WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7J4_LEIMA

TriTrypDb:

LmjF.30.1090 , LMJLV39_300017300 , LMJSD75_300016900

Length:

996

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q7J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J4

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0007165	signal transduction	2	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2

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Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003713	transcription coactivator activity	3	2
GO:0140110	transcription regulator activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	605	609	PF00656	0.656
CLV_C14_Caspase3-7	675	679	PF00656	0.670
CLV_NRD_NRD_1	160	162	PF00675	0.577
CLV_NRD_NRD_1	476	478	PF00675	0.661
CLV_NRD_NRD_1	495	497	PF00675	0.319
CLV_NRD_NRD_1	553	555	PF00675	0.656
CLV_NRD_NRD_1	660	662	PF00675	0.557
CLV_NRD_NRD_1	883	885	PF00675	0.580
CLV_PCSK_FUR_1	551	555	PF00082	0.583
CLV_PCSK_KEX2_1	476	478	PF00082	0.661

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA79	Leptomonas seymouri	62%	74%
A0A3R7MCD8	Trypanosoma rangeli	33%	100%
A0A3S7X3B4	Leishmania donovani	92%	100%
A4HI63	Leishmania braziliensis	72%	100%
A4I5E0	Leishmania infantum	92%	100%
E9B0N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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