Ribosome biogenesis regulatory protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis regulatory protein (RRS1), putative

Species:

Leishmania major

UniProt:

Q4Q7P4_LEIMA

TriTrypDb:

LmjF.30.0620 , LMJLV39_300011800 , LMJSD75_300011600

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

Q4Q7P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P4

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	2
GO:0000055	ribosomal large subunit export from nucleus	4	2
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	2
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	2
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0031503	protein-containing complex localization	2	2
GO:0033750	ribosome localization	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051656	establishment of organelle localization	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0042254	ribosome biogenesis	5	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.304
CLV_NRD_NRD_1	182	184	PF00675	0.282
CLV_NRD_NRD_1	201	203	PF00675	0.492
CLV_NRD_NRD_1	53	55	PF00675	0.378
CLV_PCSK_KEX2_1	149	151	PF00082	0.291
CLV_PCSK_KEX2_1	182	184	PF00082	0.283
CLV_PCSK_KEX2_1	200	202	PF00082	0.574
CLV_PCSK_KEX2_1	242	244	PF00082	0.694
CLV_PCSK_KEX2_1	53	55	PF00082	0.378
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.304
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.488
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.694
CLV_PCSK_SKI1_1	111	115	PF00082	0.311
CLV_PCSK_SKI1_1	118	122	PF00082	0.315
CLV_PCSK_SKI1_1	162	166	PF00082	0.416
CLV_PCSK_SKI1_1	182	186	PF00082	0.118
CLV_PCSK_SKI1_1	235	239	PF00082	0.666
CLV_PCSK_SKI1_1	67	71	PF00082	0.325
DOC_MAPK_gen_1	81	91	PF00069	0.215
DOC_USP7_MATH_1	224	228	PF00917	0.535
DOC_USP7_UBL2_3	105	109	PF12436	0.304
DOC_USP7_UBL2_3	118	122	PF12436	0.304
DOC_USP7_UBL2_3	191	195	PF12436	0.323
DOC_USP7_UBL2_3	235	239	PF12436	0.576
DOC_WW_Pin1_4	6	11	PF00397	0.456
LIG_14-3-3_CanoR_1	201	207	PF00244	0.573
LIG_14-3-3_CanoR_1	221	231	PF00244	0.343
LIG_AP2alpha_2	176	178	PF02296	0.304
LIG_FHA_1	201	207	PF00498	0.497
LIG_FHA_1	239	245	PF00498	0.717
LIG_FHA_1	61	67	PF00498	0.304
LIG_FHA_2	39	45	PF00498	0.416
LIG_FHA_2	81	87	PF00498	0.449
LIG_LIR_Apic_2	4	10	PF02991	0.458
LIG_LIR_Gen_1	114	121	PF02991	0.304
LIG_LIR_Gen_1	156	166	PF02991	0.347
LIG_LIR_Gen_1	72	80	PF02991	0.416
LIG_LIR_Nem_3	114	119	PF02991	0.304
LIG_LIR_Nem_3	156	161	PF02991	0.347
LIG_LIR_Nem_3	72	76	PF02991	0.449
LIG_NRBOX	65	71	PF00104	0.416
LIG_SH2_CRK	7	11	PF00017	0.455
LIG_SH2_SRC	11	14	PF00017	0.453
LIG_SH2_STAP1	85	89	PF00017	0.215
LIG_SH2_STAT5	11	14	PF00017	0.453
LIG_SH2_STAT5	24	27	PF00017	0.336
LIG_SH3_1	7	13	PF00018	0.453
LIG_SH3_3	104	110	PF00018	0.247
LIG_SH3_3	17	23	PF00018	0.395
LIG_SH3_3	45	51	PF00018	0.351
LIG_SH3_3	7	13	PF00018	0.453
LIG_SH3_3	71	77	PF00018	0.416
LIG_SH3_3	89	95	PF00018	0.323
LIG_SUMO_SIM_par_1	38	44	PF11976	0.377
LIG_TRAF2_1	209	212	PF00917	0.463
LIG_WW_3	18	22	PF00397	0.438
MOD_CK1_1	46	52	PF00069	0.307
MOD_CK1_1	60	66	PF00069	0.296
MOD_CK1_1	87	93	PF00069	0.416
MOD_CK2_1	80	86	PF00069	0.416
MOD_Cter_Amidation	147	150	PF01082	0.291
MOD_GlcNHglycan	216	219	PF01048	0.551
MOD_GlcNHglycan	48	51	PF01048	0.304
MOD_GlcNHglycan	86	89	PF01048	0.416
MOD_GSK3_1	24	31	PF00069	0.620
MOD_GSK3_1	40	47	PF00069	0.366
MOD_GSK3_1	58	65	PF00069	0.381
MOD_GSK3_1	80	87	PF00069	0.416
MOD_LATS_1	198	204	PF00433	0.474
MOD_NEK2_1	231	236	PF00069	0.586
MOD_NEK2_1	58	63	PF00069	0.323
MOD_NEK2_2	62	67	PF00069	0.215
MOD_PKA_1	200	206	PF00069	0.480
MOD_PKA_1	238	244	PF00069	0.679
MOD_PKA_2	200	206	PF00069	0.498
MOD_Plk_1	43	49	PF00069	0.323
MOD_Plk_4	87	93	PF00069	0.323
MOD_ProDKin_1	6	12	PF00069	0.456
MOD_SUMO_rev_2	159	166	PF00179	0.416
MOD_SUMO_rev_2	211	216	PF00179	0.519
MOD_SUMO_rev_2	75	83	PF00179	0.403
TRG_DiLeu_BaEn_4	211	217	PF01217	0.467
TRG_ENDOCYTIC_2	158	161	PF00928	0.365
TRG_ER_diArg_1	52	54	PF00400	0.378
TRG_NLS_MonoExtC_3	234	239	PF00514	0.591
TRG_NLS_MonoExtC_3	80	86	PF00514	0.305
TRG_NLS_MonoExtN_4	233	239	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW0	Leptomonas seymouri	93%	100%
A0A0S4JMK3	Bodo saltans	63%	100%
A0A1X0P2F9	Trypanosomatidae	71%	100%
A0A3Q8IEM7	Leishmania donovani	98%	100%
A0A3R7KCB8	Trypanosoma rangeli	70%	100%
A1A5P2	Rattus norvegicus	34%	67%
A4HI13	Leishmania braziliensis	92%	100%
A4I590	Leishmania infantum	98%	100%
C9ZQM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B0I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q08746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q15050	Homo sapiens	33%	67%
Q2KIH4	Bos taurus	33%	67%
Q9CYH6	Mus musculus	34%	67%
Q9SH88	Arabidopsis thaliana	36%	77%
Q9XVT0	Caenorhabditis elegans	32%	74%