DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved hypothetical protein, putative

Species:

Leishmania major

UniProt:

Q4Q7L0_LEIMA

TriTrypDb:

LmjF.30.0930 , LMJLV39_300015600 , LMJSD75_300015300

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

Q4Q7L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7L0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016829	lyase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.435
CLV_NRD_NRD_1	319	321	PF00675	0.381
CLV_NRD_NRD_1	462	464	PF00675	0.302
CLV_PCSK_KEX2_1	166	168	PF00082	0.475
CLV_PCSK_KEX2_1	318	320	PF00082	0.455
CLV_PCSK_KEX2_1	462	464	PF00082	0.326
CLV_PCSK_KEX2_1	558	560	PF00082	0.435
CLV_PCSK_KEX2_1	98	100	PF00082	0.552
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.438
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.617
CLV_PCSK_PC7_1	458	464	PF00082	0.331
CLV_PCSK_SKI1_1	166	170	PF00082	0.478
CLV_PCSK_SKI1_1	209	213	PF00082	0.478
DEG_APCC_DBOX_1	177	185	PF00400	0.557
DEG_APCC_KENBOX_2	333	337	PF00400	0.268
DEG_SPOP_SBC_1	471	475	PF00917	0.287
DOC_CKS1_1	328	333	PF01111	0.231
DOC_CKS1_1	571	576	PF01111	0.475
DOC_CYCLIN_yClb1_LxF_4	387	392	PF00134	0.458
DOC_MAPK_gen_1	555	565	PF00069	0.467
DOC_MAPK_MEF2A_6	397	404	PF00069	0.450
DOC_MAPK_RevD_3	306	320	PF00069	0.231
DOC_PP1_RVXF_1	387	393	PF00149	0.458
DOC_PP4_FxxP_1	24	27	PF00568	0.379
DOC_PP4_FxxP_1	328	331	PF00568	0.268
DOC_PP4_FxxP_1	337	340	PF00568	0.185
DOC_PP4_MxPP_1	301	304	PF00568	0.268
DOC_USP7_MATH_1	158	162	PF00917	0.480
DOC_USP7_MATH_1	32	36	PF00917	0.557
DOC_USP7_MATH_1	418	422	PF00917	0.381
DOC_USP7_MATH_1	491	495	PF00917	0.483
DOC_USP7_UBL2_3	94	98	PF12436	0.512
DOC_WW_Pin1_4	239	244	PF00397	0.350
DOC_WW_Pin1_4	280	285	PF00397	0.329
DOC_WW_Pin1_4	286	291	PF00397	0.342
DOC_WW_Pin1_4	327	332	PF00397	0.506
DOC_WW_Pin1_4	436	441	PF00397	0.336
DOC_WW_Pin1_4	570	575	PF00397	0.560
DOC_WW_Pin1_4	73	78	PF00397	0.453
LIG_14-3-3_CanoR_1	178	182	PF00244	0.498
LIG_14-3-3_CanoR_1	276	284	PF00244	0.460
LIG_14-3-3_CanoR_1	3	7	PF00244	0.535
LIG_APCC_ABBA_1	13	18	PF00400	0.422
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	324	328	PF00533	0.268
LIG_BRCT_BRCA1_1	420	424	PF00533	0.428
LIG_Clathr_ClatBox_1	181	185	PF01394	0.328
LIG_deltaCOP1_diTrp_1	44	51	PF00928	0.421
LIG_deltaCOP1_diTrp_1	546	551	PF00928	0.413
LIG_FHA_1	177	183	PF00498	0.485
LIG_FHA_1	213	219	PF00498	0.492
LIG_FHA_1	224	230	PF00498	0.463
LIG_FHA_1	451	457	PF00498	0.370
LIG_FHA_1	497	503	PF00498	0.386
LIG_FHA_1	51	57	PF00498	0.423
LIG_FHA_1	535	541	PF00498	0.453
LIG_FHA_1	542	548	PF00498	0.466
LIG_FHA_2	178	184	PF00498	0.462
LIG_FHA_2	266	272	PF00498	0.315
LIG_FHA_2	410	416	PF00498	0.450
LIG_FHA_2	552	558	PF00498	0.436
LIG_Integrin_RGD_1	133	135	PF01839	0.528
LIG_LIR_Apic_2	23	27	PF02991	0.377
LIG_LIR_Apic_2	298	303	PF02991	0.268
LIG_LIR_Apic_2	325	331	PF02991	0.268
LIG_LIR_Apic_2	335	340	PF02991	0.427
LIG_LIR_Apic_2	360	365	PF02991	0.458
LIG_LIR_Gen_1	269	279	PF02991	0.321
LIG_LIR_Gen_1	412	420	PF02991	0.413
LIG_LIR_Gen_1	48	58	PF02991	0.455
LIG_LIR_LC3C_4	213	218	PF02991	0.536
LIG_LIR_LC3C_4	226	230	PF02991	0.531
LIG_LIR_Nem_3	269	275	PF02991	0.313
LIG_LIR_Nem_3	412	417	PF02991	0.433
LIG_LIR_Nem_3	44	49	PF02991	0.448
LIG_LIR_Nem_3	50	54	PF02991	0.467
LIG_MYND_1	291	295	PF01753	0.458
LIG_Pex14_1	241	245	PF04695	0.343
LIG_Pex14_2	561	565	PF04695	0.324
LIG_REV1ctd_RIR_1	160	171	PF16727	0.561
LIG_RPA_C_Plants	167	178	PF08784	0.399
LIG_SH2_CRK	362	366	PF00017	0.458
LIG_SH2_NCK_1	362	366	PF00017	0.458
LIG_SH2_NCK_1	414	418	PF00017	0.496
LIG_SH2_SRC	362	365	PF00017	0.458
LIG_SH2_STAP1	245	249	PF00017	0.353
LIG_SH2_STAP1	260	264	PF00017	0.323
LIG_SH2_STAP1	414	418	PF00017	0.287
LIG_SH2_STAP1	483	487	PF00017	0.350
LIG_SH2_STAT5	485	488	PF00017	0.364
LIG_SH3_3	26	32	PF00018	0.469
LIG_SH3_3	289	295	PF00018	0.435
LIG_SH3_3	300	306	PF00018	0.395
LIG_SH3_3	337	343	PF00018	0.431
LIG_SH3_3	390	396	PF00018	0.404
LIG_SH3_3	568	574	PF00018	0.523
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.319
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.466
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.309
LIG_SUMO_SIM_par_1	179	186	PF11976	0.514
LIG_SUMO_SIM_par_1	228	233	PF11976	0.491
LIG_SUMO_SIM_par_1	35	41	PF11976	0.505
LIG_SUMO_SIM_par_1	498	504	PF11976	0.356
LIG_SUMO_SIM_par_1	536	541	PF11976	0.449
LIG_TRAF2_1	440	443	PF00917	0.409
LIG_TYR_ITSM	410	417	PF00017	0.323
LIG_WRC_WIRS_1	159	164	PF05994	0.566
MOD_CDC14_SPxK_1	76	79	PF00782	0.456
MOD_CDK_SPxK_1	73	79	PF00069	0.457
MOD_CDK_SPxxK_3	327	334	PF00069	0.231
MOD_CK1_1	2	8	PF00069	0.508
MOD_CK1_1	280	286	PF00069	0.336
MOD_CK1_1	327	333	PF00069	0.397
MOD_CK1_1	357	363	PF00069	0.335
MOD_CK1_1	447	453	PF00069	0.355
MOD_CK1_1	466	472	PF00069	0.241
MOD_CK1_1	474	480	PF00069	0.440
MOD_CK2_1	207	213	PF00069	0.513
MOD_CK2_1	251	257	PF00069	0.503
MOD_CK2_1	409	415	PF00069	0.446
MOD_CK2_1	436	442	PF00069	0.531
MOD_CK2_1	551	557	PF00069	0.413
MOD_CMANNOS	294	297	PF00535	0.458
MOD_GlcNHglycan	129	132	PF01048	0.597
MOD_GlcNHglycan	141	144	PF01048	0.692
MOD_GlcNHglycan	201	204	PF01048	0.562
MOD_GlcNHglycan	209	212	PF01048	0.506
MOD_GlcNHglycan	223	226	PF01048	0.515
MOD_GlcNHglycan	236	239	PF01048	0.503
MOD_GlcNHglycan	24	27	PF01048	0.533
MOD_GlcNHglycan	260	263	PF01048	0.479
MOD_GlcNHglycan	32	35	PF01048	0.446
MOD_GlcNHglycan	404	407	PF01048	0.453
MOD_GlcNHglycan	493	496	PF01048	0.456
MOD_GSK3_1	158	165	PF00069	0.514
MOD_GSK3_1	230	237	PF00069	0.373
MOD_GSK3_1	322	329	PF00069	0.471
MOD_GSK3_1	353	360	PF00069	0.335
MOD_GSK3_1	450	457	PF00069	0.419
MOD_GSK3_1	463	470	PF00069	0.360
MOD_GSK3_1	547	554	PF00069	0.368
MOD_N-GLC_1	357	362	PF02516	0.423
MOD_N-GLC_1	409	414	PF02516	0.345
MOD_N-GLC_1	430	435	PF02516	0.401
MOD_N-GLC_1	73	78	PF02516	0.453
MOD_NEK2_1	127	132	PF00069	0.585
MOD_NEK2_1	162	167	PF00069	0.532
MOD_NEK2_1	177	182	PF00069	0.399
MOD_NEK2_1	212	217	PF00069	0.449
MOD_NEK2_1	22	27	PF00069	0.460
MOD_NEK2_1	277	282	PF00069	0.363
MOD_NEK2_1	404	409	PF00069	0.442
MOD_NEK2_1	444	449	PF00069	0.335
MOD_NEK2_1	472	477	PF00069	0.344
MOD_NEK2_1	551	556	PF00069	0.419
MOD_NEK2_2	158	163	PF00069	0.440
MOD_NEK2_2	366	371	PF00069	0.308
MOD_PIKK_1	430	436	PF00454	0.432
MOD_PIKK_1	474	480	PF00454	0.367
MOD_PKA_2	177	183	PF00069	0.546
MOD_PKA_2	193	199	PF00069	0.513
MOD_PKA_2	2	8	PF00069	0.586
MOD_PKA_2	277	283	PF00069	0.440
MOD_PKA_2	295	301	PF00069	0.243
MOD_PKA_2	382	388	PF00069	0.265
MOD_PKA_2	78	84	PF00069	0.616
MOD_PKB_1	276	284	PF00069	0.458
MOD_Plk_1	212	218	PF00069	0.436
MOD_Plk_1	230	236	PF00069	0.228
MOD_Plk_1	357	363	PF00069	0.403
MOD_Plk_1	430	436	PF00069	0.386
MOD_Plk_1	444	450	PF00069	0.411
MOD_Plk_1	466	472	PF00069	0.432
MOD_Plk_2-3	536	542	PF00069	0.278
MOD_Plk_4	11	17	PF00069	0.405
MOD_Plk_4	158	164	PF00069	0.500
MOD_Plk_4	177	183	PF00069	0.349
MOD_Plk_4	212	218	PF00069	0.445
MOD_Plk_4	32	38	PF00069	0.377
MOD_Plk_4	357	363	PF00069	0.478
MOD_Plk_4	467	473	PF00069	0.483
MOD_Plk_4	496	502	PF00069	0.357
MOD_ProDKin_1	239	245	PF00069	0.350
MOD_ProDKin_1	280	286	PF00069	0.329
MOD_ProDKin_1	327	333	PF00069	0.506
MOD_ProDKin_1	436	442	PF00069	0.336
MOD_ProDKin_1	570	576	PF00069	0.568
MOD_ProDKin_1	73	79	PF00069	0.457
MOD_SUMO_for_1	533	536	PF00179	0.278
MOD_SUMO_for_1	8	11	PF00179	0.405
TRG_ENDOCYTIC_2	414	417	PF00928	0.398
TRG_ER_diArg_1	275	278	PF00400	0.440
TRG_ER_diArg_1	318	320	PF00400	0.461
TRG_ER_diArg_1	389	392	PF00400	0.474
TRG_ER_diArg_1	461	463	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	25%	92%
A0A0N1IA86	Leptomonas seymouri	59%	100%
A0A0S4JNB4	Bodo saltans	30%	100%
A0A0S4KK03	Bodo saltans	25%	95%
A0A1X0P222	Trypanosomatidae	31%	94%
A0A3Q8IFG9	Leishmania donovani	25%	90%
A0A3Q8IHT6	Leishmania donovani	94%	100%
A0A422P4V3	Trypanosoma rangeli	30%	100%
A4HHL0	Leishmania braziliensis	25%	90%
A4HI48	Leishmania braziliensis	81%	100%
A4I4S0	Leishmania infantum	25%	90%
A4I5C4	Leishmania infantum	94%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
E9AE72	Leishmania major	26%	100%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	90%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQS5	Trypanosoma cruzi	34%	100%