Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase B, putative

Species:

Leishmania major

UniProt:

Q4Q7K3_LEIMA

TriTrypDb:

LmjF.30.1000 , LMJLV39_300016400 , LMJSD75_300016000

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	12
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.543
CLV_C14_Caspase3-7	381	385	PF00656	0.416
CLV_C14_Caspase3-7	466	470	PF00656	0.622
CLV_NRD_NRD_1	293	295	PF00675	0.572
CLV_NRD_NRD_1	305	307	PF00675	0.262
CLV_NRD_NRD_1	394	396	PF00675	0.429
CLV_NRD_NRD_1	430	432	PF00675	0.424
CLV_NRD_NRD_1	453	455	PF00675	0.596
CLV_PCSK_FUR_1	290	294	PF00082	0.673
CLV_PCSK_FUR_1	451	455	PF00082	0.630
CLV_PCSK_KEX2_1	174	176	PF00082	0.338
CLV_PCSK_KEX2_1	290	292	PF00082	0.610
CLV_PCSK_KEX2_1	293	295	PF00082	0.555
CLV_PCSK_KEX2_1	304	306	PF00082	0.304
CLV_PCSK_KEX2_1	394	396	PF00082	0.427
CLV_PCSK_KEX2_1	413	415	PF00082	0.167
CLV_PCSK_KEX2_1	430	432	PF00082	0.482
CLV_PCSK_KEX2_1	453	455	PF00082	0.636
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.330
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.425
CLV_PCSK_SKI1_1	174	178	PF00082	0.302
CLV_PCSK_SKI1_1	216	220	PF00082	0.252
CLV_PCSK_SKI1_1	293	297	PF00082	0.577
CLV_PCSK_SKI1_1	405	409	PF00082	0.384
CLV_PCSK_SKI1_1	431	435	PF00082	0.391
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DEG_SPOP_SBC_1	180	184	PF00917	0.515
DOC_CKS1_1	565	570	PF01111	0.737
DOC_CYCLIN_RxL_1	184	193	PF00134	0.515
DOC_CYCLIN_RxL_1	400	410	PF00134	0.218
DOC_MAPK_gen_1	216	225	PF00069	0.452
DOC_MAPK_gen_1	228	236	PF00069	0.464
DOC_MAPK_gen_1	290	297	PF00069	0.621
DOC_MAPK_JIP1_4	20	26	PF00069	0.510
DOC_MAPK_MEF2A_6	370	379	PF00069	0.390
DOC_MAPK_MEF2A_6	46	55	PF00069	0.486
DOC_PP1_RVXF_1	185	192	PF00149	0.493
DOC_PP1_RVXF_1	374	380	PF00149	0.422
DOC_PP4_FxxP_1	512	515	PF00568	0.529
DOC_USP7_MATH_1	12	16	PF00917	0.605
DOC_USP7_MATH_1	136	140	PF00917	0.502
DOC_USP7_MATH_1	141	145	PF00917	0.462
DOC_USP7_MATH_1	164	168	PF00917	0.546
DOC_USP7_MATH_1	180	184	PF00917	0.403
DOC_USP7_MATH_1	268	272	PF00917	0.694
DOC_USP7_MATH_1	285	289	PF00917	0.711
DOC_USP7_MATH_1	31	35	PF00917	0.365
DOC_USP7_MATH_1	488	492	PF00917	0.684
DOC_USP7_MATH_1	499	503	PF00917	0.406
DOC_USP7_MATH_1	553	557	PF00917	0.600
DOC_USP7_MATH_1	569	573	PF00917	0.721
DOC_USP7_UBL2_3	58	62	PF12436	0.452
DOC_WW_Pin1_4	142	147	PF00397	0.530
DOC_WW_Pin1_4	315	320	PF00397	0.305
DOC_WW_Pin1_4	5	10	PF00397	0.666
DOC_WW_Pin1_4	564	569	PF00397	0.663
LIG_14-3-3_CanoR_1	292	298	PF00244	0.553
LIG_14-3-3_CanoR_1	305	311	PF00244	0.278
LIG_14-3-3_CanoR_1	405	411	PF00244	0.313
LIG_14-3-3_CanoR_1	523	531	PF00244	0.631
LIG_Actin_WH2_2	33	48	PF00022	0.502
LIG_APCC_ABBA_1	415	420	PF00400	0.468
LIG_APCC_ABBA_1	509	514	PF00400	0.462
LIG_APCC_ABBAyCdc20_2	414	420	PF00400	0.374
LIG_BIR_III_2	527	531	PF00653	0.538
LIG_BIR_III_4	382	386	PF00653	0.374
LIG_BIR_III_4	480	484	PF00653	0.595
LIG_Clathr_ClatBox_1	233	237	PF01394	0.452
LIG_deltaCOP1_diTrp_1	324	334	PF00928	0.362
LIG_FHA_1	196	202	PF00498	0.455
LIG_FHA_1	236	242	PF00498	0.464
LIG_FHA_1	565	571	PF00498	0.726
LIG_FHA_2	352	358	PF00498	0.452
LIG_FHA_2	364	370	PF00498	0.253
LIG_FHA_2	461	467	PF00498	0.707
LIG_FXI_DFP_1	233	237	PF00024	0.252
LIG_LIR_Apic_2	313	319	PF02991	0.305
LIG_LIR_Gen_1	190	199	PF02991	0.468
LIG_LIR_Gen_1	354	363	PF02991	0.342
LIG_LIR_Gen_1	505	515	PF02991	0.443
LIG_LIR_Nem_3	101	107	PF02991	0.540
LIG_LIR_Nem_3	190	194	PF02991	0.468
LIG_LIR_Nem_3	354	359	PF02991	0.432
LIG_LIR_Nem_3	372	377	PF02991	0.265
LIG_LIR_Nem_3	505	510	PF02991	0.423
LIG_LIR_Nem_3	514	520	PF02991	0.333
LIG_PCNA_yPIPBox_3	62	75	PF02747	0.538
LIG_Pex14_2	105	109	PF04695	0.557
LIG_SH2_CRK	507	511	PF00017	0.429
LIG_SH2_NCK_1	341	345	PF00017	0.362
LIG_SH2_PTP2	316	319	PF00017	0.321
LIG_SH2_STAP1	341	345	PF00017	0.384
LIG_SH2_STAP1	517	521	PF00017	0.428
LIG_SH2_STAT3	121	124	PF00017	0.541
LIG_SH2_STAT5	104	107	PF00017	0.381
LIG_SH2_STAT5	121	124	PF00017	0.449
LIG_SH2_STAT5	316	319	PF00017	0.308
LIG_SH2_STAT5	367	370	PF00017	0.413
LIG_SH2_STAT5	520	523	PF00017	0.443
LIG_SH2_STAT5	596	599	PF00017	0.666
LIG_SH2_STAT5	89	92	PF00017	0.500
LIG_SH3_3	155	161	PF00018	0.405
LIG_SH3_3	251	257	PF00018	0.572
LIG_SH3_3	48	54	PF00018	0.497
LIG_SH3_3	562	568	PF00018	0.726
LIG_SH3_3	6	12	PF00018	0.637
LIG_SUMO_SIM_par_1	201	206	PF11976	0.530
LIG_SxIP_EBH_1	174	185	PF03271	0.557
LIG_TRAF2_1	442	445	PF00917	0.518
LIG_TYR_ITIM	339	344	PF00017	0.339
LIG_WRC_WIRS_1	447	452	PF05994	0.541
MOD_CK1_1	139	145	PF00069	0.514
MOD_CK1_1	167	173	PF00069	0.519
MOD_CK1_1	3	9	PF00069	0.649
MOD_CK1_1	328	334	PF00069	0.305
MOD_CK1_1	351	357	PF00069	0.423
MOD_CK1_1	460	466	PF00069	0.675
MOD_CK1_1	479	485	PF00069	0.611
MOD_CK1_1	502	508	PF00069	0.443
MOD_CK2_1	351	357	PF00069	0.425
MOD_CK2_1	363	369	PF00069	0.425
MOD_CK2_1	460	466	PF00069	0.549
MOD_CK2_1	569	575	PF00069	0.708
MOD_CK2_1	96	102	PF00069	0.436
MOD_Cter_Amidation	392	395	PF01082	0.257
MOD_GlcNHglycan	155	158	PF01048	0.332
MOD_GlcNHglycan	165	169	PF01048	0.335
MOD_GlcNHglycan	287	290	PF01048	0.619
MOD_GlcNHglycan	33	36	PF01048	0.281
MOD_GlcNHglycan	350	353	PF01048	0.358
MOD_GlcNHglycan	466	469	PF01048	0.665
MOD_GlcNHglycan	480	484	PF01048	0.672
MOD_GlcNHglycan	485	488	PF01048	0.580
MOD_GlcNHglycan	555	558	PF01048	0.696
MOD_GlcNHglycan	559	562	PF01048	0.613
MOD_GSK3_1	137	144	PF00069	0.471
MOD_GSK3_1	166	173	PF00069	0.491
MOD_GSK3_1	295	302	PF00069	0.609
MOD_GSK3_1	306	313	PF00069	0.443
MOD_GSK3_1	31	38	PF00069	0.476
MOD_GSK3_1	456	463	PF00069	0.615
MOD_GSK3_1	464	471	PF00069	0.647
MOD_GSK3_1	479	486	PF00069	0.677
MOD_GSK3_1	498	505	PF00069	0.438
MOD_GSK3_1	533	540	PF00069	0.636
MOD_GSK3_1	553	560	PF00069	0.766
MOD_NEK2_1	295	300	PF00069	0.524
MOD_NEK2_1	310	315	PF00069	0.287
MOD_NEK2_1	424	429	PF00069	0.423
MOD_NEK2_1	457	462	PF00069	0.632
MOD_NEK2_1	594	599	PF00069	0.733
MOD_NEK2_1	93	98	PF00069	0.444
MOD_PIKK_1	295	301	PF00454	0.651
MOD_PIKK_1	35	41	PF00454	0.509
MOD_PIKK_1	351	357	PF00454	0.405
MOD_PIKK_1	533	539	PF00454	0.605
MOD_PK_1	70	76	PF00069	0.538
MOD_PKA_1	174	180	PF00069	0.539
MOD_PKA_1	293	299	PF00069	0.553
MOD_PKA_1	304	310	PF00069	0.275
MOD_PKA_2	174	180	PF00069	0.539
MOD_PKA_2	293	299	PF00069	0.551
MOD_PKA_2	304	310	PF00069	0.321
MOD_PKA_2	522	528	PF00069	0.608
MOD_PKB_1	291	299	PF00069	0.689
MOD_PKB_1	304	312	PF00069	0.394
MOD_Plk_1	424	430	PF00069	0.426
MOD_Plk_2-3	575	581	PF00069	0.707
MOD_Plk_4	363	369	PF00069	0.374
MOD_Plk_4	575	581	PF00069	0.733
MOD_Plk_4	70	76	PF00069	0.531
MOD_ProDKin_1	142	148	PF00069	0.530
MOD_ProDKin_1	315	321	PF00069	0.305
MOD_ProDKin_1	5	11	PF00069	0.663
MOD_ProDKin_1	564	570	PF00069	0.661
MOD_SUMO_for_1	218	221	PF00179	0.452
MOD_SUMO_rev_2	318	328	PF00179	0.425
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.218
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.502
TRG_ENDOCYTIC_2	104	107	PF00928	0.452
TRG_ENDOCYTIC_2	341	344	PF00928	0.321
TRG_ENDOCYTIC_2	507	510	PF00928	0.437
TRG_ER_diArg_1	290	293	PF00400	0.657
TRG_ER_diArg_1	303	306	PF00400	0.511
TRG_ER_diArg_1	394	396	PF00400	0.427
TRG_ER_diArg_1	429	431	PF00400	0.481
TRG_ER_diArg_1	450	453	PF00400	0.600
TRG_NES_CRM1_1	193	206	PF08389	0.530
TRG_NES_CRM1_1	347	360	PF08389	0.257
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.218

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	57%	99%
A0A0S4IZ51	Bodo saltans	39%	100%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A3S7X363	Leishmania donovani	94%	100%
A0A422P4X7	Trypanosoma rangeli	40%	100%
A4HI55	Leishmania braziliensis	77%	100%
A4I5D1	Leishmania infantum	94%	100%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B0M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q94E49	Oryza sativa subsp. japonica	24%	100%
V5BU83	Trypanosoma cruzi	41%	100%