Putative DREV methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DREV methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q7J3_LEIMA

TriTrypDb:

LmjF.30.1100 , LMJLV39_300017400 , LMJSD75_300017000

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0106370	protein-L-histidine N-pros-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.307
CLV_NRD_NRD_1	154	156	PF00675	0.348
CLV_NRD_NRD_1	177	179	PF00675	0.298
CLV_NRD_NRD_1	297	299	PF00675	0.371
CLV_NRD_NRD_1	95	97	PF00675	0.411
CLV_PCSK_FUR_1	151	155	PF00082	0.411
CLV_PCSK_KEX2_1	153	155	PF00082	0.351
CLV_PCSK_KEX2_1	177	179	PF00082	0.297
CLV_PCSK_KEX2_1	231	233	PF00082	0.328
CLV_PCSK_KEX2_1	299	301	PF00082	0.506
CLV_PCSK_KEX2_1	95	97	PF00082	0.411
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.402
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.497
CLV_PCSK_PC7_1	149	155	PF00082	0.411
CLV_PCSK_SKI1_1	18	22	PF00082	0.479
CLV_PCSK_SKI1_1	61	65	PF00082	0.376
CLV_PCSK_SKI1_1	95	99	PF00082	0.351
CLV_Separin_Metazoa	268	272	PF03568	0.399
DEG_Nend_UBRbox_3	1	3	PF02207	0.605
DOC_MAPK_JIP1_4	207	213	PF00069	0.399
DOC_MAPK_MEF2A_6	207	216	PF00069	0.330
DOC_MAPK_MEF2A_6	256	265	PF00069	0.411
DOC_PP2B_LxvP_1	98	101	PF13499	0.411
DOC_USP7_MATH_1	108	112	PF00917	0.204
DOC_USP7_MATH_1	25	29	PF00917	0.360
DOC_WW_Pin1_4	104	109	PF00397	0.402
LIG_14-3-3_CanoR_1	246	251	PF00244	0.348
LIG_14-3-3_CanoR_1	26	30	PF00244	0.407
LIG_14-3-3_CanoR_1	55	60	PF00244	0.433
LIG_14-3-3_CanoR_1	74	81	PF00244	0.130
LIG_AP2alpha_2	164	166	PF02296	0.343
LIG_APCC_ABBA_1	159	164	PF00400	0.343
LIG_DLG_GKlike_1	246	254	PF00625	0.348
LIG_DLG_GKlike_1	55	62	PF00625	0.379
LIG_FHA_1	104	110	PF00498	0.434
LIG_FHA_1	127	133	PF00498	0.316
LIG_FHA_1	25	31	PF00498	0.352
LIG_FHA_1	46	52	PF00498	0.339
LIG_FHA_1	89	95	PF00498	0.383
LIG_GBD_Chelix_1	64	72	PF00786	0.360
LIG_Integrin_RGD_1	300	302	PF01839	0.574
LIG_IRF3_LxIS_1	8	13	PF10401	0.471
LIG_LIR_Gen_1	112	123	PF02991	0.376
LIG_LIR_Gen_1	286	295	PF02991	0.292
LIG_LIR_Gen_1	66	72	PF02991	0.356
LIG_LIR_Nem_3	112	118	PF02991	0.337
LIG_LIR_Nem_3	176	182	PF02991	0.335
LIG_LIR_Nem_3	286	290	PF02991	0.292
LIG_LIR_Nem_3	66	70	PF02991	0.350
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.413
LIG_Pex14_2	67	71	PF04695	0.399
LIG_RPA_C_Fungi	50	62	PF08784	0.397
LIG_RPA_C_Fungi	69	81	PF08784	0.175
LIG_SH2_CRK	287	291	PF00017	0.307
LIG_SH2_STAT5	11	14	PF00017	0.555
LIG_SH2_STAT5	140	143	PF00017	0.396
LIG_SH2_STAT5	179	182	PF00017	0.378
LIG_SH2_STAT5	277	280	PF00017	0.307
LIG_SH3_3	213	219	PF00018	0.291
LIG_SH3_3	258	264	PF00018	0.291
LIG_SH3_3	98	104	PF00018	0.394
LIG_TYR_ITIM	285	290	PF00017	0.376
LIG_UBA3_1	198	207	PF00899	0.376
MOD_CK1_1	28	34	PF00069	0.243
MOD_CK1_1	73	79	PF00069	0.292
MOD_GlcNHglycan	12	15	PF01048	0.446
MOD_GSK3_1	104	111	PF00069	0.412
MOD_GSK3_1	24	31	PF00069	0.351
MOD_GSK3_1	246	253	PF00069	0.291
MOD_GSK3_1	51	58	PF00069	0.320
MOD_GSK3_1	66	73	PF00069	0.373
MOD_N-GLC_1	55	60	PF02516	0.351
MOD_NEK2_1	10	15	PF00069	0.466
MOD_NEK2_1	144	149	PF00069	0.404
MOD_NEK2_1	202	207	PF00069	0.286
MOD_NEK2_1	250	255	PF00069	0.333
MOD_NEK2_1	51	56	PF00069	0.397
MOD_NEK2_1	72	77	PF00069	0.316
MOD_PKA_1	231	237	PF00069	0.358
MOD_PKA_2	202	208	PF00069	0.307
MOD_PKA_2	231	237	PF00069	0.358
MOD_PKA_2	25	31	PF00069	0.438
MOD_PKA_2	270	276	PF00069	0.411
MOD_PKA_2	73	79	PF00069	0.326
MOD_PKB_1	53	61	PF00069	0.438
MOD_Plk_1	142	148	PF00069	0.223
MOD_Plk_1	250	256	PF00069	0.294
MOD_Plk_1	45	51	PF00069	0.376
MOD_Plk_1	55	61	PF00069	0.266
MOD_Plk_4	114	120	PF00069	0.291
MOD_Plk_4	194	200	PF00069	0.358
MOD_Plk_4	25	31	PF00069	0.427
MOD_Plk_4	55	61	PF00069	0.324
MOD_Plk_4	66	72	PF00069	0.366
MOD_ProDKin_1	104	110	PF00069	0.402
TRG_DiLeu_BaEn_2	45	51	PF01217	0.411
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.376
TRG_ENDOCYTIC_2	157	160	PF00928	0.291
TRG_ENDOCYTIC_2	179	182	PF00928	0.293
TRG_ENDOCYTIC_2	287	290	PF00928	0.291
TRG_ER_diArg_1	150	153	PF00400	0.356
TRG_ER_diArg_1	16	19	PF00400	0.428
TRG_ER_diArg_1	177	179	PF00400	0.335
TRG_ER_diArg_1	297	300	PF00400	0.411
TRG_ER_diArg_1	52	55	PF00400	0.454
TRG_ER_diArg_1	94	96	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ8	Leptomonas seymouri	73%	100%
A0A0S4J0V6	Bodo saltans	48%	100%
A0A1X0P223	Trypanosomatidae	53%	91%
A0A3Q8IJA6	Leishmania donovani	96%	99%
A0A3S5ISQ6	Trypanosoma rangeli	52%	98%
A4HI64	Leishmania braziliensis	83%	99%
A4I5E1	Leishmania infantum	95%	99%
C9ZQS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	95%
E9B0N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0VCJ8	Bos taurus	38%	95%
Q5ZMH6	Gallus gallus	37%	94%
Q9EPL4	Mus musculus	40%	95%
Q9H1A3	Homo sapiens	39%	95%
V5DQR7	Trypanosoma cruzi	54%	96%