PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pdz domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7P2_LEIMA

TriTrypDb:

LmjF.30.0660 , LMJLV39_300012300 , LMJSD75_300012100

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7P2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0007165	signal transduction	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0035556	intracellular signal transduction	3	12
GO:0044238	primary metabolic process	2	12
GO:0048015	phosphatidylinositol-mediated signaling	5	2
GO:0048017	inositol lipid-mediated signaling	4	2
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004435	phosphatidylinositol phospholipase C activity	7	2
GO:0004620	phospholipase activity	5	2
GO:0004629	phospholipase C activity	6	2
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.343
CLV_C14_Caspase3-7	575	579	PF00656	0.567
CLV_C14_Caspase3-7	619	623	PF00656	0.442
CLV_NRD_NRD_1	495	497	PF00675	0.410
CLV_NRD_NRD_1	554	556	PF00675	0.433
CLV_PCSK_KEX2_1	19	21	PF00082	0.820
CLV_PCSK_KEX2_1	313	315	PF00082	0.426
CLV_PCSK_KEX2_1	495	497	PF00082	0.466
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.820
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.426
CLV_PCSK_SKI1_1	132	136	PF00082	0.394
CLV_PCSK_SKI1_1	157	161	PF00082	0.449
CLV_PCSK_SKI1_1	556	560	PF00082	0.535
CLV_PCSK_SKI1_1	66	70	PF00082	0.533
CLV_PCSK_SKI1_1	689	693	PF00082	0.470
DEG_APCC_DBOX_1	116	124	PF00400	0.461
DEG_APCC_DBOX_1	479	487	PF00400	0.323
DEG_APCC_DBOX_1	495	503	PF00400	0.455
DEG_SCF_FBW7_1	367	373	PF00400	0.273
DOC_ANK_TNKS_1	313	320	PF00023	0.390
DOC_ANK_TNKS_1	76	83	PF00023	0.249
DOC_CKS1_1	367	372	PF01111	0.302
DOC_CYCLIN_RxL_1	129	140	PF00134	0.424
DOC_CYCLIN_RxL_1	154	164	PF00134	0.451
DOC_MAPK_gen_1	113	122	PF00069	0.380
DOC_MAPK_gen_1	424	431	PF00069	0.445
DOC_MAPK_MEF2A_6	113	122	PF00069	0.395
DOC_MAPK_MEF2A_6	424	431	PF00069	0.421
DOC_MAPK_MEF2A_6	438	445	PF00069	0.216
DOC_MAPK_MEF2A_6	582	590	PF00069	0.454
DOC_MAPK_MEF2A_6	625	633	PF00069	0.332
DOC_MAPK_MEF2A_6	705	712	PF00069	0.446
DOC_MAPK_MEF2A_6	97	104	PF00069	0.361
DOC_MAPK_NFAT4_5	115	123	PF00069	0.527
DOC_MAPK_NFAT4_5	97	105	PF00069	0.444
DOC_PP1_RVXF_1	191	198	PF00149	0.452
DOC_PP2B_LxvP_1	134	137	PF13499	0.485
DOC_USP7_MATH_1	283	287	PF00917	0.529
DOC_USP7_MATH_1	517	521	PF00917	0.411
DOC_USP7_MATH_1	544	548	PF00917	0.492
DOC_USP7_MATH_1	570	574	PF00917	0.579
DOC_USP7_MATH_1	644	648	PF00917	0.480
DOC_USP7_MATH_1	68	72	PF00917	0.304
DOC_USP7_MATH_1	706	710	PF00917	0.539
DOC_USP7_UBL2_3	115	119	PF12436	0.432
DOC_USP7_UBL2_3	552	556	PF12436	0.508
DOC_WW_Pin1_4	14	19	PF00397	0.713
DOC_WW_Pin1_4	363	368	PF00397	0.299
DOC_WW_Pin1_4	370	375	PF00397	0.299
DOC_WW_Pin1_4	405	410	PF00397	0.270
DOC_WW_Pin1_4	449	454	PF00397	0.270
DOC_WW_Pin1_4	623	628	PF00397	0.658
DOC_WW_Pin1_4	640	645	PF00397	0.361
LIG_14-3-3_CanoR_1	284	292	PF00244	0.476
LIG_14-3-3_CanoR_1	689	699	PF00244	0.463
LIG_Actin_WH2_2	464	482	PF00022	0.302
LIG_BIR_III_4	578	582	PF00653	0.565
LIG_BRCT_BRCA1_1	193	197	PF00533	0.309
LIG_BRCT_BRCA1_1	522	526	PF00533	0.483
LIG_BRCT_BRCA1_1	708	712	PF00533	0.340
LIG_BRCT_BRCA1_2	522	528	PF00533	0.462
LIG_deltaCOP1_diTrp_1	287	296	PF00928	0.390
LIG_FHA_1	122	128	PF00498	0.374
LIG_FHA_1	170	176	PF00498	0.462
LIG_FHA_1	182	188	PF00498	0.395
LIG_FHA_1	283	289	PF00498	0.398
LIG_FHA_1	318	324	PF00498	0.409
LIG_FHA_1	356	362	PF00498	0.368
LIG_FHA_1	538	544	PF00498	0.427
LIG_FHA_1	548	554	PF00498	0.394
LIG_FHA_1	55	61	PF00498	0.528
LIG_FHA_1	655	661	PF00498	0.453
LIG_FHA_1	672	678	PF00498	0.320
LIG_FHA_2	342	348	PF00498	0.318
LIG_FHA_2	552	558	PF00498	0.489
LIG_FHA_2	617	623	PF00498	0.557
LIG_GBD_Chelix_1	379	387	PF00786	0.299
LIG_Integrin_isoDGR_2	610	612	PF01839	0.429
LIG_LIR_Gen_1	152	163	PF02991	0.332
LIG_LIR_Gen_1	194	205	PF02991	0.317
LIG_LIR_Gen_1	215	223	PF02991	0.483
LIG_LIR_Gen_1	286	296	PF02991	0.376
LIG_LIR_Gen_1	39	48	PF02991	0.542
LIG_LIR_Nem_3	152	158	PF02991	0.317
LIG_LIR_Nem_3	184	189	PF02991	0.378
LIG_LIR_Nem_3	194	200	PF02991	0.266
LIG_LIR_Nem_3	215	221	PF02991	0.424
LIG_LIR_Nem_3	293	299	PF02991	0.479
LIG_LIR_Nem_3	356	362	PF02991	0.287
LIG_LIR_Nem_3	39	44	PF02991	0.539
LIG_LIR_Nem_3	523	529	PF02991	0.368
LIG_LIR_Nem_3	84	90	PF02991	0.519
LIG_LYPXL_yS_3	359	362	PF13949	0.270
LIG_PCNA_PIPBox_1	179	188	PF02747	0.472
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.512
LIG_Pex14_2	254	258	PF04695	0.528
LIG_Pex14_2	691	695	PF04695	0.318
LIG_PTB_Apo_2	163	170	PF02174	0.437
LIG_PTB_Apo_2	180	187	PF02174	0.439
LIG_PTB_Phospho_1	180	186	PF10480	0.566
LIG_REV1ctd_RIR_1	524	532	PF16727	0.477
LIG_SH2_CRK	265	269	PF00017	0.327
LIG_SH2_CRK	41	45	PF00017	0.553
LIG_SH2_CRK	704	708	PF00017	0.329
LIG_SH2_CRK	726	730	PF00017	0.334
LIG_SH2_STAT3	23	26	PF00017	0.577
LIG_SH2_STAT5	186	189	PF00017	0.464
LIG_SH2_STAT5	256	259	PF00017	0.397
LIG_SH2_STAT5	615	618	PF00017	0.329
LIG_SH2_STAT5	726	729	PF00017	0.324
LIG_SH3_1	705	711	PF00018	0.451
LIG_SH3_3	364	370	PF00018	0.359
LIG_SH3_3	705	711	PF00018	0.422
LIG_SUMO_SIM_anti_2	121	129	PF11976	0.443
LIG_SUMO_SIM_anti_2	630	635	PF11976	0.305
LIG_SUMO_SIM_anti_2	674	679	PF11976	0.326
LIG_SUMO_SIM_par_1	123	129	PF11976	0.381
LIG_SUMO_SIM_par_1	98	103	PF11976	0.344
LIG_UBA3_1	126	135	PF00899	0.348
MOD_CAAXbox	727	730	PF01239	0.333
MOD_CDC14_SPxK_1	17	20	PF00782	0.540
MOD_CDK_SPK_2	14	19	PF00069	0.786
MOD_CDK_SPxK_1	14	20	PF00069	0.655
MOD_CDK_SPxxK_3	449	456	PF00069	0.270
MOD_CK1_1	227	233	PF00069	0.562
MOD_CK1_1	243	249	PF00069	0.376
MOD_CK1_1	273	279	PF00069	0.377
MOD_CK1_1	366	372	PF00069	0.469
MOD_CK1_1	39	45	PF00069	0.661
MOD_CK1_1	420	426	PF00069	0.525
MOD_CK1_1	520	526	PF00069	0.493
MOD_CK1_1	547	553	PF00069	0.455
MOD_CK1_1	6	12	PF00069	0.770
MOD_CK1_1	623	629	PF00069	0.552
MOD_CK1_1	643	649	PF00069	0.513
MOD_CK1_1	663	669	PF00069	0.433
MOD_CK2_1	104	110	PF00069	0.346
MOD_CK2_1	341	347	PF00069	0.299
MOD_CK2_1	5	11	PF00069	0.786
MOD_CK2_1	75	81	PF00069	0.345
MOD_GlcNHglycan	208	211	PF01048	0.329
MOD_GlcNHglycan	388	391	PF01048	0.287
MOD_GlcNHglycan	41	44	PF01048	0.553
MOD_GlcNHglycan	517	520	PF01048	0.371
MOD_GlcNHglycan	568	571	PF01048	0.474
MOD_GlcNHglycan	622	625	PF01048	0.471
MOD_GlcNHglycan	692	695	PF01048	0.370
MOD_GlcNHglycan	70	73	PF01048	0.586
MOD_GlcNHglycan	87	90	PF01048	0.295
MOD_GSK3_1	100	107	PF00069	0.352
MOD_GSK3_1	121	128	PF00069	0.422
MOD_GSK3_1	161	168	PF00069	0.384
MOD_GSK3_1	169	176	PF00069	0.407
MOD_GSK3_1	266	273	PF00069	0.352
MOD_GSK3_1	290	297	PF00069	0.361
MOD_GSK3_1	366	373	PF00069	0.376
MOD_GSK3_1	513	520	PF00069	0.388
MOD_GSK3_1	543	550	PF00069	0.439
MOD_GSK3_1	566	573	PF00069	0.430
MOD_GSK3_1	6	13	PF00069	0.693
MOD_GSK3_1	616	623	PF00069	0.446
MOD_GSK3_1	640	647	PF00069	0.502
MOD_N-GLC_1	191	196	PF02516	0.336
MOD_N-GLC_1	270	275	PF02516	0.491
MOD_N-GLC_1	640	645	PF02516	0.537
MOD_N-GLC_1	648	653	PF02516	0.473
MOD_N-GLC_1	660	665	PF02516	0.278
MOD_N-GLC_2	106	108	PF02516	0.318
MOD_NEK2_1	102	107	PF00069	0.240
MOD_NEK2_1	126	131	PF00069	0.383
MOD_NEK2_1	169	174	PF00069	0.525
MOD_NEK2_1	292	297	PF00069	0.432
MOD_NEK2_1	417	422	PF00069	0.363
MOD_NEK2_1	479	484	PF00069	0.302
MOD_NEK2_1	548	553	PF00069	0.520
MOD_NEK2_1	629	634	PF00069	0.430
MOD_NEK2_1	648	653	PF00069	0.375
MOD_NEK2_1	75	80	PF00069	0.433
MOD_NEK2_1	85	90	PF00069	0.421
MOD_NMyristoyl	1	7	PF02799	0.594
MOD_PIKK_1	290	296	PF00454	0.345
MOD_PIKK_1	660	666	PF00454	0.465
MOD_PIKK_1	90	96	PF00454	0.423
MOD_PKA_2	283	289	PF00069	0.402
MOD_PKA_2	443	449	PF00069	0.273
MOD_PKA_2	479	485	PF00069	0.302
MOD_PKA_2	605	611	PF00069	0.465
MOD_PKA_2	715	721	PF00069	0.536
MOD_Plk_1	139	145	PF00069	0.490
MOD_Plk_1	191	197	PF00069	0.400
MOD_Plk_1	490	496	PF00069	0.283
MOD_Plk_1	627	633	PF00069	0.408
MOD_Plk_1	648	654	PF00069	0.582
MOD_Plk_1	687	693	PF00069	0.413
MOD_Plk_2-3	341	347	PF00069	0.416
MOD_Plk_2-3	54	60	PF00069	0.536
MOD_Plk_4	181	187	PF00069	0.411
MOD_Plk_4	270	276	PF00069	0.336
MOD_Plk_4	341	347	PF00069	0.325
MOD_Plk_4	629	635	PF00069	0.546
MOD_ProDKin_1	14	20	PF00069	0.716
MOD_ProDKin_1	363	369	PF00069	0.299
MOD_ProDKin_1	370	376	PF00069	0.299
MOD_ProDKin_1	405	411	PF00069	0.270
MOD_ProDKin_1	449	455	PF00069	0.270
MOD_ProDKin_1	623	629	PF00069	0.647
MOD_ProDKin_1	640	646	PF00069	0.359
MOD_SPalmitoyl_4	1	7	PF01529	0.653
MOD_SUMO_rev_2	27	37	PF00179	0.614
MOD_SUMO_rev_2	307	315	PF00179	0.439
MOD_SUMO_rev_2	398	408	PF00179	0.264
MOD_SUMO_rev_2	497	505	PF00179	0.413
MOD_SUMO_rev_2	530	537	PF00179	0.536
MOD_SUMO_rev_2	575	584	PF00179	0.376
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.472
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.464
TRG_ENDOCYTIC_2	265	268	PF00928	0.322
TRG_ENDOCYTIC_2	359	362	PF00928	0.270
TRG_ENDOCYTIC_2	41	44	PF00928	0.553
TRG_ENDOCYTIC_2	704	707	PF00928	0.322
TRG_ENDOCYTIC_2	726	729	PF00928	0.324
TRG_ER_diArg_1	494	496	PF00400	0.416
TRG_ER_diArg_1	604	607	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S8	Leptomonas seymouri	73%	99%
A0A0S4KHF2	Bodo saltans	41%	100%
A0A1X0P2U3	Trypanosomatidae	47%	100%
A0A3Q8IES3	Leishmania donovani	98%	100%
A0A3R7MG69	Trypanosoma rangeli	43%	96%
A4HI17	Leishmania braziliensis	86%	100%
A4I594	Leishmania infantum	98%	100%
C9ZQM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B0J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
V5AS75	Trypanosoma cruzi	48%	100%