Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7L3_LEIMA

TriTrypDb:

LmjF.30.0900 , LMJLV39_300015300 , LMJSD75_300015000

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.705
CLV_NRD_NRD_1	180	182	PF00675	0.686
CLV_NRD_NRD_1	410	412	PF00675	0.855
CLV_NRD_NRD_1	458	460	PF00675	0.747
CLV_NRD_NRD_1	489	491	PF00675	0.701
CLV_NRD_NRD_1	553	555	PF00675	0.767
CLV_PCSK_KEX2_1	179	181	PF00082	0.695
CLV_PCSK_KEX2_1	226	228	PF00082	0.525
CLV_PCSK_KEX2_1	245	247	PF00082	0.590
CLV_PCSK_KEX2_1	410	412	PF00082	0.855
CLV_PCSK_KEX2_1	458	460	PF00082	0.701
CLV_PCSK_KEX2_1	489	491	PF00082	0.701
CLV_PCSK_KEX2_1	553	555	PF00082	0.686
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.525
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.590
CLV_PCSK_SKI1_1	201	205	PF00082	0.696
CLV_PCSK_SKI1_1	272	276	PF00082	0.613
CLV_PCSK_SKI1_1	293	297	PF00082	0.500
CLV_PCSK_SKI1_1	395	399	PF00082	0.832
CLV_PCSK_SKI1_1	518	522	PF00082	0.667
CLV_PCSK_SKI1_1	619	623	PF00082	0.759
CLV_PCSK_SKI1_1	634	638	PF00082	0.402
CLV_Separin_Metazoa	40	44	PF03568	0.733
DEG_APCC_DBOX_1	105	113	PF00400	0.739
DEG_APCC_DBOX_1	271	279	PF00400	0.530
DEG_APCC_DBOX_1	517	525	PF00400	0.652
DEG_APCC_DBOX_1	633	641	PF00400	0.629
DEG_Nend_UBRbox_2	1	3	PF02207	0.745
DEG_SCF_FBW7_1	434	440	PF00400	0.751
DEG_SPOP_SBC_1	84	88	PF00917	0.617
DOC_CKS1_1	31	36	PF01111	0.736
DOC_CKS1_1	396	401	PF01111	0.757
DOC_CKS1_1	434	439	PF01111	0.748
DOC_CYCLIN_RxL_1	287	299	PF00134	0.502
DOC_CYCLIN_RxL_1	629	641	PF00134	0.634
DOC_MAPK_gen_1	164	171	PF00069	0.791
DOC_MAPK_gen_1	339	348	PF00069	0.636
DOC_PP1_RVXF_1	285	292	PF00149	0.526
DOC_PP4_FxxP_1	207	210	PF00568	0.628
DOC_PP4_FxxP_1	31	34	PF00568	0.731
DOC_USP7_MATH_1	113	117	PF00917	0.649
DOC_USP7_MATH_1	139	143	PF00917	0.671
DOC_USP7_MATH_1	162	166	PF00917	0.782
DOC_USP7_MATH_1	193	197	PF00917	0.653
DOC_USP7_MATH_1	208	212	PF00917	0.624
DOC_USP7_MATH_1	305	309	PF00917	0.773
DOC_USP7_MATH_1	364	368	PF00917	0.801
DOC_USP7_MATH_1	382	386	PF00917	0.566
DOC_USP7_MATH_1	406	410	PF00917	0.773
DOC_USP7_MATH_1	414	418	PF00917	0.691
DOC_USP7_MATH_1	429	433	PF00917	0.739
DOC_USP7_MATH_1	451	455	PF00917	0.728
DOC_USP7_MATH_1	466	470	PF00917	0.596
DOC_USP7_MATH_1	475	479	PF00917	0.688
DOC_USP7_MATH_1	531	535	PF00917	0.751
DOC_USP7_MATH_1	584	588	PF00917	0.707
DOC_USP7_MATH_1	67	71	PF00917	0.756
DOC_USP7_UBL2_3	307	311	PF12436	0.682
DOC_WW_Pin1_4	1	6	PF00397	0.798
DOC_WW_Pin1_4	131	136	PF00397	0.776
DOC_WW_Pin1_4	182	187	PF00397	0.742
DOC_WW_Pin1_4	213	218	PF00397	0.719
DOC_WW_Pin1_4	30	35	PF00397	0.774
DOC_WW_Pin1_4	360	365	PF00397	0.740
DOC_WW_Pin1_4	395	400	PF00397	0.717
DOC_WW_Pin1_4	433	438	PF00397	0.759
DOC_WW_Pin1_4	440	445	PF00397	0.718
DOC_WW_Pin1_4	470	475	PF00397	0.711
DOC_WW_Pin1_4	527	532	PF00397	0.721
DOC_WW_Pin1_4	541	546	PF00397	0.700
DOC_WW_Pin1_4	547	552	PF00397	0.679
DOC_WW_Pin1_4	554	559	PF00397	0.805
DOC_WW_Pin1_4	608	613	PF00397	0.716
DOC_WW_Pin1_4	619	624	PF00397	0.459
DOC_WW_Pin1_4	63	68	PF00397	0.793
DOC_WW_Pin1_4	77	82	PF00397	0.570
LIG_14-3-3_CanoR_1	127	131	PF00244	0.574
LIG_14-3-3_CanoR_1	180	186	PF00244	0.655
LIG_14-3-3_CanoR_1	246	250	PF00244	0.534
LIG_14-3-3_CanoR_1	309	317	PF00244	0.500
LIG_14-3-3_CanoR_1	323	329	PF00244	0.440
LIG_14-3-3_CanoR_1	370	376	PF00244	0.676
LIG_14-3-3_CanoR_1	413	419	PF00244	0.617
LIG_14-3-3_CanoR_1	465	474	PF00244	0.769
LIG_14-3-3_CanoR_1	553	557	PF00244	0.718
LIG_14-3-3_CanoR_1	593	597	PF00244	0.767
LIG_14-3-3_CanoR_1	607	612	PF00244	0.596
LIG_14-3-3_CanoR_1	82	91	PF00244	0.688
LIG_Actin_WH2_2	333	349	PF00022	0.516
LIG_Actin_WH2_2	675	690	PF00022	0.540
LIG_APCC_ABBA_1	204	209	PF00400	0.565
LIG_BIR_III_4	96	100	PF00653	0.720
LIG_BRCT_BRCA1_1	556	560	PF00533	0.691
LIG_FHA_1	183	189	PF00498	0.719
LIG_FHA_1	214	220	PF00498	0.589
LIG_FHA_1	235	241	PF00498	0.551
LIG_FHA_1	497	503	PF00498	0.606
LIG_FHA_1	623	629	PF00498	0.531
LIG_FHA_1	86	92	PF00498	0.733
LIG_FHA_2	219	225	PF00498	0.579
LIG_FHA_2	325	331	PF00498	0.479
LIG_FHA_2	35	41	PF00498	0.693
LIG_LIR_Apic_2	205	210	PF02991	0.629
LIG_LIR_Apic_2	608	612	PF02991	0.706
LIG_LIR_Apic_2	664	669	PF02991	0.497
LIG_LIR_Gen_1	448	457	PF02991	0.584
LIG_LIR_Nem_3	315	320	PF02991	0.500
LIG_LIR_Nem_3	322	328	PF02991	0.503
LIG_LIR_Nem_3	448	452	PF02991	0.591
LIG_LIR_Nem_3	544	549	PF02991	0.724
LIG_LRP6_Inhibitor_1	333	339	PF00058	0.534
LIG_Pex14_2	560	564	PF04695	0.685
LIG_SH2_CRK	546	550	PF00017	0.824
LIG_SH2_CRK	609	613	PF00017	0.707
LIG_SH2_SRC	228	231	PF00017	0.612
LIG_SH2_STAP1	643	647	PF00017	0.560
LIG_SH2_STAT3	285	288	PF00017	0.598
LIG_SH2_STAT3	540	543	PF00017	0.829
LIG_SH2_STAT5	130	133	PF00017	0.675
LIG_SH2_STAT5	228	231	PF00017	0.490
LIG_SH2_STAT5	285	288	PF00017	0.598
LIG_SH2_STAT5	320	323	PF00017	0.466
LIG_SH2_STAT5	326	329	PF00017	0.428
LIG_SH2_STAT5	675	678	PF00017	0.420
LIG_SH3_1	263	269	PF00018	0.688
LIG_SH3_2	485	490	PF14604	0.724
LIG_SH3_3	21	27	PF00018	0.754
LIG_SH3_3	263	269	PF00018	0.688
LIG_SH3_3	3	9	PF00018	0.819
LIG_SH3_3	393	399	PF00018	0.761
LIG_SH3_3	431	437	PF00018	0.731
LIG_SH3_3	479	485	PF00018	0.836
LIG_SH3_3	78	84	PF00018	0.621
LIG_SH3_CIN85_PxpxPR_1	5	10	PF14604	0.704
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.676
LIG_TRAF2_1	210	213	PF00917	0.760
LIG_TRAF2_1	220	223	PF00917	0.469
LIG_TRAF2_1	332	335	PF00917	0.600
LIG_UBA3_1	636	645	PF00899	0.627
LIG_WW_3	40	44	PF00397	0.811
MOD_CDC14_SPxK_1	550	553	PF00782	0.718
MOD_CDK_SPK_2	395	400	PF00069	0.730
MOD_CDK_SPK_2	608	613	PF00069	0.803
MOD_CDK_SPK_2	77	82	PF00069	0.625
MOD_CDK_SPxK_1	547	553	PF00069	0.725
MOD_CDK_SPxxK_3	395	402	PF00069	0.723
MOD_CDK_SPxxK_3	541	548	PF00069	0.801
MOD_CK1_1	105	111	PF00069	0.750
MOD_CK1_1	191	197	PF00069	0.664
MOD_CK1_1	312	318	PF00069	0.487
MOD_CK1_1	356	362	PF00069	0.804
MOD_CK1_1	376	382	PF00069	0.700
MOD_CK1_1	390	396	PF00069	0.630
MOD_CK1_1	417	423	PF00069	0.780
MOD_CK1_1	432	438	PF00069	0.580
MOD_CK1_1	445	451	PF00069	0.643
MOD_CK1_1	470	476	PF00069	0.741
MOD_CK1_1	478	484	PF00069	0.686
MOD_CK1_1	507	513	PF00069	0.618
MOD_CK1_1	587	593	PF00069	0.749
MOD_CK2_1	162	168	PF00069	0.697
MOD_CK2_1	217	223	PF00069	0.600
MOD_CK2_1	245	251	PF00069	0.466
MOD_CK2_1	34	40	PF00069	0.730
MOD_CK2_1	378	384	PF00069	0.602
MOD_GlcNHglycan	115	118	PF01048	0.688
MOD_GlcNHglycan	142	145	PF01048	0.665
MOD_GlcNHglycan	173	176	PF01048	0.733
MOD_GlcNHglycan	190	193	PF01048	0.669
MOD_GlcNHglycan	367	370	PF01048	0.717
MOD_GlcNHglycan	378	381	PF01048	0.831
MOD_GlcNHglycan	406	409	PF01048	0.723
MOD_GlcNHglycan	422	425	PF01048	0.706
MOD_GlcNHglycan	469	472	PF01048	0.717
MOD_GlcNHglycan	477	480	PF01048	0.740
MOD_GlcNHglycan	494	497	PF01048	0.618
MOD_GlcNHglycan	509	512	PF01048	0.507
MOD_GlcNHglycan	58	61	PF01048	0.681
MOD_GlcNHglycan	582	585	PF01048	0.738
MOD_GlcNHglycan	91	94	PF01048	0.766
MOD_GSK3_1	122	129	PF00069	0.717
MOD_GSK3_1	213	220	PF00069	0.738
MOD_GSK3_1	30	37	PF00069	0.755
MOD_GSK3_1	305	312	PF00069	0.637
MOD_GSK3_1	356	363	PF00069	0.660
MOD_GSK3_1	378	385	PF00069	0.842
MOD_GSK3_1	387	394	PF00069	0.821
MOD_GSK3_1	414	421	PF00069	0.780
MOD_GSK3_1	429	436	PF00069	0.809
MOD_GSK3_1	466	473	PF00069	0.829
MOD_GSK3_1	492	499	PF00069	0.698
MOD_GSK3_1	501	508	PF00069	0.717
MOD_GSK3_1	527	534	PF00069	0.802
MOD_GSK3_1	560	567	PF00069	0.642
MOD_GSK3_1	580	587	PF00069	0.678
MOD_GSK3_1	608	615	PF00069	0.669
MOD_GSK3_1	63	70	PF00069	0.722
MOD_GSK3_1	85	92	PF00069	0.763
MOD_GSK3_1	98	105	PF00069	0.648
MOD_N-GLC_1	140	145	PF02516	0.653
MOD_N-GLC_1	34	39	PF02516	0.775
MOD_N-GLC_1	440	445	PF02516	0.761
MOD_N-GLC_1	564	569	PF02516	0.727
MOD_N-GLC_1	74	79	PF02516	0.858
MOD_N-GLC_1	97	102	PF02516	0.659
MOD_NEK2_1	102	107	PF00069	0.629
MOD_NEK2_1	112	117	PF00069	0.577
MOD_NEK2_1	171	176	PF00069	0.749
MOD_NEK2_1	188	193	PF00069	0.523
MOD_NEK2_1	324	329	PF00069	0.460
MOD_NEK2_1	340	345	PF00069	0.519
MOD_NEK2_1	353	358	PF00069	0.554
MOD_NEK2_1	560	565	PF00069	0.761
MOD_NEK2_1	591	596	PF00069	0.779
MOD_NEK2_2	122	127	PF00069	0.674
MOD_PIKK_1	193	199	PF00454	0.660
MOD_PIKK_1	218	224	PF00454	0.601
MOD_PIKK_1	53	59	PF00454	0.781
MOD_PIKK_1	539	545	PF00454	0.778
MOD_PK_1	245	251	PF00069	0.487
MOD_PKA_1	245	251	PF00069	0.487
MOD_PKA_2	105	111	PF00069	0.643
MOD_PKA_2	126	132	PF00069	0.704
MOD_PKA_2	245	251	PF00069	0.453
MOD_PKA_2	340	346	PF00069	0.562
MOD_PKA_2	376	382	PF00069	0.713
MOD_PKA_2	390	396	PF00069	0.585
MOD_PKA_2	552	558	PF00069	0.674
MOD_PKA_2	592	598	PF00069	0.743
MOD_PKA_2	612	618	PF00069	0.604
MOD_PKB_1	179	187	PF00069	0.696
MOD_Plk_1	312	318	PF00069	0.492
MOD_Plk_1	564	570	PF00069	0.717
MOD_Plk_1	591	597	PF00069	0.578
MOD_Plk_4	126	132	PF00069	0.688
MOD_Plk_4	202	208	PF00069	0.606
MOD_Plk_4	281	287	PF00069	0.538
MOD_Plk_4	452	458	PF00069	0.742
MOD_ProDKin_1	1	7	PF00069	0.797
MOD_ProDKin_1	131	137	PF00069	0.777
MOD_ProDKin_1	182	188	PF00069	0.745
MOD_ProDKin_1	213	219	PF00069	0.706
MOD_ProDKin_1	30	36	PF00069	0.775
MOD_ProDKin_1	360	366	PF00069	0.740
MOD_ProDKin_1	395	401	PF00069	0.718
MOD_ProDKin_1	433	439	PF00069	0.760
MOD_ProDKin_1	440	446	PF00069	0.709
MOD_ProDKin_1	470	476	PF00069	0.716
MOD_ProDKin_1	527	533	PF00069	0.723
MOD_ProDKin_1	541	547	PF00069	0.700
MOD_ProDKin_1	554	560	PF00069	0.805
MOD_ProDKin_1	608	614	PF00069	0.714
MOD_ProDKin_1	619	625	PF00069	0.455
MOD_ProDKin_1	63	69	PF00069	0.791
MOD_ProDKin_1	77	83	PF00069	0.570
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.698
TRG_ENDOCYTIC_2	325	328	PF00928	0.513
TRG_ENDOCYTIC_2	546	549	PF00928	0.728
TRG_ER_diArg_1	164	167	PF00400	0.775
TRG_ER_diArg_1	179	181	PF00400	0.663
TRG_ER_diArg_1	338	341	PF00400	0.529
TRG_ER_diArg_1	410	413	PF00400	0.752
TRG_ER_diArg_1	457	459	PF00400	0.748
TRG_ER_diArg_1	488	490	PF00400	0.691
TRG_ER_diArg_1	631	634	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T3	Leptomonas seymouri	39%	100%
A0A3Q8IE52	Leishmania donovani	87%	100%
A4HI45	Leishmania braziliensis	53%	100%
A4I5C1	Leishmania infantum	87%	100%
E9B0L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%