Putative nitrate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitrate reductase, putative

Species:

Leishmania major

UniProt:

Q4Q7P5_LEIMA

TriTrypDb:

LmjF.30.0610 , LMJLV39_300011700 , LMJSD75_300011500

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	2
GO:0005488	binding	1	10
GO:0008940	nitrate reductase activity	4	8
GO:0009703	nitrate reductase (NADH) activity	6	8
GO:0016491	oxidoreductase activity	2	11
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	2
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	2
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	8
GO:0020037	heme binding	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	8
GO:0046872	metal ion binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0050463	nitrate reductase [NAD(P)H] activity	5	8
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.292
CLV_C14_Caspase3-7	513	517	PF00656	0.326
CLV_NRD_NRD_1	126	128	PF00675	0.281
CLV_NRD_NRD_1	146	148	PF00675	0.160
CLV_PCSK_KEX2_1	126	128	PF00082	0.281
CLV_PCSK_SKI1_1	122	126	PF00082	0.463
CLV_PCSK_SKI1_1	131	135	PF00082	0.335
CLV_PCSK_SKI1_1	195	199	PF00082	0.369
CLV_PCSK_SKI1_1	301	305	PF00082	0.349
CLV_PCSK_SKI1_1	460	464	PF00082	0.386
CLV_PCSK_SKI1_1	82	86	PF00082	0.543
DEG_SPOP_SBC_1	160	164	PF00917	0.504
DEG_SPOP_SBC_1	475	479	PF00917	0.259
DOC_CKS1_1	332	337	PF01111	0.292
DOC_CKS1_1	429	434	PF01111	0.394
DOC_MAPK_gen_1	211	220	PF00069	0.590
DOC_MAPK_MEF2A_6	213	222	PF00069	0.403
DOC_MAPK_MEF2A_6	456	465	PF00069	0.407
DOC_PP2B_LxvP_1	157	160	PF13499	0.601
DOC_PP2B_LxvP_1	71	74	PF13499	0.637
DOC_PP4_FxxP_1	305	308	PF00568	0.326
DOC_PP4_FxxP_1	332	335	PF00568	0.292
DOC_PP4_FxxP_1	370	373	PF00568	0.444
DOC_USP7_MATH_1	6	10	PF00917	0.666
DOC_USP7_MATH_2	159	165	PF00917	0.497
DOC_USP7_UBL2_3	242	246	PF12436	0.373
DOC_WW_Pin1_4	167	172	PF00397	0.734
DOC_WW_Pin1_4	258	263	PF00397	0.535
DOC_WW_Pin1_4	274	279	PF00397	0.489
DOC_WW_Pin1_4	331	336	PF00397	0.316
DOC_WW_Pin1_4	428	433	PF00397	0.394
DOC_WW_Pin1_4	45	50	PF00397	0.801
DOC_WW_Pin1_4	466	471	PF00397	0.292
LIG_14-3-3_CanoR_1	301	306	PF00244	0.445
LIG_14-3-3_CanoR_1	447	454	PF00244	0.273
LIG_14-3-3_CanoR_1	489	495	PF00244	0.454
LIG_14-3-3_CanoR_1	7	13	PF00244	0.748
LIG_14-3-3_CanoR_1	80	85	PF00244	0.542
LIG_Actin_WH2_2	249	266	PF00022	0.424
LIG_APCC_ABBA_1	198	203	PF00400	0.422
LIG_BRCT_BRCA1_1	476	480	PF00533	0.270
LIG_FHA_1	110	116	PF00498	0.330
LIG_FHA_1	170	176	PF00498	0.616
LIG_FHA_1	184	190	PF00498	0.306
LIG_FHA_1	284	290	PF00498	0.418
LIG_FHA_1	295	301	PF00498	0.379
LIG_FHA_1	456	462	PF00498	0.358
LIG_FHA_1	68	74	PF00498	0.586
LIG_FHA_1	98	104	PF00498	0.454
LIG_FHA_2	429	435	PF00498	0.335
LIG_FHA_2	511	517	PF00498	0.292
LIG_FHA_2	52	58	PF00498	0.624
LIG_FHA_2	83	89	PF00498	0.530
LIG_Integrin_isoDGR_2	225	227	PF01839	0.447
LIG_Integrin_isoDGR_2	352	354	PF01839	0.292
LIG_LIR_Apic_2	304	308	PF02991	0.330
LIG_LIR_Apic_2	329	335	PF02991	0.384
LIG_LIR_Apic_2	367	373	PF02991	0.289
LIG_LIR_Gen_1	231	241	PF02991	0.508
LIG_LIR_Gen_1	417	426	PF02991	0.278
LIG_LIR_Nem_3	231	236	PF02991	0.468
LIG_LIR_Nem_3	299	305	PF02991	0.492
LIG_LIR_Nem_3	330	336	PF02991	0.310
LIG_LIR_Nem_3	417	423	PF02991	0.401
LIG_OCRL_FandH_1	232	244	PF00620	0.405
LIG_Pex14_2	332	336	PF04695	0.335
LIG_SH2_CRK	312	316	PF00017	0.270
LIG_SH2_CRK	322	326	PF00017	0.308
LIG_SH2_GRB2like	322	325	PF00017	0.335
LIG_SH2_STAP1	448	452	PF00017	0.335
LIG_SH2_STAT5	249	252	PF00017	0.378
LIG_SH2_STAT5	302	305	PF00017	0.475
LIG_SH2_STAT5	333	336	PF00017	0.295
LIG_SH2_STAT5	358	361	PF00017	0.349
LIG_SH3_3	259	265	PF00018	0.516
LIG_SH3_3	275	281	PF00018	0.504
LIG_SH3_3	370	376	PF00018	0.271
LIG_SH3_3	426	432	PF00018	0.394
LIG_SH3_3	46	52	PF00018	0.767
LIG_SH3_3	505	511	PF00018	0.292
LIG_SUMO_SIM_anti_2	100	106	PF11976	0.317
LIG_SUMO_SIM_anti_2	421	428	PF11976	0.237
LIG_SUMO_SIM_par_1	100	106	PF11976	0.335
LIG_SUMO_SIM_par_1	196	203	PF11976	0.315
LIG_SUMO_SIM_par_1	285	293	PF11976	0.347
LIG_SUMO_SIM_par_1	460	466	PF11976	0.439
LIG_TRAF2_1	14	17	PF00917	0.788
LIG_TRAF2_1	166	169	PF00917	0.716
LIG_TRAF2_1	390	393	PF00917	0.500
LIG_TRFH_1	248	252	PF08558	0.413
LIG_UBA3_1	359	363	PF00899	0.204
LIG_WRC_WIRS_1	111	116	PF05994	0.349
LIG_WRC_WIRS_1	302	307	PF05994	0.335
LIG_WRC_WIRS_1	340	345	PF05994	0.371
MOD_CDC14_SPxK_1	261	264	PF00782	0.531
MOD_CDK_SPxK_1	258	264	PF00069	0.568
MOD_CDK_SPxK_1	331	337	PF00069	0.384
MOD_CK1_1	139	145	PF00069	0.475
MOD_CK1_1	293	299	PF00069	0.287
MOD_CK1_1	341	347	PF00069	0.344
MOD_CK1_1	410	416	PF00069	0.491
MOD_CK1_1	421	427	PF00069	0.430
MOD_CK1_1	428	434	PF00069	0.322
MOD_CK1_1	466	472	PF00069	0.349
MOD_CK1_1	474	480	PF00069	0.319
MOD_CK2_1	51	57	PF00069	0.619
MOD_CK2_1	82	88	PF00069	0.500
MOD_GlcNHglycan	10	13	PF01048	0.696
MOD_GlcNHglycan	122	125	PF01048	0.441
MOD_GlcNHglycan	141	144	PF01048	0.335
MOD_GlcNHglycan	163	166	PF01048	0.573
MOD_GlcNHglycan	355	358	PF01048	0.335
MOD_GlcNHglycan	63	66	PF01048	0.743
MOD_GSK3_1	110	117	PF00069	0.359
MOD_GSK3_1	183	190	PF00069	0.552
MOD_GSK3_1	22	29	PF00069	0.755
MOD_GSK3_1	270	277	PF00069	0.560
MOD_GSK3_1	290	297	PF00069	0.271
MOD_GSK3_1	327	334	PF00069	0.480
MOD_GSK3_1	335	342	PF00069	0.314
MOD_GSK3_1	415	422	PF00069	0.332
MOD_GSK3_1	43	50	PF00069	0.673
MOD_GSK3_1	471	478	PF00069	0.436
MOD_GSK3_1	491	498	PF00069	0.363
MOD_GSK3_1	57	64	PF00069	0.756
MOD_GSK3_1	80	87	PF00069	0.465
MOD_LATS_1	318	324	PF00433	0.384
MOD_LATS_1	5	11	PF00433	0.598
MOD_LATS_1	78	84	PF00433	0.441
MOD_N-GLC_1	294	299	PF02516	0.384
MOD_NEK2_1	114	119	PF00069	0.327
MOD_NEK2_1	303	308	PF00069	0.402
MOD_NEK2_1	425	430	PF00069	0.287
MOD_NEK2_1	43	48	PF00069	0.584
MOD_NEK2_1	463	468	PF00069	0.371
MOD_NEK2_2	136	141	PF00069	0.335
MOD_PIKK_1	415	421	PF00454	0.335
MOD_PIKK_1	528	534	PF00454	0.451
MOD_PKA_2	353	359	PF00069	0.433
MOD_PKA_2	446	452	PF00069	0.405
MOD_PKA_2	488	494	PF00069	0.406
MOD_PKA_2	6	12	PF00069	0.756
MOD_Plk_1	109	115	PF00069	0.272
MOD_Plk_1	205	211	PF00069	0.280
MOD_Plk_1	271	277	PF00069	0.687
MOD_Plk_1	294	300	PF00069	0.255
MOD_Plk_1	471	477	PF00069	0.377
MOD_Plk_1	97	103	PF00069	0.372
MOD_Plk_2-3	206	212	PF00069	0.300
MOD_Plk_4	110	116	PF00069	0.444
MOD_Plk_4	216	222	PF00069	0.495
MOD_Plk_4	229	235	PF00069	0.464
MOD_Plk_4	421	427	PF00069	0.298
MOD_ProDKin_1	167	173	PF00069	0.732
MOD_ProDKin_1	258	264	PF00069	0.527
MOD_ProDKin_1	274	280	PF00069	0.485
MOD_ProDKin_1	331	337	PF00069	0.316
MOD_ProDKin_1	428	434	PF00069	0.394
MOD_ProDKin_1	45	51	PF00069	0.799
MOD_ProDKin_1	466	472	PF00069	0.292
TRG_DiLeu_BaEn_1	88	93	PF01217	0.335
TRG_ENDOCYTIC_2	302	305	PF00928	0.485
TRG_ENDOCYTIC_2	322	325	PF00928	0.150
TRG_ENDOCYTIC_2	333	336	PF00928	0.289
TRG_ER_diArg_1	125	127	PF00400	0.281
TRG_ER_diArg_1	179	182	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN6	Leptomonas seymouri	42%	85%
A0A1X0P389	Trypanosomatidae	34%	100%
A0A3Q8IJ69	Leishmania donovani	89%	100%
A0A422NIH2	Trypanosoma rangeli	32%	100%
A4HI12	Leishmania braziliensis	70%	100%
A4I589	Leishmania infantum	89%	100%
C9ZQM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5B7R2	Trypanosoma cruzi	35%	100%