Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7K1_LEIMA

TriTrypDb:

LmjF.30.1020 , LMJLV39_300016600 , LMJSD75_300016200

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.669
CLV_C14_Caspase3-7	49	53	PF00656	0.721
CLV_NRD_NRD_1	138	140	PF00675	0.591
CLV_NRD_NRD_1	246	248	PF00675	0.670
CLV_NRD_NRD_1	35	37	PF00675	0.783
CLV_NRD_NRD_1	389	391	PF00675	0.609
CLV_NRD_NRD_1	438	440	PF00675	0.549
CLV_NRD_NRD_1	54	56	PF00675	0.578
CLV_PCSK_FUR_1	21	25	PF00082	0.684
CLV_PCSK_FUR_1	244	248	PF00082	0.697
CLV_PCSK_FUR_1	39	43	PF00082	0.533
CLV_PCSK_KEX2_1	138	140	PF00082	0.591
CLV_PCSK_KEX2_1	23	25	PF00082	0.690
CLV_PCSK_KEX2_1	246	248	PF00082	0.638
CLV_PCSK_KEX2_1	365	367	PF00082	0.541
CLV_PCSK_KEX2_1	41	43	PF00082	0.535
CLV_PCSK_KEX2_1	438	440	PF00082	0.515
CLV_PCSK_KEX2_1	54	56	PF00082	0.621
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.690
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.541
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.535
CLV_PCSK_PC7_1	19	25	PF00082	0.679
CLV_PCSK_SKI1_1	15	19	PF00082	0.619
CLV_PCSK_SKI1_1	159	163	PF00082	0.534
CLV_PCSK_SKI1_1	173	177	PF00082	0.576
CLV_PCSK_SKI1_1	193	197	PF00082	0.322
CLV_PCSK_SKI1_1	390	394	PF00082	0.607
CLV_Separin_Metazoa	340	344	PF03568	0.546
CLV_Separin_Metazoa	415	419	PF03568	0.599
DEG_APCC_DBOX_1	172	180	PF00400	0.534
DEG_APCC_DBOX_1	231	239	PF00400	0.476
DEG_APCC_DBOX_1	409	417	PF00400	0.502
DEG_APCC_DBOX_1	437	445	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DEG_SPOP_SBC_1	275	279	PF00917	0.586
DOC_CYCLIN_RxL_1	473	484	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.682
DOC_MAPK_DCC_7	438	446	PF00069	0.526
DOC_MAPK_gen_1	365	371	PF00069	0.548
DOC_MAPK_gen_1	390	399	PF00069	0.730
DOC_MAPK_gen_1	438	446	PF00069	0.478
DOC_MAPK_MEF2A_6	244	252	PF00069	0.606
DOC_MAPK_MEF2A_6	438	447	PF00069	0.473
DOC_PP2B_LxvP_1	76	79	PF13499	0.568
DOC_USP7_MATH_1	293	297	PF00917	0.744
DOC_USP7_MATH_1	330	334	PF00917	0.707
DOC_USP7_MATH_1	359	363	PF00917	0.544
DOC_USP7_MATH_1	409	413	PF00917	0.526
DOC_USP7_MATH_1	464	468	PF00917	0.719
DOC_USP7_MATH_1	491	495	PF00917	0.574
DOC_USP7_UBL2_3	37	41	PF12436	0.544
DOC_WW_Pin1_4	199	204	PF00397	0.705
DOC_WW_Pin1_4	239	244	PF00397	0.702
DOC_WW_Pin1_4	257	262	PF00397	0.777
DOC_WW_Pin1_4	263	268	PF00397	0.524
LIG_14-3-3_CanoR_1	193	203	PF00244	0.669
LIG_14-3-3_CanoR_1	223	231	PF00244	0.522
LIG_14-3-3_CanoR_1	257	261	PF00244	0.688
LIG_14-3-3_CanoR_1	3	9	PF00244	0.648
LIG_14-3-3_CanoR_1	407	417	PF00244	0.531
LIG_14-3-3_CanoR_1	42	50	PF00244	0.636
LIG_14-3-3_CanoR_1	438	442	PF00244	0.551
LIG_14-3-3_CanoR_1	460	469	PF00244	0.665
LIG_14-3-3_CanoR_1	476	481	PF00244	0.509
LIG_Actin_WH2_2	112	130	PF00022	0.627
LIG_BIR_III_2	432	436	PF00653	0.685
LIG_BIR_III_4	328	332	PF00653	0.677
LIG_BRCT_BRCA1_1	13	17	PF00533	0.649
LIG_BRCT_BRCA1_1	259	263	PF00533	0.688
LIG_BRCT_BRCA1_1	276	280	PF00533	0.710
LIG_BRCT_BRCA1_1	483	487	PF00533	0.506
LIG_Clathr_ClatBox_1	444	448	PF01394	0.476
LIG_CSL_BTD_1	504	507	PF09270	0.504
LIG_deltaCOP1_diTrp_1	503	511	PF00928	0.546
LIG_eIF4E_1	225	231	PF01652	0.579
LIG_EVH1_2	267	271	PF00568	0.775
LIG_FHA_1	122	128	PF00498	0.595
LIG_FHA_1	225	231	PF00498	0.544
LIG_FHA_1	279	285	PF00498	0.707
LIG_FHA_1	376	382	PF00498	0.773
LIG_FHA_1	387	393	PF00498	0.673
LIG_FHA_1	45	51	PF00498	0.771
LIG_FHA_2	3	9	PF00498	0.733
LIG_FHA_2	306	312	PF00498	0.742
LIG_GBD_Chelix_1	157	165	PF00786	0.567
LIG_IBAR_NPY_1	104	106	PF08397	0.557
LIG_LIR_Apic_2	95	100	PF02991	0.600
LIG_LIR_Gen_1	152	161	PF02991	0.521
LIG_LIR_Gen_1	448	456	PF02991	0.594
LIG_LIR_LC3C_4	126	131	PF02991	0.352
LIG_LIR_Nem_3	152	157	PF02991	0.549
LIG_LIR_Nem_3	448	452	PF02991	0.529
LIG_LIR_Nem_3	484	490	PF02991	0.471
LIG_SH2_CRK	40	44	PF00017	0.639
LIG_SH2_CRK	449	453	PF00017	0.567
LIG_SH2_NCK_1	449	453	PF00017	0.602
LIG_SH2_STAP1	449	453	PF00017	0.543
LIG_SH2_STAT5	421	424	PF00017	0.479
LIG_SH2_STAT5	514	517	PF00017	0.647
LIG_SH3_3	128	134	PF00018	0.436
LIG_SH3_3	378	384	PF00018	0.676
LIG_SUMO_SIM_par_1	201	207	PF11976	0.563
LIG_SUMO_SIM_par_1	442	448	PF11976	0.483
LIG_TRAF2_1	88	91	PF00917	0.543
LIG_TYR_ITIM	447	452	PF00017	0.563
MOD_CDK_SPK_2	239	244	PF00069	0.533
MOD_CDK_SPxxK_3	239	246	PF00069	0.535
MOD_CK1_1	259	265	PF00069	0.717
MOD_CK1_1	274	280	PF00069	0.662
MOD_CK1_1	364	370	PF00069	0.664
MOD_CK1_1	376	382	PF00069	0.649
MOD_CK1_1	44	50	PF00069	0.775
MOD_CK1_1	463	469	PF00069	0.685
MOD_CK1_1	85	91	PF00069	0.570
MOD_CK2_1	300	306	PF00069	0.684
MOD_CK2_1	343	349	PF00069	0.531
MOD_CK2_1	409	415	PF00069	0.535
MOD_CK2_1	85	91	PF00069	0.570
MOD_Cter_Amidation	34	37	PF01082	0.769
MOD_Cter_Amidation	52	55	PF01082	0.581
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.692
MOD_GlcNHglycan	170	173	PF01048	0.584
MOD_GlcNHglycan	273	276	PF01048	0.776
MOD_GlcNHglycan	316	319	PF01048	0.762
MOD_GlcNHglycan	321	324	PF01048	0.701
MOD_GlcNHglycan	344	348	PF01048	0.605
MOD_GlcNHglycan	361	364	PF01048	0.644
MOD_GlcNHglycan	462	465	PF01048	0.687
MOD_GlcNHglycan	483	486	PF01048	0.603
MOD_GSK3_1	182	189	PF00069	0.463
MOD_GSK3_1	194	201	PF00069	0.559
MOD_GSK3_1	257	264	PF00069	0.678
MOD_GSK3_1	271	278	PF00069	0.653
MOD_GSK3_1	289	296	PF00069	0.528
MOD_GSK3_1	319	326	PF00069	0.645
MOD_GSK3_1	41	48	PF00069	0.717
MOD_GSK3_1	460	467	PF00069	0.667
MOD_LATS_1	458	464	PF00433	0.548
MOD_N-GLC_1	100	105	PF02516	0.563
MOD_N-GLC_1	121	126	PF02516	0.545
MOD_NEK2_1	121	126	PF00069	0.545
MOD_NEK2_1	168	173	PF00069	0.520
MOD_NEK2_1	186	191	PF00069	0.456
MOD_NEK2_1	2	7	PF00069	0.676
MOD_NEK2_1	224	229	PF00069	0.559
MOD_NEK2_1	230	235	PF00069	0.632
MOD_NEK2_1	256	261	PF00069	0.599
MOD_NEK2_1	280	285	PF00069	0.688
MOD_NEK2_1	408	413	PF00069	0.582
MOD_NEK2_1	490	495	PF00069	0.565
MOD_NEK2_2	123	128	PF00069	0.379
MOD_PIKK_1	293	299	PF00454	0.756
MOD_PIKK_1	458	464	PF00454	0.719
MOD_PK_1	42	48	PF00069	0.769
MOD_PKA_1	41	47	PF00069	0.637
MOD_PKA_2	2	8	PF00069	0.670
MOD_PKA_2	256	262	PF00069	0.687
MOD_PKA_2	286	292	PF00069	0.704
MOD_PKA_2	30	36	PF00069	0.639
MOD_PKA_2	409	415	PF00069	0.519
MOD_PKA_2	41	47	PF00069	0.637
MOD_PKA_2	437	443	PF00069	0.543
MOD_Plk_1	121	127	PF00069	0.536
MOD_Plk_1	186	192	PF00069	0.566
MOD_Plk_1	447	453	PF00069	0.581
MOD_Plk_1	491	497	PF00069	0.518
MOD_Plk_2-3	207	213	PF00069	0.499
MOD_Plk_4	115	121	PF00069	0.524
MOD_Plk_4	153	159	PF00069	0.510
MOD_Plk_4	280	286	PF00069	0.669
MOD_Plk_4	295	301	PF00069	0.564
MOD_Plk_4	469	475	PF00069	0.598
MOD_Plk_4	491	497	PF00069	0.518
MOD_ProDKin_1	199	205	PF00069	0.707
MOD_ProDKin_1	239	245	PF00069	0.703
MOD_ProDKin_1	257	263	PF00069	0.778
MOD_SUMO_rev_2	111	119	PF00179	0.600
MOD_SUMO_rev_2	155	164	PF00179	0.527
MOD_SUMO_rev_2	201	211	PF00179	0.641
MOD_SUMO_rev_2	328	338	PF00179	0.536
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.522
TRG_ENDOCYTIC_2	40	43	PF00928	0.642
TRG_ENDOCYTIC_2	449	452	PF00928	0.505
TRG_ER_diArg_1	138	140	PF00400	0.580
TRG_ER_diArg_1	18	21	PF00400	0.636
TRG_ER_diArg_1	231	234	PF00400	0.643
TRG_ER_diArg_1	243	246	PF00400	0.671
TRG_NLS_Bipartite_1	23	40	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGI0	Leptomonas seymouri	48%	93%
A0A1X0P334	Trypanosomatidae	37%	100%
A0A3Q8IFQ7	Leishmania donovani	91%	100%
A4HI57	Leishmania braziliensis	75%	100%
A4I5D3	Leishmania infantum	91%	100%
C9ZQR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%