Putative serine-threonine kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rac serine-threonine kinase, putative

Species:

Leishmania major

UniProt:

Q4Q7M5_LEIMA

TriTrypDb:

LmjF.30.0800 , LMJLV39_300014000 , LMJSD75_300013700

Length:

510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	9
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	345	347	PF00675	0.400
CLV_NRD_NRD_1	369	371	PF00675	0.445
CLV_NRD_NRD_1	437	439	PF00675	0.754
CLV_NRD_NRD_1	495	497	PF00675	0.762
CLV_NRD_NRD_1	79	81	PF00675	0.487
CLV_PCSK_FUR_1	435	439	PF00082	0.758
CLV_PCSK_KEX2_1	345	347	PF00082	0.400
CLV_PCSK_KEX2_1	437	439	PF00082	0.754
CLV_PCSK_KEX2_1	442	444	PF00082	0.738
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.587
CLV_PCSK_PC7_1	438	444	PF00082	0.564
CLV_PCSK_SKI1_1	109	113	PF00082	0.462
CLV_PCSK_SKI1_1	154	158	PF00082	0.365
CLV_PCSK_SKI1_1	227	231	PF00082	0.341
CLV_PCSK_SKI1_1	313	317	PF00082	0.447
CLV_PCSK_SKI1_1	336	340	PF00082	0.371
CLV_PCSK_SKI1_1	370	374	PF00082	0.533
CLV_PCSK_SKI1_1	388	392	PF00082	0.428
CLV_PCSK_SKI1_1	48	52	PF00082	0.501
CLV_PCSK_SKI1_1	497	501	PF00082	0.797
DEG_APCC_DBOX_1	153	161	PF00400	0.399
DOC_CKS1_1	375	380	PF01111	0.582
DOC_CYCLIN_RxL_1	40	51	PF00134	0.447
DOC_CYCLIN_yClb1_LxF_4	297	303	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.611
DOC_MAPK_gen_1	227	236	PF00069	0.447
DOC_MAPK_gen_1	354	364	PF00069	0.568
DOC_PP1_RVXF_1	279	286	PF00149	0.365
DOC_PP2B_LxvP_1	372	375	PF13499	0.608
DOC_PP2B_PxIxI_1	322	328	PF00149	0.423
DOC_PP4_FxxP_1	505	508	PF00568	0.751
DOC_USP7_UBL2_3	126	130	PF12436	0.379
DOC_USP7_UBL2_3	503	507	PF12436	0.748
DOC_WW_Pin1_4	374	379	PF00397	0.560
DOC_WW_Pin1_4	397	402	PF00397	0.679
DOC_WW_Pin1_4	420	425	PF00397	0.809
DOC_WW_Pin1_4	449	454	PF00397	0.825
DOC_WW_Pin1_4	462	467	PF00397	0.620
DOC_WW_Pin1_4	6	11	PF00397	0.423
LIG_14-3-3_CanoR_1	345	351	PF00244	0.447
LIG_14-3-3_CanoR_1	460	466	PF00244	0.754
LIG_14-3-3_CanoR_1	80	88	PF00244	0.476
LIG_Actin_WH2_2	38	55	PF00022	0.447
LIG_APCC_ABBAyCdc20_2	222	228	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_EH1_1	178	186	PF00400	0.447
LIG_eIF4E_1	179	185	PF01652	0.447
LIG_eIF4E_1	268	274	PF01652	0.447
LIG_FHA_1	14	20	PF00498	0.501
LIG_FHA_1	314	320	PF00498	0.421
LIG_FHA_1	329	335	PF00498	0.436
LIG_FHA_1	389	395	PF00498	0.645
LIG_FHA_1	58	64	PF00498	0.444
LIG_FHA_2	100	106	PF00498	0.544
LIG_FHA_2	190	196	PF00498	0.414
LIG_FHA_2	29	35	PF00498	0.501
LIG_FHA_2	427	433	PF00498	0.757
LIG_FHA_2	49	55	PF00498	0.170
LIG_LIR_Apic_2	265	271	PF02991	0.365
LIG_LIR_Apic_2	504	508	PF02991	0.748
LIG_LIR_Gen_1	15	26	PF02991	0.447
LIG_LIR_Gen_1	189	199	PF02991	0.425
LIG_LIR_Gen_1	2	10	PF02991	0.447
LIG_LIR_Gen_1	294	303	PF02991	0.418
LIG_LIR_Gen_1	363	372	PF02991	0.346
LIG_LIR_Nem_3	116	120	PF02991	0.407
LIG_LIR_Nem_3	15	21	PF02991	0.416
LIG_LIR_Nem_3	189	194	PF02991	0.373
LIG_LIR_Nem_3	2	7	PF02991	0.403
LIG_LIR_Nem_3	284	288	PF02991	0.365
LIG_LIR_Nem_3	294	300	PF02991	0.365
LIG_LIR_Nem_3	363	367	PF02991	0.429
LIG_Pex14_1	14	18	PF04695	0.447
LIG_Pex14_2	106	110	PF04695	0.447
LIG_Pex14_2	386	390	PF04695	0.511
LIG_PTB_Apo_2	358	365	PF02174	0.564
LIG_SH2_CRK	117	121	PF00017	0.447
LIG_SH2_PTP2	18	21	PF00017	0.501
LIG_SH2_SRC	18	21	PF00017	0.501
LIG_SH2_SRC	218	221	PF00017	0.399
LIG_SH2_STAP1	208	212	PF00017	0.384
LIG_SH2_STAP1	413	417	PF00017	0.580
LIG_SH2_STAT3	170	173	PF00017	0.365
LIG_SH2_STAT3	193	196	PF00017	0.501
LIG_SH2_STAT5	18	21	PF00017	0.293
LIG_SH2_STAT5	193	196	PF00017	0.469
LIG_SH2_STAT5	218	221	PF00017	0.401
LIG_SH2_STAT5	262	265	PF00017	0.384
LIG_SH2_STAT5	268	271	PF00017	0.343
LIG_SH2_STAT5	4	7	PF00017	0.391
LIG_SH2_STAT5	411	414	PF00017	0.591
LIG_SH2_STAT5	72	75	PF00017	0.399
LIG_SH3_3	251	257	PF00018	0.501
LIG_SH3_3	316	322	PF00018	0.447
LIG_SH3_3	372	378	PF00018	0.479
LIG_SH3_3	4	10	PF00018	0.423
LIG_SH3_3	52	58	PF00018	0.456
LIG_TRAF2_1	171	174	PF00917	0.407
LIG_TRAF2_1	418	421	PF00917	0.759
LIG_TYR_ITIM	224	229	PF00017	0.365
LIG_TYR_ITSM	14	21	PF00017	0.447
LIG_UBA3_1	334	341	PF00899	0.447
MOD_CDK_SPxxK_3	6	13	PF00069	0.423
MOD_CK1_1	462	468	PF00069	0.849
MOD_CK1_1	93	99	PF00069	0.648
MOD_CK2_1	168	174	PF00069	0.421
MOD_CK2_1	189	195	PF00069	0.364
MOD_CK2_1	415	421	PF00069	0.683
MOD_CK2_1	426	432	PF00069	0.757
MOD_CK2_1	48	54	PF00069	0.403
MOD_CK2_1	93	99	PF00069	0.732
MOD_GlcNHglycan	1	4	PF01048	0.401
MOD_GlcNHglycan	136	140	PF01048	0.407
MOD_GlcNHglycan	36	40	PF01048	0.465
MOD_GlcNHglycan	95	98	PF01048	0.645
MOD_GSK3_1	258	265	PF00069	0.356
MOD_GSK3_1	420	427	PF00069	0.810
MOD_GSK3_1	445	452	PF00069	0.777
MOD_GSK3_1	458	465	PF00069	0.835
MOD_GSK3_1	497	504	PF00069	0.815
MOD_GSK3_1	53	60	PF00069	0.465
MOD_GSK3_1	91	98	PF00069	0.662
MOD_N-GLC_1	397	402	PF02516	0.747
MOD_N-GLC_1	445	450	PF02516	0.809
MOD_N-GLC_1	458	463	PF02516	0.828
MOD_N-GLC_1	501	506	PF02516	0.817
MOD_N-GLC_1	91	96	PF02516	0.626
MOD_NEK2_1	168	173	PF00069	0.378
MOD_NEK2_2	84	89	PF00069	0.501
MOD_PIKK_1	399	405	PF00454	0.689
MOD_PKA_1	125	131	PF00069	0.399
MOD_PKA_1	437	443	PF00069	0.743
MOD_PKA_1	497	503	PF00069	0.803
MOD_PKA_2	437	443	PF00069	0.784
MOD_PKA_2	459	465	PF00069	0.774
MOD_PKA_2	79	85	PF00069	0.501
MOD_PKB_1	435	443	PF00069	0.780
MOD_Plk_1	501	507	PF00069	0.819
MOD_Plk_1	68	74	PF00069	0.501
MOD_Plk_2-3	189	195	PF00069	0.388
MOD_Plk_2-3	99	105	PF00069	0.632
MOD_Plk_4	68	74	PF00069	0.423
MOD_ProDKin_1	374	380	PF00069	0.572
MOD_ProDKin_1	397	403	PF00069	0.684
MOD_ProDKin_1	420	426	PF00069	0.812
MOD_ProDKin_1	449	455	PF00069	0.826
MOD_ProDKin_1	462	468	PF00069	0.621
MOD_ProDKin_1	6	12	PF00069	0.423
MOD_SUMO_for_1	229	232	PF00179	0.365
MOD_SUMO_rev_2	105	111	PF00179	0.497
MOD_SUMO_rev_2	140	150	PF00179	0.447
MOD_SUMO_rev_2	20	26	PF00179	0.437
MOD_SUMO_rev_2	329	334	PF00179	0.501
MOD_SUMO_rev_2	44	50	PF00179	0.494
MOD_SUMO_rev_2	76	82	PF00179	0.434
TRG_DiLeu_BaEn_1	330	335	PF01217	0.447
TRG_ENDOCYTIC_2	117	120	PF00928	0.447
TRG_ENDOCYTIC_2	179	182	PF00928	0.368
TRG_ENDOCYTIC_2	18	21	PF00928	0.302
TRG_ENDOCYTIC_2	226	229	PF00928	0.365
TRG_ENDOCYTIC_2	4	7	PF00928	0.397
TRG_ER_diArg_1	345	347	PF00400	0.406
TRG_ER_diArg_1	434	437	PF00400	0.751
TRG_NLS_Bipartite_1	480	500	PF00514	0.808
TRG_NLS_MonoExtN_4	438	445	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J7	Leptomonas seymouri	28%	100%
A0A0N1I191	Leptomonas seymouri	26%	69%
A0A0S4JER5	Bodo saltans	44%	100%
A0A0S4JI67	Bodo saltans	30%	100%
A0A1X0P3J5	Trypanosomatidae	40%	100%
A0A3Q8IC87	Leishmania donovani	29%	100%
A0A3Q8IIG1	Leishmania donovani	27%	100%
A0A3Q8INQ4	Leishmania donovani	33%	100%
A0A3Q8IRT6	Leishmania donovani	98%	100%
A0A3S5H5U5	Leishmania donovani	28%	100%
A0A3S5H7M0	Leishmania donovani	28%	98%
A0A3S7WTN9	Leishmania donovani	31%	100%
A0A3S7WWE7	Leishmania donovani	25%	100%
A0A3S7X7Y2	Leishmania donovani	25%	100%
A0A3S7X9R4	Leishmania donovani	41%	100%
A0A3S7X9S2	Leishmania donovani	39%	100%
A0A422NZ62	Trypanosoma rangeli	36%	74%
A0A422P4V9	Trypanosoma rangeli	41%	100%
A4H4S9	Leishmania braziliensis	27%	100%
A4H8C4	Leishmania braziliensis	32%	100%
A4HAS1	Leishmania braziliensis	26%	100%
A4HBL4	Leishmania braziliensis	26%	100%
A4HCD7	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	28%	100%
A4HED7	Leishmania braziliensis	35%	100%
A4HFF3	Leishmania braziliensis	26%	100%
A4HI35	Leishmania braziliensis	93%	100%
A4HN71	Leishmania braziliensis	41%	100%
A4HNT2	Leishmania braziliensis	24%	100%
A4HWP5	Leishmania infantum	31%	100%
A4HZA2	Leishmania infantum	25%	100%
A4HZV1	Leishmania infantum	29%	100%
A4I1T4	Leishmania infantum	33%	100%
A4I435	Leishmania infantum	27%	100%
A4I4X5	Leishmania infantum	28%	98%
A4I5B1	Leishmania infantum	98%	100%
A4I9Y5	Leishmania infantum	25%	100%
A4IBT4	Leishmania infantum	40%	100%
A4IBT9	Leishmania infantum	41%	100%
C6K3W8	Leptomonas seymouri	73%	97%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZTP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AET0	Leishmania major	24%	100%
E9AFM1	Leishmania major	39%	100%
E9AG71	Leishmania infantum	28%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P05126	Bos taurus	33%	76%
P05771	Homo sapiens	33%	76%
P05772	Oryctolagus cuniculus	33%	76%
P18961	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	75%
P23443	Homo sapiens	42%	97%
P28867	Mus musculus	33%	76%
P31748	AKT8 murine leukemia virus	36%	100%
P31749	Homo sapiens	35%	100%
P31750	Mus musculus	36%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	97%
P47196	Rattus norvegicus	36%	100%
P53894	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	67%
P54265	Mus musculus	29%	81%
P54644	Dictyostelium discoideum	37%	100%
P67998	Oryctolagus cuniculus	42%	97%
P67999	Rattus norvegicus	42%	97%
P68403	Rattus norvegicus	33%	76%
P68404	Mus musculus	33%	76%
Q01314	Bos taurus	35%	100%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	90%
Q09898	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	84%
Q4Q204	Leishmania major	24%	100%
Q4Q2Z2	Leishmania major	25%	100%
Q4Q7W2	Leishmania major	27%	100%
Q4Q9K2	Leishmania major	34%	100%
Q4QBQ2	Leishmania major	28%	100%
Q4QBR6	Leishmania major	29%	100%
Q4QCK0	Leishmania major	25%	100%
Q4QF23	Leishmania major	33%	100%
Q4QFK4	Leishmania major	25%	81%
Q4QHY3	Leishmania major	21%	100%
Q4QHY4	Leishmania major	21%	100%
Q4QIV8	Leishmania major	27%	100%
Q54IH8	Dictyostelium discoideum	28%	94%
Q5AP53	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	70%
Q5R7A7	Pongo abelii	37%	100%
Q63531	Rattus norvegicus	40%	69%
Q6BLJ9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	71%
Q6CFS5	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	87%
Q6TGC6	Pneumocystis carinii	31%	100%
Q6TJY3	Bos taurus	42%	97%
Q7LZQ8	Xenopus laevis	33%	76%
Q8BSK8	Mus musculus	42%	97%
Q8R4V0	Rattus norvegicus	38%	100%
Q96BR1	Homo sapiens	37%	100%
Q98TY9	Xenopus laevis	34%	100%
Q9ERE3	Mus musculus	38%	100%
Q9GNR4	Leishmania major	41%	100%
Q9UBS0	Homo sapiens	40%	100%
Q9UK32	Homo sapiens	25%	68%
Q9Z1M4	Mus musculus	40%	100%
V5BCH2	Trypanosoma cruzi	34%	100%
V5BPJ0	Trypanosoma cruzi	27%	100%
V5DQT5	Trypanosoma cruzi	41%	100%