Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7K7_LEIMA

TriTrypDb:

LmjF.30.0960 , LMJLV39_300016000 , LMJSD75_300015600

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.585
CLV_NRD_NRD_1	192	194	PF00675	0.803
CLV_NRD_NRD_1	198	200	PF00675	0.815
CLV_NRD_NRD_1	67	69	PF00675	0.712
CLV_NRD_NRD_1	91	93	PF00675	0.617
CLV_PCSK_KEX2_1	192	194	PF00082	0.762
CLV_PCSK_KEX2_1	198	200	PF00082	0.786
CLV_PCSK_KEX2_1	45	47	PF00082	0.706
CLV_PCSK_KEX2_1	91	93	PF00082	0.617
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.706
CLV_PCSK_SKI1_1	135	139	PF00082	0.538
CLV_PCSK_SKI1_1	396	400	PF00082	0.542
CLV_PCSK_SKI1_1	446	450	PF00082	0.592
CLV_PCSK_SKI1_1	69	73	PF00082	0.596
DOC_CDC14_PxL_1	267	275	PF14671	0.633
DOC_CKS1_1	241	246	PF01111	0.576
DOC_CKS1_1	77	82	PF01111	0.663
DOC_CYCLIN_yClb1_LxF_4	399	405	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.608
DOC_PP2B_LxvP_1	151	154	PF13499	0.646
DOC_PP4_FxxP_1	404	407	PF00568	0.555
DOC_PP4_FxxP_1	410	413	PF00568	0.524
DOC_PP4_MxPP_1	78	81	PF00568	0.529
DOC_USP7_MATH_1	157	161	PF00917	0.619
DOC_USP7_MATH_1	170	174	PF00917	0.642
DOC_USP7_MATH_1	307	311	PF00917	0.636
DOC_USP7_MATH_1	379	383	PF00917	0.485
DOC_WW_Pin1_4	116	121	PF00397	0.584
DOC_WW_Pin1_4	153	158	PF00397	0.642
DOC_WW_Pin1_4	240	245	PF00397	0.644
DOC_WW_Pin1_4	274	279	PF00397	0.664
DOC_WW_Pin1_4	327	332	PF00397	0.688
DOC_WW_Pin1_4	359	364	PF00397	0.634
DOC_WW_Pin1_4	375	380	PF00397	0.470
DOC_WW_Pin1_4	6	11	PF00397	0.636
DOC_WW_Pin1_4	76	81	PF00397	0.656
LIG_14-3-3_CanoR_1	161	168	PF00244	0.704
LIG_14-3-3_CanoR_1	300	305	PF00244	0.634
LIG_14-3-3_CanoR_1	361	367	PF00244	0.611
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BIR_III_4	217	221	PF00653	0.580
LIG_Clathr_ClatBox_1	402	406	PF01394	0.547
LIG_CtBP_PxDLS_1	48	52	PF00389	0.654
LIG_FHA_1	178	184	PF00498	0.762
LIG_FHA_1	283	289	PF00498	0.609
LIG_FHA_1	397	403	PF00498	0.538
LIG_FHA_2	104	110	PF00498	0.651
LIG_FHA_2	260	266	PF00498	0.632
LIG_FHA_2	424	430	PF00498	0.549
LIG_FHA_2	62	68	PF00498	0.596
LIG_HCF-1_HBM_1	420	423	PF13415	0.564
LIG_LIR_Apic_2	74	80	PF02991	0.653
LIG_LIR_Gen_1	256	266	PF02991	0.742
LIG_LIR_Nem_3	256	261	PF02991	0.757
LIG_LIR_Nem_3	262	267	PF02991	0.628
LIG_PDZ_Class_1	446	451	PF00595	0.600
LIG_Pex14_2	394	398	PF04695	0.543
LIG_SH2_CRK	77	81	PF00017	0.596
LIG_SH3_1	275	281	PF00018	0.671
LIG_SH3_3	109	115	PF00018	0.581
LIG_SH3_3	151	157	PF00018	0.632
LIG_SH3_3	238	244	PF00018	0.815
LIG_SH3_3	266	272	PF00018	0.617
LIG_SH3_3	275	281	PF00018	0.587
LIG_SH3_3	29	35	PF00018	0.643
LIG_SH3_3	349	355	PF00018	0.652
LIG_SH3_3	402	408	PF00018	0.549
LIG_SH3_3	7	13	PF00018	0.635
LIG_SUMO_SIM_par_1	412	417	PF11976	0.576
LIG_TRAF2_1	143	146	PF00917	0.600
LIG_TRAF2_1	338	341	PF00917	0.644
LIG_TRAF2_1	435	438	PF00917	0.579
LIG_WW_3	58	62	PF00397	0.617
LIG_WW_3	79	83	PF00397	0.537
MOD_CDK_SPK_2	274	279	PF00069	0.664
MOD_CDK_SPxK_1	76	82	PF00069	0.660
MOD_CK1_1	107	113	PF00069	0.604
MOD_CK1_1	160	166	PF00069	0.643
MOD_CK1_1	234	240	PF00069	0.597
MOD_CK1_1	253	259	PF00069	0.526
MOD_CK1_1	282	288	PF00069	0.635
MOD_CK1_1	318	324	PF00069	0.665
MOD_CK1_1	330	336	PF00069	0.664
MOD_CK1_1	357	363	PF00069	0.611
MOD_CK1_1	390	396	PF00069	0.510
MOD_CK2_1	140	146	PF00069	0.614
MOD_CK2_1	153	159	PF00069	0.547
MOD_CK2_1	318	324	PF00069	0.674
MOD_CK2_1	432	438	PF00069	0.582
MOD_CK2_1	61	67	PF00069	0.601
MOD_GlcNHglycan	162	165	PF01048	0.714
MOD_GlcNHglycan	19	23	PF01048	0.681
MOD_GlcNHglycan	32	35	PF01048	0.594
MOD_GlcNHglycan	387	392	PF01048	0.529
MOD_GSK3_1	100	107	PF00069	0.625
MOD_GSK3_1	136	143	PF00069	0.615
MOD_GSK3_1	153	160	PF00069	0.558
MOD_GSK3_1	177	184	PF00069	0.576
MOD_GSK3_1	209	216	PF00069	0.626
MOD_GSK3_1	250	257	PF00069	0.542
MOD_GSK3_1	298	305	PF00069	0.631
MOD_GSK3_1	326	333	PF00069	0.783
MOD_GSK3_1	353	360	PF00069	0.599
MOD_GSK3_1	361	368	PF00069	0.529
MOD_GSK3_1	375	382	PF00069	0.470
MOD_GSK3_1	92	99	PF00069	0.685
MOD_N-GLC_1	107	112	PF02516	0.652
MOD_N-GLC_1	298	303	PF02516	0.561
MOD_NEK2_1	18	23	PF00069	0.690
MOD_NEK2_1	273	278	PF00069	0.734
MOD_NEK2_1	298	303	PF00069	0.578
MOD_NEK2_1	30	35	PF00069	0.611
MOD_NEK2_1	326	331	PF00069	0.715
MOD_NEK2_1	54	59	PF00069	0.591
MOD_NEK2_1	71	76	PF00069	0.636
MOD_NEK2_1	96	101	PF00069	0.748
MOD_NEK2_2	20	25	PF00069	0.569
MOD_NEK2_2	379	384	PF00069	0.484
MOD_PIKK_1	203	209	PF00454	0.688
MOD_PIKK_1	282	288	PF00454	0.635
MOD_PIKK_1	54	60	PF00454	0.656
MOD_PKA_2	160	166	PF00069	0.709
MOD_PKA_2	181	187	PF00069	0.624
MOD_PKA_2	299	305	PF00069	0.625
MOD_Plk_1	107	113	PF00069	0.653
MOD_Plk_1	250	256	PF00069	0.640
MOD_Plk_1	379	385	PF00069	0.483
MOD_Plk_2-3	432	438	PF00069	0.582
MOD_Plk_4	107	113	PF00069	0.631
MOD_Plk_4	279	285	PF00069	0.678
MOD_Plk_4	423	429	PF00069	0.549
MOD_ProDKin_1	116	122	PF00069	0.584
MOD_ProDKin_1	153	159	PF00069	0.646
MOD_ProDKin_1	240	246	PF00069	0.643
MOD_ProDKin_1	274	280	PF00069	0.667
MOD_ProDKin_1	327	333	PF00069	0.689
MOD_ProDKin_1	359	365	PF00069	0.634
MOD_ProDKin_1	375	381	PF00069	0.469
MOD_ProDKin_1	6	12	PF00069	0.637
MOD_ProDKin_1	76	82	PF00069	0.660
MOD_SUMO_rev_2	437	445	PF00179	0.568
MOD_SUMO_rev_2	63	71	PF00179	0.653
TRG_DiLeu_BaEn_3	49	55	PF01217	0.575
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.632
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.637
TRG_ER_diArg_1	191	193	PF00400	0.684
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRU8	Leishmania donovani	84%	77%
A4HI51	Leishmania braziliensis	63%	100%
A4I5C7	Leishmania infantum	84%	100%
E9B0M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%