Armadillo-type fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Armadillo-type fold

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7M9_LEIMA

TriTrypDb:

LmjF.30.0760 , LMJLV39_300013500 , LMJSD75_300013300

Length:

1057

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.488
CLV_C14_Caspase3-7	502	506	PF00656	0.529
CLV_C14_Caspase3-7	76	80	PF00656	0.496
CLV_MEL_PAP_1	952	958	PF00089	0.781
CLV_NRD_NRD_1	1021	1023	PF00675	0.796
CLV_NRD_NRD_1	1039	1041	PF00675	0.504
CLV_NRD_NRD_1	304	306	PF00675	0.504
CLV_NRD_NRD_1	349	351	PF00675	0.530
CLV_NRD_NRD_1	518	520	PF00675	0.418
CLV_NRD_NRD_1	799	801	PF00675	0.482
CLV_NRD_NRD_1	868	870	PF00675	0.814
CLV_NRD_NRD_1	895	897	PF00675	0.718
CLV_NRD_NRD_1	919	921	PF00675	0.760
CLV_NRD_NRD_1	958	960	PF00675	0.768
CLV_PCSK_KEX2_1	1021	1023	PF00082	0.756
CLV_PCSK_KEX2_1	1039	1041	PF00082	0.502
CLV_PCSK_KEX2_1	349	351	PF00082	0.530
CLV_PCSK_KEX2_1	518	520	PF00082	0.418
CLV_PCSK_KEX2_1	562	564	PF00082	0.519
CLV_PCSK_KEX2_1	868	870	PF00082	0.810
CLV_PCSK_KEX2_1	894	896	PF00082	0.722
CLV_PCSK_KEX2_1	919	921	PF00082	0.760
CLV_PCSK_KEX2_1	958	960	PF00082	0.764
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.519
CLV_PCSK_PC7_1	1035	1041	PF00082	0.699
CLV_PCSK_PC7_1	890	896	PF00082	0.694
CLV_PCSK_SKI1_1	130	134	PF00082	0.517
CLV_PCSK_SKI1_1	241	245	PF00082	0.508
CLV_PCSK_SKI1_1	590	594	PF00082	0.383
CLV_PCSK_SKI1_1	60	64	PF00082	0.472
CLV_PCSK_SKI1_1	718	722	PF00082	0.382
CLV_PCSK_SKI1_1	749	753	PF00082	0.370
CLV_PCSK_SKI1_1	796	800	PF00082	0.493
CLV_PCSK_SKI1_1	973	977	PF00082	0.770
CLV_PCSK_SKI1_1	99	103	PF00082	0.500
CLV_Separin_Metazoa	258	262	PF03568	0.404
DOC_CKS1_1	824	829	PF01111	0.763
DOC_CKS1_1	858	863	PF01111	0.575
DOC_CYCLIN_RxL_1	653	663	PF00134	0.389
DOC_CYCLIN_RxL_1	793	803	PF00134	0.469
DOC_MAPK_gen_1	562	569	PF00069	0.519
DOC_MAPK_gen_1	606	616	PF00069	0.497
DOC_MAPK_MEF2A_6	379	387	PF00069	0.409
DOC_MAPK_MEF2A_6	532	539	PF00069	0.381
DOC_MAPK_MEF2A_6	562	569	PF00069	0.525
DOC_MAPK_MEF2A_6	594	602	PF00069	0.495
DOC_MAPK_MEF2A_6	609	616	PF00069	0.530
DOC_PP1_RVXF_1	204	211	PF00149	0.511
DOC_PP1_RVXF_1	794	800	PF00149	0.457
DOC_PP4_FxxP_1	42	45	PF00568	0.437
DOC_USP7_MATH_1	120	124	PF00917	0.562
DOC_USP7_MATH_1	411	415	PF00917	0.483
DOC_USP7_MATH_1	56	60	PF00917	0.490
DOC_USP7_MATH_1	711	715	PF00917	0.405
DOC_USP7_UBL2_3	609	613	PF12436	0.546
DOC_WW_Pin1_4	169	174	PF00397	0.477
DOC_WW_Pin1_4	538	543	PF00397	0.444
DOC_WW_Pin1_4	608	613	PF00397	0.537
DOC_WW_Pin1_4	802	807	PF00397	0.559
DOC_WW_Pin1_4	811	816	PF00397	0.627
DOC_WW_Pin1_4	823	828	PF00397	0.570
DOC_WW_Pin1_4	835	840	PF00397	0.651
DOC_WW_Pin1_4	857	862	PF00397	0.752
LIG_14-3-3_CanoR_1	121	127	PF00244	0.548
LIG_14-3-3_CanoR_1	532	538	PF00244	0.373
LIG_14-3-3_CanoR_1	606	612	PF00244	0.525
LIG_14-3-3_CanoR_1	705	712	PF00244	0.371
LIG_14-3-3_CanoR_1	735	745	PF00244	0.390
LIG_14-3-3_CanoR_1	800	808	PF00244	0.633
LIG_APCC_ABBA_1	36	41	PF00400	0.389
LIG_BIR_III_2	681	685	PF00653	0.509
LIG_BIR_III_4	128	132	PF00653	0.514
LIG_BRCT_BRCA1_1	122	126	PF00533	0.484
LIG_Clathr_ClatBox_1	224	228	PF01394	0.474
LIG_deltaCOP1_diTrp_1	209	217	PF00928	0.410
LIG_eIF4E_1	394	400	PF01652	0.385
LIG_eIF4E_1	724	730	PF01652	0.493
LIG_FHA_1	100	106	PF00498	0.247
LIG_FHA_1	1002	1008	PF00498	0.708
LIG_FHA_1	147	153	PF00498	0.395
LIG_FHA_1	248	254	PF00498	0.413
LIG_FHA_1	286	292	PF00498	0.388
LIG_FHA_1	33	39	PF00498	0.459
LIG_FHA_1	426	432	PF00498	0.448
LIG_FHA_1	502	508	PF00498	0.485
LIG_FHA_1	534	540	PF00498	0.390
LIG_FHA_1	738	744	PF00498	0.419
LIG_FHA_1	782	788	PF00498	0.569
LIG_FHA_1	824	830	PF00498	0.787
LIG_FHA_1	83	89	PF00498	0.472
LIG_FHA_2	102	108	PF00498	0.507
LIG_FHA_2	131	137	PF00498	0.523
LIG_FHA_2	218	224	PF00498	0.410
LIG_FHA_2	455	461	PF00498	0.523
LIG_GBD_Chelix_1	174	182	PF00786	0.410
LIG_HCF-1_HBM_1	847	850	PF13415	0.762
LIG_LIR_Apic_2	40	45	PF02991	0.447
LIG_LIR_Apic_2	847	853	PF02991	0.753
LIG_LIR_Apic_2	976	982	PF02991	0.655
LIG_LIR_Gen_1	209	217	PF02991	0.398
LIG_LIR_Gen_1	278	287	PF02991	0.407
LIG_LIR_Gen_1	37	47	PF02991	0.418
LIG_LIR_Gen_1	546	557	PF02991	0.525
LIG_LIR_Gen_1	650	660	PF02991	0.438
LIG_LIR_LC3C_4	222	226	PF02991	0.482
LIG_LIR_Nem_3	107	111	PF02991	0.368
LIG_LIR_Nem_3	117	122	PF02991	0.408
LIG_LIR_Nem_3	209	213	PF02991	0.419
LIG_LIR_Nem_3	278	282	PF02991	0.382
LIG_LIR_Nem_3	37	42	PF02991	0.425
LIG_LIR_Nem_3	546	552	PF02991	0.543
LIG_LIR_Nem_3	650	655	PF02991	0.467
LIG_LIR_Nem_3	70	75	PF02991	0.405
LIG_LIR_Nem_3	723	727	PF02991	0.304
LIG_LIR_Nem_3	826	831	PF02991	0.722
LIG_LIR_Nem_3	859	865	PF02991	0.790
LIG_PCNA_PIPBox_1	387	396	PF02747	0.393
LIG_PCNA_yPIPBox_3	144	152	PF02747	0.412
LIG_PCNA_yPIPBox_3	767	776	PF02747	0.466
LIG_SH2_CRK	471	475	PF00017	0.396
LIG_SH2_CRK	724	728	PF00017	0.294
LIG_SH2_CRK	850	854	PF00017	0.671
LIG_SH2_GRB2like	831	834	PF00017	0.734
LIG_SH2_NCK_1	440	444	PF00017	0.399
LIG_SH2_NCK_1	831	835	PF00017	0.734
LIG_SH2_SRC	75	78	PF00017	0.505
LIG_SH2_SRC	831	834	PF00017	0.734
LIG_SH2_STAT5	151	154	PF00017	0.405
LIG_SH2_STAT5	177	180	PF00017	0.386
LIG_SH2_STAT5	207	210	PF00017	0.412
LIG_SH2_STAT5	248	251	PF00017	0.465
LIG_SH2_STAT5	279	282	PF00017	0.378
LIG_SH2_STAT5	29	32	PF00017	0.404
LIG_SH2_STAT5	394	397	PF00017	0.404
LIG_SH2_STAT5	453	456	PF00017	0.381
LIG_SH2_STAT5	753	756	PF00017	0.384
LIG_SH2_STAT5	865	868	PF00017	0.767
LIG_SH3_1	831	837	PF00018	0.734
LIG_SH3_3	810	816	PF00018	0.706
LIG_SH3_3	831	837	PF00018	0.746
LIG_SH3_5	861	865	PF00018	0.578
LIG_Sin3_3	554	561	PF02671	0.475
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.397
LIG_SUMO_SIM_par_1	31	41	PF11976	0.419
LIG_SUMO_SIM_par_1	533	538	PF11976	0.372
LIG_TRAF2_1	268	271	PF00917	0.368
LIG_TRAF2_1	389	392	PF00917	0.467
LIG_TRAF2_1	840	843	PF00917	0.830
LIG_UBA3_1	297	306	PF00899	0.407
LIG_UBA3_1	344	353	PF00899	0.395
LIG_UBA3_1	601	609	PF00899	0.386
LIG_WRC_WIRS_1	279	284	PF05994	0.404
LIG_WRC_WIRS_1	426	431	PF05994	0.286
MOD_CDK_SPK_2	608	613	PF00069	0.537
MOD_CDK_SPxxK_3	538	545	PF00069	0.430
MOD_CDK_SPxxK_3	804	811	PF00069	0.617
MOD_CDK_SPxxK_3	823	830	PF00069	0.725
MOD_CK1_1	275	281	PF00069	0.360
MOD_CK1_1	322	328	PF00069	0.374
MOD_CK1_1	37	43	PF00069	0.414
MOD_CK1_1	452	458	PF00069	0.389
MOD_CK1_1	499	505	PF00069	0.510
MOD_CK1_1	538	544	PF00069	0.416
MOD_CK1_1	93	99	PF00069	0.515
MOD_CK2_1	101	107	PF00069	0.468
MOD_CK2_1	130	136	PF00069	0.477
MOD_CK2_1	217	223	PF00069	0.406
MOD_CK2_1	287	293	PF00069	0.509
MOD_CK2_1	37	43	PF00069	0.518
MOD_CK2_1	480	486	PF00069	0.323
MOD_Cter_Amidation	350	353	PF01082	0.542
MOD_Cter_Amidation	917	920	PF01082	0.777
MOD_Cter_Amidation	956	959	PF01082	0.809
MOD_GlcNHglycan	1041	1044	PF01048	0.752
MOD_GlcNHglycan	161	164	PF01048	0.425
MOD_GlcNHglycan	293	296	PF01048	0.517
MOD_GlcNHglycan	315	318	PF01048	0.358
MOD_GlcNHglycan	321	324	PF01048	0.344
MOD_GlcNHglycan	396	399	PF01048	0.447
MOD_GlcNHglycan	419	424	PF01048	0.447
MOD_GlcNHglycan	622	625	PF01048	0.363
MOD_GlcNHglycan	850	853	PF01048	0.768
MOD_GlcNHglycan	881	884	PF01048	0.816
MOD_GlcNHglycan	922	925	PF01048	0.753
MOD_GlcNHglycan	969	972	PF01048	0.719
MOD_GSK3_1	28	35	PF00069	0.474
MOD_GSK3_1	281	288	PF00069	0.419
MOD_GSK3_1	499	506	PF00069	0.472
MOD_GSK3_1	604	611	PF00069	0.477
MOD_GSK3_1	660	667	PF00069	0.353
MOD_GSK3_1	737	744	PF00069	0.397
MOD_GSK3_1	800	807	PF00069	0.595
MOD_N-GLC_1	157	162	PF02516	0.387
MOD_N-GLC_1	217	222	PF02516	0.505
MOD_N-GLC_1	327	332	PF02516	0.492
MOD_N-GLC_1	496	501	PF02516	0.488
MOD_N-GLC_1	521	526	PF02516	0.530
MOD_N-GLC_2	359	361	PF02516	0.375
MOD_N-GLC_2	402	404	PF02516	0.350
MOD_N-GLC_2	617	619	PF02516	0.364
MOD_N-GLC_2	90	92	PF02516	0.544
MOD_NEK2_1	1003	1008	PF00069	0.735
MOD_NEK2_1	217	222	PF00069	0.476
MOD_NEK2_1	232	237	PF00069	0.261
MOD_NEK2_1	313	318	PF00069	0.360
MOD_NEK2_1	34	39	PF00069	0.440
MOD_NEK2_1	503	508	PF00069	0.512
MOD_NEK2_1	627	632	PF00069	0.435
MOD_NEK2_1	660	665	PF00069	0.355
MOD_NEK2_1	699	704	PF00069	0.366
MOD_NEK2_1	799	804	PF00069	0.621
MOD_NEK2_2	212	217	PF00069	0.418
MOD_PIKK_1	120	126	PF00454	0.512
MOD_PIKK_1	705	711	PF00454	0.366
MOD_PIKK_1	756	762	PF00454	0.454
MOD_PIKK_1	79	85	PF00454	0.371
MOD_PKA_1	1039	1045	PF00069	0.631
MOD_PKA_1	800	806	PF00069	0.568
MOD_PKA_2	1039	1045	PF00069	0.726
MOD_PKA_2	120	126	PF00069	0.461
MOD_PKA_2	799	805	PF00069	0.635
MOD_PKA_2	911	917	PF00069	0.783
MOD_PKB_1	888	896	PF00069	0.747
MOD_Plk_1	106	112	PF00069	0.283
MOD_Plk_1	146	152	PF00069	0.393
MOD_Plk_1	16	22	PF00069	0.458
MOD_Plk_1	32	38	PF00069	0.288
MOD_Plk_1	499	505	PF00069	0.498
MOD_Plk_1	627	633	PF00069	0.427
MOD_Plk_1	756	762	PF00069	0.454
MOD_Plk_1	93	99	PF00069	0.482
MOD_Plk_4	107	113	PF00069	0.297
MOD_Plk_4	147	153	PF00069	0.472
MOD_Plk_4	212	218	PF00069	0.407
MOD_Plk_4	272	278	PF00069	0.349
MOD_Plk_4	34	40	PF00069	0.400
MOD_Plk_4	449	455	PF00069	0.361
MOD_Plk_4	535	541	PF00069	0.394
MOD_Plk_4	596	602	PF00069	0.412
MOD_Plk_4	64	70	PF00069	0.448
MOD_Plk_4	660	666	PF00069	0.354
MOD_Plk_4	749	755	PF00069	0.363
MOD_Plk_4	761	767	PF00069	0.414
MOD_Plk_4	93	99	PF00069	0.472
MOD_ProDKin_1	169	175	PF00069	0.469
MOD_ProDKin_1	538	544	PF00069	0.435
MOD_ProDKin_1	608	614	PF00069	0.530
MOD_ProDKin_1	802	808	PF00069	0.565
MOD_ProDKin_1	811	817	PF00069	0.627
MOD_ProDKin_1	823	829	PF00069	0.575
MOD_ProDKin_1	835	841	PF00069	0.652
MOD_ProDKin_1	857	863	PF00069	0.754
MOD_SUMO_for_1	143	146	PF00179	0.320
MOD_SUMO_rev_2	123	132	PF00179	0.505
MOD_SUMO_rev_2	371	375	PF00179	0.407
TRG_DiLeu_BaEn_1	272	277	PF01217	0.430
TRG_DiLeu_BaEn_1	293	298	PF01217	0.502
TRG_DiLeu_BaEn_2	227	233	PF01217	0.383
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.390
TRG_ENDOCYTIC_2	1014	1017	PF00928	0.708
TRG_ENDOCYTIC_2	112	115	PF00928	0.554
TRG_ENDOCYTIC_2	279	282	PF00928	0.388
TRG_ENDOCYTIC_2	471	474	PF00928	0.399
TRG_ENDOCYTIC_2	549	552	PF00928	0.552
TRG_ENDOCYTIC_2	724	727	PF00928	0.292
TRG_ER_diArg_1	1038	1040	PF00400	0.673
TRG_ER_diArg_1	1044	1047	PF00400	0.681
TRG_ER_diArg_1	203	206	PF00400	0.462
TRG_ER_diArg_1	348	350	PF00400	0.525
TRG_ER_diArg_1	517	519	PF00400	0.412
TRG_ER_diArg_1	654	657	PF00400	0.421
TRG_ER_diArg_1	894	896	PF00400	0.722
TRG_ER_diArg_1	958	960	PF00400	0.799
TRG_ER_diArg_1	962	965	PF00400	0.801
TRG_NES_CRM1_1	228	242	PF08389	0.456
TRG_NLS_MonoExtN_4	349	356	PF00514	0.531
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	991	995	PF00026	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAU2	Bodo saltans	58%	88%
A0A1X0P218	Trypanosomatidae	62%	96%
A0A3Q8IET2	Leishmania donovani	97%	100%
A0A422P4T6	Trypanosoma rangeli	59%	97%
A4HI31	Leishmania braziliensis	92%	93%
A4I5A7	Leishmania infantum	97%	100%
C6K3W4	Leptomonas seymouri	79%	92%
C9ZQP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9B0K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BPP6	Trypanosoma cruzi	60%	97%