Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania major

UniProt:

Q4Q7L6_LEIMA

TriTrypDb:

LmjF.30.0870 , LMJLV39_300014900 , LMJSD75_300014600

Length:

221

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 184
NetGPI	no	yes: 0, no: 195

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

Expansion

Sequence features

Q4Q7L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_MDM2_SWIB_1	114	121	PF02201	0.201
DEG_SPOP_SBC_1	212	216	PF00917	0.493
DOC_CKS1_1	152	157	PF01111	0.391
DOC_MAPK_gen_1	125	135	PF00069	0.490
DOC_MAPK_MEF2A_6	127	135	PF00069	0.581
DOC_MAPK_MEF2A_6	14	23	PF00069	0.561
DOC_MAPK_NFAT4_5	128	136	PF00069	0.400
DOC_USP7_MATH_1	137	141	PF00917	0.253
DOC_USP7_MATH_1	195	199	PF00917	0.505
DOC_WW_Pin1_4	151	156	PF00397	0.270
DOC_WW_Pin1_4	33	38	PF00397	0.368
DOC_WW_Pin1_4	81	86	PF00397	0.309
LIG_14-3-3_CanoR_1	80	87	PF00244	0.286
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_FHA_1	176	182	PF00498	0.346
LIG_FHA_1	28	34	PF00498	0.396
LIG_LIR_Apic_2	149	155	PF02991	0.238
LIG_LIR_Gen_1	100	110	PF02991	0.260
LIG_LIR_Gen_1	142	153	PF02991	0.315
LIG_LIR_Gen_1	25	33	PF02991	0.327
LIG_LIR_Nem_3	100	105	PF02991	0.263
LIG_LIR_Nem_3	117	121	PF02991	0.327
LIG_LIR_Nem_3	142	148	PF02991	0.300
LIG_LIR_Nem_3	154	159	PF02991	0.275
LIG_Pex14_2	114	118	PF04695	0.406
LIG_Pex14_2	22	26	PF04695	0.461
LIG_PTB_Apo_2	57	64	PF02174	0.202
LIG_PTB_Apo_2	6	13	PF02174	0.510
LIG_PTB_Phospho_1	6	12	PF10480	0.510
LIG_SH2_CRK	173	177	PF00017	0.204
LIG_SH2_STAP1	12	16	PF00017	0.483
LIG_SH2_STAP1	173	177	PF00017	0.317
LIG_SH2_STAP1	77	81	PF00017	0.298
LIG_SH2_STAT5	153	156	PF00017	0.266
LIG_SUMO_SIM_par_1	103	109	PF11976	0.402
LIG_SUMO_SIM_par_1	39	45	PF11976	0.270
LIG_WRC_WIRS_1	177	182	PF05994	0.295
LIG_WRC_WIRS_1	23	28	PF05994	0.236
MOD_CK1_1	215	221	PF00069	0.607
MOD_CK1_1	51	57	PF00069	0.346
MOD_CK1_1	70	76	PF00069	0.346
MOD_CK2_1	42	48	PF00069	0.261
MOD_CK2_1	50	56	PF00069	0.241
MOD_GlcNHglycan	217	220	PF01048	0.390
MOD_GlcNHglycan	48	53	PF01048	0.540
MOD_GSK3_1	160	167	PF00069	0.227
MOD_GSK3_1	207	214	PF00069	0.616
MOD_GSK3_1	29	36	PF00069	0.269
MOD_GSK3_1	75	82	PF00069	0.289
MOD_N-GLC_1	195	200	PF02516	0.318
MOD_N-GLC_1	87	92	PF02516	0.513
MOD_NEK2_1	114	119	PF00069	0.345
MOD_NEK2_1	162	167	PF00069	0.395
MOD_NEK2_1	175	180	PF00069	0.278
MOD_NEK2_1	22	27	PF00069	0.357
MOD_NEK2_1	29	34	PF00069	0.333
MOD_NEK2_1	42	47	PF00069	0.323
MOD_NEK2_1	50	55	PF00069	0.324
MOD_NEK2_2	75	80	PF00069	0.288
MOD_PKA_2	79	85	PF00069	0.334
MOD_Plk_1	75	81	PF00069	0.366
MOD_Plk_4	114	120	PF00069	0.359
MOD_Plk_4	176	182	PF00069	0.296
MOD_Plk_4	22	28	PF00069	0.320
MOD_Plk_4	3	9	PF00069	0.685
MOD_ProDKin_1	151	157	PF00069	0.270
MOD_ProDKin_1	33	39	PF00069	0.368
MOD_ProDKin_1	81	87	PF00069	0.309
TRG_ENDOCYTIC_2	153	156	PF00928	0.271
TRG_ENDOCYTIC_2	173	176	PF00928	0.218
TRG_NES_CRM1_1	183	194	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	23%	100%
A0A0N0P547	Leptomonas seymouri	29%	100%
A0A0N0P993	Leptomonas seymouri	53%	99%
A0A0N1PAD5	Leptomonas seymouri	26%	88%
A0A0N1PDH0	Leptomonas seymouri	27%	100%
A0A1X0NQ58	Trypanosomatidae	26%	100%
A0A1X0NUH1	Trypanosomatidae	25%	97%
A0A1X0NYN9	Trypanosomatidae	26%	67%
A0A1X0P2R3	Trypanosomatidae	39%	100%
A0A1X0P988	Trypanosomatidae	32%	100%
A0A381MTA7	Leishmania infantum	28%	100%
A0A381MTB8	Leishmania infantum	29%	100%
A0A381MTC7	Leishmania infantum	27%	100%
A0A381MTN2	Leishmania infantum	27%	100%
A0A381MVY0	Leishmania infantum	27%	100%
A0A3Q8ID16	Leishmania donovani	26%	100%
A0A3Q8IEC2	Leishmania donovani	27%	100%
A0A3Q8IEI1	Leishmania donovani	25%	100%
A0A3Q8IF65	Leishmania donovani	23%	100%
A0A3Q8IFH7	Leishmania donovani	27%	100%
A0A3Q8IFI8	Leishmania donovani	28%	100%
A0A3Q8IH65	Leishmania donovani	29%	100%
A0A3Q8IHN2	Leishmania donovani	26%	100%
A0A3Q8IHW7	Leishmania donovani	28%	100%
A0A3Q8IHZ6	Leishmania donovani	25%	100%
A0A3Q8IIH1	Leishmania donovani	28%	100%
A0A3Q8IL03	Leishmania donovani	25%	100%
A0A3Q8IMR4	Leishmania donovani	25%	100%
A0A3Q8IUK8	Leishmania donovani	28%	100%
A0A3Q8IUR5	Leishmania donovani	27%	100%
A0A3S5H662	Leishmania donovani	22%	100%
A0A3S5H663	Leishmania donovani	22%	100%
A0A3S5H665	Leishmania donovani	23%	100%
A0A3S5H666	Leishmania donovani	25%	100%
A0A3S5H667	Leishmania donovani	22%	100%
A0A3S5H7L2	Leishmania donovani	28%	100%
A0A3S5H7V9	Leishmania donovani	26%	100%
A0A3S5H7W2	Leishmania donovani	27%	100%
A0A3S5H7W6	Leishmania donovani	27%	97%
A0A3S7WQA0	Leishmania donovani	22%	100%
A0A3S7WQA8	Leishmania donovani	24%	100%
A0A3S7WQC1	Leishmania donovani	23%	100%
A0A3S7X2E6	Leishmania donovani	28%	100%
A0A3S7X357	Leishmania donovani	96%	100%
A0A3S7X381	Leishmania donovani	28%	100%
A0A3S7X453	Leishmania donovani	24%	96%
A0A3S7X472	Leishmania donovani	25%	100%
A0A3S7X7E5	Leishmania donovani	27%	88%
A0A3S7X7M4	Leishmania donovani	25%	100%
A0A3S7X7U1	Leishmania donovani	28%	100%
A0A3S7X7U4	Leishmania donovani	23%	85%
A0A3S7X7W2	Leishmania donovani	27%	100%
A0A3S7X7Y0	Leishmania donovani	27%	100%
A0A422MVT4	Trypanosoma rangeli	26%	69%
A4H5D1	Leishmania braziliensis	28%	100%
A4H5D2	Leishmania braziliensis	27%	100%
A4H5G0	Leishmania braziliensis	29%	100%
A4H5G9	Leishmania braziliensis	26%	100%
A4H5H0	Leishmania braziliensis	27%	100%
A4H5H1	Leishmania braziliensis	30%	100%
A4H5H2	Leishmania braziliensis	28%	100%
A4H6C8	Leishmania braziliensis	30%	100%
A4H7D7	Leishmania braziliensis	28%	100%
A4H9E8	Leishmania braziliensis	26%	100%
A4H9E9	Leishmania braziliensis	25%	100%
A4HAJ4	Leishmania braziliensis	25%	100%
A4HAL2	Leishmania braziliensis	26%	100%
A4HAM2	Leishmania braziliensis	22%	100%
A4HAR1	Leishmania braziliensis	26%	100%
A4HAZ8	Leishmania braziliensis	29%	100%
A4HB47	Leishmania braziliensis	29%	100%
A4HBJ0	Leishmania braziliensis	25%	100%
A4HBJ1	Leishmania braziliensis	22%	100%
A4HBJ2	Leishmania braziliensis	29%	100%
A4HDI3	Leishmania braziliensis	24%	100%
A4HDI4	Leishmania braziliensis	25%	100%
A4HDL3	Leishmania braziliensis	27%	100%
A4HDL4	Leishmania braziliensis	24%	100%
A4HI41	Leishmania braziliensis	26%	100%
A4HI43	Leishmania braziliensis	68%	100%
A4HTM3	Leishmania infantum	24%	100%
A4HTM4	Leishmania infantum	24%	100%
A4HTM5	Leishmania infantum	26%	100%
A4I0W3	Leishmania infantum	27%	100%
A4I0W5	Leishmania infantum	26%	100%
A4I0W6	Leishmania infantum	25%	75%
A4I4J2	Leishmania infantum	27%	100%
A4I4J3	Leishmania infantum	26%	86%
A4I5B8	Leishmania infantum	28%	100%
A4I5B9	Leishmania infantum	96%	100%
A4I6E5	Leishmania infantum	26%	100%
A4I9Q4	Leishmania infantum	26%	100%
A4I9R4	Leishmania infantum	27%	100%
A4I9R7	Leishmania infantum	29%	100%
A4I9W8	Leishmania infantum	23%	85%
A4I9X0	Leishmania infantum	27%	100%
A4IA59	Leishmania infantum	27%	85%
A4IAL7	Leishmania infantum	28%	100%
A4IAM1	Leishmania infantum	25%	100%
A4IAM2	Leishmania infantum	27%	100%
C6K3X5	Leptomonas seymouri	29%	100%
C6K3X9	Leptomonas seymouri	27%	100%
E8NHC3	Leishmania infantum	24%	100%
E8NHD3	Leishmania infantum	29%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	98%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
E9AG81	Leishmania infantum	25%	94%
E9AG82	Leishmania infantum	25%	94%
E9AG83	Leishmania infantum	24%	100%
E9AG85	Leishmania infantum	25%	94%
E9AHI9	Leishmania infantum	29%	100%
E9AHT2	Leishmania infantum	24%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	99%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	86%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	93%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	93%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q1U9	Leishmania major	26%	95%
Q4Q305	Leishmania major	26%	100%
Q4Q309	Leishmania major	27%	99%
Q4Q313	Leishmania major	26%	100%
Q4Q317	Leishmania major	26%	100%
Q4Q325	Leishmania major	27%	99%
Q4Q327	Leishmania major	28%	99%
Q4Q329	Leishmania major	29%	100%
Q4Q333	Leishmania major	27%	100%
Q4Q335	Leishmania major	27%	100%
Q4Q337	Leishmania major	26%	100%
Q4Q339	Leishmania major	26%	100%
Q4Q341	Leishmania major	29%	95%
Q4Q397	Leishmania major	26%	100%
Q4Q3A8	Leishmania major	24%	99%
Q4Q3A9	Leishmania major	27%	100%
Q4Q3F7	Leishmania major	25%	100%
Q4Q6L8	Leishmania major	25%	96%
Q4Q7L7	Leishmania major	29%	100%
Q4Q7L8	Leishmania major	28%	100%
Q4QAK4	Leishmania major	26%	100%
Q4QAK5	Leishmania major	29%	100%
Q4QAK7	Leishmania major	26%	100%
Q4QI84	Leishmania major	29%	100%
Q4QI85	Leishmania major	27%	100%
Q4QI86	Leishmania major	29%	100%
Q4QI87	Leishmania major	26%	100%
Q4QI88	Leishmania major	26%	100%
Q4QI92	Leishmania major	27%	100%
Q4QI93	Leishmania major	27%	100%
Q4QI95	Leishmania major	27%	100%
Q4QI97	Leishmania major	27%	100%
Q4QIA0	Leishmania major	25%	100%
Q4QIA1	Leishmania major	25%	100%