Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q7J2_LEIMA

TriTrypDb:

LmjF.30.1110 , LMJLV39_300017500 , LMJSD75_300017100

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7J2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.690
CLV_NRD_NRD_1	144	146	PF00675	0.715
CLV_NRD_NRD_1	355	357	PF00675	0.628
CLV_NRD_NRD_1	427	429	PF00675	0.791
CLV_NRD_NRD_1	50	52	PF00675	0.616
CLV_NRD_NRD_1	617	619	PF00675	0.641
CLV_PCSK_FUR_1	614	618	PF00082	0.687
CLV_PCSK_KEX2_1	112	114	PF00082	0.690
CLV_PCSK_KEX2_1	144	146	PF00082	0.705
CLV_PCSK_KEX2_1	354	356	PF00082	0.620
CLV_PCSK_KEX2_1	429	431	PF00082	0.793
CLV_PCSK_KEX2_1	50	52	PF00082	0.616
CLV_PCSK_KEX2_1	504	506	PF00082	0.449
CLV_PCSK_KEX2_1	515	517	PF00082	0.429
CLV_PCSK_KEX2_1	614	616	PF00082	0.593
CLV_PCSK_KEX2_1	617	619	PF00082	0.634
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.793
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.449
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.429
CLV_PCSK_SKI1_1	150	154	PF00082	0.792
CLV_PCSK_SKI1_1	20	24	PF00082	0.606
CLV_PCSK_SKI1_1	484	488	PF00082	0.566
CLV_PCSK_SKI1_1	504	508	PF00082	0.282
CLV_PCSK_SKI1_1	515	519	PF00082	0.414
DEG_APCC_DBOX_1	591	599	PF00400	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DOC_MAPK_gen_1	188	196	PF00069	0.595
DOC_MAPK_gen_1	213	222	PF00069	0.595
DOC_MAPK_gen_1	601	610	PF00069	0.595
DOC_MAPK_MEF2A_6	215	224	PF00069	0.703
DOC_MAPK_MEF2A_6	334	342	PF00069	0.526
DOC_PP1_RVXF_1	337	343	PF00149	0.472
DOC_PP1_RVXF_1	561	567	PF00149	0.606
DOC_PP2B_LxvP_1	140	143	PF13499	0.745
DOC_PP2B_LxvP_1	292	295	PF13499	0.565
DOC_PP2B_LxvP_1	404	407	PF13499	0.717
DOC_USP7_MATH_1	16	20	PF00917	0.650
DOC_USP7_MATH_1	182	186	PF00917	0.584
DOC_USP7_MATH_1	237	241	PF00917	0.821
DOC_USP7_MATH_1	492	496	PF00917	0.376
DOC_WW_Pin1_4	267	272	PF00397	0.548
DOC_WW_Pin1_4	333	338	PF00397	0.621
DOC_WW_Pin1_4	457	462	PF00397	0.501
DOC_WW_Pin1_4	488	493	PF00397	0.487
LIG_14-3-3_CanoR_1	339	343	PF00244	0.483
LIG_14-3-3_CanoR_1	440	445	PF00244	0.517
LIG_14-3-3_CanoR_1	563	567	PF00244	0.541
LIG_Actin_WH2_2	468	486	PF00022	0.547
LIG_BIR_III_4	235	239	PF00653	0.735
LIG_BRCT_BRCA1_1	42	46	PF00533	0.505
LIG_DLG_GKlike_1	440	448	PF00625	0.519
LIG_EH1_1	544	552	PF00400	0.517
LIG_eIF4E_1	545	551	PF01652	0.518
LIG_FHA_1	204	210	PF00498	0.520
LIG_FHA_1	270	276	PF00498	0.472
LIG_FHA_1	3	9	PF00498	0.471
LIG_FHA_1	522	528	PF00498	0.413
LIG_FHA_1	530	536	PF00498	0.492
LIG_FHA_1	563	569	PF00498	0.516
LIG_FHA_2	348	354	PF00498	0.548
LIG_FHA_2	80	86	PF00498	0.648
LIG_LIR_Gen_1	174	183	PF02991	0.596
LIG_LIR_Gen_1	43	53	PF02991	0.532
LIG_LIR_Nem_3	174	180	PF02991	0.513
LIG_LIR_Nem_3	254	258	PF02991	0.729
LIG_LIR_Nem_3	290	296	PF02991	0.461
LIG_LIR_Nem_3	43	49	PF02991	0.590
LIG_LIR_Nem_3	531	537	PF02991	0.531
LIG_MYND_1	105	109	PF01753	0.541
LIG_NRBOX	440	446	PF00104	0.518
LIG_NRBOX	545	551	PF00104	0.523
LIG_Pex14_1	9	13	PF04695	0.588
LIG_SH2_CRK	255	259	PF00017	0.733
LIG_SH2_CRK	44	48	PF00017	0.472
LIG_SH2_CRK	490	494	PF00017	0.492
LIG_SH2_NCK_1	13	17	PF00017	0.646
LIG_SH2_NCK_1	199	203	PF00017	0.595
LIG_SH2_NCK_1	349	353	PF00017	0.664
LIG_SH2_SRC	13	16	PF00017	0.642
LIG_SH2_STAP1	587	591	PF00017	0.573
LIG_SH2_STAT3	587	590	PF00017	0.640
LIG_SH2_STAT5	167	170	PF00017	0.610
LIG_SH2_STAT5	276	279	PF00017	0.485
LIG_SH2_STAT5	349	352	PF00017	0.663
LIG_SH2_STAT5	534	537	PF00017	0.533
LIG_SH2_STAT5	545	548	PF00017	0.412
LIG_SH2_STAT5	81	84	PF00017	0.649
LIG_SH3_1	136	142	PF00018	0.824
LIG_SH3_1	507	513	PF00018	0.566
LIG_SH3_2	139	144	PF14604	0.804
LIG_SH3_2	510	515	PF14604	0.568
LIG_SH3_3	136	142	PF00018	0.791
LIG_SH3_3	176	182	PF00018	0.595
LIG_SH3_3	507	513	PF00018	0.566
LIG_SH3_3	86	92	PF00018	0.682
LIG_SH3_CIN85_PxpxPR_1	139	144	PF14604	0.792
LIG_SUMO_SIM_par_1	547	554	PF11976	0.483
LIG_TRAF2_1	82	85	PF00917	0.661
LIG_TYR_ITIM	197	202	PF00017	0.595
LIG_WRC_WIRS_1	568	573	PF05994	0.605
LIG_WW_3	141	145	PF00397	0.795
MOD_CDC14_SPxK_1	491	494	PF00782	0.590
MOD_CDK_SPxK_1	333	339	PF00069	0.625
MOD_CDK_SPxK_1	488	494	PF00069	0.591
MOD_CK1_1	184	190	PF00069	0.595
MOD_CK2_1	475	481	PF00069	0.559
MOD_CK2_1	79	85	PF00069	0.574
MOD_GlcNHglycan	239	242	PF01048	0.749
MOD_GlcNHglycan	477	480	PF01048	0.575
MOD_GlcNHglycan	558	561	PF01048	0.586
MOD_GSK3_1	314	321	PF00069	0.613
MOD_GSK3_1	440	447	PF00069	0.570
MOD_GSK3_1	475	482	PF00069	0.574
MOD_GSK3_1	488	495	PF00069	0.415
MOD_GSK3_1	550	557	PF00069	0.443
MOD_N-GLC_1	267	272	PF02516	0.530
MOD_N-GLC_1	345	350	PF02516	0.549
MOD_N-GLC_1	73	78	PF02516	0.607
MOD_N-GLC_2	450	452	PF02516	0.523
MOD_NEK2_1	189	194	PF00069	0.575
MOD_NEK2_1	299	304	PF00069	0.436
MOD_NEK2_1	34	39	PF00069	0.612
MOD_NEK2_1	382	387	PF00069	0.702
MOD_NEK2_1	444	449	PF00069	0.519
MOD_NEK2_1	610	615	PF00069	0.666
MOD_NEK2_1	73	78	PF00069	0.607
MOD_NEK2_2	208	213	PF00069	0.595
MOD_NEK2_2	479	484	PF00069	0.590
MOD_NEK2_2	492	497	PF00069	0.511
MOD_PIKK_1	459	465	PF00454	0.586
MOD_PKA_2	338	344	PF00069	0.493
MOD_PKA_2	49	55	PF00069	0.566
MOD_PKA_2	562	568	PF00069	0.564
MOD_Plk_1	318	324	PF00069	0.587
MOD_Plk_1	34	40	PF00069	0.536
MOD_Plk_1	345	351	PF00069	0.551
MOD_Plk_4	4	10	PF00069	0.455
MOD_Plk_4	440	446	PF00069	0.590
MOD_Plk_4	562	568	PF00069	0.534
MOD_ProDKin_1	267	273	PF00069	0.538
MOD_ProDKin_1	333	339	PF00069	0.625
MOD_ProDKin_1	457	463	PF00069	0.497
MOD_ProDKin_1	488	494	PF00069	0.486
MOD_SUMO_for_1	602	605	PF00179	0.520
MOD_SUMO_rev_2	149	155	PF00179	0.753
MOD_SUMO_rev_2	283	289	PF00179	0.623
MOD_SUMO_rev_2	35	43	PF00179	0.662
MOD_SUMO_rev_2	53	58	PF00179	0.438
TRG_DiLeu_BaEn_4	83	89	PF01217	0.737
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.614
TRG_ENDOCYTIC_2	199	202	PF00928	0.595
TRG_ENDOCYTIC_2	255	258	PF00928	0.733
TRG_ENDOCYTIC_2	296	299	PF00928	0.571
TRG_ENDOCYTIC_2	44	47	PF00928	0.471
TRG_ENDOCYTIC_2	490	493	PF00928	0.494
TRG_ENDOCYTIC_2	534	537	PF00928	0.527
TRG_ENDOCYTIC_2	545	548	PF00928	0.383
TRG_ENDOCYTIC_2	75	78	PF00928	0.533
TRG_ER_diArg_1	112	115	PF00400	0.693
TRG_ER_diArg_1	143	145	PF00400	0.716
TRG_ER_diArg_1	354	356	PF00400	0.615
TRG_ER_diArg_1	49	51	PF00400	0.603
TRG_ER_diArg_1	614	617	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ3	Leptomonas seymouri	72%	72%
A0A0S4IX72	Bodo saltans	35%	84%
A0A1X0P281	Trypanosomatidae	47%	79%
A0A3R7N4R9	Trypanosoma rangeli	46%	80%
A0A3S7X388	Leishmania donovani	99%	100%
A4HI65	Leishmania braziliensis	91%	100%
A4I5E2	Leishmania infantum	99%	100%
C9ZQS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	82%
E9B0P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B929	Trypanosoma cruzi	47%	83%