Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gamma-tubulin complex component 4

Species:

Leishmania major

UniProt:

Q4Q7K9_LEIMA

TriTrypDb:

LmjF.30.0940 , LMJLV39_300015700 , LMJSD75_300015400

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	11
GO:0000923	equatorial microtubule organizing center	3	2
GO:0000930	gamma-tubulin complex	2	2
GO:0005737	cytoplasm	2	11
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	11
GO:0005874	microtubule	6	11
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q7K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K9

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	11
GO:0000278	mitotic cell cycle	3	2
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0007017	microtubule-based process	2	11
GO:0007020	microtubule nucleation	4	11
GO:0007049	cell cycle	2	2
GO:0007051	spindle organization	3	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0022607	cellular component assembly	4	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0051225	spindle assembly	4	2
GO:0051321	meiotic cell cycle	2	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0097435	supramolecular fiber organization	4	2
GO:0140694	non-membrane-bounded organelle assembly	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0043015	gamma-tubulin binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.608
CLV_MEL_PAP_1	539	545	PF00089	0.249
CLV_NRD_NRD_1	168	170	PF00675	0.468
CLV_NRD_NRD_1	258	260	PF00675	0.334
CLV_NRD_NRD_1	50	52	PF00675	0.630
CLV_NRD_NRD_1	570	572	PF00675	0.283
CLV_NRD_NRD_1	750	752	PF00675	0.791
CLV_NRD_NRD_1	778	780	PF00675	0.702
CLV_PCSK_KEX2_1	168	170	PF00082	0.473
CLV_PCSK_KEX2_1	258	260	PF00082	0.334
CLV_PCSK_KEX2_1	50	52	PF00082	0.473
CLV_PCSK_KEX2_1	570	572	PF00082	0.280
CLV_PCSK_KEX2_1	618	620	PF00082	0.250
CLV_PCSK_KEX2_1	750	752	PF00082	0.791
CLV_PCSK_KEX2_1	778	780	PF00082	0.708
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.250
CLV_PCSK_SKI1_1	104	108	PF00082	0.455
CLV_PCSK_SKI1_1	168	172	PF00082	0.419
CLV_PCSK_SKI1_1	258	262	PF00082	0.348
CLV_PCSK_SKI1_1	30	34	PF00082	0.511
CLV_PCSK_SKI1_1	342	346	PF00082	0.263
CLV_PCSK_SKI1_1	500	504	PF00082	0.236
CLV_PCSK_SKI1_1	533	537	PF00082	0.332
CLV_PCSK_SKI1_1	552	556	PF00082	0.184
CLV_PCSK_SKI1_1	570	574	PF00082	0.236
DEG_APCC_DBOX_1	459	467	PF00400	0.389
DEG_APCC_DBOX_1	499	507	PF00400	0.449
DEG_APCC_DBOX_1	532	540	PF00400	0.461
DEG_APCC_DBOX_1	541	549	PF00400	0.418
DEG_APCC_DBOX_1	679	687	PF00400	0.531
DEG_Nend_UBRbox_2	1	3	PF02207	0.370
DOC_CYCLIN_RxL_1	102	112	PF00134	0.348
DOC_CYCLIN_RxL_1	165	174	PF00134	0.450
DOC_CYCLIN_RxL_1	497	507	PF00134	0.517
DOC_CYCLIN_RxL_1	549	557	PF00134	0.539
DOC_CYCLIN_RxL_1	65	75	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	727	733	PF00134	0.456
DOC_MAPK_DCC_7	327	336	PF00069	0.393
DOC_MAPK_gen_1	50	58	PF00069	0.457
DOC_MAPK_HePTP_8	324	336	PF00069	0.432
DOC_MAPK_MEF2A_6	146	153	PF00069	0.401
DOC_MAPK_MEF2A_6	327	336	PF00069	0.522
DOC_MAPK_MEF2A_6	729	736	PF00069	0.567
DOC_PP1_RVXF_1	102	109	PF00149	0.345
DOC_PP1_RVXF_1	714	720	PF00149	0.436
DOC_PP2B_LxvP_1	20	23	PF13499	0.482
DOC_USP7_MATH_1	216	220	PF00917	0.719
DOC_USP7_MATH_1	340	344	PF00917	0.476
DOC_USP7_MATH_1	41	45	PF00917	0.628
DOC_USP7_MATH_1	418	422	PF00917	0.545
DOC_USP7_MATH_1	425	429	PF00917	0.549
DOC_USP7_MATH_1	491	495	PF00917	0.465
DOC_USP7_MATH_1	610	614	PF00917	0.509
DOC_USP7_MATH_1	644	648	PF00917	0.483
DOC_USP7_MATH_1	735	739	PF00917	0.631
DOC_USP7_MATH_1	760	764	PF00917	0.718
DOC_WW_Pin1_4	116	121	PF00397	0.410
DOC_WW_Pin1_4	378	383	PF00397	0.535
DOC_WW_Pin1_4	387	392	PF00397	0.564
DOC_WW_Pin1_4	672	677	PF00397	0.531
LIG_14-3-3_CanoR_1	17	21	PF00244	0.378
LIG_14-3-3_CanoR_1	433	441	PF00244	0.451
LIG_14-3-3_CanoR_1	542	546	PF00244	0.472
LIG_14-3-3_CanoR_1	552	560	PF00244	0.552
LIG_14-3-3_CanoR_1	570	576	PF00244	0.392
LIG_14-3-3_CanoR_1	643	649	PF00244	0.574
LIG_14-3-3_CanoR_1	680	690	PF00244	0.503
LIG_14-3-3_CanoR_1	737	746	PF00244	0.675
LIG_14-3-3_CanoR_1	74	80	PF00244	0.382
LIG_14-3-3_CanoR_1	753	760	PF00244	0.756
LIG_14-3-3_CanoR_1	762	767	PF00244	0.738
LIG_14-3-3_CanoR_1	81	88	PF00244	0.350
LIG_Actin_WH2_2	1	19	PF00022	0.301
LIG_Actin_WH2_2	321	337	PF00022	0.297
LIG_Actin_WH2_2	436	451	PF00022	0.517
LIG_AP2alpha_1	620	624	PF02296	0.482
LIG_BRCT_BRCA1_1	220	224	PF00533	0.585
LIG_BRCT_BRCA1_1	435	439	PF00533	0.469
LIG_Clathr_ClatBox_1	503	507	PF01394	0.451
LIG_deltaCOP1_diTrp_1	351	356	PF00928	0.436
LIG_DLG_GKlike_1	571	578	PF00625	0.435
LIG_eIF4E_1	531	537	PF01652	0.435
LIG_FHA_1	127	133	PF00498	0.356
LIG_FHA_1	212	218	PF00498	0.635
LIG_FHA_1	234	240	PF00498	0.429
LIG_FHA_1	382	388	PF00498	0.389
LIG_FHA_1	418	424	PF00498	0.443
LIG_FHA_1	456	462	PF00498	0.495
LIG_FHA_1	493	499	PF00498	0.546
LIG_FHA_1	549	555	PF00498	0.531
LIG_FHA_1	597	603	PF00498	0.464
LIG_FHA_1	697	703	PF00498	0.422
LIG_FHA_2	133	139	PF00498	0.499
LIG_FHA_2	279	285	PF00498	0.397
LIG_FHA_2	610	616	PF00498	0.482
LIG_FHA_2	673	679	PF00498	0.507
LIG_Integrin_RGD_1	349	351	PF01839	0.236
LIG_LIR_Gen_1	133	141	PF02991	0.400
LIG_LIR_Gen_1	173	184	PF02991	0.376
LIG_LIR_Gen_1	198	205	PF02991	0.503
LIG_LIR_Gen_1	351	362	PF02991	0.436
LIG_LIR_Gen_1	451	461	PF02991	0.432
LIG_LIR_Gen_1	574	582	PF02991	0.471
LIG_LIR_Gen_1	75	82	PF02991	0.400
LIG_LIR_Nem_3	133	137	PF02991	0.409
LIG_LIR_Nem_3	173	179	PF02991	0.344
LIG_LIR_Nem_3	198	203	PF02991	0.384
LIG_LIR_Nem_3	351	357	PF02991	0.470
LIG_LIR_Nem_3	451	457	PF02991	0.447
LIG_LIR_Nem_3	507	513	PF02991	0.520
LIG_LIR_Nem_3	574	579	PF02991	0.531
LIG_LIR_Nem_3	699	704	PF02991	0.389
LIG_LIR_Nem_3	718	722	PF02991	0.418
LIG_LIR_Nem_3	75	79	PF02991	0.461
LIG_NRBOX	574	580	PF00104	0.441
LIG_PCNA_yPIPBox_3	591	601	PF02747	0.451
LIG_PCNA_yPIPBox_3	689	698	PF02747	0.531
LIG_Pex14_2	290	294	PF04695	0.462
LIG_Pex14_2	620	624	PF04695	0.482
LIG_Pex14_2	719	723	PF04695	0.531
LIG_SH2_CRK	531	535	PF00017	0.436
LIG_SH2_CRK	662	666	PF00017	0.475
LIG_SH2_CRK	76	80	PF00017	0.465
LIG_SH2_PTP2	513	516	PF00017	0.436
LIG_SH2_SRC	110	113	PF00017	0.335
LIG_SH2_SRC	513	516	PF00017	0.467
LIG_SH2_STAP1	130	134	PF00017	0.419
LIG_SH2_STAP1	235	239	PF00017	0.420
LIG_SH2_STAP1	656	660	PF00017	0.404
LIG_SH2_STAT3	273	276	PF00017	0.442
LIG_SH2_STAT3	588	591	PF00017	0.436
LIG_SH2_STAT3	722	725	PF00017	0.581
LIG_SH2_STAT5	110	113	PF00017	0.304
LIG_SH2_STAT5	181	184	PF00017	0.301
LIG_SH2_STAT5	186	189	PF00017	0.314
LIG_SH2_STAT5	199	202	PF00017	0.471
LIG_SH2_STAT5	235	238	PF00017	0.496
LIG_SH2_STAT5	273	276	PF00017	0.486
LIG_SH2_STAT5	430	433	PF00017	0.482
LIG_SH2_STAT5	510	513	PF00017	0.446
LIG_SH2_STAT5	52	55	PF00017	0.521
LIG_SH2_STAT5	656	659	PF00017	0.436
LIG_SH2_STAT5	701	704	PF00017	0.389
LIG_SH2_STAT5	722	725	PF00017	0.597
LIG_SH3_3	146	152	PF00018	0.476
LIG_SH3_3	383	389	PF00018	0.586
LIG_SH3_3	54	60	PF00018	0.525
LIG_SH3_3	727	733	PF00018	0.691
LIG_SUMO_SIM_par_1	501	507	PF11976	0.588
LIG_SUMO_SIM_par_1	518	524	PF11976	0.473
LIG_SUMO_SIM_par_1	593	599	PF11976	0.449
LIG_SUMO_SIM_par_1	693	699	PF11976	0.454
LIG_TRAF2_1	228	231	PF00917	0.524
LIG_TRAF2_1	82	85	PF00917	0.410
LIG_TYR_ITIM	352	357	PF00017	0.531
LIG_TYR_ITIM	664	669	PF00017	0.531
LIG_UBA3_1	249	256	PF00899	0.312
LIG_UBA3_1	519	526	PF00899	0.482
LIG_WRC_WIRS_1	154	159	PF05994	0.347
LIG_WRC_WIRS_1	8	13	PF05994	0.368
MOD_CK1_1	207	213	PF00069	0.506
MOD_CK1_1	381	387	PF00069	0.480
MOD_CK1_1	421	427	PF00069	0.463
MOD_CK1_1	553	559	PF00069	0.520
MOD_CK1_1	596	602	PF00069	0.531
MOD_CK1_1	629	635	PF00069	0.412
MOD_CK1_1	647	653	PF00069	0.487
MOD_CK1_1	7	13	PF00069	0.411
MOD_CK1_1	742	748	PF00069	0.716
MOD_CK1_1	75	81	PF00069	0.437
MOD_CK1_1	761	767	PF00069	0.488
MOD_CK1_1	777	783	PF00069	0.621
MOD_CK2_1	132	138	PF00069	0.498
MOD_CK2_1	278	284	PF00069	0.551
MOD_CK2_1	41	47	PF00069	0.586
MOD_CK2_1	672	678	PF00069	0.507
MOD_CK2_1	681	687	PF00069	0.471
MOD_GlcNHglycan	12	15	PF01048	0.474
MOD_GlcNHglycan	120	123	PF01048	0.440
MOD_GlcNHglycan	218	221	PF01048	0.751
MOD_GlcNHglycan	24	27	PF01048	0.607
MOD_GlcNHglycan	373	376	PF01048	0.309
MOD_GlcNHglycan	427	430	PF01048	0.363
MOD_GlcNHglycan	44	47	PF01048	0.313
MOD_GlcNHglycan	565	568	PF01048	0.267
MOD_GlcNHglycan	607	610	PF01048	0.235
MOD_GlcNHglycan	683	686	PF01048	0.235
MOD_GlcNHglycan	739	742	PF01048	0.613
MOD_GlcNHglycan	780	783	PF01048	0.659
MOD_GSK3_1	126	133	PF00069	0.490
MOD_GSK3_1	207	214	PF00069	0.659
MOD_GSK3_1	330	337	PF00069	0.298
MOD_GSK3_1	417	424	PF00069	0.403
MOD_GSK3_1	605	612	PF00069	0.482
MOD_GSK3_1	647	654	PF00069	0.484
MOD_GSK3_1	735	742	PF00069	0.596
MOD_GSK3_1	749	756	PF00069	0.637
MOD_GSK3_1	758	765	PF00069	0.684
MOD_GSK3_1	773	780	PF00069	0.729
MOD_N-GLC_1	672	677	PF02516	0.297
MOD_N-GLC_2	649	651	PF02516	0.331
MOD_NEK2_1	132	137	PF00069	0.464
MOD_NEK2_1	153	158	PF00069	0.383
MOD_NEK2_1	171	176	PF00069	0.226
MOD_NEK2_1	179	184	PF00069	0.276
MOD_NEK2_1	334	339	PF00069	0.496
MOD_NEK2_1	417	422	PF00069	0.395
MOD_NEK2_1	441	446	PF00069	0.434
MOD_NEK2_1	448	453	PF00069	0.419
MOD_NEK2_1	521	526	PF00069	0.467
MOD_NEK2_1	548	553	PF00069	0.563
MOD_NEK2_1	581	586	PF00069	0.452
MOD_NEK2_1	72	77	PF00069	0.417
MOD_NEK2_2	340	345	PF00069	0.435
MOD_NEK2_2	651	656	PF00069	0.468
MOD_OFUCOSY	645	651	PF10250	0.317
MOD_PIKK_1	278	284	PF00454	0.530
MOD_PIKK_1	721	727	PF00454	0.620
MOD_PIKK_1	80	86	PF00454	0.411
MOD_PK_1	762	768	PF00069	0.591
MOD_PKA_2	16	22	PF00069	0.491
MOD_PKA_2	262	268	PF00069	0.417
MOD_PKA_2	418	424	PF00069	0.568
MOD_PKA_2	448	454	PF00069	0.443
MOD_PKA_2	482	488	PF00069	0.482
MOD_PKA_2	541	547	PF00069	0.455
MOD_PKA_2	563	569	PF00069	0.516
MOD_PKA_2	679	685	PF00069	0.556
MOD_PKA_2	749	755	PF00069	0.711
MOD_PKA_2	761	767	PF00069	0.640
MOD_PKA_2	777	783	PF00069	0.712
MOD_PKA_2	80	86	PF00069	0.411
MOD_PKB_1	751	759	PF00069	0.580
MOD_Plk_1	582	588	PF00069	0.482
MOD_Plk_1	629	635	PF00069	0.531
MOD_Plk_4	153	159	PF00069	0.450
MOD_Plk_4	171	177	PF00069	0.321
MOD_Plk_4	289	295	PF00069	0.413
MOD_Plk_4	315	321	PF00069	0.391
MOD_Plk_4	4	10	PF00069	0.364
MOD_Plk_4	629	635	PF00069	0.436
MOD_Plk_4	651	657	PF00069	0.470
MOD_Plk_4	75	81	PF00069	0.401
MOD_ProDKin_1	116	122	PF00069	0.407
MOD_ProDKin_1	378	384	PF00069	0.535
MOD_ProDKin_1	387	393	PF00069	0.564
MOD_ProDKin_1	672	678	PF00069	0.531
MOD_SUMO_for_1	600	603	PF00179	0.517
MOD_SUMO_rev_2	2	7	PF00179	0.404
TRG_DiLeu_BaEn_1	246	251	PF01217	0.347
TRG_DiLeu_BaEn_1	257	262	PF01217	0.279
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.466
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.454
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.435
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.484
TRG_ENDOCYTIC_2	354	357	PF00928	0.531
TRG_ENDOCYTIC_2	454	457	PF00928	0.449
TRG_ENDOCYTIC_2	531	534	PF00928	0.436
TRG_ENDOCYTIC_2	589	592	PF00928	0.492
TRG_ENDOCYTIC_2	666	669	PF00928	0.499
TRG_ENDOCYTIC_2	701	704	PF00928	0.389
TRG_ENDOCYTIC_2	76	79	PF00928	0.462
TRG_ER_diArg_1	167	169	PF00400	0.467
TRG_ER_diArg_1	258	260	PF00400	0.334
TRG_ER_diArg_1	49	51	PF00400	0.471
TRG_ER_diArg_1	569	571	PF00400	0.480
TRG_ER_diArg_1	749	751	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC04	Leptomonas seymouri	65%	98%
A0A1X0P204	Trypanosomatidae	44%	100%
A0A3Q8IEU3	Leishmania donovani	89%	100%
A0A422P4W6	Trypanosoma rangeli	44%	100%
A4HI49	Leishmania braziliensis	82%	100%
A4I5C5	Leishmania infantum	90%	100%
C9ZQQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B937	Trypanosoma cruzi	44%	100%