Putative nuclear movement protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear movement protein, putative

Species:

Leishmania major

UniProt:

Q4Q7N8_LEIMA

TriTrypDb:

LmjF.30.0700 , LMJLV39_300012700 , LMJSD75_300012500

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7N8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.478
CLV_PCSK_KEX2_1	152	154	PF00082	0.629
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.629
CLV_PCSK_SKI1_1	122	126	PF00082	0.423
CLV_PCSK_SKI1_1	34	38	PF00082	0.350
DEG_ODPH_VHL_1	42	55	PF01847	0.478
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.484
DOC_MAPK_DCC_7	122	131	PF00069	0.492
DOC_MAPK_gen_1	122	131	PF00069	0.492
DOC_MAPK_gen_1	47	55	PF00069	0.478
DOC_MAPK_gen_1	56	64	PF00069	0.412
DOC_MAPK_HePTP_8	119	131	PF00069	0.470
DOC_MAPK_MEF2A_6	122	131	PF00069	0.492
DOC_MAPK_MEF2A_6	47	55	PF00069	0.411
DOC_MAPK_MEF2A_6	56	64	PF00069	0.412
DOC_PP2B_LxvP_1	124	127	PF13499	0.490
LIG_14-3-3_CanoR_1	47	52	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_BRCT_BRCA1_1	127	131	PF00533	0.527
LIG_FHA_1	37	43	PF00498	0.444
LIG_FHA_1	83	89	PF00498	0.424
LIG_FHA_1	9	15	PF00498	0.372
LIG_FHA_2	99	105	PF00498	0.509
LIG_LIR_Gen_1	128	138	PF02991	0.508
LIG_LIR_LC3C_4	93	96	PF02991	0.500
LIG_LIR_Nem_3	106	112	PF02991	0.325
LIG_LIR_Nem_3	128	134	PF02991	0.592
LIG_LIR_Nem_3	23	27	PF02991	0.387
LIG_LIR_Nem_3	74	79	PF02991	0.424
LIG_PCNA_yPIPBox_3	139	153	PF02747	0.454
LIG_PDZ_Class_1	156	161	PF00595	0.565
LIG_SH2_CRK	76	80	PF00017	0.424
LIG_SH2_STAP1	105	109	PF00017	0.396
LIG_SH2_STAT5	24	27	PF00017	0.541
LIG_SH3_3	38	44	PF00018	0.440
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.478
LIG_SUMO_SIM_par_1	93	99	PF11976	0.415
LIG_TRAF2_1	5	8	PF00917	0.388
LIG_WRC_WIRS_1	26	31	PF05994	0.337
MOD_CK2_1	29	35	PF00069	0.491
MOD_CK2_1	98	104	PF00069	0.467
MOD_GSK3_1	125	132	PF00069	0.502
MOD_GSK3_1	25	32	PF00069	0.352
MOD_GSK3_1	43	50	PF00069	0.411
MOD_NEK2_1	98	103	PF00069	0.516
MOD_NEK2_2	22	27	PF00069	0.441
MOD_PIKK_1	3	9	PF00454	0.403
MOD_PK_1	125	131	PF00069	0.515
MOD_PKA_2	129	135	PF00069	0.517
MOD_Plk_1	22	28	PF00069	0.412
MOD_Plk_1	34	40	PF00069	0.404
MOD_Plk_1	81	87	PF00069	0.425
MOD_Plk_4	22	28	PF00069	0.416
MOD_Plk_4	66	72	PF00069	0.507
MOD_SUMO_rev_2	116	124	PF00179	0.362
MOD_SUMO_rev_2	50	57	PF00179	0.478
MOD_SUMO_rev_2	84	94	PF00179	0.412
TRG_ENDOCYTIC_2	76	79	PF00928	0.409
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KHK6	Bodo saltans	56%	89%
A0A1X0P2C4	Trypanosomatidae	59%	92%
A0A3R7L0Q9	Trypanosoma rangeli	56%	92%
A0A3S7X365	Leishmania donovani	97%	100%
A4HI21	Leishmania braziliensis	85%	100%
A4I598	Leishmania infantum	97%	100%
E9B0J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O60166	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	97%
P17624	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	81%
Q54M64	Dictyostelium discoideum	33%	94%
Q5M823	Rattus norvegicus	30%	100%
Q8WVJ2	Homo sapiens	30%	100%
Q9CQ48	Mus musculus	30%	100%