Autophagy protein 5 (ATG5)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 5

Species:

Leishmania major

UniProt:

Q4Q7K5_LEIMA

TriTrypDb:

LmjF.30.0980 , LMJLV39_300016200 , LMJSD75_300015800

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	423	425	PF00675	0.461
CLV_PCSK_KEX2_1	423	425	PF00082	0.461
CLV_PCSK_SKI1_1	225	229	PF00082	0.637
CLV_PCSK_SKI1_1	357	361	PF00082	0.701
CLV_PCSK_SKI1_1	452	456	PF00082	0.447
CLV_PCSK_SKI1_1	7	11	PF00082	0.410
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DOC_CDC14_PxL_1	300	308	PF14671	0.412
DOC_CKS1_1	227	232	PF01111	0.549
DOC_CKS1_1	436	441	PF01111	0.441
DOC_CYCLIN_RxL_1	222	229	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.538
DOC_MAPK_gen_1	398	406	PF00069	0.525
DOC_MAPK_MEF2A_6	264	273	PF00069	0.616
DOC_MAPK_MEF2A_6	452	460	PF00069	0.440
DOC_PP1_RVXF_1	237	243	PF00149	0.569
DOC_PP1_RVXF_1	421	428	PF00149	0.452
DOC_PP4_FxxP_1	211	214	PF00568	0.631
DOC_PP4_FxxP_1	301	304	PF00568	0.408
DOC_SPAK_OSR1_1	426	430	PF12202	0.523
DOC_USP7_MATH_1	180	184	PF00917	0.526
DOC_USP7_MATH_1	250	254	PF00917	0.614
DOC_USP7_MATH_1	327	331	PF00917	0.612
DOC_USP7_MATH_1	412	416	PF00917	0.655
DOC_USP7_MATH_1	70	74	PF00917	0.482
DOC_USP7_UBL2_3	127	131	PF12436	0.433
DOC_WW_Pin1_4	197	202	PF00397	0.650
DOC_WW_Pin1_4	210	215	PF00397	0.629
DOC_WW_Pin1_4	226	231	PF00397	0.506
DOC_WW_Pin1_4	31	36	PF00397	0.422
DOC_WW_Pin1_4	319	324	PF00397	0.640
DOC_WW_Pin1_4	370	375	PF00397	0.602
DOC_WW_Pin1_4	415	420	PF00397	0.565
DOC_WW_Pin1_4	435	440	PF00397	0.434
DOC_WW_Pin1_4	62	67	PF00397	0.608
LIG_14-3-3_CanoR_1	264	271	PF00244	0.668
LIG_BRCT_BRCA1_1	205	209	PF00533	0.582
LIG_CtBP_PxDLS_1	89	93	PF00389	0.406
LIG_FHA_1	106	112	PF00498	0.611
LIG_FHA_1	22	28	PF00498	0.510
LIG_FHA_1	358	364	PF00498	0.562
LIG_FHA_2	274	280	PF00498	0.607
LIG_FHA_2	371	377	PF00498	0.573
LIG_LIR_Apic_2	37	41	PF02991	0.427
LIG_LIR_Gen_1	212	223	PF02991	0.504
LIG_LIR_Gen_1	338	349	PF02991	0.510
LIG_LIR_Nem_3	135	141	PF02991	0.457
LIG_LIR_Nem_3	212	218	PF02991	0.508
LIG_LIR_Nem_3	219	223	PF02991	0.546
LIG_LIR_Nem_3	25	31	PF02991	0.388
LIG_LIR_Nem_3	254	260	PF02991	0.586
LIG_LIR_Nem_3	338	344	PF02991	0.522
LIG_NRBOX	223	229	PF00104	0.627
LIG_PCNA_yPIPBox_3	221	231	PF02747	0.518
LIG_PDZ_Class_2	455	460	PF00595	0.523
LIG_PTB_Apo_2	189	196	PF02174	0.659
LIG_PTB_Phospho_1	189	195	PF10480	0.661
LIG_SH2_CRK	134	138	PF00017	0.445
LIG_SH2_CRK	205	209	PF00017	0.675
LIG_SH2_CRK	220	224	PF00017	0.462
LIG_SH2_CRK	341	345	PF00017	0.441
LIG_SH2_GRB2like	112	115	PF00017	0.457
LIG_SH2_GRB2like	48	51	PF00017	0.451
LIG_SH2_NCK_1	205	209	PF00017	0.612
LIG_SH2_NCK_1	352	356	PF00017	0.566
LIG_SH2_SRC	352	355	PF00017	0.469
LIG_SH2_STAP1	134	138	PF00017	0.445
LIG_SH2_STAP1	16	20	PF00017	0.479
LIG_SH2_STAT5	112	115	PF00017	0.457
LIG_SH2_STAT5	134	137	PF00017	0.440
LIG_SH2_STAT5	215	218	PF00017	0.616
LIG_SH2_STAT5	236	239	PF00017	0.466
LIG_SH2_STAT5	257	260	PF00017	0.585
LIG_SH2_STAT5	48	51	PF00017	0.422
LIG_SH3_3	371	377	PF00018	0.577
LIG_SH3_3	63	69	PF00018	0.510
LIG_SUMO_SIM_par_1	87	93	PF11976	0.451
LIG_TRAF2_1	167	170	PF00917	0.552
LIG_TYR_ITIM	113	118	PF00017	0.449
LIG_TYR_ITIM	218	223	PF00017	0.437
LIG_WRPW_2	13	16	PF00400	0.557
LIG_WRPW_2	161	164	PF00400	0.510
LIG_WW_3	354	358	PF00397	0.618
MOD_CDK_SPK_2	226	231	PF00069	0.528
MOD_CK1_1	182	188	PF00069	0.564
MOD_CK1_1	197	203	PF00069	0.676
MOD_CK1_1	274	280	PF00069	0.494
MOD_CK1_1	322	328	PF00069	0.681
MOD_CK1_1	415	421	PF00069	0.536
MOD_CK1_1	62	68	PF00069	0.704
MOD_CK2_1	273	279	PF00069	0.595
MOD_CK2_1	332	338	PF00069	0.691
MOD_CK2_1	370	376	PF00069	0.677
MOD_CK2_1	438	444	PF00069	0.459
MOD_CMANNOS	380	383	PF00535	0.452
MOD_GlcNHglycan	149	152	PF01048	0.594
MOD_GlcNHglycan	182	185	PF01048	0.625
MOD_GlcNHglycan	205	208	PF01048	0.629
MOD_GlcNHglycan	254	257	PF01048	0.581
MOD_GlcNHglycan	265	268	PF01048	0.534
MOD_GlcNHglycan	329	332	PF01048	0.683
MOD_GlcNHglycan	414	417	PF01048	0.542
MOD_GlcNHglycan	61	64	PF01048	0.613
MOD_GlcNHglycan	72	75	PF01048	0.536
MOD_GSK3_1	193	200	PF00069	0.705
MOD_GSK3_1	27	34	PF00069	0.406
MOD_GSK3_1	271	278	PF00069	0.619
MOD_GSK3_1	315	322	PF00069	0.592
MOD_GSK3_1	411	418	PF00069	0.480
MOD_GSK3_1	434	441	PF00069	0.533
MOD_GSK3_1	61	68	PF00069	0.551
MOD_GSK3_1	77	84	PF00069	0.651
MOD_GSK3_1	97	104	PF00069	0.405
MOD_N-GLC_1	319	324	PF02516	0.531
MOD_N-GLC_2	50	52	PF02516	0.425
MOD_NEK2_1	105	110	PF00069	0.569
MOD_NEK2_1	209	214	PF00069	0.670
MOD_NEK2_1	271	276	PF00069	0.635
MOD_NEK2_1	344	349	PF00069	0.400
MOD_NEK2_1	369	374	PF00069	0.691
MOD_NEK2_1	61	66	PF00069	0.622
MOD_NEK2_1	77	82	PF00069	0.487
MOD_NEK2_1	90	95	PF00069	0.416
MOD_PIKK_1	22	28	PF00454	0.420
MOD_PKA_2	263	269	PF00069	0.518
MOD_Plk_1	22	28	PF00069	0.420
MOD_Plk_1	337	343	PF00069	0.540
MOD_Plk_1	90	96	PF00069	0.396
MOD_Plk_4	132	138	PF00069	0.577
MOD_Plk_4	329	335	PF00069	0.508
MOD_Plk_4	34	40	PF00069	0.509
MOD_Plk_4	438	444	PF00069	0.478
MOD_Plk_4	81	87	PF00069	0.521
MOD_ProDKin_1	197	203	PF00069	0.649
MOD_ProDKin_1	210	216	PF00069	0.627
MOD_ProDKin_1	226	232	PF00069	0.504
MOD_ProDKin_1	31	37	PF00069	0.423
MOD_ProDKin_1	319	325	PF00069	0.640
MOD_ProDKin_1	370	376	PF00069	0.597
MOD_ProDKin_1	415	421	PF00069	0.562
MOD_ProDKin_1	435	441	PF00069	0.441
MOD_ProDKin_1	62	68	PF00069	0.609
MOD_SUMO_rev_2	119	129	PF00179	0.530
TRG_DiLeu_BaEn_1	219	224	PF01217	0.610
TRG_ENDOCYTIC_2	115	118	PF00928	0.451
TRG_ENDOCYTIC_2	134	137	PF00928	0.440
TRG_ENDOCYTIC_2	161	164	PF00928	0.510
TRG_ENDOCYTIC_2	215	218	PF00928	0.533
TRG_ENDOCYTIC_2	220	223	PF00928	0.519
TRG_ENDOCYTIC_2	341	344	PF00928	0.409
TRG_ER_diArg_1	422	424	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W7	Leptomonas seymouri	56%	86%
A0A3S7X356	Leishmania donovani	94%	100%
A4HI53	Leishmania braziliensis	82%	100%
A4I5C9	Leishmania infantum	94%	100%
E9B0M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%