Mrr_cat_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7N5_LEIMA

TriTrypDb:

LmjF.30.0720 , LMJLV39_300012900 , LMJSD75_300012700

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.313
CLV_PCSK_KEX2_1	119	121	PF00082	0.410
CLV_PCSK_KEX2_1	183	185	PF00082	0.385
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.435
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.409
CLV_PCSK_SKI1_1	23	27	PF00082	0.390
DEG_MDM2_SWIB_1	203	210	PF02201	0.314
DEG_MDM2_SWIB_1	26	34	PF02201	0.410
DEG_Nend_Nbox_1	1	3	PF02207	0.375
DEG_SCF_FBW7_1	156	163	PF00400	0.482
DOC_CKS1_1	157	162	PF01111	0.416
DOC_CKS1_1	215	220	PF01111	0.419
DOC_CYCLIN_RxL_1	17	29	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	227	230	PF00134	0.405
DOC_MAPK_DCC_7	127	135	PF00069	0.451
DOC_MAPK_gen_1	118	126	PF00069	0.450
DOC_MAPK_gen_1	183	189	PF00069	0.391
DOC_MAPK_MEF2A_6	127	135	PF00069	0.462
DOC_MAPK_MEF2A_6	142	150	PF00069	0.223
DOC_PP1_RVXF_1	9	16	PF00149	0.340
DOC_PP2B_LxvP_1	227	230	PF13499	0.405
DOC_USP7_MATH_1	76	80	PF00917	0.414
DOC_USP7_MATH_1	88	92	PF00917	0.284
DOC_WW_Pin1_4	156	161	PF00397	0.400
DOC_WW_Pin1_4	214	219	PF00397	0.363
LIG_14-3-3_CanoR_1	142	147	PF00244	0.336
LIG_APCC_ABBAyCdc20_2	158	164	PF00400	0.471
LIG_BRCT_BRCA1_1	11	15	PF00533	0.368
LIG_CtBP_PxDLS_1	218	222	PF00389	0.466
LIG_deltaCOP1_diTrp_1	28	33	PF00928	0.424
LIG_FHA_1	51	57	PF00498	0.413
LIG_FHA_2	215	221	PF00498	0.350
LIG_FHA_2	27	33	PF00498	0.450
LIG_LIR_Apic_2	213	218	PF02991	0.414
LIG_LIR_Gen_1	159	170	PF02991	0.351
LIG_LIR_Gen_1	28	37	PF02991	0.391
LIG_LIR_Nem_3	12	18	PF02991	0.358
LIG_LIR_Nem_3	159	165	PF02991	0.371
LIG_LIR_Nem_3	28	33	PF02991	0.440
LIG_PCNA_PIPBox_1	55	64	PF02747	0.410
LIG_Pex14_2	203	207	PF04695	0.317
LIG_Pex14_2	26	30	PF04695	0.421
LIG_PTB_Apo_2	188	195	PF02174	0.385
LIG_SH2_CRK	18	22	PF00017	0.309
LIG_SH2_STAP1	205	209	PF00017	0.389
LIG_SH3_3	128	134	PF00018	0.400
LIG_SH3_3	154	160	PF00018	0.373
LIG_SH3_3	18	24	PF00018	0.345
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.364
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.332
LIG_SUMO_SIM_par_1	111	117	PF11976	0.436
LIG_TRAF2_1	29	32	PF00917	0.447
LIG_UBA3_1	68	73	PF00899	0.429
MOD_CK1_1	163	169	PF00069	0.335
MOD_CK1_1	214	220	PF00069	0.351
MOD_CK2_1	214	220	PF00069	0.351
MOD_CK2_1	26	32	PF00069	0.441
MOD_CK2_1	95	101	PF00069	0.426
MOD_GlcNHglycan	48	51	PF01048	0.480
MOD_GlcNHglycan	78	81	PF01048	0.401
MOD_GSK3_1	142	149	PF00069	0.339
MOD_GSK3_1	152	159	PF00069	0.405
MOD_GSK3_1	46	53	PF00069	0.407
MOD_N-GLC_1	76	81	PF02516	0.478
MOD_NEK2_1	114	119	PF00069	0.470
MOD_NEK2_1	174	179	PF00069	0.314
MOD_NEK2_1	26	31	PF00069	0.406
MOD_PIKK_1	90	96	PF00454	0.464
MOD_PK_1	142	148	PF00069	0.339
MOD_PKA_1	211	217	PF00069	0.322
MOD_PKA_2	141	147	PF00069	0.316
MOD_Plk_1	163	169	PF00069	0.336
MOD_Plk_4	108	114	PF00069	0.404
MOD_Plk_4	146	152	PF00069	0.330
MOD_Plk_4	211	217	PF00069	0.315
MOD_ProDKin_1	156	162	PF00069	0.392
MOD_ProDKin_1	214	220	PF00069	0.376
MOD_SUMO_rev_2	147	156	PF00179	0.414
MOD_SUMO_rev_2	3	13	PF00179	0.411
MOD_SUMO_rev_2	66	75	PF00179	0.463
TRG_DiLeu_BaEn_1	223	228	PF01217	0.369
TRG_DiLeu_BaEn_2	15	21	PF01217	0.315
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.392
TRG_ENDOCYTIC_2	172	175	PF00928	0.306
TRG_ENDOCYTIC_2	18	21	PF00928	0.285
TRG_ER_FFAT_1	79	91	PF00635	0.456
TRG_NLS_MonoExtC_3	117	123	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC7	Leptomonas seymouri	75%	83%
A0A0S4JDI3	Bodo saltans	37%	67%
A0A1X0P267	Trypanosomatidae	54%	78%
A0A3Q8IE40	Leishmania donovani	97%	73%
A0A422P4V6	Trypanosoma rangeli	54%	78%
A4HI24	Leishmania braziliensis	89%	100%
A4I5A1	Leishmania infantum	97%	83%
C9ZQN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	78%
E9B0J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	83%