Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7M3_LEIMA

TriTrypDb:

LmjF.30.0808 , LMJLV39_300014200 , LMJSD75_300013900

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q7M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.596
CLV_PCSK_KEX2_1	135	137	PF00082	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.532
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	232	238	PF00134	0.795
DOC_PP2B_LxvP_1	222	225	PF13499	0.819
DOC_PP2B_LxvP_1	232	235	PF13499	0.714
DOC_USP7_MATH_1	225	229	PF00917	0.789
DOC_USP7_MATH_1	40	44	PF00917	0.729
DOC_USP7_MATH_1	71	75	PF00917	0.524
DOC_USP7_MATH_1	9	13	PF00917	0.515
DOC_WW_Pin1_4	181	186	PF00397	0.782
LIG_14-3-3_CanoR_1	105	109	PF00244	0.725
LIG_14-3-3_CanoR_1	136	146	PF00244	0.794
LIG_BRCT_BRCA1_1	56	60	PF00533	0.524
LIG_FHA_1	166	172	PF00498	0.704
LIG_FHA_1	224	230	PF00498	0.824
LIG_FHA_1	243	249	PF00498	0.600
LIG_FHA_2	138	144	PF00498	0.777
LIG_LIR_Apic_2	216	221	PF02991	0.819
LIG_LIR_Nem_3	107	112	PF02991	0.685
LIG_LIR_Nem_3	13	19	PF02991	0.524
LIG_LIR_Nem_3	187	192	PF02991	0.832
LIG_LIR_Nem_3	48	54	PF02991	0.524
LIG_PDZ_Class_2	244	249	PF00595	0.822
LIG_Pex14_1	96	100	PF04695	0.524
LIG_Pex14_2	47	51	PF04695	0.524
LIG_REV1ctd_RIR_1	99	109	PF16727	0.484
LIG_SH2_CRK	16	20	PF00017	0.524
LIG_SH2_CRK	218	222	PF00017	0.822
LIG_SH2_NCK_1	139	143	PF00017	0.792
LIG_SH2_STAT3	236	239	PF00017	0.794
LIG_SH2_STAT5	100	103	PF00017	0.661
LIG_SH2_STAT5	108	111	PF00017	0.676
LIG_SH2_STAT5	137	140	PF00017	0.791
LIG_SH2_STAT5	192	195	PF00017	0.803
LIG_SH2_STAT5	236	239	PF00017	0.794
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.289
LIG_SUMO_SIM_par_1	220	226	PF11976	0.819
LIG_UBA3_1	25	34	PF00899	0.681
MOD_CK1_1	213	219	PF00069	0.696
MOD_CK1_1	242	248	PF00069	0.711
MOD_GlcNHglycan	12	15	PF01048	0.474
MOD_GlcNHglycan	131	134	PF01048	0.501
MOD_GlcNHglycan	213	216	PF01048	0.559
MOD_GSK3_1	50	57	PF00069	0.524
MOD_NEK2_1	50	55	PF00069	0.368
MOD_NEK2_2	45	50	PF00069	0.375
MOD_PIKK_1	184	190	PF00454	0.824
MOD_PKA_2	104	110	PF00069	0.723
MOD_Plk_1	239	245	PF00069	0.818
MOD_Plk_4	104	110	PF00069	0.743
MOD_Plk_4	213	219	PF00069	0.809
MOD_Plk_4	54	60	PF00069	0.524
MOD_ProDKin_1	181	187	PF00069	0.782
TRG_DiLeu_BaEn_1	75	80	PF01217	0.432
TRG_ENDOCYTIC_2	16	19	PF00928	0.524
TRG_ER_diArg_1	135	137	PF00400	0.796

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X345	Leishmania donovani	90%	100%
A4I5B3	Leishmania infantum	89%	100%
E9B0K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%