Adenosine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenosine kinase

Gene product:

adenosine kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q7L4_LEIMA

TriTrypDb:

LmjF.30.0890 , LMJLV39_300015200 , LMJSD75_300014900

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

Q4Q7L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	15
GO:0006144	purine nucleobase metabolic process	5	3
GO:0006163	purine nucleotide metabolic process	5	15
GO:0006164	purine nucleotide biosynthetic process	6	15
GO:0006166	purine ribonucleoside salvage	5	15
GO:0006167	AMP biosynthetic process	8	15
GO:0006725	cellular aromatic compound metabolic process	3	15
GO:0006753	nucleoside phosphate metabolic process	4	15
GO:0006793	phosphorus metabolic process	3	15
GO:0006796	phosphate-containing compound metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009112	nucleobase metabolic process	4	3
GO:0009116	nucleoside metabolic process	4	15
GO:0009117	nucleotide metabolic process	5	15
GO:0009119	ribonucleoside metabolic process	5	15
GO:0009123	nucleoside monophosphate metabolic process	5	15
GO:0009124	nucleoside monophosphate biosynthetic process	6	15
GO:0009126	purine nucleoside monophosphate metabolic process	6	15
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	15
GO:0009150	purine ribonucleotide metabolic process	6	15
GO:0009152	purine ribonucleotide biosynthetic process	7	15
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	15
GO:0009161	ribonucleoside monophosphate metabolic process	6	15
GO:0009163	nucleoside biosynthetic process	5	15
GO:0009165	nucleotide biosynthetic process	6	15
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	15
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	15
GO:0009259	ribonucleotide metabolic process	5	15
GO:0009260	ribonucleotide biosynthetic process	6	15
GO:0009987	cellular process	1	15
GO:0016310	phosphorylation	5	15
GO:0018130	heterocycle biosynthetic process	4	15
GO:0019438	aromatic compound biosynthetic process	4	15
GO:0019637	organophosphate metabolic process	3	15
GO:0019693	ribose phosphate metabolic process	4	15
GO:0032261	purine nucleotide salvage	5	15
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034654	nucleobase-containing compound biosynthetic process	4	15
GO:0042278	purine nucleoside metabolic process	5	15
GO:0042451	purine nucleoside biosynthetic process	6	15
GO:0042455	ribonucleoside biosynthetic process	6	15
GO:0043094	cellular metabolic compound salvage	3	15
GO:0043101	purine-containing compound salvage	4	15
GO:0043173	nucleotide salvage	4	15
GO:0043174	nucleoside salvage	4	15
GO:0044209	AMP salvage	7	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0044281	small molecule metabolic process	2	15
GO:0044283	small molecule biosynthetic process	3	15
GO:0046033	AMP metabolic process	7	15
GO:0046128	purine ribonucleoside metabolic process	6	15
GO:0046129	purine ribonucleoside biosynthetic process	7	15
GO:0046390	ribose phosphate biosynthetic process	5	15
GO:0046483	heterocycle metabolic process	3	15
GO:0055086	nucleobase-containing small molecule metabolic process	3	15
GO:0071704	organic substance metabolic process	2	15
GO:0072521	purine-containing compound metabolic process	4	15
GO:0072522	purine-containing compound biosynthetic process	5	15
GO:0090407	organophosphate biosynthetic process	4	15
GO:0106380	purine ribonucleotide salvage	6	15
GO:1901135	carbohydrate derivative metabolic process	3	15
GO:1901137	carbohydrate derivative biosynthetic process	4	15
GO:1901293	nucleoside phosphate biosynthetic process	5	15
GO:1901360	organic cyclic compound metabolic process	3	15
GO:1901362	organic cyclic compound biosynthetic process	4	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:1901657	glycosyl compound metabolic process	4	15
GO:1901659	glycosyl compound biosynthetic process	5	15

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004001	adenosine kinase activity	5	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016301	kinase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0019205	nucleobase-containing compound kinase activity	5	15
GO:0019206	nucleoside kinase activity	6	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.425
CLV_NRD_NRD_1	183	185	PF00675	0.303
CLV_PCSK_KEX2_1	183	185	PF00082	0.282
CLV_PCSK_KEX2_1	34	36	PF00082	0.225
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.225
CLV_PCSK_PC7_1	179	185	PF00082	0.175
CLV_PCSK_SKI1_1	170	174	PF00082	0.261
CLV_PCSK_SKI1_1	75	79	PF00082	0.225
DEG_APCC_DBOX_1	34	42	PF00400	0.425
DEG_APCC_DBOX_1	91	99	PF00400	0.408
DEG_Nend_Nbox_1	1	3	PF02207	0.261
DOC_MAPK_gen_1	34	40	PF00069	0.375
DOC_MAPK_gen_1	90	97	PF00069	0.521
DOC_USP7_MATH_1	200	204	PF00917	0.530
DOC_USP7_MATH_1	84	88	PF00917	0.396
LIG_14-3-3_CanoR_1	102	107	PF00244	0.486
LIG_14-3-3_CanoR_1	247	255	PF00244	0.482
LIG_14-3-3_CanoR_1	75	81	PF00244	0.488
LIG_14-3-3_CanoR_1	90	96	PF00244	0.493
LIG_FHA_1	23	29	PF00498	0.449
LIG_FHA_1	252	258	PF00498	0.488
LIG_FHA_1	47	53	PF00498	0.425
LIG_FHA_1	92	98	PF00498	0.468
LIG_FHA_2	103	109	PF00498	0.425
LIG_FHA_2	22	28	PF00498	0.404
LIG_GBD_Chelix_1	167	175	PF00786	0.192
LIG_LIR_Gen_1	82	91	PF02991	0.513
LIG_LIR_LC3C_4	47	52	PF02991	0.392
LIG_LIR_Nem_3	82	88	PF02991	0.477
LIG_Pex14_2	227	231	PF04695	0.465
LIG_SH2_CRK	85	89	PF00017	0.513
LIG_SH2_NCK_1	81	85	PF00017	0.513
LIG_SH2_STAP1	149	153	PF00017	0.392
LIG_SH2_STAP1	196	200	PF00017	0.425
LIG_SH2_STAP1	81	85	PF00017	0.513
LIG_SH2_STAT5	2	5	PF00017	0.454
LIG_SH2_STAT5	81	84	PF00017	0.454
LIG_SH3_3	48	54	PF00018	0.525
LIG_SUMO_SIM_par_1	260	268	PF11976	0.485
LIG_TRAF2_1	69	72	PF00917	0.489
LIG_TYR_ITSM	81	88	PF00017	0.513
MOD_CK1_1	160	166	PF00069	0.408
MOD_CK1_1	260	266	PF00069	0.556
MOD_CK1_1	55	61	PF00069	0.513
MOD_CK1_1	76	82	PF00069	0.485
MOD_CK2_1	14	20	PF00069	0.469
MOD_CK2_1	196	202	PF00069	0.516
MOD_CK2_1	21	27	PF00069	0.426
MOD_GlcNHglycan	16	19	PF01048	0.254
MOD_GlcNHglycan	198	201	PF01048	0.302
MOD_GlcNHglycan	202	205	PF01048	0.287
MOD_GlcNHglycan	214	217	PF01048	0.133
MOD_GlcNHglycan	248	251	PF01048	0.278
MOD_GlcNHglycan	35	38	PF01048	0.279
MOD_GlcNHglycan	55	58	PF01048	0.333
MOD_GlcNHglycan	66	69	PF01048	0.274
MOD_GlcNHglycan	75	78	PF01048	0.246
MOD_GSK3_1	196	203	PF00069	0.511
MOD_GSK3_1	208	215	PF00069	0.485
MOD_GSK3_1	29	36	PF00069	0.475
MOD_GSK3_1	52	59	PF00069	0.425
MOD_GSK3_1	76	83	PF00069	0.507
MOD_GSK3_1	98	105	PF00069	0.567
MOD_N-GLC_1	257	262	PF02516	0.192
MOD_NEK2_1	218	223	PF00069	0.403
MOD_NEK2_1	64	69	PF00069	0.465
MOD_NEK2_1	97	102	PF00069	0.536
MOD_PKA_2	246	252	PF00069	0.375
MOD_PKA_2	91	97	PF00069	0.479
MOD_Plk_1	257	263	PF00069	0.550
MOD_Plk_2-3	22	28	PF00069	0.392
MOD_Plk_4	251	257	PF00069	0.488
MOD_Plk_4	76	82	PF00069	0.472
MOD_Plk_4	84	90	PF00069	0.491
TRG_DiLeu_BaEn_4	146	152	PF01217	0.513
TRG_ENDOCYTIC_2	85	88	PF00928	0.513
TRG_ER_diArg_1	182	184	PF00400	0.511
TRG_ER_diArg_1	89	92	PF00400	0.557
TRG_NES_CRM1_1	108	121	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X0	Leptomonas seymouri	32%	80%
A0A0N1PDV7	Leptomonas seymouri	59%	75%
A0A0S4IRE7	Bodo saltans	32%	81%
A0A1X0P296	Trypanosomatidae	31%	77%
A0A3S5H7M6	Leishmania donovani	34%	80%
A0A3S7X395	Leishmania donovani	86%	100%
A0A422P4V2	Trypanosoma rangeli	30%	80%
A4HI44	Leishmania braziliensis	32%	80%
A4I5C0	Leishmania infantum	34%	80%
C9ZQQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
E9B0L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	80%
E9B0L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O49923	Physcomitrium patens	29%	80%
O93919	Schizophyllum commune	28%	80%
P47143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	81%
P55262	Cricetulus griseus	23%	76%
P55263	Homo sapiens	24%	76%
P55264	Mus musculus	26%	76%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	81%
Q4Q7L5	Leishmania major	34%	80%
Q54MB5	Dictyostelium discoideum	24%	81%
Q64640	Rattus norvegicus	24%	76%
Q9LZG0	Arabidopsis thaliana	24%	80%
Q9SF85	Arabidopsis thaliana	27%	80%
Q9TVW2	Toxoplasma gondii	25%	76%
V5B941	Trypanosoma cruzi	31%	80%