Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7K4_LEIMA

TriTrypDb:

LmjF.30.0990 , LMJLV39_300016300 , LMJSD75_300015900

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.744
CLV_C14_Caspase3-7	517	521	PF00656	0.636
CLV_NRD_NRD_1	135	137	PF00675	0.548
CLV_NRD_NRD_1	238	240	PF00675	0.818
CLV_NRD_NRD_1	292	294	PF00675	0.751
CLV_NRD_NRD_1	295	297	PF00675	0.717
CLV_NRD_NRD_1	333	335	PF00675	0.714
CLV_NRD_NRD_1	375	377	PF00675	0.669
CLV_NRD_NRD_1	479	481	PF00675	0.470
CLV_PCSK_FUR_1	293	297	PF00082	0.754
CLV_PCSK_KEX2_1	135	137	PF00082	0.548
CLV_PCSK_KEX2_1	238	240	PF00082	0.741
CLV_PCSK_KEX2_1	276	278	PF00082	0.554
CLV_PCSK_KEX2_1	292	294	PF00082	0.644
CLV_PCSK_KEX2_1	295	297	PF00082	0.649
CLV_PCSK_KEX2_1	333	335	PF00082	0.644
CLV_PCSK_KEX2_1	375	377	PF00082	0.669
CLV_PCSK_KEX2_1	479	481	PF00082	0.470
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.554
CLV_PCSK_SKI1_1	175	179	PF00082	0.709
CLV_PCSK_SKI1_1	266	270	PF00082	0.529
CLV_PCSK_SKI1_1	277	281	PF00082	0.638
CLV_PCSK_SKI1_1	375	379	PF00082	0.562
CLV_PCSK_SKI1_1	42	46	PF00082	0.527
CLV_PCSK_SKI1_1	479	483	PF00082	0.466
DEG_SCF_TRCP1_1	104	110	PF00400	0.555
DEG_SPOP_SBC_1	12	16	PF00917	0.649
DEG_SPOP_SBC_1	319	323	PF00917	0.779
DEG_SPOP_SBC_1	370	374	PF00917	0.450
DOC_CKS1_1	1	6	PF01111	0.645
DOC_CKS1_1	302	307	PF01111	0.691
DOC_CKS1_1	379	384	PF01111	0.456
DOC_CKS1_1	409	414	PF01111	0.701
DOC_CYCLIN_RxL_1	189	200	PF00134	0.523
DOC_CYCLIN_RxL_1	270	283	PF00134	0.459
DOC_CYCLIN_RxL_1	372	381	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.638
DOC_MAPK_gen_1	135	142	PF00069	0.548
DOC_MAPK_gen_1	276	282	PF00069	0.557
DOC_MAPK_gen_1	292	303	PF00069	0.700
DOC_MAPK_gen_1	333	340	PF00069	0.691
DOC_MAPK_MEF2A_6	29	36	PF00069	0.639
DOC_MAPK_MEF2A_6	333	340	PF00069	0.625
DOC_MAPK_RevD_3	122	136	PF00069	0.516
DOC_PP1_RVXF_1	40	47	PF00149	0.506
DOC_PP2B_LxvP_1	394	397	PF13499	0.494
DOC_PP2B_LxvP_1	488	491	PF13499	0.438
DOC_USP7_MATH_1	12	16	PF00917	0.751
DOC_USP7_MATH_1	307	311	PF00917	0.746
DOC_USP7_MATH_1	319	323	PF00917	0.630
DOC_USP7_MATH_1	348	352	PF00917	0.746
DOC_USP7_MATH_1	368	372	PF00917	0.634
DOC_USP7_MATH_1	491	495	PF00917	0.619
DOC_USP7_MATH_1	550	554	PF00917	0.666
DOC_USP7_MATH_1	88	92	PF00917	0.726
DOC_USP7_MATH_1	97	101	PF00917	0.628
DOC_WW_Pin1_4	181	186	PF00397	0.730
DOC_WW_Pin1_4	19	24	PF00397	0.634
DOC_WW_Pin1_4	199	204	PF00397	0.701
DOC_WW_Pin1_4	242	247	PF00397	0.704
DOC_WW_Pin1_4	301	306	PF00397	0.662
DOC_WW_Pin1_4	34	39	PF00397	0.637
DOC_WW_Pin1_4	344	349	PF00397	0.552
DOC_WW_Pin1_4	378	383	PF00397	0.467
DOC_WW_Pin1_4	408	413	PF00397	0.716
DOC_WW_Pin1_4	8	13	PF00397	0.771
DOC_WW_Pin1_4	90	95	PF00397	0.587
LIG_14-3-3_CanoR_1	175	180	PF00244	0.755
LIG_14-3-3_CanoR_1	238	242	PF00244	0.712
LIG_14-3-3_CanoR_1	287	291	PF00244	0.610
LIG_14-3-3_CanoR_1	295	301	PF00244	0.676
LIG_14-3-3_CanoR_1	524	533	PF00244	0.501
LIG_14-3-3_CanoR_1	66	71	PF00244	0.746
LIG_BIR_III_4	115	119	PF00653	0.666
LIG_eIF4E_1	560	566	PF01652	0.670
LIG_FHA_1	1	7	PF00498	0.621
LIG_FHA_1	214	220	PF00498	0.605
LIG_FHA_1	22	28	PF00498	0.713
LIG_FHA_1	259	265	PF00498	0.649
LIG_FHA_1	322	328	PF00498	0.745
LIG_FHA_1	357	363	PF00498	0.527
LIG_FHA_1	365	371	PF00498	0.593
LIG_FHA_1	372	378	PF00498	0.417
LIG_FHA_1	509	515	PF00498	0.634
LIG_FHA_1	82	88	PF00498	0.823
LIG_FHA_2	188	194	PF00498	0.679
LIG_LIR_Gen_1	128	137	PF02991	0.648
LIG_LIR_Gen_1	353	363	PF02991	0.571
LIG_LIR_Gen_1	484	491	PF02991	0.598
LIG_LIR_Nem_3	128	133	PF02991	0.530
LIG_LIR_Nem_3	353	358	PF02991	0.525
LIG_LIR_Nem_3	484	488	PF02991	0.589
LIG_MYND_1	414	418	PF01753	0.721
LIG_NBox_RRM_1	339	349	PF00076	0.595
LIG_NRBOX	264	270	PF00104	0.528
LIG_NRBOX	357	363	PF00104	0.626
LIG_NRBOX	40	46	PF00104	0.504
LIG_PCNA_TLS_4	333	340	PF02747	0.566
LIG_SH2_GRB2like	70	73	PF00017	0.690
LIG_SH2_PTP2	485	488	PF00017	0.531
LIG_SH2_SRC	560	563	PF00017	0.619
LIG_SH2_STAP1	70	74	PF00017	0.650
LIG_SH2_STAT5	485	488	PF00017	0.483
LIG_SH3_3	179	185	PF00018	0.705
LIG_SH3_3	24	30	PF00018	0.603
LIG_SH3_3	299	305	PF00018	0.767
LIG_SH3_3	379	385	PF00018	0.532
LIG_SH3_3	406	412	PF00018	0.648
LIG_SH3_3	48	54	PF00018	0.569
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.679
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.521
LIG_SUMO_SIM_par_1	225	232	PF11976	0.647
LIG_SUMO_SIM_par_1	299	304	PF11976	0.520
LIG_SUMO_SIM_par_1	32	37	PF11976	0.605
LIG_SUMO_SIM_par_1	376	381	PF11976	0.530
LIG_TRAF2_1	313	316	PF00917	0.702
LIG_TRAF2_2	109	114	PF00917	0.686
LIG_TYR_ITIM	483	488	PF00017	0.531
MOD_CDK_SPxxK_3	199	206	PF00069	0.648
MOD_CK1_1	102	108	PF00069	0.637
MOD_CK1_1	11	17	PF00069	0.662
MOD_CK1_1	167	173	PF00069	0.609
MOD_CK1_1	184	190	PF00069	0.483
MOD_CK1_1	202	208	PF00069	0.755
MOD_CK1_1	211	217	PF00069	0.557
MOD_CK1_1	22	28	PF00069	0.790
MOD_CK1_1	232	238	PF00069	0.711
MOD_CK1_1	310	316	PF00069	0.762
MOD_CK1_1	321	327	PF00069	0.593
MOD_CK1_1	351	357	PF00069	0.641
MOD_CK1_1	366	372	PF00069	0.424
MOD_CK1_1	407	413	PF00069	0.759
MOD_CK1_1	493	499	PF00069	0.591
MOD_CK1_1	507	513	PF00069	0.602
MOD_CK1_1	553	559	PF00069	0.490
MOD_CK1_1	95	101	PF00069	0.766
MOD_CK2_1	187	193	PF00069	0.678
MOD_CK2_1	310	316	PF00069	0.697
MOD_CK2_1	491	497	PF00069	0.595
MOD_CK2_1	80	86	PF00069	0.697
MOD_DYRK1A_RPxSP_1	408	412	PF00069	0.705
MOD_GlcNHglycan	101	104	PF01048	0.713
MOD_GlcNHglycan	15	18	PF01048	0.706
MOD_GlcNHglycan	166	169	PF01048	0.628
MOD_GlcNHglycan	198	202	PF01048	0.772
MOD_GlcNHglycan	210	213	PF01048	0.668
MOD_GlcNHglycan	231	234	PF01048	0.667
MOD_GlcNHglycan	282	285	PF01048	0.667
MOD_GlcNHglycan	350	353	PF01048	0.737
MOD_GlcNHglycan	552	555	PF01048	0.510
MOD_GlcNHglycan	57	60	PF01048	0.640
MOD_GSK3_1	228	235	PF00069	0.559
MOD_GSK3_1	242	249	PF00069	0.653
MOD_GSK3_1	307	314	PF00069	0.799
MOD_GSK3_1	344	351	PF00069	0.550
MOD_GSK3_1	362	369	PF00069	0.564
MOD_GSK3_1	404	411	PF00069	0.699
MOD_GSK3_1	504	511	PF00069	0.598
MOD_GSK3_1	8	15	PF00069	0.668
MOD_GSK3_1	88	95	PF00069	0.715
MOD_LATS_1	294	300	PF00433	0.655
MOD_N-GLC_1	504	509	PF02516	0.660
MOD_NEK2_1	164	169	PF00069	0.642
MOD_NEK2_1	229	234	PF00069	0.740
MOD_NEK2_1	525	530	PF00069	0.578
MOD_NEK2_1	55	60	PF00069	0.579
MOD_NEK2_2	307	312	PF00069	0.681
MOD_NEK2_2	444	449	PF00069	0.599
MOD_OFUCOSY	489	495	PF10250	0.600
MOD_PIKK_1	107	113	PF00454	0.716
MOD_PIKK_1	237	243	PF00454	0.539
MOD_PIKK_1	508	514	PF00454	0.556
MOD_PK_1	296	302	PF00069	0.556
MOD_PKA_2	237	243	PF00069	0.695
MOD_PKA_2	286	292	PF00069	0.558
MOD_PKA_2	407	413	PF00069	0.699
MOD_PKB_1	173	181	PF00069	0.650
MOD_Plk_1	504	510	PF00069	0.653
MOD_Plk_4	2	8	PF00069	0.673
MOD_Plk_4	296	302	PF00069	0.597
MOD_Plk_4	321	327	PF00069	0.719
MOD_Plk_4	356	362	PF00069	0.632
MOD_Plk_4	444	450	PF00069	0.654
MOD_Plk_4	564	570	PF00069	0.598
MOD_ProDKin_1	181	187	PF00069	0.730
MOD_ProDKin_1	19	25	PF00069	0.633
MOD_ProDKin_1	199	205	PF00069	0.703
MOD_ProDKin_1	242	248	PF00069	0.705
MOD_ProDKin_1	301	307	PF00069	0.662
MOD_ProDKin_1	34	40	PF00069	0.630
MOD_ProDKin_1	344	350	PF00069	0.550
MOD_ProDKin_1	378	384	PF00069	0.455
MOD_ProDKin_1	408	414	PF00069	0.714
MOD_ProDKin_1	8	14	PF00069	0.772
MOD_ProDKin_1	90	96	PF00069	0.587
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.665
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.447
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.625
TRG_DiLeu_LyEn_5	35	40	PF01217	0.641
TRG_ENDOCYTIC_2	485	488	PF00928	0.589
TRG_ER_diArg_1	122	125	PF00400	0.544
TRG_ER_diArg_1	291	293	PF00400	0.742
TRG_ER_diArg_1	375	377	PF00400	0.667
TRG_ER_diArg_1	478	480	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	538	542	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA3	Leptomonas seymouri	43%	82%
A0A3S7X3A4	Leishmania donovani	92%	100%
A4HI54	Leishmania braziliensis	70%	100%
A4I5D0	Leishmania infantum	92%	100%
E9B0M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%