Succinate dehydrogenase assembly factor 2, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavinator of succinate dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q7J6_LEIMA

TriTrypDb:

LmjF.30.1070 , LMJLV39_300017100 , LMJSD75_300016700

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q7J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006099	tricarboxylic acid cycle	3	2
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0016043	cellular component organization	3	2
GO:0018293	protein-FAD linkage	5	7
GO:0019538	protein metabolic process	3	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022607	cellular component assembly	4	2
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0034552	respiratory chain complex II assembly	6	2
GO:0034553	mitochondrial respiratory chain complex II assembly	7	2
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045333	cellular respiration	5	7
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.443
CLV_C14_Caspase3-7	173	177	PF00656	0.494
CLV_NRD_NRD_1	146	148	PF00675	0.244
CLV_NRD_NRD_1	218	220	PF00675	0.247
CLV_PCSK_KEX2_1	144	146	PF00082	0.379
CLV_PCSK_KEX2_1	218	220	PF00082	0.294
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.379
CLV_PCSK_SKI1_1	219	223	PF00082	0.317
CLV_PCSK_SKI1_1	225	229	PF00082	0.399
CLV_PCSK_SKI1_1	4	8	PF00082	0.698
DEG_APCC_DBOX_1	168	176	PF00400	0.444
DEG_SCF_FBW7_1	88	95	PF00400	0.471
DEG_SCF_SKP2-CKS1_1	87	94	PF00560	0.470
DOC_CKS1_1	99	104	PF01111	0.520
DOC_MAPK_gen_1	153	162	PF00069	0.444
DOC_MAPK_MEF2A_6	155	164	PF00069	0.444
DOC_USP7_MATH_1	105	109	PF00917	0.543
DOC_USP7_MATH_1	137	141	PF00917	0.447
DOC_USP7_MATH_1	45	49	PF00917	0.502
DOC_USP7_MATH_1	50	54	PF00917	0.514
DOC_WW_Pin1_4	28	33	PF00397	0.540
DOC_WW_Pin1_4	72	77	PF00397	0.468
DOC_WW_Pin1_4	88	93	PF00397	0.642
DOC_WW_Pin1_4	98	103	PF00397	0.617
LIG_14-3-3_CanoR_1	33	39	PF00244	0.592
LIG_BRCT_BRCA1_1	191	195	PF00533	0.444
LIG_BRCT_BRCA1_1	47	51	PF00533	0.484
LIG_BRCT_BRCA1_1	64	68	PF00533	0.489
LIG_EH_1	48	52	PF12763	0.498
LIG_FHA_1	17	23	PF00498	0.493
LIG_FHA_1	224	230	PF00498	0.411
LIG_FHA_1	50	56	PF00498	0.588
LIG_FHA_1	77	83	PF00498	0.468
LIG_FHA_2	126	132	PF00498	0.481
LIG_FHA_2	56	62	PF00498	0.519
LIG_LIR_Gen_1	181	190	PF02991	0.444
LIG_LIR_Gen_1	65	76	PF02991	0.482
LIG_LIR_Nem_3	161	167	PF02991	0.458
LIG_LIR_Nem_3	181	186	PF02991	0.444
LIG_LIR_Nem_3	192	198	PF02991	0.446
LIG_LIR_Nem_3	65	71	PF02991	0.509
LIG_PCNA_PIPBox_1	160	169	PF02747	0.444
LIG_Pex14_2	64	68	PF04695	0.489
LIG_RPA_C_Fungi	4	16	PF08784	0.505
LIG_SH2_CRK	183	187	PF00017	0.280
LIG_SH2_STAP1	183	187	PF00017	0.280
LIG_SH3_3	131	137	PF00018	0.439
LIG_SH3_3	199	205	PF00018	0.349
LIG_SH3_3	93	99	PF00018	0.564
LIG_SUMO_SIM_par_1	16	21	PF11976	0.527
MOD_CDK_SPK_2	28	33	PF00069	0.464
MOD_CDK_SPK_2	72	77	PF00069	0.468
MOD_CDK_SPK_2	92	97	PF00069	0.517
MOD_CDK_SPxK_1	88	94	PF00069	0.472
MOD_CK1_1	124	130	PF00069	0.594
MOD_CK1_1	23	29	PF00069	0.624
MOD_CK1_1	36	42	PF00069	0.528
MOD_CK2_1	105	111	PF00069	0.547
MOD_CK2_1	55	61	PF00069	0.484
MOD_CK2_1	72	78	PF00069	0.471
MOD_GlcNHglycan	25	28	PF01048	0.562
MOD_GlcNHglycan	52	55	PF01048	0.552
MOD_GSK3_1	101	108	PF00069	0.591
MOD_GSK3_1	121	128	PF00069	0.483
MOD_GSK3_1	16	23	PF00069	0.591
MOD_GSK3_1	171	178	PF00069	0.298
MOD_GSK3_1	33	40	PF00069	0.502
MOD_GSK3_1	45	52	PF00069	0.535
MOD_GSK3_1	72	79	PF00069	0.564
MOD_GSK3_1	84	91	PF00069	0.481
MOD_NEK2_1	129	134	PF00069	0.475
MOD_NEK2_1	175	180	PF00069	0.330
MOD_NEK2_1	18	23	PF00069	0.514
MOD_NEK2_1	5	10	PF00069	0.556
MOD_PIKK_1	62	68	PF00454	0.478
MOD_PKA_2	129	135	PF00069	0.445
MOD_Plk_1	175	181	PF00069	0.330
MOD_Plk_1	223	229	PF00069	0.330
MOD_Plk_4	175	181	PF00069	0.330
MOD_ProDKin_1	28	34	PF00069	0.542
MOD_ProDKin_1	72	78	PF00069	0.466
MOD_ProDKin_1	88	94	PF00069	0.640
MOD_ProDKin_1	98	104	PF00069	0.615
MOD_SUMO_for_1	221	224	PF00179	0.422
MOD_SUMO_rev_2	131	140	PF00179	0.416
TRG_DiLeu_BaEn_1	182	187	PF01217	0.280
TRG_DiLeu_BaEn_1	224	229	PF01217	0.394
TRG_DiLeu_BaEn_2	215	221	PF01217	0.280
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.280
TRG_ENDOCYTIC_2	154	157	PF00928	0.280
TRG_ENDOCYTIC_2	183	186	PF00928	0.280
TRG_ER_diArg_1	145	147	PF00400	0.280
TRG_ER_diArg_1	217	219	PF00400	0.349
TRG_NES_CRM1_1	189	203	PF08389	0.280
TRG_NLS_MonoCore_2	143	148	PF00514	0.367
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P987	Leptomonas seymouri	69%	100%
A0A3S7X377	Leishmania donovani	88%	99%
A4HI62	Leishmania braziliensis	71%	100%
A4I5D8	Leishmania infantum	89%	100%
B6HRA4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	30%	75%
E9B0N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q0CSY3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	79%