Putative mitochondrial oligo_U binding protein TBRGG1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial oligo_U binding protein TBRGG1, putative

Species:

Leishmania major

UniProt:

Q4Q7M7_LEIMA

TriTrypDb:

LmjF.30.0780 , LMJLV39_300013800 , LMJSD75_300013500

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.634
CLV_NRD_NRD_1	112	114	PF00675	0.579
CLV_NRD_NRD_1	131	133	PF00675	0.642
CLV_NRD_NRD_1	169	171	PF00675	0.466
CLV_NRD_NRD_1	173	175	PF00675	0.501
CLV_PCSK_KEX2_1	101	103	PF00082	0.634
CLV_PCSK_KEX2_1	112	114	PF00082	0.579
CLV_PCSK_KEX2_1	131	133	PF00082	0.652
CLV_PCSK_KEX2_1	169	171	PF00082	0.576
CLV_PCSK_KEX2_1	173	175	PF00082	0.490
CLV_PCSK_PC7_1	169	175	PF00082	0.414
CLV_PCSK_SKI1_1	153	157	PF00082	0.571
CLV_PCSK_SKI1_1	169	173	PF00082	0.512
CLV_PCSK_SKI1_1	4	8	PF00082	0.721
CLV_PCSK_SKI1_1	427	431	PF00082	0.504
CLV_PCSK_SKI1_1	501	505	PF00082	0.598
CLV_PCSK_SKI1_1	579	583	PF00082	0.375
DEG_APCC_DBOX_1	578	586	PF00400	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.788
DOC_CDC14_PxL_1	349	357	PF14671	0.341
DOC_MAPK_gen_1	598	606	PF00069	0.277
DOC_MAPK_MEF2A_6	257	266	PF00069	0.476
DOC_PP4_FxxP_1	197	200	PF00568	0.450
DOC_SPAK_OSR1_1	161	165	PF12202	0.463
DOC_USP7_MATH_1	251	255	PF00917	0.412
DOC_USP7_MATH_1	292	296	PF00917	0.400
DOC_USP7_MATH_1	436	440	PF00917	0.503
DOC_USP7_MATH_1	491	495	PF00917	0.542
DOC_USP7_MATH_1	508	512	PF00917	0.634
DOC_USP7_MATH_1	638	642	PF00917	0.568
DOC_USP7_UBL2_3	149	153	PF12436	0.433
DOC_WW_Pin1_4	218	223	PF00397	0.393
DOC_WW_Pin1_4	233	238	PF00397	0.376
DOC_WW_Pin1_4	504	509	PF00397	0.546
DOC_WW_Pin1_4	574	579	PF00397	0.514
DOC_WW_Pin1_4	623	628	PF00397	0.589
LIG_14-3-3_CanoR_1	126	130	PF00244	0.643
LIG_14-3-3_CanoR_1	16	22	PF00244	0.530
LIG_14-3-3_CanoR_1	368	375	PF00244	0.399
LIG_14-3-3_CanoR_1	392	398	PF00244	0.521
LIG_14-3-3_CanoR_1	4	9	PF00244	0.710
LIG_14-3-3_CanoR_1	471	477	PF00244	0.389
LIG_14-3-3_CanoR_1	543	547	PF00244	0.534
LIG_14-3-3_CanoR_1	579	588	PF00244	0.458
LIG_14-3-3_CanoR_1	598	606	PF00244	0.392
LIG_14-3-3_CanoR_1	84	89	PF00244	0.561
LIG_Actin_WH2_2	558	573	PF00022	0.460
LIG_BRCT_BRCA1_1	532	536	PF00533	0.417
LIG_FHA_1	194	200	PF00498	0.438
LIG_FHA_1	368	374	PF00498	0.409
LIG_FHA_1	401	407	PF00498	0.507
LIG_FHA_1	476	482	PF00498	0.457
LIG_FHA_1	581	587	PF00498	0.411
LIG_FHA_2	173	179	PF00498	0.483
LIG_FHA_2	516	522	PF00498	0.698
LIG_FHA_2	536	542	PF00498	0.491
LIG_FHA_2	562	568	PF00498	0.521
LIG_IRF3_LxIS_1	539	545	PF10401	0.344
LIG_LIR_Apic_2	196	200	PF02991	0.442
LIG_LIR_Gen_1	207	217	PF02991	0.442
LIG_LIR_Nem_3	460	464	PF02991	0.450
LIG_LIR_Nem_3	533	539	PF02991	0.389
LIG_MYND_1	623	627	PF01753	0.360
LIG_PCNA_PIPBox_1	283	292	PF02747	0.434
LIG_PCNA_yPIPBox_3	241	249	PF02747	0.412
LIG_PCNA_yPIPBox_3	359	368	PF02747	0.392
LIG_SH2_CRK	18	22	PF00017	0.624
LIG_SH2_GRB2like	109	112	PF00017	0.714
LIG_SH2_GRB2like	81	84	PF00017	0.779
LIG_SH2_GRB2like	88	91	PF00017	0.721
LIG_SH2_NCK_1	435	439	PF00017	0.427
LIG_SH2_SRC	435	438	PF00017	0.530
LIG_SH2_SRC	88	91	PF00017	0.676
LIG_SH2_STAP1	18	22	PF00017	0.643
LIG_SH2_STAP1	532	536	PF00017	0.384
LIG_SH2_STAT3	137	140	PF00017	0.574
LIG_SH2_STAT3	57	60	PF00017	0.637
LIG_SH2_STAT5	109	112	PF00017	0.495
LIG_SH2_STAT5	137	140	PF00017	0.574
LIG_SH2_STAT5	95	98	PF00017	0.650
LIG_SH3_2	499	504	PF14604	0.569
LIG_SH3_3	392	398	PF00018	0.518
LIG_SH3_3	438	444	PF00018	0.434
LIG_SH3_3	494	500	PF00018	0.533
LIG_SH3_3	93	99	PF00018	0.575
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.419
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.345
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.350
LIG_SUMO_SIM_anti_2	485	491	PF11976	0.446
LIG_TRAF2_1	405	408	PF00917	0.488
LIG_TRAF2_1	446	449	PF00917	0.423
LIG_TRAF2_1	507	510	PF00917	0.585
LIG_UBA3_1	145	153	PF00899	0.405
LIG_UBA3_1	413	419	PF00899	0.473
LIG_UBA3_1	472	480	PF00899	0.415
LIG_WRC_WIRS_1	458	463	PF05994	0.566
LIG_WW_3	498	502	PF00397	0.480
MOD_CDK_SPK_2	574	579	PF00069	0.494
MOD_CK1_1	313	319	PF00069	0.605
MOD_CK1_1	396	402	PF00069	0.529
MOD_CK1_1	475	481	PF00069	0.450
MOD_CK2_1	178	184	PF00069	0.426
MOD_CK2_1	233	239	PF00069	0.407
MOD_CK2_1	285	291	PF00069	0.477
MOD_CK2_1	436	442	PF00069	0.451
MOD_CK2_1	504	510	PF00069	0.543
MOD_CK2_1	515	521	PF00069	0.695
MOD_CK2_1	535	541	PF00069	0.497
MOD_CK2_1	561	567	PF00069	0.494
MOD_GlcNHglycan	127	130	PF01048	0.712
MOD_GlcNHglycan	385	388	PF01048	0.406
MOD_GlcNHglycan	420	423	PF01048	0.457
MOD_GlcNHglycan	427	430	PF01048	0.351
MOD_GlcNHglycan	444	447	PF01048	0.377
MOD_GlcNHglycan	482	485	PF01048	0.447
MOD_GlcNHglycan	642	645	PF01048	0.540
MOD_GSK3_1	300	307	PF00069	0.437
MOD_GSK3_1	396	403	PF00069	0.567
MOD_GSK3_1	504	511	PF00069	0.497
MOD_GSK3_1	515	522	PF00069	0.750
MOD_N-GLC_1	491	496	PF02516	0.429
MOD_N-GLC_1	598	603	PF02516	0.449
MOD_N-GLC_1	84	89	PF02516	0.550
MOD_NEK2_1	172	177	PF00069	0.453
MOD_NEK2_1	355	360	PF00069	0.489
MOD_NEK2_1	472	477	PF00069	0.439
MOD_NEK2_1	561	566	PF00069	0.406
MOD_NEK2_1	633	638	PF00069	0.442
MOD_PIKK_1	136	142	PF00454	0.580
MOD_PIKK_1	178	184	PF00454	0.426
MOD_PIKK_1	355	361	PF00454	0.422
MOD_PIKK_1	475	481	PF00454	0.425
MOD_PKA_2	125	131	PF00069	0.635
MOD_PKA_2	172	178	PF00069	0.529
MOD_PKA_2	367	373	PF00069	0.460
MOD_PKA_2	542	548	PF00069	0.536
MOD_PKB_1	14	22	PF00069	0.559
MOD_PKB_1	72	80	PF00069	0.648
MOD_Plk_1	183	189	PF00069	0.385
MOD_Plk_1	491	497	PF00069	0.471
MOD_Plk_1	84	90	PF00069	0.772
MOD_Plk_2-3	515	521	PF00069	0.480
MOD_Plk_4	17	23	PF00069	0.592
MOD_Plk_4	251	257	PF00069	0.475
MOD_Plk_4	304	310	PF00069	0.429
MOD_Plk_4	485	491	PF00069	0.342
MOD_ProDKin_1	218	224	PF00069	0.387
MOD_ProDKin_1	233	239	PF00069	0.380
MOD_ProDKin_1	504	510	PF00069	0.549
MOD_ProDKin_1	574	580	PF00069	0.508
MOD_ProDKin_1	623	629	PF00069	0.579
MOD_SUMO_for_1	201	204	PF00179	0.465
MOD_SUMO_rev_2	236	243	PF00179	0.388
TRG_DiLeu_BaEn_1	167	172	PF01217	0.464
TRG_DiLeu_BaEn_1	344	349	PF01217	0.346
TRG_DiLeu_BaEn_4	277	283	PF01217	0.414
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.391
TRG_DiLeu_LyEn_5	167	172	PF01217	0.517
TRG_ENDOCYTIC_2	18	21	PF00928	0.624
TRG_ER_diArg_1	13	16	PF00400	0.679
TRG_ER_diArg_1	130	132	PF00400	0.718
TRG_ER_diArg_1	169	171	PF00400	0.444
TRG_ER_diArg_1	172	174	PF00400	0.451
TRG_NES_CRM1_1	258	272	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I169	Leptomonas seymouri	43%	98%
A0A0S4JB89	Bodo saltans	23%	88%
A0A1X0P251	Trypanosomatidae	39%	100%
A0A3S7X349	Leishmania donovani	92%	97%
A0A422P4U2	Trypanosoma rangeli	38%	100%
A4HI33	Leishmania braziliensis	78%	94%
A4I5A9	Leishmania infantum	92%	97%
C9ZQP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
E9B0K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%