Putative 4-methyl-5(Beta-hydroxyethyl)-thiazole monophosphate synthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein, putative

Species:

Leishmania major

UniProt:

Q4Q7N0_LEIMA

TriTrypDb:

LmjF.30.0750 , LMJLV39_300013400 , LMJSD75_300013200

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q7N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7N0

Function

Biological processes
Term	Name	Level	Count
GO:0006081	cellular aldehyde metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1903189	glyoxal metabolic process	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	176	180	PF00082	0.464
CLV_PCSK_SKI1_1	39	43	PF00082	0.418
CLV_PCSK_SKI1_1	85	89	PF00082	0.356
DOC_MAPK_MEF2A_6	25	32	PF00069	0.373
DOC_PP1_SILK_1	165	170	PF00149	0.444
DOC_USP7_MATH_1	163	167	PF00917	0.385
DOC_USP7_MATH_1	8	12	PF00917	0.409
DOC_USP7_UBL2_3	136	140	PF12436	0.250
DOC_WW_Pin1_4	167	172	PF00397	0.556
LIG_Actin_WH2_2	69	87	PF00022	0.484
LIG_FHA_1	137	143	PF00498	0.428
LIG_FHA_1	18	24	PF00498	0.275
LIG_GBD_Chelix_1	173	181	PF00786	0.491
LIG_LIR_Gen_1	62	69	PF02991	0.431
LIG_LIR_Nem_3	122	127	PF02991	0.371
LIG_LIR_Nem_3	156	162	PF02991	0.423
LIG_LIR_Nem_3	62	66	PF02991	0.379
LIG_SH2_CRK	63	67	PF00017	0.352
LIG_SH2_CRK	98	102	PF00017	0.352
LIG_SH2_STAP1	63	67	PF00017	0.484
LIG_SH2_STAT5	159	162	PF00017	0.467
LIG_SH3_3	63	69	PF00018	0.352
LIG_SUMO_SIM_anti_2	11	18	PF11976	0.452
LIG_SUMO_SIM_par_1	15	21	PF11976	0.422
LIG_TYR_ITIM	61	66	PF00017	0.406
MOD_CK2_1	31	37	PF00069	0.391
MOD_CK2_1	56	62	PF00069	0.486
MOD_Cter_Amidation	93	96	PF01082	0.484
MOD_GlcNHglycan	57	61	PF01048	0.353
MOD_GSK3_1	131	138	PF00069	0.500
MOD_GSK3_1	163	170	PF00069	0.452
MOD_GSK3_1	17	24	PF00069	0.250
MOD_GSK3_1	31	38	PF00069	0.371
MOD_Plk_2-3	15	21	PF00069	0.425
MOD_Plk_4	163	169	PF00069	0.425
MOD_Plk_4	31	37	PF00069	0.352
MOD_ProDKin_1	167	173	PF00069	0.552
MOD_SUMO_for_1	143	146	PF00179	0.406
MOD_SUMO_rev_2	34	41	PF00179	0.498
TRG_DiLeu_BaEn_1	12	17	PF01217	0.449
TRG_ENDOCYTIC_2	124	127	PF00928	0.345
TRG_ENDOCYTIC_2	159	162	PF00928	0.484
TRG_ENDOCYTIC_2	63	66	PF00928	0.352
TRG_ENDOCYTIC_2	98	101	PF00928	0.352
TRG_NES_CRM1_1	172	184	PF08389	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDE5	Bodo saltans	44%	98%
A0A1X0P220	Trypanosomatidae	58%	99%
A0A3Q8IHS5	Leishmania donovani	96%	100%
A0A422P4U5	Trypanosoma rangeli	51%	99%
A1Z9J4	Drosophila melanogaster	34%	90%
A4HI30	Leishmania braziliensis	79%	100%
A4I5A6	Leishmania infantum	95%	100%
C6K3W3	Leptomonas seymouri	70%	100%
C9ZQP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	99%
E9B0K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O06006	Bacillus subtilis (strain 168)	30%	100%
O16228	Caenorhabditis elegans	31%	100%
O59413	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O88767	Rattus norvegicus	37%	100%
P47275	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	27%	100%
P55880	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P90994	Caenorhabditis elegans	36%	100%
Q10356	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q46948	Escherichia coli (strain K12)	34%	100%
Q51732	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
Q58377	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	96%
Q5E946	Bos taurus	37%	100%
Q5JGM7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	31%	100%
Q5XJ36	Danio rerio	37%	100%
Q7TQ35	Mesocricetus auratus	36%	100%
Q8UW59	Gallus gallus	35%	100%
Q95LI9	Chlorocebus aethiops	37%	100%
Q99497	Homo sapiens	37%	100%
Q99LX0	Mus musculus	37%	100%
Q9V1F8	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
Q9VA37	Drosophila melanogaster	36%	100%
V5DQT9	Trypanosoma cruzi	57%	69%