Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7M4_LEIMA

TriTrypDb:

LmjF.30.0805 , LMJLV39_300014100 , LMJSD75_300013800

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q7M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.738
CLV_NRD_NRD_1	182	184	PF00675	0.438
CLV_PCSK_KEX2_1	193	195	PF00082	0.491
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.669
DEG_SPOP_SBC_1	26	30	PF00917	0.474
DOC_MAPK_MEF2A_6	9	18	PF00069	0.358
DOC_PP1_RVXF_1	73	80	PF00149	0.382
DOC_PP2B_LxvP_1	172	175	PF13499	0.653
DOC_PP2B_LxvP_1	177	180	PF13499	0.654
DOC_USP7_MATH_1	104	108	PF00917	0.426
DOC_USP7_MATH_1	144	148	PF00917	0.359
DOC_USP7_MATH_1	26	30	PF00917	0.630
DOC_USP7_MATH_1	73	77	PF00917	0.411
DOC_WW_Pin1_4	138	143	PF00397	0.542
DOC_WW_Pin1_4	27	32	PF00397	0.401
LIG_14-3-3_CanoR_1	75	80	PF00244	0.456
LIG_14-3-3_CanoR_1	9	15	PF00244	0.249
LIG_Actin_WH2_2	95	112	PF00022	0.425
LIG_BRCT_BRCA1_1	75	79	PF00533	0.362
LIG_Clathr_ClatBox_1	99	103	PF01394	0.451
LIG_FHA_1	11	17	PF00498	0.404
LIG_FHA_1	117	123	PF00498	0.417
LIG_FHA_1	32	38	PF00498	0.387
LIG_FHA_1	60	66	PF00498	0.382
LIG_FHA_1	72	78	PF00498	0.375
LIG_FHA_1	90	96	PF00498	0.257
LIG_IRF3_LxIS_1	120	127	PF10401	0.423
LIG_LIR_Gen_1	34	43	PF02991	0.291
LIG_LIR_Gen_1	76	87	PF02991	0.382
LIG_LIR_Nem_3	34	39	PF02991	0.410
LIG_LIR_Nem_3	76	82	PF02991	0.321
LIG_MAD2	167	175	PF02301	0.670
LIG_PCNA_yPIPBox_3	46	58	PF02747	0.373
LIG_SH2_GRB2like	6	9	PF00017	0.522
LIG_SH2_PTP2	52	55	PF00017	0.350
LIG_SH2_STAT5	52	55	PF00017	0.367
LIG_SH3_3	90	96	PF00018	0.415
LIG_Sin3_3	149	156	PF02671	0.312
LIG_SUMO_SIM_par_1	167	173	PF11976	0.733
LIG_SUMO_SIM_par_1	90	97	PF11976	0.394
LIG_WRC_WIRS_1	186	191	PF05994	0.648
MOD_CK1_1	111	117	PF00069	0.452
MOD_CK1_1	127	133	PF00069	0.329
MOD_CK1_1	147	153	PF00069	0.403
MOD_CK1_1	188	194	PF00069	0.712
MOD_CK1_1	85	91	PF00069	0.328
MOD_CK2_1	127	133	PF00069	0.454
MOD_GlcNHglycan	110	113	PF01048	0.633
MOD_GlcNHglycan	146	149	PF01048	0.388
MOD_GlcNHglycan	67	70	PF01048	0.612
MOD_GlcNHglycan	84	87	PF01048	0.476
MOD_GSK3_1	104	111	PF00069	0.399
MOD_GSK3_1	112	119	PF00069	0.433
MOD_GSK3_1	140	147	PF00069	0.488
MOD_GSK3_1	185	192	PF00069	0.646
MOD_GSK3_1	27	34	PF00069	0.455
MOD_GSK3_1	71	78	PF00069	0.348
MOD_GSK3_1	81	88	PF00069	0.363
MOD_NEK2_1	10	15	PF00069	0.257
MOD_NEK2_1	102	107	PF00069	0.454
MOD_NEK2_1	116	121	PF00069	0.373
MOD_NEK2_1	124	129	PF00069	0.370
MOD_NEK2_1	189	194	PF00069	0.642
MOD_NEK2_1	25	30	PF00069	0.559
MOD_NEK2_1	71	76	PF00069	0.331
MOD_PK_1	167	173	PF00069	0.666
MOD_Plk_1	89	95	PF00069	0.474
MOD_Plk_4	10	16	PF00069	0.447
MOD_Plk_4	104	110	PF00069	0.417
MOD_Plk_4	167	173	PF00069	0.626
MOD_ProDKin_1	138	144	PF00069	0.539
MOD_ProDKin_1	27	33	PF00069	0.399
TRG_ENDOCYTIC_2	52	55	PF00928	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM14	Leptomonas seymouri	48%	100%
A0A1X0P359	Trypanosomatidae	33%	100%
A0A3S7X383	Leishmania donovani	92%	100%
A0A422P4T9	Trypanosoma rangeli	31%	100%
A4HI36	Leishmania braziliensis	79%	89%
A4I5B2	Leishmania infantum	92%	100%
C9ZQP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B0K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%