Putative surface protein amastin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface protein amastin, putative

Species:

Leishmania major

UniProt:

Q4Q7L7_LEIMA

TriTrypDb:

LmjF.30.0860 , LMJLV39_300014800 , LMJSD75_300014500

Length:

195

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 97
NetGPI	no	yes: 0, no: 104

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	91
GO:0110165	cellular anatomical entity	1	91

Expansion

Sequence features

Q4Q7L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	112	116	PF00082	0.240
CLV_PCSK_SKI1_1	78	82	PF00082	0.504
DOC_CYCLIN_RxL_1	75	85	PF00134	0.202
DOC_MAPK_gen_1	110	118	PF00069	0.528
DOC_MAPK_gen_1	7	14	PF00069	0.470
DOC_MAPK_MEF2A_6	110	118	PF00069	0.545
DOC_MAPK_MEF2A_6	7	16	PF00069	0.526
DOC_USP7_MATH_1	160	164	PF00917	0.210
LIG_BRCT_BRCA1_1	83	87	PF00533	0.256
LIG_EH1_1	87	95	PF00400	0.353
LIG_FHA_1	144	150	PF00498	0.329
LIG_FHA_1	182	188	PF00498	0.332
LIG_GBD_Chelix_1	89	97	PF00786	0.419
LIG_LIR_Gen_1	122	133	PF02991	0.348
LIG_LIR_Nem_3	122	128	PF02991	0.350
LIG_LIR_Nem_3	84	90	PF02991	0.254
LIG_NRBOX	113	119	PF00104	0.464
LIG_Pex14_1	137	141	PF04695	0.314
LIG_SH2_STAT5	105	108	PF00017	0.302
LIG_SH2_STAT5	141	144	PF00017	0.289
LIG_SH2_STAT5	88	91	PF00017	0.365
LIG_SUMO_SIM_par_1	116	122	PF11976	0.270
LIG_TRFH_1	125	129	PF08558	0.336
LIG_WRC_WIRS_1	93	98	PF05994	0.365
MOD_CK1_1	46	52	PF00069	0.334
MOD_CK1_1	95	101	PF00069	0.340
MOD_GlcNHglycan	101	104	PF01048	0.372
MOD_GlcNHglycan	152	155	PF01048	0.563
MOD_GlcNHglycan	171	174	PF01048	0.459
MOD_GlcNHglycan	28	31	PF01048	0.380
MOD_GSK3_1	12	19	PF00069	0.401
MOD_GSK3_1	165	172	PF00069	0.205
MOD_GSK3_1	26	33	PF00069	0.327
MOD_GSK3_1	95	102	PF00069	0.293
MOD_N-GLC_1	149	154	PF02516	0.518
MOD_N-GLC_2	140	142	PF02516	0.522
MOD_N-GLC_2	58	60	PF02516	0.518
MOD_NEK2_1	16	21	PF00069	0.380
MOD_NEK2_1	165	170	PF00069	0.284
MOD_NEK2_1	25	30	PF00069	0.352
MOD_NEK2_2	143	148	PF00069	0.333
MOD_PIKK_1	181	187	PF00454	0.211
MOD_PIKK_1	30	36	PF00454	0.391
MOD_PK_1	68	74	PF00069	0.205
MOD_PKA_2	165	171	PF00069	0.370
MOD_PKA_2	67	73	PF00069	0.362
MOD_Plk_4	12	18	PF00069	0.307
MOD_Plk_4	160	166	PF00069	0.211
MOD_Plk_4	49	55	PF00069	0.321
MOD_Plk_4	92	98	PF00069	0.332
TRG_ER_diArg_1	35	38	PF00400	0.267
TRG_ER_diArg_1	6	9	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	30%	100%
A0A0N0P547	Leptomonas seymouri	25%	100%
A0A0N0P993	Leptomonas seymouri	27%	87%
A0A0N1PAD5	Leptomonas seymouri	24%	78%
A0A0N1PDH0	Leptomonas seymouri	26%	97%
A0A0S4J784	Bodo saltans	24%	87%
A0A1X0NQ58	Trypanosomatidae	29%	100%
A0A1X0NUH1	Trypanosomatidae	24%	86%
A0A1X0NVN5	Trypanosomatidae	25%	100%
A0A1X0NX02	Trypanosomatidae	27%	100%
A0A1X0P2R3	Trypanosomatidae	27%	92%
A0A1X0P988	Trypanosomatidae	27%	100%
A0A381MTB8	Leishmania infantum	25%	100%
A0A381MTN2	Leishmania infantum	25%	100%
A0A3Q8ID16	Leishmania donovani	21%	100%
A0A3Q8IEC2	Leishmania donovani	24%	100%
A0A3Q8IEI1	Leishmania donovani	26%	100%
A0A3Q8IFI8	Leishmania donovani	94%	98%
A0A3Q8IHN2	Leishmania donovani	25%	100%
A0A3Q8IIH1	Leishmania donovani	24%	100%
A0A3Q8IL03	Leishmania donovani	23%	100%
A0A3Q8IMR4	Leishmania donovani	24%	100%
A0A3Q8IUK8	Leishmania donovani	27%	100%
A0A3Q8IUR5	Leishmania donovani	25%	100%
A0A3S5H666	Leishmania donovani	25%	100%
A0A3S5H7D2	Leishmania donovani	26%	100%
A0A3S5H7L2	Leishmania donovani	23%	95%
A0A3S5H7V9	Leishmania donovani	26%	98%
A0A3S7WQA8	Leishmania donovani	25%	100%
A0A3S7WQC1	Leishmania donovani	22%	100%
A0A3S7X2E6	Leishmania donovani	23%	100%
A0A3S7X357	Leishmania donovani	29%	88%
A0A3S7X381	Leishmania donovani	94%	98%
A0A3S7X7E5	Leishmania donovani	28%	78%
A0A3S7X7W2	Leishmania donovani	25%	93%
A0A3S7X7Y0	Leishmania donovani	24%	100%
A4H5G0	Leishmania braziliensis	24%	100%
A4H5G9	Leishmania braziliensis	23%	100%
A4H5H2	Leishmania braziliensis	24%	100%
A4H6C8	Leishmania braziliensis	22%	100%
A4H7D7	Leishmania braziliensis	23%	100%
A4HAM2	Leishmania braziliensis	23%	100%
A4HAM4	Leishmania braziliensis	23%	100%
A4HAZ8	Leishmania braziliensis	27%	100%
A4HB47	Leishmania braziliensis	26%	96%
A4HBJ1	Leishmania braziliensis	22%	100%
A4HDI2	Leishmania braziliensis	24%	100%
A4HDI3	Leishmania braziliensis	25%	81%
A4HDL3	Leishmania braziliensis	25%	100%
A4HI41	Leishmania braziliensis	76%	98%
A4HI43	Leishmania braziliensis	28%	92%
A4HTM3	Leishmania infantum	25%	100%
A4HTM4	Leishmania infantum	24%	100%
A4HTM5	Leishmania infantum	21%	100%
A4I0W4	Leishmania infantum	26%	100%
A4I0W5	Leishmania infantum	21%	100%
A4I4J2	Leishmania infantum	25%	95%
A4I5B8	Leishmania infantum	94%	98%
A4I5B9	Leishmania infantum	29%	88%
A4I9X0	Leishmania infantum	25%	93%
A4IA59	Leishmania infantum	25%	75%
A4IAL7	Leishmania infantum	25%	100%
A4IAM1	Leishmania infantum	25%	100%
A4IAM2	Leishmania infantum	27%	100%
C6K3X5	Leptomonas seymouri	59%	97%
C6K3X9	Leptomonas seymouri	26%	100%
E8NHD3	Leishmania infantum	24%	95%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	95%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AG83	Leishmania infantum	23%	98%
E9AHI9	Leishmania infantum	24%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	88%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	98%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	98%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
Q4Q313	Leishmania major	24%	100%
Q4Q317	Leishmania major	24%	100%
Q4Q335	Leishmania major	23%	100%
Q4Q339	Leishmania major	24%	100%
Q4Q341	Leishmania major	23%	100%
Q4Q3A8	Leishmania major	27%	96%
Q4Q7L6	Leishmania major	29%	100%
Q4Q7L8	Leishmania major	99%	100%
Q4QAK4	Leishmania major	24%	100%
Q4QAK5	Leishmania major	22%	100%
Q4QAK6	Leishmania major	26%	100%
Q4QAK7	Leishmania major	24%	100%
Q4QI84	Leishmania major	26%	100%
Q4QI85	Leishmania major	24%	100%
Q4QI86	Leishmania major	24%	100%
Q4QI87	Leishmania major	23%	100%
Q4QI88	Leishmania major	22%	100%