Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone-binding protein RBBP4 or subunit C of CAF1 complex/WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q7K8_LEIMA

TriTrypDb:

LmjF.30.0950 , LMJLV39_300015800 , LMJSD75_300015500

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4Q7K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K8

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006338	chromatin remodeling	5	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016043	cellular component organization	3	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.598
CLV_C14_Caspase3-7	144	148	PF00656	0.507
CLV_C14_Caspase3-7	152	156	PF00656	0.573
CLV_C14_Caspase3-7	385	389	PF00656	0.390
CLV_C14_Caspase3-7	477	481	PF00656	0.453
CLV_C14_Caspase3-7	7	11	PF00656	0.590
CLV_NRD_NRD_1	132	134	PF00675	0.612
CLV_NRD_NRD_1	135	137	PF00675	0.601
CLV_NRD_NRD_1	178	180	PF00675	0.649
CLV_NRD_NRD_1	395	397	PF00675	0.586
CLV_NRD_NRD_1	533	535	PF00675	0.383
CLV_NRD_NRD_1	77	79	PF00675	0.666
CLV_PCSK_FUR_1	133	137	PF00082	0.660
CLV_PCSK_KEX2_1	132	134	PF00082	0.610
CLV_PCSK_KEX2_1	135	137	PF00082	0.603
CLV_PCSK_KEX2_1	178	180	PF00082	0.649
CLV_PCSK_KEX2_1	325	327	PF00082	0.540
CLV_PCSK_KEX2_1	395	397	PF00082	0.586
CLV_PCSK_KEX2_1	533	535	PF00082	0.383
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.501
CLV_PCSK_SKI1_1	547	551	PF00082	0.294
CLV_PCSK_SKI1_1	570	574	PF00082	0.398
CLV_PCSK_SKI1_1	70	74	PF00082	0.552
DEG_APCC_DBOX_1	569	577	PF00400	0.407
DEG_MDM2_SWIB_1	399	406	PF02201	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.548
DEG_SPOP_SBC_1	492	496	PF00917	0.397
DOC_CYCLIN_RxL_1	212	222	PF00134	0.524
DOC_CYCLIN_yClb5_NLxxxL_5	368	377	PF00134	0.370
DOC_MAPK_MEF2A_6	283	291	PF00069	0.446
DOC_PP1_RVXF_1	568	575	PF00149	0.328
DOC_PP2B_LxvP_1	590	593	PF13499	0.467
DOC_PP4_FxxP_1	254	257	PF00568	0.453
DOC_USP7_MATH_1	12	16	PF00917	0.678
DOC_USP7_MATH_1	159	163	PF00917	0.590
DOC_USP7_MATH_1	177	181	PF00917	0.616
DOC_USP7_MATH_1	475	479	PF00917	0.466
DOC_USP7_MATH_1	492	496	PF00917	0.418
DOC_USP7_MATH_1	500	504	PF00917	0.420
DOC_USP7_MATH_1	523	527	PF00917	0.373
DOC_USP7_MATH_1	593	597	PF00917	0.478
DOC_USP7_MATH_1	92	96	PF00917	0.670
DOC_USP7_MATH_2	186	192	PF00917	0.619
DOC_WW_Pin1_4	110	115	PF00397	0.629
DOC_WW_Pin1_4	18	23	PF00397	0.621
DOC_WW_Pin1_4	552	557	PF00397	0.345
LIG_14-3-3_CanoR_1	39	49	PF00244	0.624
LIG_14-3-3_CanoR_1	489	497	PF00244	0.457
LIG_14-3-3_CanoR_1	533	540	PF00244	0.380
LIG_14-3-3_CanoR_1	605	611	PF00244	0.339
LIG_BIR_III_2	89	93	PF00653	0.563
LIG_BIR_III_4	140	144	PF00653	0.649
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.473
LIG_FHA_1	234	240	PF00498	0.453
LIG_FHA_1	241	247	PF00498	0.453
LIG_FHA_1	305	311	PF00498	0.489
LIG_FHA_1	35	41	PF00498	0.634
LIG_FHA_1	354	360	PF00498	0.349
LIG_FHA_1	428	434	PF00498	0.642
LIG_FHA_1	446	452	PF00498	0.176
LIG_FHA_1	558	564	PF00498	0.408
LIG_FHA_1	57	63	PF00498	0.640
LIG_FHA_1	578	584	PF00498	0.295
LIG_FHA_1	625	631	PF00498	0.419
LIG_FHA_2	111	117	PF00498	0.602
LIG_FHA_2	142	148	PF00498	0.630
LIG_FHA_2	376	382	PF00498	0.470
LIG_FHA_2	383	389	PF00498	0.440
LIG_FHA_2	442	448	PF00498	0.539
LIG_FHA_2	613	619	PF00498	0.343
LIG_FHA_2	75	81	PF00498	0.664
LIG_LIR_Apic_2	251	257	PF02991	0.453
LIG_LIR_Gen_1	262	272	PF02991	0.459
LIG_LIR_Gen_1	402	411	PF02991	0.352
LIG_LIR_Gen_1	594	603	PF02991	0.362
LIG_LIR_Nem_3	240	244	PF02991	0.453
LIG_LIR_Nem_3	262	268	PF02991	0.459
LIG_LIR_Nem_3	296	302	PF02991	0.537
LIG_LIR_Nem_3	365	370	PF02991	0.312
LIG_LIR_Nem_3	402	406	PF02991	0.355
LIG_LIR_Nem_3	416	422	PF02991	0.335
LIG_LIR_Nem_3	594	600	PF02991	0.436
LIG_LIR_Nem_3	642	646	PF02991	0.588
LIG_NRBOX	45	51	PF00104	0.461
LIG_Pex14_1	540	544	PF04695	0.379
LIG_Pex14_2	399	403	PF04695	0.329
LIG_PTAP_UEV_1	30	35	PF05743	0.551
LIG_SH2_CRK	371	375	PF00017	0.367
LIG_SH2_CRK	633	637	PF00017	0.417
LIG_SH2_GRB2like	419	422	PF00017	0.327
LIG_SH2_STAP1	261	265	PF00017	0.481
LIG_SH2_STAT3	261	264	PF00017	0.453
LIG_SH2_STAT5	233	236	PF00017	0.561
LIG_SH2_STAT5	261	264	PF00017	0.453
LIG_SH2_STAT5	265	268	PF00017	0.453
LIG_SH2_STAT5	419	422	PF00017	0.378
LIG_SH3_2	22	27	PF14604	0.655
LIG_SH3_3	19	25	PF00018	0.764
LIG_SH3_3	236	242	PF00018	0.453
LIG_SH3_3	28	34	PF00018	0.550
LIG_SH3_3	284	290	PF00018	0.453
LIG_SH3_3	59	65	PF00018	0.665
LIG_SH3_3	629	635	PF00018	0.335
LIG_SH3_5	257	261	PF00018	0.453
LIG_SUMO_SIM_par_1	242	247	PF11976	0.507
LIG_SUMO_SIM_par_1	355	363	PF11976	0.334
LIG_SUMO_SIM_par_1	429	435	PF11976	0.531
LIG_SUMO_SIM_par_1	559	564	PF11976	0.400
LIG_SxIP_EBH_1	489	503	PF03271	0.417
LIG_TRAF2_1	123	126	PF00917	0.597
LIG_TRAF2_1	615	618	PF00917	0.362
LIG_TYR_ITIM	263	268	PF00017	0.469
LIG_TYR_ITIM	420	425	PF00017	0.330
MOD_CDC14_SPxK_1	21	24	PF00782	0.629
MOD_CDK_SPxK_1	18	24	PF00069	0.624
MOD_CDK_SPxxK_3	110	117	PF00069	0.529
MOD_CK1_1	171	177	PF00069	0.625
MOD_CK1_1	491	497	PF00069	0.413
MOD_CK1_1	503	509	PF00069	0.351
MOD_CK1_1	56	62	PF00069	0.641
MOD_CK1_1	610	616	PF00069	0.464
MOD_CK1_1	623	629	PF00069	0.294
MOD_CK1_1	95	101	PF00069	0.670
MOD_CK2_1	375	381	PF00069	0.461
MOD_CK2_1	441	447	PF00069	0.531
MOD_CK2_1	611	617	PF00069	0.470
MOD_CK2_1	74	80	PF00069	0.649
MOD_Cter_Amidation	323	326	PF01082	0.532
MOD_GlcNHglycan	108	111	PF01048	0.695
MOD_GlcNHglycan	144	147	PF01048	0.744
MOD_GlcNHglycan	175	178	PF01048	0.633
MOD_GlcNHglycan	179	182	PF01048	0.607
MOD_GlcNHglycan	183	186	PF01048	0.579
MOD_GlcNHglycan	190	193	PF01048	0.633
MOD_GlcNHglycan	275	278	PF01048	0.394
MOD_GlcNHglycan	31	34	PF01048	0.660
MOD_GlcNHglycan	364	367	PF01048	0.352
MOD_GlcNHglycan	412	415	PF01048	0.316
MOD_GlcNHglycan	490	493	PF01048	0.429
MOD_GlcNHglycan	498	501	PF01048	0.418
MOD_GlcNHglycan	502	505	PF01048	0.426
MOD_GlcNHglycan	622	625	PF01048	0.411
MOD_GSK3_1	106	113	PF00069	0.731
MOD_GSK3_1	173	180	PF00069	0.637
MOD_GSK3_1	188	195	PF00069	0.647
MOD_GSK3_1	34	41	PF00069	0.661
MOD_GSK3_1	423	430	PF00069	0.435
MOD_GSK3_1	441	448	PF00069	0.507
MOD_GSK3_1	488	495	PF00069	0.442
MOD_GSK3_1	496	503	PF00069	0.394
MOD_GSK3_1	52	59	PF00069	0.517
MOD_GSK3_1	557	564	PF00069	0.337
MOD_GSK3_1	607	614	PF00069	0.442
MOD_GSK3_1	620	627	PF00069	0.273
MOD_GSK3_1	92	99	PF00069	0.770
MOD_LATS_1	545	551	PF00433	0.300
MOD_N-GLC_1	159	164	PF02516	0.553
MOD_N-GLC_1	4	9	PF02516	0.590
MOD_N-GLC_1	611	616	PF02516	0.425
MOD_NEK2_1	106	111	PF00069	0.644
MOD_NEK2_1	399	404	PF00069	0.327
MOD_NEK2_1	410	415	PF00069	0.339
MOD_NEK2_1	473	478	PF00069	0.453
MOD_NEK2_1	557	562	PF00069	0.545
MOD_NEK2_1	576	581	PF00069	0.259
MOD_PIKK_1	267	273	PF00454	0.462
MOD_PIKK_1	375	381	PF00454	0.464
MOD_PIKK_1	40	46	PF00454	0.572
MOD_PIKK_1	445	451	PF00454	0.449
MOD_PIKK_1	466	472	PF00454	0.453
MOD_PKA_1	135	141	PF00069	0.542
MOD_PKA_2	135	141	PF00069	0.542
MOD_PKA_2	177	183	PF00069	0.544
MOD_PKA_2	23	29	PF00069	0.634
MOD_PKA_2	38	44	PF00069	0.603
MOD_PKA_2	427	433	PF00069	0.469
MOD_PKA_2	488	494	PF00069	0.453
MOD_PKA_2	532	538	PF00069	0.381
MOD_PKA_2	604	610	PF00069	0.342
MOD_PKB_1	133	141	PF00069	0.540
MOD_PKB_1	200	208	PF00069	0.766
MOD_Plk_1	12	18	PF00069	0.610
MOD_Plk_1	259	265	PF00069	0.453
MOD_Plk_1	336	342	PF00069	0.337
MOD_Plk_1	593	599	PF00069	0.355
MOD_Plk_1	607	613	PF00069	0.348
MOD_Plk_4	557	563	PF00069	0.342
MOD_Plk_4	593	599	PF00069	0.355
MOD_ProDKin_1	110	116	PF00069	0.628
MOD_ProDKin_1	18	24	PF00069	0.625
MOD_ProDKin_1	552	558	PF00069	0.348
MOD_SUMO_rev_2	222	230	PF00179	0.372
MOD_SUMO_rev_2	68	75	PF00179	0.600
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.473
TRG_ENDOCYTIC_2	265	268	PF00928	0.476
TRG_ENDOCYTIC_2	371	374	PF00928	0.359
TRG_ENDOCYTIC_2	422	425	PF00928	0.338
TRG_ENDOCYTIC_2	633	636	PF00928	0.346
TRG_ER_diArg_1	132	135	PF00400	0.598
TRG_ER_diArg_1	532	534	PF00400	0.383
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W9	Leptomonas seymouri	58%	97%
A0A3S7X390	Leishmania donovani	92%	100%
A0A3S7X6T4	Leishmania donovani	23%	100%
A4HI50	Leishmania braziliensis	74%	97%
A4I5C6	Leishmania infantum	92%	100%
A4I953	Leishmania infantum	23%	100%
E9B0M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B428	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O22607	Arabidopsis thaliana	22%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	100%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%