Amastin-like surface protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein-like protein

Species:

Leishmania major

UniProt:

Q4Q7L6_LEIMA

TriTrypDb:

LmjF.30.0870 , LMJLV39_300014900 , LMJSD75_300014600

Length:

221

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 184
NetGPI	no	yes: 0, no: 195

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

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Expansion

Sequence features

Q4Q7L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L6

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_MDM2_SWIB_1	114	121	PF02201	0.201
DEG_SPOP_SBC_1	212	216	PF00917	0.493
DOC_CKS1_1	152	157	PF01111	0.391
DOC_MAPK_gen_1	125	135	PF00069	0.490
DOC_MAPK_MEF2A_6	127	135	PF00069	0.581
DOC_MAPK_MEF2A_6	14	23	PF00069	0.561
DOC_MAPK_NFAT4_5	128	136	PF00069	0.400
DOC_USP7_MATH_1	137	141	PF00917	0.253
DOC_USP7_MATH_1	195	199	PF00917	0.505
DOC_WW_Pin1_4	151	156	PF00397	0.270

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	23%	100%
A0A0N0P547	Leptomonas seymouri	29%	100%
A0A0N0P993	Leptomonas seymouri	53%	99%
A0A0N1PAD5	Leptomonas seymouri	26%	88%
A0A0N1PDH0	Leptomonas seymouri	27%	100%
A0A1X0NQ58	Trypanosomatidae	26%	100%
A0A1X0NUH1	Trypanosomatidae	25%	97%
A0A1X0NYN9	Trypanosomatidae	26%	67%
A0A1X0P2R3	Trypanosomatidae	39%	100%
A0A1X0P988	Trypanosomatidae	32%	100%

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