Putative p22 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p22 protein precursor, putative

Species:

Leishmania major

UniProt:

Q4Q7K6_LEIMA

TriTrypDb:

LmjF.30.0970 , LMJLV39_300016100 , LMJSD75_300015700

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	20
GO:0031974	membrane-enclosed lumen	2	20
GO:0043233	organelle lumen	3	20
GO:0070013	intracellular organelle lumen	4	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

Q4Q7K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K6

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.460
CLV_C14_Caspase3-7	74	78	PF00656	0.645
CLV_NRD_NRD_1	11	13	PF00675	0.563
CLV_NRD_NRD_1	24	26	PF00675	0.516
CLV_NRD_NRD_1	49	51	PF00675	0.446
CLV_PCSK_KEX2_1	11	13	PF00082	0.562
CLV_PCSK_KEX2_1	133	135	PF00082	0.308
CLV_PCSK_KEX2_1	160	162	PF00082	0.374
CLV_PCSK_KEX2_1	24	26	PF00082	0.512
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.356
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.374
DOC_CKS1_1	39	44	PF01111	0.610
DOC_PP2B_LxvP_1	7	10	PF13499	0.562
DOC_USP7_MATH_1	10	14	PF00917	0.724
DOC_WW_Pin1_4	38	43	PF00397	0.616
LIG_14-3-3_CanoR_1	11	19	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_CtBP_PxDLS_1	65	71	PF00389	0.520
LIG_deltaCOP1_diTrp_1	184	193	PF00928	0.480
LIG_FHA_1	137	143	PF00498	0.549
LIG_FHA_1	54	60	PF00498	0.479
LIG_FHA_2	124	130	PF00498	0.505
LIG_FHA_2	154	160	PF00498	0.470
LIG_FHA_2	21	27	PF00498	0.482
LIG_FHA_2	72	78	PF00498	0.583
LIG_GBD_Chelix_1	142	150	PF00786	0.374
LIG_LIR_Apic_2	136	141	PF02991	0.486
LIG_LIR_Gen_1	145	155	PF02991	0.574
LIG_LIR_Gen_1	169	178	PF02991	0.574
LIG_LIR_LC3C_4	66	70	PF02991	0.518
LIG_LIR_Nem_3	145	151	PF02991	0.513
LIG_LIR_Nem_3	169	173	PF02991	0.555
LIG_LRP6_Inhibitor_1	109	115	PF00058	0.374
LIG_PTB_Apo_2	110	117	PF02174	0.525
LIG_SH2_CRK	138	142	PF00017	0.511
LIG_SH2_CRK	148	152	PF00017	0.511
LIG_SH2_NCK_1	117	121	PF00017	0.575
LIG_SH2_SRC	117	120	PF00017	0.560
LIG_SH2_STAP1	117	121	PF00017	0.610
LIG_SH2_STAP1	174	178	PF00017	0.492
LIG_SH2_STAP1	183	187	PF00017	0.464
LIG_SH2_STAT3	89	92	PF00017	0.574
LIG_SH2_STAT5	138	141	PF00017	0.559
LIG_SH2_STAT5	157	160	PF00017	0.457
LIG_SH2_STAT5	89	92	PF00017	0.530
LIG_SH3_3	34	40	PF00018	0.539
LIG_SH3_3	46	52	PF00018	0.480
LIG_TRAF2_1	103	106	PF00917	0.574
LIG_TYR_ITIM	146	151	PF00017	0.551
LIG_UBA3_1	86	93	PF00899	0.485
LIG_WRC_WIRS_1	173	178	PF05994	0.567
MOD_CK1_1	2	8	PF00069	0.735
MOD_CK2_1	100	106	PF00069	0.575
MOD_CK2_1	123	129	PF00069	0.511
MOD_CK2_1	153	159	PF00069	0.536
MOD_CK2_1	20	26	PF00069	0.434
MOD_GlcNHglycan	1	4	PF01048	0.654
MOD_GlcNHglycan	12	15	PF01048	0.475
MOD_GSK3_1	53	60	PF00069	0.444
MOD_GSK3_1	71	78	PF00069	0.609
MOD_NEK2_1	57	62	PF00069	0.418
MOD_PIKK_1	88	94	PF00454	0.470
MOD_PKA_2	10	16	PF00069	0.650
MOD_PKA_2	70	76	PF00069	0.548
MOD_Plk_1	100	106	PF00069	0.564
MOD_Plk_4	153	159	PF00069	0.494
MOD_Plk_4	172	178	PF00069	0.494
MOD_ProDKin_1	38	44	PF00069	0.620
MOD_SUMO_rev_2	159	167	PF00179	0.574
TRG_DiLeu_BaEn_1	105	110	PF01217	0.536
TRG_DiLeu_BaEn_1	64	69	PF01217	0.539
TRG_ENDOCYTIC_2	148	151	PF00928	0.551
TRG_ER_diArg_1	10	12	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	86%	84%
A0A0N1HS24	Leptomonas seymouri	24%	76%
A0A0S4ITN8	Bodo saltans	40%	86%
A0A1X0NTH7	Trypanosomatidae	25%	75%
A0A1X0P207	Trypanosomatidae	46%	87%
A0A3Q8IBW7	Leishmania donovani	98%	84%
A0A3Q8IFM4	Leishmania donovani	28%	76%
A0A422P4Z7	Trypanosoma rangeli	40%	87%
A4HCI6	Leishmania braziliensis	28%	79%
A4HI52	Leishmania braziliensis	93%	100%
A4I007	Leishmania infantum	28%	76%
A4I5C8	Leishmania infantum	98%	96%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	86%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	75%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	84%
Q4QBJ9	Leishmania major	28%	78%
V5BDB3	Trypanosoma cruzi	25%	75%