MI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MA3 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7I8_LEIMA

TriTrypDb:

LmjF.30.1150 , LMJLV39_300018000 , LMJSD75_300017600

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042274	ribosomal small subunit biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.547
CLV_C14_Caspase3-7	36	40	PF00656	0.585
CLV_C14_Caspase3-7	578	582	PF00656	0.403
CLV_C14_Caspase3-7	789	793	PF00656	0.689
CLV_C14_Caspase3-7	813	817	PF00656	0.788
CLV_MEL_PAP_1	261	267	PF00089	0.330
CLV_NRD_NRD_1	183	185	PF00675	0.323
CLV_NRD_NRD_1	380	382	PF00675	0.407
CLV_NRD_NRD_1	410	412	PF00675	0.442
CLV_NRD_NRD_1	414	416	PF00675	0.438
CLV_NRD_NRD_1	446	448	PF00675	0.455
CLV_NRD_NRD_1	47	49	PF00675	0.384
CLV_NRD_NRD_1	52	54	PF00675	0.385
CLV_NRD_NRD_1	613	615	PF00675	0.253
CLV_NRD_NRD_1	735	737	PF00675	0.366
CLV_NRD_NRD_1	804	806	PF00675	0.487
CLV_NRD_NRD_1	93	95	PF00675	0.454
CLV_PCSK_KEX2_1	112	114	PF00082	0.526
CLV_PCSK_KEX2_1	183	185	PF00082	0.323
CLV_PCSK_KEX2_1	380	382	PF00082	0.410
CLV_PCSK_KEX2_1	414	416	PF00082	0.388
CLV_PCSK_KEX2_1	446	448	PF00082	0.369
CLV_PCSK_KEX2_1	450	452	PF00082	0.333
CLV_PCSK_KEX2_1	51	53	PF00082	0.389
CLV_PCSK_KEX2_1	545	547	PF00082	0.489
CLV_PCSK_KEX2_1	569	571	PF00082	0.230
CLV_PCSK_KEX2_1	735	737	PF00082	0.364
CLV_PCSK_KEX2_1	753	755	PF00082	0.436
CLV_PCSK_KEX2_1	804	806	PF00082	0.506
CLV_PCSK_KEX2_1	95	97	PF00082	0.427
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.526
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.318
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.480
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.230
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.403
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.433
CLV_PCSK_PC7_1	446	452	PF00082	0.418
CLV_PCSK_PC7_1	48	54	PF00082	0.374
CLV_PCSK_SKI1_1	101	105	PF00082	0.513
CLV_PCSK_SKI1_1	118	122	PF00082	0.543
CLV_PCSK_SKI1_1	307	311	PF00082	0.469
CLV_PCSK_SKI1_1	363	367	PF00082	0.293
CLV_PCSK_SKI1_1	387	391	PF00082	0.431
CLV_PCSK_SKI1_1	415	419	PF00082	0.426
CLV_PCSK_SKI1_1	447	451	PF00082	0.323
CLV_PCSK_SKI1_1	570	574	PF00082	0.219
CLV_PCSK_SKI1_1	697	701	PF00082	0.252
CLV_PCSK_SKI1_1	702	706	PF00082	0.252
CLV_PCSK_SKI1_1	735	739	PF00082	0.322
CLV_PCSK_SKI1_1	823	827	PF00082	0.438
CLV_PCSK_SKI1_1	851	855	PF00082	0.295
DEG_APCC_DBOX_1	696	704	PF00400	0.433
DEG_APCC_KENBOX_2	511	515	PF00400	0.669
DEG_Nend_UBRbox_1	1	4	PF02207	0.652
DEG_SCF_FBW7_1	205	211	PF00400	0.505
DEG_SPOP_SBC_1	233	237	PF00917	0.559
DEG_SPOP_SBC_1	330	334	PF00917	0.445
DOC_CKS1_1	205	210	PF01111	0.505
DOC_CYCLIN_RxL_1	304	314	PF00134	0.440
DOC_CYCLIN_RxL_1	446	456	PF00134	0.608
DOC_CYCLIN_RxL_1	631	644	PF00134	0.513
DOC_CYCLIN_RxL_1	678	688	PF00134	0.470
DOC_CYCLIN_RxL_1	732	739	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.526
DOC_MAPK_DCC_7	475	483	PF00069	0.584
DOC_MAPK_gen_1	446	454	PF00069	0.549
DOC_MAPK_gen_1	56	64	PF00069	0.652
DOC_MAPK_MEF2A_6	475	483	PF00069	0.584
DOC_MAPK_MEF2A_6	697	705	PF00069	0.446
DOC_PP1_RVXF_1	262	268	PF00149	0.545
DOC_PP1_RVXF_1	634	641	PF00149	0.513
DOC_PP2B_LxvP_1	705	708	PF13499	0.438
DOC_USP7_MATH_1	102	106	PF00917	0.688
DOC_USP7_MATH_1	148	152	PF00917	0.720
DOC_USP7_MATH_1	163	167	PF00917	0.719
DOC_USP7_MATH_1	208	212	PF00917	0.557
DOC_USP7_MATH_1	29	33	PF00917	0.698
DOC_USP7_MATH_1	325	329	PF00917	0.495
DOC_USP7_MATH_1	330	334	PF00917	0.474
DOC_USP7_MATH_1	498	502	PF00917	0.733
DOC_USP7_MATH_1	525	529	PF00917	0.687
DOC_USP7_MATH_1	81	85	PF00917	0.629
DOC_USP7_MATH_1	819	823	PF00917	0.698
DOC_WW_Pin1_4	204	209	PF00397	0.539
DOC_WW_Pin1_4	332	337	PF00397	0.447
DOC_WW_Pin1_4	365	370	PF00397	0.604
LIG_14-3-3_CanoR_1	212	216	PF00244	0.472
LIG_14-3-3_CanoR_1	264	270	PF00244	0.552
LIG_14-3-3_CanoR_1	33	41	PF00244	0.565
LIG_14-3-3_CanoR_1	380	389	PF00244	0.549
LIG_14-3-3_CanoR_1	414	424	PF00244	0.594
LIG_14-3-3_CanoR_1	451	459	PF00244	0.526
LIG_14-3-3_CanoR_1	563	572	PF00244	0.510
LIG_14-3-3_CanoR_1	574	583	PF00244	0.419
LIG_14-3-3_CanoR_1	63	70	PF00244	0.672
LIG_14-3-3_CanoR_1	711	717	PF00244	0.583
LIG_14-3-3_CanoR_1	809	815	PF00244	0.714
LIG_Actin_WH2_2	295	313	PF00022	0.267
LIG_Actin_WH2_2	350	368	PF00022	0.319
LIG_Actin_WH2_2	839	856	PF00022	0.478
LIG_APCC_ABBA_1	588	593	PF00400	0.419
LIG_BRCT_BRCA1_1	742	746	PF00533	0.499
LIG_CaM_IQ_9	87	103	PF13499	0.586
LIG_EH1_1	618	626	PF00400	0.499
LIG_eIF4E_1	619	625	PF01652	0.513
LIG_FAT_LD_1	424	432	PF03623	0.514
LIG_FHA_1	196	202	PF00498	0.482
LIG_FHA_1	205	211	PF00498	0.494
LIG_FHA_1	235	241	PF00498	0.542
LIG_FHA_1	282	288	PF00498	0.507
LIG_FHA_1	312	318	PF00498	0.405
LIG_FHA_1	453	459	PF00498	0.524
LIG_FHA_1	689	695	PF00498	0.522
LIG_FHA_1	729	735	PF00498	0.497
LIG_FHA_2	324	330	PF00498	0.483
LIG_FHA_2	368	374	PF00498	0.529
LIG_FHA_2	424	430	PF00498	0.545
LIG_FHA_2	466	472	PF00498	0.587
LIG_FHA_2	576	582	PF00498	0.488
LIG_FHA_2	765	771	PF00498	0.487
LIG_FHA_2	795	801	PF00498	0.755
LIG_FHA_2	811	817	PF00498	0.605
LIG_IBAR_NPY_1	617	619	PF08397	0.419
LIG_LIR_Gen_1	392	402	PF02991	0.494
LIG_LIR_Gen_1	463	471	PF02991	0.506
LIG_LIR_Gen_1	584	594	PF02991	0.419
LIG_LIR_Gen_1	597	607	PF02991	0.421
LIG_LIR_Gen_1	739	747	PF02991	0.517
LIG_LIR_Gen_1	758	765	PF02991	0.600
LIG_LIR_Nem_3	239	245	PF02991	0.467
LIG_LIR_Nem_3	392	398	PF02991	0.498
LIG_LIR_Nem_3	463	467	PF02991	0.550
LIG_LIR_Nem_3	571	576	PF02991	0.432
LIG_LIR_Nem_3	584	589	PF02991	0.419
LIG_LIR_Nem_3	593	599	PF02991	0.419
LIG_LIR_Nem_3	613	619	PF02991	0.435
LIG_LIR_Nem_3	644	649	PF02991	0.442
LIG_LIR_Nem_3	739	744	PF02991	0.516
LIG_LIR_Nem_3	758	763	PF02991	0.577
LIG_MLH1_MIPbox_1	742	746	PF16413	0.499
LIG_NRBOX	305	311	PF00104	0.428
LIG_NRBOX	733	739	PF00104	0.557
LIG_OCRL_FandH_1	6	18	PF00620	0.680
LIG_PCNA_yPIPBox_3	647	660	PF02747	0.442
LIG_Pex14_1	755	759	PF04695	0.482
LIG_PTB_Apo_2	614	621	PF02174	0.419
LIG_PTB_Phospho_1	614	620	PF10480	0.419
LIG_SH2_CRK	850	854	PF00017	0.534
LIG_SH2_GRB2like	659	662	PF00017	0.419
LIG_SH2_NCK_1	760	764	PF00017	0.498
LIG_SH2_PTP2	620	623	PF00017	0.499
LIG_SH2_SRC	22	25	PF00017	0.682
LIG_SH2_SRC	477	480	PF00017	0.623
LIG_SH2_STAP1	760	764	PF00017	0.472
LIG_SH2_STAT3	619	622	PF00017	0.419
LIG_SH2_STAT5	292	295	PF00017	0.255
LIG_SH2_STAT5	477	480	PF00017	0.598
LIG_SH2_STAT5	596	599	PF00017	0.513
LIG_SH2_STAT5	620	623	PF00017	0.433
LIG_SH2_STAT5	659	662	PF00017	0.443
LIG_SH2_STAT5	745	748	PF00017	0.470
LIG_SH3_3	478	484	PF00018	0.502
LIG_Sin3_3	395	402	PF02671	0.567
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.531
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.473
LIG_SUMO_SIM_par_1	193	198	PF11976	0.524
LIG_TRAF2_1	275	278	PF00917	0.565
LIG_TRAF2_1	375	378	PF00917	0.591
LIG_TRAF2_1	797	800	PF00917	0.657
LIG_TYR_ITIM	848	853	PF00017	0.525
LIG_WW_3	472	476	PF00397	0.548
MOD_CK1_1	211	217	PF00069	0.547
MOD_CK1_1	328	334	PF00069	0.482
MOD_CK1_1	460	466	PF00069	0.551
MOD_CK1_1	485	491	PF00069	0.665
MOD_CK1_1	5	11	PF00069	0.799
MOD_CK1_1	523	529	PF00069	0.684
MOD_CK1_1	710	716	PF00069	0.573
MOD_CK1_1	786	792	PF00069	0.680
MOD_CK1_1	831	837	PF00069	0.589
MOD_CK2_1	102	108	PF00069	0.677
MOD_CK2_1	365	371	PF00069	0.605
MOD_CK2_1	372	378	PF00069	0.596
MOD_CK2_1	423	429	PF00069	0.544
MOD_CK2_1	465	471	PF00069	0.591
MOD_CK2_1	794	800	PF00069	0.733
MOD_Cter_Amidation	110	113	PF01082	0.466
MOD_GlcNHglycan	4	7	PF01048	0.431
MOD_GlcNHglycan	459	462	PF01048	0.379
MOD_GlcNHglycan	484	487	PF01048	0.525
MOD_GlcNHglycan	494	498	PF01048	0.565
MOD_GlcNHglycan	500	503	PF01048	0.460
MOD_GlcNHglycan	504	507	PF01048	0.596
MOD_GlcNHglycan	527	530	PF01048	0.496
MOD_GlcNHglycan	559	562	PF01048	0.373
MOD_GlcNHglycan	628	631	PF01048	0.241
MOD_GlcNHglycan	722	725	PF01048	0.465
MOD_GlcNHglycan	770	774	PF01048	0.383
MOD_GlcNHglycan	785	788	PF01048	0.377
MOD_GlcNHglycan	830	833	PF01048	0.445
MOD_GSK3_1	195	202	PF00069	0.485
MOD_GSK3_1	204	211	PF00069	0.527
MOD_GSK3_1	232	239	PF00069	0.542
MOD_GSK3_1	29	36	PF00069	0.741
MOD_GSK3_1	301	308	PF00069	0.296
MOD_GSK3_1	325	332	PF00069	0.541
MOD_GSK3_1	453	460	PF00069	0.496
MOD_GSK3_1	493	500	PF00069	0.753
MOD_GSK3_1	520	527	PF00069	0.698
MOD_GSK3_1	736	743	PF00069	0.566
MOD_GSK3_1	824	831	PF00069	0.678
MOD_N-GLC_1	387	392	PF02516	0.425
MOD_N-GLC_1	675	680	PF02516	0.330
MOD_N-GLC_1	688	693	PF02516	0.216
MOD_N-GLC_1	749	754	PF02516	0.372
MOD_N-GLC_1	794	799	PF02516	0.524
MOD_N-GLC_2	133	135	PF02516	0.531
MOD_NEK2_1	150	155	PF00069	0.680
MOD_NEK2_1	234	239	PF00069	0.543
MOD_NEK2_1	301	306	PF00069	0.257
MOD_NEK2_1	372	377	PF00069	0.555
MOD_NEK2_1	452	457	PF00069	0.499
MOD_NEK2_1	62	67	PF00069	0.570
MOD_NEK2_1	685	690	PF00069	0.506
MOD_NEK2_1	769	774	PF00069	0.619
MOD_NEK2_1	783	788	PF00069	0.723
MOD_NEK2_1	826	831	PF00069	0.632
MOD_PIKK_1	441	447	PF00454	0.636
MOD_PIKK_1	62	68	PF00454	0.595
MOD_PIKK_1	710	716	PF00454	0.566
MOD_PK_1	645	651	PF00069	0.525
MOD_PKA_1	380	386	PF00069	0.561
MOD_PKA_2	128	134	PF00069	0.684
MOD_PKA_2	211	217	PF00069	0.548
MOD_PKA_2	263	269	PF00069	0.549
MOD_PKA_2	380	386	PF00069	0.552
MOD_PKA_2	62	68	PF00069	0.672
MOD_PKA_2	710	716	PF00069	0.566
MOD_PKA_2	81	87	PF00069	0.586
MOD_Plk_1	372	378	PF00069	0.644
MOD_Plk_1	675	681	PF00069	0.533
MOD_Plk_1	688	694	PF00069	0.413
MOD_Plk_1	729	735	PF00069	0.523
MOD_Plk_2-3	367	373	PF00069	0.589
MOD_Plk_2-3	37	43	PF00069	0.600
MOD_Plk_2-3	530	536	PF00069	0.654
MOD_Plk_4	211	217	PF00069	0.502
MOD_Plk_4	281	287	PF00069	0.557
MOD_Plk_4	301	307	PF00069	0.180
MOD_Plk_4	337	343	PF00069	0.308
MOD_Plk_4	423	429	PF00069	0.516
MOD_Plk_4	430	436	PF00069	0.501
MOD_Plk_4	675	681	PF00069	0.579
MOD_Plk_4	729	735	PF00069	0.573
MOD_Plk_4	740	746	PF00069	0.563
MOD_Plk_4	810	816	PF00069	0.684
MOD_ProDKin_1	204	210	PF00069	0.535
MOD_ProDKin_1	332	338	PF00069	0.441
MOD_ProDKin_1	365	371	PF00069	0.605
MOD_SUMO_for_1	544	547	PF00179	0.588
MOD_SUMO_rev_2	43	50	PF00179	0.636
MOD_SUMO_rev_2	55	62	PF00179	0.595
MOD_SUMO_rev_2	831	839	PF00179	0.487
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.350
TRG_DiLeu_BaLyEn_6	699	704	PF01217	0.444
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.561
TRG_ENDOCYTIC_2	596	599	PF00928	0.513
TRG_ENDOCYTIC_2	620	623	PF00928	0.419
TRG_ENDOCYTIC_2	659	662	PF00928	0.419
TRG_ENDOCYTIC_2	760	763	PF00928	0.496
TRG_ENDOCYTIC_2	850	853	PF00928	0.545
TRG_ER_diArg_1	182	184	PF00400	0.525
TRG_ER_diArg_1	51	53	PF00400	0.589
TRG_ER_diArg_1	734	736	PF00400	0.563
TRG_ER_diArg_1	803	805	PF00400	0.701
TRG_NES_CRM1_1	534	547	PF08389	0.546
TRG_NLS_MonoExtC_3	410	415	PF00514	0.673
TRG_NLS_MonoExtC_3	93	98	PF00514	0.659
TRG_NLS_MonoExtN_4	409	415	PF00514	0.669
TRG_NLS_MonoExtN_4	92	99	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	681	686	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	702	706	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W4	Leptomonas seymouri	61%	99%
A0A1X0P271	Trypanosomatidae	42%	100%
A0A3S7X3B0	Leishmania donovani	91%	100%
A0A422P4Z6	Trypanosoma rangeli	40%	100%
A4HI69	Leishmania braziliensis	77%	95%
A4I5E6	Leishmania infantum	92%	100%
C9ZQT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B0P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q5C9Z4	Homo sapiens	23%	100%
V5BPM5	Trypanosoma cruzi	38%	100%