 PF01048 0.675
MOD_GSK3_1 113 120 PF00069 0.486
MOD_GSK3_1 152 159 PF00069 0.647
MOD_GSK3_1 162 169 PF00069 0.646
MOD_GSK3_1 171 178 PF00069 0.502
MOD_GSK3_1 189 196 PF00069 0.526
MOD_GSK3_1 203 210 PF00069 0.592
MOD_GSK3_1 21 28 PF00069 0.585
MOD_GSK3_1 226 233 PF00069 0.694
MOD_GSK3_1 280 287 PF00069 0.647
MOD_GSK3_1 290 297 PF00069 0.571
MOD_GSK3_1 300 307 PF00069 0.486
MOD_GSK3_1 321 328 PF00069 0.798
MOD_GSK3_1 331 338 PF00069 0.593
MOD_GSK3_1 440 447 PF00069 0.317
MOD_GSK3_1 449 456 PF00069 0.331
MOD_GSK3_1 509 516 PF00069 0.310
MOD_GSK3_1 53 60 PF00069 0.660
MOD_GSK3_1 619 626 PF00069 0.582
MOD_GSK3_1 64 71 PF00069 0.646
MOD_GSK3_1 680 687 PF00069 0.696
MOD_GSK3_1 709 716 PF00069 0.634
MOD_GSK3_1 717 724 PF00069 0.633
MOD_GSK3_1 738 745 PF00069 0.760
MOD_GSK3_1 749 756 PF00069 0.602
MOD_GSK3_1 78 85 PF00069 0.483
MOD_GSK3_1 841 848 PF00069 0.679
MOD_GSK3_1 862 869 PF00069 0.666
MOD_GSK3_1 892 899 PF00069 0.722
MOD_GSK3_1 93 100 PF00069 0.593
MOD_N-GLC_1 326 331 PF02516 0.723
MOD_N-GLC_1 425 430 PF02516 0.325
MOD_N-GLC_1 713 718 PF02516 0.647
MOD_N-GLC_1 862 867 PF02516 0.699
MOD_N-GLC_1 892 897 PF02516 0.763
MOD_N-GLC_1 900 905 PF02516 0.654
MOD_NEK2_1 119 124 PF00069 0.612
MOD_NEK2_1 135 140 PF00069 0.601
MOD_NEK2_1 181 186 PF00069 0.729
MOD_NEK2_1 340 345 PF00069 0.536
MOD_NEK2_1 470 475 PF00069 0.304
MOD_NEK2_1 504 509 PF00069 0.304
MOD_NEK2_1 668 673 PF00069 0.600
MOD_NEK2_1 738 743 PF00069 0.652
MOD_NEK2_1 770 775 PF00069 0.671
MOD_NEK2_2 881 886 PF00069 0.658
MOD_PIKK_1 599 605 PF00454 0.304
MOD_PK_1 349 355 PF00069 0.509
MOD_PK_1 444 450 PF00069 0.369
MOD_PK_1 887 893 PF00069 0.578
MOD_PKA_1 845 851 PF00069 0.636
MOD_PKA_2 122 128 PF00069 0.679
MOD_PKA_2 135 141 PF00069 0.536
MOD_PKA_2 221 227 PF00069 0.654
MOD_PKA_2 250 256 PF00069 0.593
MOD_PKA_2 294 300 PF00069 0.629
MOD_PKA_2 360 366 PF00069 0.304
MOD_PKA_2 597 603 PF00069 0.272
MOD_PKA_2 773 779 PF00069 0.616
MOD_PKA_2 845 851 PF00069 0.636
MOD_PKA_2 886 892 PF00069 0.659
MOD_PKA_2 901 907 PF00069 0.567
MOD_PKA_2 915 921 PF00069 0.794
MOD_PKB_1 347 355 PF00069 0.523
MOD_Plk_1 147 153 PF00069 0.601
MOD_Plk_1 425 431 PF00069 0.325
MOD_Plk_1 668 674 PF00069 0.523
MOD_Plk_1 76 82 PF00069 0.562
MOD_Plk_2-3 746 752 PF00069 0.660
MOD_Plk_2-3 93 99 PF00069 0.656
MOD_Plk_4 156 162 PF00069 0.601
MOD_Plk_4 226 232 PF00069 0.600
MOD_Plk_4 415 421 PF00069 0.304
MOD_Plk_4 504 510 PF00069 0.304
MOD_Plk_4 515 521 PF00069 0.304
MOD_Plk_4 784 790 PF00069 0.707
MOD_Plk_4 881 887 PF00069 0.640
MOD_Plk_4 99 105 PF00069 0.606
MOD_ProDKin_1 280 286 PF00069 0.612
MOD_ProDKin_1 335 341 PF00069 0.639
MOD_ProDKin_1 513 519 PF00069 0.304
MOD_ProDKin_1 687 693 PF00069 0.669
MOD_ProDKin_1 714 720 PF00069 0.713
MOD_ProDKin_1 739 745 PF00069 0.699
MOD_ProDKin_1 753 759 PF00069 0.532
MOD_ProDKin_1 778 784 PF00069 0.765
MOD_ProDKin_1 804 810 PF00069 0.833
MOD_ProDKin_1 823 829 PF00069 0.513
MOD_ProDKin_1 848 854 PF00069 0.651
MOD_ProDKin_1 856 862 PF00069 0.619
MOD_ProDKin_1 867 873 PF00069 0.584
MOD_ProDKin_1 896 902 PF00069 0.661
MOD_SUMO_rev_2 194 204 PF00179 0.650
MOD_SUMO_rev_2 447 456 PF00179 0.308
MOD_SUMO_rev_2 924 928 PF00179 0.614
TRG_ENDOCYTIC_2 183 186 PF00928 0.594
TRG_ENDOCYTIC_2 469 472 PF00928 0.369
TRG_ER_diArg_1 107 110 PF00400 0.578
TRG_ER_diArg_1 131 134 PF00400 0.600
TRG_ER_diArg_1 135 137 PF00400 0.608
TRG_ER_diArg_1 347 350 PF00400 0.546
TRG_ER_diArg_1 35 37 PF00400 0.593
TRG_ER_diArg_1 408 410 PF00400 0.304
TRG_ER_diArg_1 604 606 PF00400 0.303
TRG_ER_diArg_1 673 676 PF00400 0.550
TRG_ER_diArg_1 772 775 PF00400 0.580
TRG_ER_diArg_1 802 805 PF00400 0.717
TRG_ER_diArg_1 827 830 PF00400 0.594
TRG_NLS_MonoExtN_4 906 912 PF00514 0.630
TRG_Pf-PMV_PEXEL_1 478 483 PF00026 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILR5 Leptomonas seymouri 55% 99%
A0A3S7X353 Leishmania donovani 95% 100%
A4HI11 Leishmania braziliensis 80% 100%
A4I588 Leishmania infantum 95% 100%
E9B0I5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS