Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7I9_LEIMA

TriTrypDb:

LmjF.30.1140 , LMJLV39_300017800 , LMJSD75_300017400

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q7I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.492
CLV_NRD_NRD_1	173	175	PF00675	0.696
CLV_PCSK_KEX2_1	133	135	PF00082	0.452
CLV_PCSK_KEX2_1	173	175	PF00082	0.696
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.452
CLV_PCSK_SKI1_1	137	141	PF00082	0.296
DEG_Nend_UBRbox_3	1	3	PF02207	0.762
DEG_ODPH_VHL_1	129	141	PF01847	0.660
DEG_SPOP_SBC_1	50	54	PF00917	0.583
DOC_CYCLIN_RxL_1	149	158	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.599
DOC_MAPK_gen_1	133	141	PF00069	0.681
DOC_PP1_RVXF_1	135	142	PF00149	0.691
DOC_PP1_RVXF_1	150	157	PF00149	0.353
DOC_PP2B_LxvP_1	128	131	PF13499	0.665
DOC_USP7_MATH_1	51	55	PF00917	0.505
DOC_WW_Pin1_4	63	68	PF00397	0.572
DOC_WW_Pin1_4	98	103	PF00397	0.764
LIG_FHA_1	103	109	PF00498	0.686
LIG_FHA_1	122	128	PF00498	0.699
LIG_FHA_1	32	38	PF00498	0.411
LIG_FHA_1	81	87	PF00498	0.364
LIG_GBD_Chelix_1	35	43	PF00786	0.280
LIG_LIR_Gen_1	71	81	PF02991	0.411
LIG_LIR_Nem_3	155	159	PF02991	0.524
LIG_LIR_Nem_3	27	32	PF02991	0.559
LIG_LIR_Nem_3	71	76	PF02991	0.411
LIG_LIR_Nem_3	88	94	PF02991	0.692
LIG_Pex14_2	153	157	PF04695	0.389
LIG_Pex14_2	69	73	PF04695	0.280
LIG_SH2_CRK	91	95	PF00017	0.756
LIG_SH2_STAT5	107	110	PF00017	0.696
LIG_SH2_STAT5	24	27	PF00017	0.763
LIG_SH3_3	113	119	PF00018	0.569
LIG_SH3_3	96	102	PF00018	0.752
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.424
LIG_SUMO_SIM_par_1	33	38	PF11976	0.509
LIG_SUMO_SIM_par_1	8	15	PF11976	0.688
LIG_SUMO_SIM_par_1	82	88	PF11976	0.506
LIG_TYR_ITIM	89	94	PF00017	0.694
LIG_WRC_WIRS_1	153	158	PF05994	0.411
LIG_WRC_WIRS_1	70	75	PF05994	0.353
MOD_CDK_SPK_2	98	103	PF00069	0.764
MOD_CK1_1	155	161	PF00069	0.459
MOD_CK1_1	38	44	PF00069	0.513
MOD_CK1_1	53	59	PF00069	0.331
MOD_CK1_1	72	78	PF00069	0.416
MOD_CK1_1	80	86	PF00069	0.513
MOD_CK2_1	2	8	PF00069	0.655
MOD_CK2_1	98	104	PF00069	0.763
MOD_CMANNOS	167	170	PF00535	0.648
MOD_GlcNHglycan	53	56	PF01048	0.651
MOD_GlcNHglycan	58	61	PF01048	0.660
MOD_GSK3_1	31	38	PF00069	0.485
MOD_GSK3_1	49	56	PF00069	0.408
MOD_GSK3_1	68	75	PF00069	0.362
MOD_GSK3_1	98	105	PF00069	0.674
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	12	17	PF00069	0.634
MOD_NEK2_1	140	145	PF00069	0.408
MOD_NEK2_1	62	67	PF00069	0.506
MOD_NEK2_1	68	73	PF00069	0.328
MOD_NEK2_1	85	90	PF00069	0.416
MOD_NEK2_2	168	173	PF00069	0.524
MOD_PIKK_1	12	18	PF00454	0.759
MOD_PKA_2	102	108	PF00069	0.674
MOD_Plk_1	121	127	PF00069	0.736
MOD_Plk_4	152	158	PF00069	0.369
MOD_Plk_4	161	167	PF00069	0.386
MOD_Plk_4	18	24	PF00069	0.735
MOD_Plk_4	38	44	PF00069	0.205
MOD_Plk_4	77	83	PF00069	0.360
MOD_Plk_4	85	91	PF00069	0.325
MOD_ProDKin_1	63	69	PF00069	0.573
MOD_ProDKin_1	98	104	PF00069	0.763
TRG_DiLeu_BaEn_2	148	154	PF01217	0.389
TRG_ENDOCYTIC_2	91	94	PF00928	0.753
TRG_ER_diArg_1	172	174	PF00400	0.506
TRG_NES_CRM1_1	16	27	PF08389	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z6	Leptomonas seymouri	55%	100%
A0A3S7X3F8	Leishmania donovani	92%	100%
A4HI68	Leishmania braziliensis	76%	100%
A4I5E5	Leishmania infantum	92%	100%
E9B0P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%