Putative DREV methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DREV methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q7J3_LEIMA

TriTrypDb:

LmjF.30.1100 , LMJLV39_300017400 , LMJSD75_300017000

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0106370	protein-L-histidine N-pros-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.307
CLV_NRD_NRD_1	154	156	PF00675	0.348
CLV_NRD_NRD_1	177	179	PF00675	0.298
CLV_NRD_NRD_1	297	299	PF00675	0.371
CLV_NRD_NRD_1	95	97	PF00675	0.411
CLV_PCSK_FUR_1	151	155	PF00082	0.411
CLV_PCSK_KEX2_1	153	155	PF00082	0.351
CLV_PCSK_KEX2_1	177	179	PF00082	0.297
CLV_PCSK_KEX2_1	231	233	PF00082	0.328
CLV_PCSK_KEX2_1	299	301	PF00082	0.506

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ8	Leptomonas seymouri	73%	100%
A0A0S4J0V6	Bodo saltans	48%	100%
A0A1X0P223	Trypanosomatidae	53%	91%
A0A3Q8IJA6	Leishmania donovani	96%	99%
A0A3S5ISQ6	Trypanosoma rangeli	52%	98%
A4HI64	Leishmania braziliensis	83%	99%
A4I5E1	Leishmania infantum	95%	99%
C9ZQS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	95%
E9B0N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0VCJ8	Bos taurus	38%	95%

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