Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7M1_LEIMA

TriTrypDb:

LmjF.30.0820 , LMJLV39_300014400 , LMJSD75_300014100

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.554
CLV_C14_Caspase3-7	380	384	PF00656	0.559
CLV_NRD_NRD_1	114	116	PF00675	0.519
CLV_NRD_NRD_1	130	132	PF00675	0.477
CLV_NRD_NRD_1	163	165	PF00675	0.544
CLV_NRD_NRD_1	180	182	PF00675	0.415
CLV_NRD_NRD_1	215	217	PF00675	0.512
CLV_NRD_NRD_1	232	234	PF00675	0.468
CLV_NRD_NRD_1	285	287	PF00675	0.575
CLV_NRD_NRD_1	455	457	PF00675	0.774
CLV_NRD_NRD_1	652	654	PF00675	0.705
CLV_NRD_NRD_1	677	679	PF00675	0.765
CLV_NRD_NRD_1	700	702	PF00675	0.694
CLV_NRD_NRD_1	703	705	PF00675	0.679
CLV_PCSK_FUR_1	178	182	PF00082	0.503
CLV_PCSK_FUR_1	701	705	PF00082	0.643
CLV_PCSK_KEX2_1	113	115	PF00082	0.493
CLV_PCSK_KEX2_1	130	132	PF00082	0.483
CLV_PCSK_KEX2_1	162	164	PF00082	0.519
CLV_PCSK_KEX2_1	180	182	PF00082	0.396
CLV_PCSK_KEX2_1	215	217	PF00082	0.515
CLV_PCSK_KEX2_1	231	233	PF00082	0.536
CLV_PCSK_KEX2_1	285	287	PF00082	0.696
CLV_PCSK_KEX2_1	455	457	PF00082	0.645
CLV_PCSK_KEX2_1	652	654	PF00082	0.688
CLV_PCSK_KEX2_1	677	679	PF00082	0.712
CLV_PCSK_KEX2_1	702	704	PF00082	0.740
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.488
CLV_PCSK_PC1ET2_1	702	704	PF00082	0.740
CLV_PCSK_PC7_1	159	165	PF00082	0.596
CLV_PCSK_SKI1_1	103	107	PF00082	0.518
CLV_PCSK_SKI1_1	147	151	PF00082	0.518
CLV_PCSK_SKI1_1	180	184	PF00082	0.583
CLV_PCSK_SKI1_1	425	429	PF00082	0.467
CLV_PCSK_SKI1_1	570	574	PF00082	0.538
CLV_PCSK_SKI1_1	695	699	PF00082	0.634
CLV_Separin_Metazoa	175	179	PF03568	0.594
DEG_APCC_DBOX_1	102	110	PF00400	0.511
DEG_APCC_DBOX_1	179	187	PF00400	0.584
DEG_APCC_DBOX_1	424	432	PF00400	0.460
DEG_SPOP_SBC_1	340	344	PF00917	0.380
DEG_SPOP_SBC_1	613	617	PF00917	0.661
DOC_ANK_TNKS_1	196	203	PF00023	0.568
DOC_CKS1_1	679	684	PF01111	0.714
DOC_CYCLIN_RxL_1	144	152	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.601
DOC_MAPK_gen_1	113	123	PF00069	0.537
DOC_PP1_RVXF_1	532	539	PF00149	0.495
DOC_PP4_FxxP_1	299	302	PF00568	0.627
DOC_PP4_FxxP_1	337	340	PF00568	0.478
DOC_USP7_MATH_1	472	476	PF00917	0.600
DOC_USP7_MATH_1	525	529	PF00917	0.511
DOC_USP7_MATH_1	613	617	PF00917	0.661
DOC_USP7_MATH_1	625	629	PF00917	0.552
DOC_USP7_MATH_1	642	646	PF00917	0.650
DOC_USP7_MATH_1	648	652	PF00917	0.729
DOC_USP7_MATH_1	686	690	PF00917	0.811
DOC_USP7_MATH_1	708	712	PF00917	0.655
DOC_USP7_MATH_1	726	730	PF00917	0.633
DOC_USP7_MATH_1	741	745	PF00917	0.526
DOC_USP7_MATH_1	90	94	PF00917	0.598
DOC_USP7_MATH_2	78	84	PF00917	0.628
DOC_USP7_UBL2_3	530	534	PF12436	0.488
DOC_USP7_UBL2_3	738	742	PF12436	0.646
DOC_WW_Pin1_4	192	197	PF00397	0.593
DOC_WW_Pin1_4	298	303	PF00397	0.779
DOC_WW_Pin1_4	342	347	PF00397	0.490
DOC_WW_Pin1_4	6	11	PF00397	0.704
DOC_WW_Pin1_4	678	683	PF00397	0.743
DOC_WW_Pin1_4	84	89	PF00397	0.689
LIG_14-3-3_CanoR_1	114	123	PF00244	0.495
LIG_14-3-3_CanoR_1	147	152	PF00244	0.558
LIG_14-3-3_CanoR_1	28	34	PF00244	0.491
LIG_14-3-3_CanoR_1	377	386	PF00244	0.484
LIG_14-3-3_CanoR_1	482	490	PF00244	0.529
LIG_14-3-3_CanoR_1	652	657	PF00244	0.647
LIG_14-3-3_CanoR_1	666	674	PF00244	0.570
LIG_14-3-3_CanoR_1	677	682	PF00244	0.604
LIG_Actin_WH2_2	360	375	PF00022	0.490
LIG_Actin_WH2_2	92	109	PF00022	0.496
LIG_AP2alpha_2	552	554	PF02296	0.512
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BRCT_BRCA1_1	295	299	PF00533	0.669
LIG_FHA_1	171	177	PF00498	0.565
LIG_FHA_1	278	284	PF00498	0.696
LIG_FHA_1	392	398	PF00498	0.509
LIG_FHA_1	40	46	PF00498	0.622
LIG_FHA_1	560	566	PF00498	0.554
LIG_FHA_1	679	685	PF00498	0.733
LIG_FHA_1	749	755	PF00498	0.660
LIG_FHA_2	276	282	PF00498	0.737
LIG_FHA_2	343	349	PF00498	0.449
LIG_FHA_2	378	384	PF00498	0.555
LIG_FHA_2	474	480	PF00498	0.641
LIG_FHA_2	95	101	PF00498	0.592
LIG_LIR_Apic_2	296	302	PF02991	0.627
LIG_LIR_Apic_2	334	340	PF02991	0.510
LIG_LIR_Apic_2	358	363	PF02991	0.463
LIG_LIR_Gen_1	392	400	PF02991	0.494
LIG_LIR_Gen_1	426	437	PF02991	0.510
LIG_LIR_Gen_1	552	561	PF02991	0.541
LIG_LIR_Gen_1	582	589	PF02991	0.546
LIG_LIR_Nem_3	392	396	PF02991	0.539
LIG_LIR_Nem_3	426	432	PF02991	0.496
LIG_LIR_Nem_3	552	557	PF02991	0.434
LIG_LIR_Nem_3	582	588	PF02991	0.515
LIG_MYND_1	682	686	PF01753	0.720
LIG_Pex14_1	409	413	PF04695	0.576
LIG_Pex14_2	217	221	PF04695	0.477
LIG_Pex14_2	337	341	PF04695	0.495
LIG_Pex14_2	554	558	PF04695	0.525
LIG_SH2_NCK_1	429	433	PF00017	0.520
LIG_SH2_PTP2	585	588	PF00017	0.498
LIG_SH2_SRC	360	363	PF00017	0.539
LIG_SH2_STAP1	413	417	PF00017	0.540
LIG_SH2_STAT5	122	125	PF00017	0.560
LIG_SH2_STAT5	267	270	PF00017	0.630
LIG_SH2_STAT5	350	353	PF00017	0.461
LIG_SH2_STAT5	390	393	PF00017	0.494
LIG_SH2_STAT5	585	588	PF00017	0.542
LIG_SH3_3	193	199	PF00018	0.689
LIG_SH3_3	547	553	PF00018	0.588
LIG_SH3_3	679	685	PF00018	0.701
LIG_Sin3_3	205	212	PF02671	0.582
LIG_SUMO_SIM_anti_2	751	756	PF11976	0.688
LIG_SUMO_SIM_par_1	628	633	PF11976	0.499
LIG_SUMO_SIM_par_1	750	756	PF11976	0.664
LIG_TRAF2_1	155	158	PF00917	0.556
LIG_TYR_ITIM	583	588	PF00017	0.521
LIG_WRC_WIRS_1	390	395	PF05994	0.446
MOD_CDK_SPK_2	192	197	PF00069	0.571
MOD_CDK_SPK_2	342	347	PF00069	0.526
MOD_CK1_1	141	147	PF00069	0.556
MOD_CK1_1	2	8	PF00069	0.690
MOD_CK1_1	279	285	PF00069	0.542
MOD_CK1_1	616	622	PF00069	0.653
MOD_CK1_1	643	649	PF00069	0.711
MOD_CK1_1	655	661	PF00069	0.638
MOD_CK1_1	688	694	PF00069	0.728
MOD_CK1_1	710	716	PF00069	0.790
MOD_CK2_1	21	27	PF00069	0.650
MOD_CK2_1	275	281	PF00069	0.704
MOD_CK2_1	294	300	PF00069	0.577
MOD_CK2_1	328	334	PF00069	0.616
MOD_CK2_1	408	414	PF00069	0.555
MOD_CK2_1	468	474	PF00069	0.706
MOD_CK2_1	617	623	PF00069	0.530
MOD_CK2_1	71	77	PF00069	0.652
MOD_CK2_1	710	716	PF00069	0.671
MOD_CK2_1	94	100	PF00069	0.560
MOD_GlcNHglycan	1	4	PF01048	0.729
MOD_GlcNHglycan	237	240	PF01048	0.574
MOD_GlcNHglycan	325	328	PF01048	0.547
MOD_GlcNHglycan	330	333	PF01048	0.540
MOD_GlcNHglycan	357	360	PF01048	0.548
MOD_GlcNHglycan	401	404	PF01048	0.510
MOD_GlcNHglycan	470	473	PF01048	0.776
MOD_GlcNHglycan	591	594	PF01048	0.535
MOD_GlcNHglycan	600	603	PF01048	0.570
MOD_GlcNHglycan	619	622	PF01048	0.707
MOD_GlcNHglycan	654	657	PF01048	0.652
MOD_GlcNHglycan	690	693	PF01048	0.808
MOD_GlcNHglycan	705	708	PF01048	0.682
MOD_GlcNHglycan	713	716	PF01048	0.627
MOD_GlcNHglycan	724	727	PF01048	0.654
MOD_GlcNHglycan	743	746	PF01048	0.573
MOD_GSK3_1	141	148	PF00069	0.556
MOD_GSK3_1	2	9	PF00069	0.689
MOD_GSK3_1	271	278	PF00069	0.612
MOD_GSK3_1	29	36	PF00069	0.586
MOD_GSK3_1	294	301	PF00069	0.658
MOD_GSK3_1	311	318	PF00069	0.673
MOD_GSK3_1	373	380	PF00069	0.544
MOD_GSK3_1	468	475	PF00069	0.623
MOD_GSK3_1	47	54	PF00069	0.579
MOD_GSK3_1	572	579	PF00069	0.549
MOD_GSK3_1	612	619	PF00069	0.680
MOD_GSK3_1	643	650	PF00069	0.667
MOD_GSK3_1	664	671	PF00069	0.643
MOD_GSK3_1	673	680	PF00069	0.666
MOD_GSK3_1	691	698	PF00069	0.564
MOD_GSK3_1	703	710	PF00069	0.571
MOD_GSK3_1	718	725	PF00069	0.729
MOD_GSK3_1	726	733	PF00069	0.673
MOD_GSK3_1	80	87	PF00069	0.714
MOD_GSK3_1	90	97	PF00069	0.450
MOD_LATS_1	145	151	PF00433	0.519
MOD_LATS_1	492	498	PF00433	0.510
MOD_N-GLC_1	315	320	PF02516	0.651
MOD_N-GLC_1	435	440	PF02516	0.328
MOD_N-GLC_1	52	57	PF02516	0.661
MOD_N-GLC_1	80	85	PF02516	0.664
MOD_NEK2_1	207	212	PF00069	0.662
MOD_NEK2_1	323	328	PF00069	0.539
MOD_NEK2_1	33	38	PF00069	0.563
MOD_NEK2_1	341	346	PF00069	0.366
MOD_NEK2_1	355	360	PF00069	0.458
MOD_NEK2_1	372	377	PF00069	0.502
MOD_NEK2_1	389	394	PF00069	0.411
MOD_NEK2_1	399	404	PF00069	0.528
MOD_NEK2_1	437	442	PF00069	0.468
MOD_NEK2_1	581	586	PF00069	0.462
MOD_NEK2_1	589	594	PF00069	0.534
MOD_NEK2_1	614	619	PF00069	0.791
MOD_NEK2_1	672	677	PF00069	0.735
MOD_NEK2_1	719	724	PF00069	0.728
MOD_NEK2_1	730	735	PF00069	0.756
MOD_NEK2_2	450	455	PF00069	0.473
MOD_NEK2_2	525	530	PF00069	0.502
MOD_OFUCOSY	637	644	PF10250	0.612
MOD_PIKK_1	115	121	PF00454	0.495
MOD_PIKK_1	170	176	PF00454	0.575
MOD_PIKK_1	306	312	PF00454	0.632
MOD_PIKK_1	362	368	PF00454	0.499
MOD_PIKK_1	391	397	PF00454	0.530
MOD_PIKK_1	481	487	PF00454	0.532
MOD_PIKK_1	614	620	PF00454	0.629
MOD_PIKK_1	94	100	PF00454	0.582
MOD_PK_1	224	230	PF00069	0.487
MOD_PKA_1	652	658	PF00069	0.690
MOD_PKA_1	677	683	PF00069	0.661
MOD_PKA_1	702	708	PF00069	0.736
MOD_PKA_2	138	144	PF00069	0.558
MOD_PKA_2	372	378	PF00069	0.498
MOD_PKA_2	481	487	PF00069	0.547
MOD_PKA_2	652	658	PF00069	0.641
MOD_PKA_2	667	673	PF00069	0.558
MOD_PKA_2	677	683	PF00069	0.618
MOD_PKA_2	702	708	PF00069	0.725
MOD_PKB_1	113	121	PF00069	0.496
MOD_PKB_1	664	672	PF00069	0.711
MOD_PKB_1	701	709	PF00069	0.646
MOD_Plk_1	473	479	PF00069	0.652
MOD_Plk_1	579	585	PF00069	0.505
MOD_Plk_2-3	21	27	PF00069	0.559
MOD_Plk_2-3	474	480	PF00069	0.641
MOD_Plk_2-3	559	565	PF00069	0.561
MOD_Plk_4	224	230	PF00069	0.509
MOD_Plk_4	279	285	PF00069	0.589
MOD_Plk_4	29	35	PF00069	0.543
MOD_Plk_4	350	356	PF00069	0.400
MOD_Plk_4	581	587	PF00069	0.483
MOD_Plk_4	61	67	PF00069	0.582
MOD_Plk_4	625	631	PF00069	0.690
MOD_ProDKin_1	192	198	PF00069	0.594
MOD_ProDKin_1	298	304	PF00069	0.783
MOD_ProDKin_1	342	348	PF00069	0.482
MOD_ProDKin_1	6	12	PF00069	0.702
MOD_ProDKin_1	678	684	PF00069	0.743
MOD_ProDKin_1	84	90	PF00069	0.683
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.495
TRG_ENDOCYTIC_2	390	393	PF00928	0.423
TRG_ENDOCYTIC_2	429	432	PF00928	0.422
TRG_ENDOCYTIC_2	551	554	PF00928	0.500
TRG_ENDOCYTIC_2	585	588	PF00928	0.559
TRG_ER_diArg_1	113	115	PF00400	0.566
TRG_ER_diArg_1	129	131	PF00400	0.551
TRG_ER_diArg_1	162	164	PF00400	0.533
TRG_ER_diArg_1	177	180	PF00400	0.440
TRG_ER_diArg_1	215	217	PF00400	0.512
TRG_ER_diArg_1	232	234	PF00400	0.468
TRG_ER_diArg_1	284	286	PF00400	0.577
TRG_ER_diArg_1	454	456	PF00400	0.502
TRG_ER_diArg_1	663	666	PF00400	0.763
TRG_ER_diArg_1	677	679	PF00400	0.694
TRG_ER_diArg_1	700	703	PF00400	0.685
TRG_NES_CRM1_1	485	499	PF08389	0.549
TRG_NLS_Bipartite_1	215	235	PF00514	0.505
TRG_NLS_MonoCore_2	700	705	PF00514	0.643
TRG_NLS_MonoExtN_4	701	706	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P210	Trypanosomatidae	30%	100%
A0A3Q8IBV7	Leishmania donovani	90%	99%
A0A3S5ISQ5	Trypanosoma rangeli	28%	100%
A4HI38	Leishmania braziliensis	72%	99%
A4I5B5	Leishmania infantum	90%	99%
C6K3X2	Leptomonas seymouri	44%	96%
E9B0L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%