Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7M6_LEIMA

TriTrypDb:

LmjF.30.0790 , LMJLV39_300013900 , LMJSD75_300013600

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.550
CLV_C14_Caspase3-7	151	155	PF00656	0.672
CLV_C14_Caspase3-7	97	101	PF00656	0.556
CLV_NRD_NRD_1	194	196	PF00675	0.624
CLV_NRD_NRD_1	214	216	PF00675	0.696
CLV_NRD_NRD_1	333	335	PF00675	0.692
CLV_NRD_NRD_1	350	352	PF00675	0.641
CLV_NRD_NRD_1	358	360	PF00675	0.567
CLV_NRD_NRD_1	58	60	PF00675	0.742
CLV_PCSK_KEX2_1	333	335	PF00082	0.655
CLV_PCSK_KEX2_1	349	351	PF00082	0.645
CLV_PCSK_KEX2_1	358	360	PF00082	0.560
CLV_PCSK_KEX2_1	417	419	PF00082	0.610
CLV_PCSK_KEX2_1	42	44	PF00082	0.611
CLV_PCSK_KEX2_1	421	423	PF00082	0.606
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.610
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.607
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.606
CLV_PCSK_PC7_1	329	335	PF00082	0.642
CLV_PCSK_SKI1_1	162	166	PF00082	0.664
CLV_PCSK_SKI1_1	216	220	PF00082	0.703
CLV_PCSK_SKI1_1	371	375	PF00082	0.670
CLV_PCSK_SKI1_1	42	46	PF00082	0.613
CLV_Separin_Metazoa	159	163	PF03568	0.657
DEG_APCC_DBOX_1	350	358	PF00400	0.624
DEG_SCF_FBW7_2	150	156	PF00400	0.676
DEG_SPOP_SBC_1	87	91	PF00917	0.556
DOC_CKS1_1	150	155	PF01111	0.676
DOC_MAPK_gen_1	349	357	PF00069	0.626
DOC_MAPK_gen_1	358	365	PF00069	0.489
DOC_USP7_MATH_1	139	143	PF00917	0.708
DOC_USP7_MATH_1	17	21	PF00917	0.673
DOC_USP7_MATH_2	310	316	PF00917	0.659
DOC_USP7_UBL2_3	417	421	PF12436	0.615
DOC_WW_Pin1_4	149	154	PF00397	0.682
DOC_WW_Pin1_4	202	207	PF00397	0.733
DOC_WW_Pin1_4	316	321	PF00397	0.728
DOC_WW_Pin1_4	393	398	PF00397	0.500
LIG_14-3-3_CanoR_1	204	212	PF00244	0.738
LIG_14-3-3_CanoR_1	224	234	PF00244	0.581
LIG_14-3-3_CanoR_1	333	338	PF00244	0.562
LIG_14-3-3_CanoR_1	43	47	PF00244	0.714
LIG_APCC_ABBA_1	61	66	PF00400	0.714
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	222	226	PF00533	0.751
LIG_BRCT_BRCA1_1	314	318	PF00533	0.667
LIG_FHA_1	127	133	PF00498	0.534
LIG_FHA_1	155	161	PF00498	0.581
LIG_FHA_1	236	242	PF00498	0.765
LIG_FHA_1	249	255	PF00498	0.645
LIG_FHA_1	279	285	PF00498	0.736
LIG_FHA_1	30	36	PF00498	0.597
LIG_FHA_1	303	309	PF00498	0.585
LIG_FHA_1	394	400	PF00498	0.617
LIG_FHA_2	198	204	PF00498	0.791
LIG_FHA_2	311	317	PF00498	0.684
LIG_FHA_2	341	347	PF00498	0.663
LIG_FHA_2	46	52	PF00498	0.713
LIG_LIR_Gen_1	125	134	PF02991	0.679
LIG_LIR_Gen_1	379	388	PF02991	0.559
LIG_LIR_Nem_3	125	130	PF02991	0.674
LIG_LIR_Nem_3	2	7	PF02991	0.690
LIG_LIR_Nem_3	379	383	PF02991	0.500
LIG_Pex14_1	107	111	PF04695	0.537
LIG_Pex14_3	160	165	PF04695	0.659
LIG_SH2_STAT5	111	114	PF00017	0.650
LIG_SH2_STAT5	360	363	PF00017	0.599
LIG_SH3_3	133	139	PF00018	0.522
LIG_SH3_3	147	153	PF00018	0.749
LIG_SH3_3	228	234	PF00018	0.742
LIG_SUMO_SIM_anti_2	156	163	PF11976	0.657
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.618
LIG_SUMO_SIM_par_1	128	133	PF11976	0.528
LIG_TRAF2_1	48	51	PF00917	0.713
LIG_WRC_WIRS_1	4	9	PF05994	0.594
MOD_CDK_SPxxK_3	393	400	PF00069	0.500
MOD_CK1_1	180	186	PF00069	0.631
MOD_CK1_1	205	211	PF00069	0.763
MOD_CK1_1	225	231	PF00069	0.521
MOD_CK1_1	235	241	PF00069	0.661
MOD_CK1_1	248	254	PF00069	0.572
MOD_CK1_1	268	274	PF00069	0.515
MOD_CK1_1	285	291	PF00069	0.652
MOD_CK1_1	336	342	PF00069	0.569
MOD_CK1_1	90	96	PF00069	0.756
MOD_CK2_1	122	128	PF00069	0.665
MOD_CK2_1	254	260	PF00069	0.741
MOD_CK2_1	286	292	PF00069	0.638
MOD_CK2_1	294	300	PF00069	0.648
MOD_CK2_1	3	9	PF00069	0.591
MOD_CK2_1	310	316	PF00069	0.679
MOD_CK2_1	340	346	PF00069	0.662
MOD_CK2_1	363	369	PF00069	0.413
MOD_CK2_1	45	51	PF00069	0.714
MOD_Cter_Amidation	419	422	PF01082	0.624
MOD_Cter_Amidation	57	60	PF01082	0.722
MOD_GlcNHglycan	1	4	PF01048	0.577
MOD_GlcNHglycan	11	14	PF01048	0.594
MOD_GlcNHglycan	168	171	PF01048	0.572
MOD_GlcNHglycan	182	185	PF01048	0.544
MOD_GlcNHglycan	19	22	PF01048	0.605
MOD_GlcNHglycan	320	323	PF01048	0.608
MOD_GlcNHglycan	365	368	PF01048	0.424
MOD_GlcNHglycan	412	415	PF01048	0.463
MOD_GSK3_1	122	129	PF00069	0.511
MOD_GSK3_1	218	225	PF00069	0.664
MOD_GSK3_1	261	268	PF00069	0.675
MOD_GSK3_1	278	285	PF00069	0.530
MOD_GSK3_1	310	317	PF00069	0.708
MOD_GSK3_1	329	336	PF00069	0.484
MOD_GSK3_1	388	395	PF00069	0.627
MOD_GSK3_1	86	93	PF00069	0.651
MOD_LATS_1	331	337	PF00433	0.569
MOD_N-GLC_1	388	393	PF02516	0.619
MOD_NEK2_1	226	231	PF00069	0.751
MOD_NEK2_1	261	266	PF00069	0.726
MOD_NEK2_1	29	34	PF00069	0.688
MOD_NEK2_1	337	342	PF00069	0.666
MOD_NEK2_1	363	368	PF00069	0.407
MOD_NEK2_1	88	93	PF00069	0.637
MOD_NEK2_2	3	8	PF00069	0.590
MOD_PIKK_1	268	274	PF00454	0.577
MOD_PIKK_1	29	35	PF00454	0.739
MOD_PIKK_1	310	316	PF00454	0.679
MOD_PIKK_1	88	94	PF00454	0.718
MOD_PKA_1	333	339	PF00069	0.562
MOD_PKA_1	42	48	PF00069	0.714
MOD_PKA_2	166	172	PF00069	0.685
MOD_PKA_2	174	180	PF00069	0.643
MOD_PKA_2	190	196	PF00069	0.527
MOD_PKA_2	226	232	PF00069	0.751
MOD_PKA_2	333	339	PF00069	0.630
MOD_PKA_2	42	48	PF00069	0.714
MOD_PKB_1	243	251	PF00069	0.727
MOD_Plk_1	279	285	PF00069	0.697
MOD_Plk_1	388	394	PF00069	0.626
MOD_Plk_1	401	407	PF00069	0.472
MOD_Plk_2-3	154	160	PF00069	0.658
MOD_Plk_4	279	285	PF00069	0.616
MOD_ProDKin_1	149	155	PF00069	0.680
MOD_ProDKin_1	202	208	PF00069	0.731
MOD_ProDKin_1	316	322	PF00069	0.725
MOD_ProDKin_1	393	399	PF00069	0.499
MOD_SUMO_for_1	399	402	PF00179	0.617
TRG_DiLeu_BaEn_1	156	161	PF01217	0.655
TRG_DiLeu_BaEn_1	352	357	PF01217	0.616
TRG_DiLeu_BaEn_4	352	358	PF01217	0.618
TRG_ENDOCYTIC_2	360	363	PF00928	0.493
TRG_ENDOCYTIC_2	380	383	PF00928	0.352
TRG_ER_diArg_1	333	335	PF00400	0.655
TRG_ER_diArg_1	348	351	PF00400	0.645
TRG_ER_diArg_1	357	359	PF00400	0.566
TRG_NES_CRM1_1	25	40	PF08389	0.692
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X346	Leishmania donovani	88%	100%
A4I5B0	Leishmania infantum	88%	100%
C6K3W7	Leptomonas seymouri	30%	100%
E9B0K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%