DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania major

UniProt:

Q4Q7K0_LEIMA

TriTrypDb:

LmjF.30.1030 , LMJLV39_300016700 , LMJSD75_300016300

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7K0

PDB structure(s): 7am2_BS

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0044183	protein folding chaperone	1	2
GO:0051082	unfolded protein binding	3	2
GO:0051087	protein-folding chaperone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.602
CLV_MEL_PAP_1	95	101	PF00089	0.350
CLV_NRD_NRD_1	112	114	PF00675	0.286
CLV_NRD_NRD_1	124	126	PF00675	0.634
CLV_NRD_NRD_1	165	167	PF00675	0.747
CLV_NRD_NRD_1	190	192	PF00675	0.601
CLV_NRD_NRD_1	225	227	PF00675	0.480
CLV_NRD_NRD_1	237	239	PF00675	0.491
CLV_NRD_NRD_1	30	32	PF00675	0.699
CLV_NRD_NRD_1	97	99	PF00675	0.413
CLV_PCSK_FUR_1	223	227	PF00082	0.485
CLV_PCSK_KEX2_1	111	113	PF00082	0.252
CLV_PCSK_KEX2_1	124	126	PF00082	0.621
CLV_PCSK_KEX2_1	165	167	PF00082	0.731
CLV_PCSK_KEX2_1	189	191	PF00082	0.614
CLV_PCSK_KEX2_1	223	225	PF00082	0.474
CLV_PCSK_KEX2_1	237	239	PF00082	0.481
CLV_PCSK_KEX2_1	30	32	PF00082	0.699
CLV_PCSK_KEX2_1	97	99	PF00082	0.405
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DEG_SPOP_SBC_1	173	177	PF00917	0.727
DEG_SPOP_SBC_1	355	359	PF00917	0.465
DEG_SPOP_SBC_1	45	49	PF00917	0.711
DOC_CKS1_1	336	341	PF01111	0.481
DOC_USP7_MATH_1	10	14	PF00917	0.674
DOC_USP7_MATH_1	156	160	PF00917	0.711
DOC_USP7_MATH_1	40	44	PF00917	0.643
DOC_USP7_MATH_1	46	50	PF00917	0.634
DOC_WW_Pin1_4	148	153	PF00397	0.763
DOC_WW_Pin1_4	256	261	PF00397	0.724
DOC_WW_Pin1_4	335	340	PF00397	0.473
DOC_WW_Pin1_4	357	362	PF00397	0.547
DOC_WW_Pin1_4	381	386	PF00397	0.675
DOC_WW_Pin1_4	61	66	PF00397	0.395
LIG_14-3-3_CanoR_1	388	393	PF00244	0.573
LIG_14-3-3_CanoR_1	97	106	PF00244	0.280
LIG_AP2alpha_1	205	209	PF02296	0.465
LIG_BIR_III_2	62	66	PF00653	0.388
LIG_BRCT_BRCA1_1	158	162	PF00533	0.520
LIG_BRCT_BRCA1_1	177	181	PF00533	0.504
LIG_BRCT_BRCA1_1	205	209	PF00533	0.302
LIG_CaM_IQ_9	218	234	PF13499	0.493
LIG_deltaCOP1_diTrp_1	365	375	PF00928	0.401
LIG_DLG_GKlike_1	388	396	PF00625	0.577
LIG_FHA_1	394	400	PF00498	0.578
LIG_FHA_1	46	52	PF00498	0.554
LIG_FHA_2	211	217	PF00498	0.489
LIG_FHA_2	280	286	PF00498	0.458
LIG_FHA_2	336	342	PF00498	0.459
LIG_FHA_2	377	383	PF00498	0.657
LIG_FHA_2	62	68	PF00498	0.254
LIG_Integrin_RGD_1	198	200	PF01839	0.417
LIG_LIR_Apic_2	411	415	PF02991	0.426
LIG_LIR_Gen_1	100	110	PF02991	0.274
LIG_LIR_Nem_3	100	106	PF02991	0.305
LIG_LIR_Nem_3	319	324	PF02991	0.439
LIG_LIR_Nem_3	365	371	PF02991	0.649
LIG_LIR_Nem_3	70	75	PF02991	0.241
LIG_LIR_Nem_3	93	99	PF02991	0.257
LIG_Pex14_2	205	209	PF04695	0.371
LIG_SH2_CRK	192	196	PF00017	0.628
LIG_SH2_CRK	412	416	PF00017	0.436
LIG_SH2_CRK	54	58	PF00017	0.254
LIG_SH2_CRK	72	76	PF00017	0.388
LIG_SH2_NCK_1	369	373	PF00017	0.389
LIG_SH2_SRC	369	372	PF00017	0.641
LIG_SH2_SRC	380	383	PF00017	0.557
LIG_SH2_SRC	398	401	PF00017	0.576
LIG_SH2_STAP1	7	11	PF00017	0.742
LIG_SH2_STAT5	398	401	PF00017	0.588
LIG_SH3_3	303	309	PF00018	0.574
LIG_SH3_3	311	317	PF00018	0.469
LIG_SH3_3	320	326	PF00018	0.348
LIG_SH3_3	328	334	PF00018	0.403
LIG_SH3_3	336	342	PF00018	0.444
LIG_TRAF2_1	64	67	PF00917	0.272
LIG_WRPW_2	324	327	PF00400	0.421
MOD_CDK_SPxxK_3	357	364	PF00069	0.576
MOD_CDK_SPxxK_3	381	388	PF00069	0.538
MOD_CK1_1	171	177	PF00069	0.640
MOD_CK1_1	250	256	PF00069	0.784
MOD_CK1_1	33	39	PF00069	0.627
MOD_CK1_1	357	363	PF00069	0.594
MOD_CK2_1	210	216	PF00069	0.546
MOD_CK2_1	279	285	PF00069	0.523
MOD_CK2_1	335	341	PF00069	0.451
MOD_CK2_1	61	67	PF00069	0.254
MOD_DYRK1A_RPxSP_1	148	152	PF00069	0.603
MOD_GlcNHglycan	12	15	PF01048	0.602
MOD_GlcNHglycan	129	132	PF01048	0.738
MOD_GlcNHglycan	138	141	PF01048	0.700
MOD_GlcNHglycan	159	162	PF01048	0.808
MOD_GlcNHglycan	266	269	PF01048	0.570
MOD_GlcNHglycan	35	38	PF01048	0.579
MOD_GlcNHglycan	388	391	PF01048	0.438
MOD_GlcNHglycan	42	45	PF01048	0.533
MOD_GSK3_1	144	151	PF00069	0.719
MOD_GSK3_1	167	174	PF00069	0.705
MOD_GSK3_1	247	254	PF00069	0.748
MOD_GSK3_1	26	33	PF00069	0.543
MOD_GSK3_1	347	354	PF00069	0.592
MOD_GSK3_1	356	363	PF00069	0.536
MOD_GSK3_1	370	377	PF00069	0.427
MOD_GSK3_1	384	391	PF00069	0.521
MOD_GSK3_1	40	47	PF00069	0.655
MOD_GSK3_1	6	13	PF00069	0.613
MOD_N-GLC_1	250	255	PF02516	0.743
MOD_NEK2_1	26	31	PF00069	0.530
MOD_NEK2_1	264	269	PF00069	0.506
MOD_PIKK_1	347	353	PF00454	0.645
MOD_PIKK_1	370	376	PF00454	0.505
MOD_PKA_1	166	172	PF00069	0.651
MOD_PKA_1	30	36	PF00069	0.698
MOD_PKA_1	97	103	PF00069	0.417
MOD_PKA_2	156	162	PF00069	0.721
MOD_PKA_2	30	36	PF00069	0.712
MOD_PKA_2	40	46	PF00069	0.770
MOD_PKA_2	97	103	PF00069	0.417
MOD_Plk_1	351	357	PF00069	0.644
MOD_Plk_2-3	210	216	PF00069	0.496
MOD_ProDKin_1	148	154	PF00069	0.763
MOD_ProDKin_1	256	262	PF00069	0.722
MOD_ProDKin_1	335	341	PF00069	0.479
MOD_ProDKin_1	357	363	PF00069	0.542
MOD_ProDKin_1	381	387	PF00069	0.671
MOD_ProDKin_1	61	67	PF00069	0.395
MOD_SUMO_rev_2	206	214	PF00179	0.418
MOD_SUMO_rev_2	62	71	PF00179	0.252
TRG_ENDOCYTIC_2	103	106	PF00928	0.274
TRG_ENDOCYTIC_2	321	324	PF00928	0.445
TRG_ENDOCYTIC_2	54	57	PF00928	0.305
TRG_ENDOCYTIC_2	72	75	PF00928	0.388
TRG_ER_diArg_1	110	113	PF00400	0.487
TRG_ER_diArg_1	189	191	PF00400	0.613
TRG_ER_diArg_1	223	226	PF00400	0.482
TRG_ER_diArg_1	30	32	PF00400	0.704
TRG_ER_diArg_1	96	98	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S6	Leptomonas seymouri	60%	100%
A0A0S4JEE6	Bodo saltans	32%	100%
A0A1X0P2B2	Trypanosomatidae	36%	100%
A0A3Q8IFJ9	Leishmania donovani	88%	98%
A0A3R7P4U9	Trypanosoma rangeli	39%	100%
A4HI58	Leishmania braziliensis	78%	100%
A4I5D4	Leishmania infantum	87%	100%
C9ZQR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
V5BPN3	Trypanosoma cruzi	36%	100%