Tat pathway signal sequence domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase subunit 7

Species:

Leishmania major

UniProt:

Q4Q7J9_LEIMA

TriTrypDb:

LmjF.30.1040 , LMJLV39_300016800 , LMJSD75_300016400

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	4	2
GO:0032991	protein-containing complex	1	2
GO:0045257	succinate dehydrogenase complex (ubiquinone)	5	2
GO:0045281	succinate dehydrogenase complex	4	2
GO:0045283	fumarate reductase complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:1902494	catalytic complex	2	2
GO:1990204	oxidoreductase complex	3	2

Expansion

Sequence features

Q4Q7J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.487
CLV_NRD_NRD_1	154	156	PF00675	0.416
CLV_NRD_NRD_1	2	4	PF00675	0.511
CLV_NRD_NRD_1	247	249	PF00675	0.568
CLV_PCSK_KEX2_1	2	4	PF00082	0.511
CLV_PCSK_KEX2_1	242	244	PF00082	0.407
CLV_PCSK_KEX2_1	247	249	PF00082	0.450
CLV_PCSK_KEX2_1	56	58	PF00082	0.457
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.407
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.457
CLV_PCSK_PC7_1	243	249	PF00082	0.503
CLV_PCSK_SKI1_1	137	141	PF00082	0.442
CLV_PCSK_SKI1_1	161	165	PF00082	0.399
CLV_PCSK_SKI1_1	243	247	PF00082	0.498
CLV_PCSK_SKI1_1	56	60	PF00082	0.454
CLV_PCSK_SKI1_1	88	92	PF00082	0.461
DEG_APCC_DBOX_1	87	95	PF00400	0.482
DEG_MDM2_SWIB_1	110	118	PF02201	0.365
DEG_Nend_UBRbox_1	1	4	PF02207	0.512
DEG_SPOP_SBC_1	26	30	PF00917	0.538
DOC_CYCLIN_RxL_1	82	95	PF00134	0.429
DOC_MAPK_gen_1	217	226	PF00069	0.455
DOC_MAPK_HePTP_8	216	228	PF00069	0.427
DOC_MAPK_MEF2A_6	217	226	PF00069	0.470
DOC_PP1_RVXF_1	159	166	PF00149	0.392
DOC_USP7_MATH_1	204	208	PF00917	0.418
DOC_USP7_MATH_1	227	231	PF00917	0.414
DOC_USP7_MATH_1	25	29	PF00917	0.598
DOC_USP7_UBL2_3	146	150	PF12436	0.396
LIG_14-3-3_CanoR_1	117	122	PF00244	0.373
LIG_14-3-3_CanoR_1	34	44	PF00244	0.575
LIG_14-3-3_CanoR_1	57	64	PF00244	0.488
LIG_BRCT_BRCA1_1	65	69	PF00533	0.506
LIG_CtBP_PxDLS_1	213	217	PF00389	0.446
LIG_deltaCOP1_diTrp_1	46	54	PF00928	0.425
LIG_DLG_GKlike_1	117	124	PF00625	0.462
LIG_eIF4E_1	159	165	PF01652	0.462
LIG_FHA_1	244	250	PF00498	0.580
LIG_LIR_Apic_2	68	73	PF02991	0.545
LIG_LIR_Gen_1	171	182	PF02991	0.369
LIG_LIR_Nem_3	108	113	PF02991	0.396
LIG_LIR_Nem_3	122	128	PF02991	0.337
LIG_LIR_Nem_3	132	138	PF02991	0.381
LIG_LIR_Nem_3	171	177	PF02991	0.361
LIG_LIR_Nem_3	38	43	PF02991	0.522
LIG_LIR_Nem_3	62	67	PF02991	0.457
LIG_LIR_Nem_3	68	72	PF02991	0.504
LIG_MYND_3	221	225	PF01753	0.419
LIG_Pex14_1	106	110	PF04695	0.384
LIG_Pex14_2	110	114	PF04695	0.357
LIG_PTB_Apo_2	159	166	PF02174	0.532
LIG_SH2_CRK	125	129	PF00017	0.376
LIG_SH2_CRK	136	140	PF00017	0.411
LIG_SH2_CRK	174	178	PF00017	0.373
LIG_SH2_NCK_1	174	178	PF00017	0.403
LIG_SH2_STAP1	174	178	PF00017	0.368
LIG_SH2_STAT3	182	185	PF00017	0.457
LIG_SH2_STAT5	129	132	PF00017	0.398
LIG_SH2_STAT5	138	141	PF00017	0.439
LIG_SH2_STAT5	159	162	PF00017	0.368
LIG_SH2_STAT5	174	177	PF00017	0.367
LIG_SH2_STAT5	183	186	PF00017	0.412
LIG_SH2_STAT5	197	200	PF00017	0.301
LIG_SH2_STAT5	37	40	PF00017	0.560
LIG_SH2_STAT5	89	92	PF00017	0.367
LIG_TYR_ITAM	122	139	PF00017	0.381
LIG_UBA3_1	153	161	PF00899	0.401
LIG_WRC_WIRS_1	205	210	PF05994	0.365
LIG_WRC_WIRS_1	64	69	PF05994	0.474
MOD_CK1_1	14	20	PF00069	0.704
MOD_CK2_1	102	108	PF00069	0.375
MOD_CK2_1	57	63	PF00069	0.511
MOD_CK2_1	89	95	PF00069	0.375
MOD_Cter_Amidation	208	211	PF01082	0.428
MOD_Cter_Amidation	240	243	PF01082	0.531
MOD_GlcNHglycan	13	16	PF01048	0.579
MOD_GlcNHglycan	8	11	PF01048	0.605
MOD_GSK3_1	14	21	PF00069	0.689
MOD_GSK3_1	35	42	PF00069	0.494
MOD_GSK3_1	59	66	PF00069	0.459
MOD_N-GLC_1	141	146	PF02516	0.384
MOD_N-GLC_1	50	55	PF02516	0.499
MOD_NEK2_1	102	107	PF00069	0.382
MOD_NEK2_1	124	129	PF00069	0.380
MOD_NEK2_1	35	40	PF00069	0.680
MOD_NEK2_2	227	232	PF00069	0.422
MOD_PIKK_1	57	63	PF00454	0.544
MOD_PKA_1	56	62	PF00069	0.459
MOD_PKA_2	56	62	PF00069	0.440
MOD_PKB_1	115	123	PF00069	0.450
MOD_Plk_1	50	56	PF00069	0.519
MOD_Plk_2-3	63	69	PF00069	0.602
MOD_Plk_4	109	115	PF00069	0.383
MOD_Plk_4	124	130	PF00069	0.337
MOD_Plk_4	50	56	PF00069	0.541
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.383
TRG_ENDOCYTIC_2	125	128	PF00928	0.366
TRG_ENDOCYTIC_2	136	139	PF00928	0.379
TRG_ENDOCYTIC_2	174	177	PF00928	0.367
TRG_ENDOCYTIC_2	64	67	PF00928	0.462
TRG_ER_diArg_1	1	3	PF00400	0.517
TRG_ER_diArg_1	247	249	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB7	Leptomonas seymouri	80%	100%
A0A0S4J0Y6	Bodo saltans	47%	100%
A0A1X0P208	Trypanosomatidae	56%	100%
A0A3R7MXF5	Trypanosoma rangeli	59%	100%
A0A3S7X3E5	Leishmania donovani	98%	100%
A4HI59	Leishmania braziliensis	85%	100%
A4I5D5	Leishmania infantum	98%	100%
C9ZQR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B0N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%